Acetylcholine: function, opening and more


acetylcholine is a neuronal transmitter in the central nervous system (CNS). It can also be found in the peripheral nervous system (PNS).Neurotransmitters are chemical signals performed by neurons to send information to related recipients, where the information is obtained or crashed and processed to the necessary actions.Acetylcholine can do both: You can stimulate or block the responses (excite or inhibit) for the desired physiological effects.

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Acetylcholine has many functions in the body.It is produced from the cholinergic nerve of the Synapses and acts on the premiumeric (transmitter) and postsynaptic receptors (receptor) of acetylcholine.

Expand blood vessels

Acetylcholine It is reproduced in regulation of blood pressure.When blood flows, it creates friction, which can be seen in the signaling technology of the image, focusing on the endothelium, the cell barrier between your blood and blood vessels.

An ex vivo (out of the live body) Animal research in the main arteries in the rats found that this friction begins the release of acetylcholine, which causes the calcium excretion of its endothelial cells,The production of nitrogen oxide (well-known Vasodilator uses relaxation or expansion of blood vessels) and the relaxation of the artery. / P>

The clinical trials of man are still necessary before the Science can be completely explain how acetylcholine works to expand blood cells in the human body.

Hire the smooth muscles

Smooth muscles -These are those coverings of the walls of the organs and the tubular structures, including the intestines, the bladder, the airway, uterus , the blood vessels and the stomach.Acetylcholine in a neuromuscular compound (located between the motor nerve and skeletal muscles), acts on nerve fibers, sending messages from the directed muscles, which tells you to respond to the movement.

Heres, as it works, according to the studies performed in mice:

  • Acetylcholine, isolated from nerve endings, is associated with acetylcholine receptors on the surface of the smooth muscles,Causing the opening of the sodium channels. This allows the action potential to navigate through the cells that cause the process that opens the type L of the calcium channel.Then, the
  • carylin is associated with a kinase of the mosine kinase, stimulating phosphorylation (built-in molecule) by a chain of mine light, which leads to a reduction in muscle mass.

Acetylcholine plays an important role in muscle actions, so any medication that affects this neurotransmitter can cause a violation of movement and even paralysis.

Erection causes

The penis Soft muscles, which are actually reduced in your virtial state.As incentives, the bloodstream increases in the region, the cholinergic receptors in the endothelial cells inside the penis are activated by acetylcholine. It offers a relaxing effect that allows an erection.

Decreases the heart rate

Acetylcholine Neurotransmitter prevailing in the parasympathetic nervous system.When its heart rate increases beyond the fact that normally, acetylcholine is released to reduce the speed of your heart rate and abbreviations until it returns to the baseline.

Stimulates the selection

Acetylcholine also works Holiesegic muscarinic receptors in organ organs to stimulate the discharge of the whole gland are susceptible to parasympathetic nerve pulses. Examples


  • digestive glands
  • The salt glands
  • excriny help >

acetylcholine sends messages to the nerve loaths throughnervous systems. All the movements of your body depend on this connection. This means any violation of the operation of acetylcholine in the commitment of this process and can cause a disease.

Acetylcholine in the brain also plays resolution of roles in memory and cognitive functioning. In order, it is associated with higher brain functions and some neurodegenerative diseases of the brain, such as Alzheimer’s.

On the back side, the acetylcholine receivers can be directed and manipulated with medications to adjust how your body works in a disease.

Abnormal muscle function

The colisterigric nerve receivers are those that are obtained and associated with acetylcholine. They can be found throughout the body, even in muscle tissue.If there is a problem with these appropriate receptors or emissions and the absorption of acetylcholine, can lead to an abnormal muscle function . In such cases, anticholinergic medications may be necessary.

Anticholinergic tools are available in the recipe to help treat conditions, such as:

  • urine incontinence urination or incontinence : work in an abnormal contraction of the uterus,What causes the feeling of need to urinate.
  • asthma or other obstructive respiratory disorders : can have a protective effect on the inflammation of the respiratory tract and changes in the respiratory tract due to pathology. ./ Li>
  • Gastrointestinal issues, such as diarrhea : can inhibit gastrointestinal abbreviations.
  • Poisoning to toxins, such as organophosphates, artificial chemicals, which are poisonous for insects and mammals : Certain poisons can work on the same receivers as acetylcholine,And the toxicity of Choline’s DenialSolinergic works works to restore the normal process. / Li>

These medications block the effects of binding to acetylcholines And, therefore, it interferes parasympathetic nerve impulses.Anticholinergic remedies have shown cognitive deceleration effects and more than 70 people should be avoided due to the risk of confusion or hallucination.


, Naturally, Acetylcholine emerging was defined for the first time in 1914 by the British physiologist Sir Henry Dale from London.It was named after its structure. Acetylcholine is made of acetic acid (ethanically acid) and hill (feeder, similar to vitamins B).For more than two decades, Dale and Otto, caught by Graz, shared the Nobel Prize for Physiology or Medicine for work on chemical neurotransmission.

Frequently asked questions

What makes acetylcholine with a heart?

Acetylcholine is crucial in the healthy functioning of your heart.It helps regulate the heartbeat, blood pressure and muscle cuts from the heart.

What enzyme breaks acetylcholine?

Acetylcholinery is a cholinergic enzyme that destroys acetylcholine to acetic acid and the hill.This enzyme was found in postsynaptic neuromuscular compounds, especially in muscles and nerves.

How are acetylcholine decreasing?

You can reduce acetylcholine levels with prescription anticholinergic preparations, but the corresponding drug depends on the body system.For example, the acetylcholine imbalance associated with brain conditions can be processed differently than that of asthmatic conditions. Your doctor can help determine that, if applicable, medicine is needed.

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