Full text biomedical articles

Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

John A. Todd, Marina Evangelou, Antony J. Cutler, Marcin L. Pekalski, Neil M. Walker, Helen E. Stevens, Linsey Porter, Deborah J. Smyth, Daniel B. Rainbow, Ricardo C. Ferreira, Laura Esposito, Kara M. D. Hunter, Kevin Loudon, Kathryn Irons, Jennie H. Yang, Charles J. M. Bell, Helen Schuilenburg, James Heywood, Ben Challis, Sankalpa Neupane, Pamela Clarke, Gillian Coleman, Sarah Dawson, Donna Goymer, Katerina Anselmiova, Jane Kennet, Judy Brown, Sarah L. Caddy, Jia Lu, Jane Greatorex, Ian Goodfellow, Chris Wallace, Tim I. Tree, Mark Evans, Adrian P. Mander, Simon Bond, Linda S. Wicker, Frank Waldron-Lynch
PLoS Med. 2016 Oct; 13(10): e1002139. Published online 2016 Oct 11. doi: 10.1371/journal.pmed.1002139


Article   |   PubReader   |   PDF–4.0M   |   Cite

Failure of low-dose recombinant human IL-2 to support the survival of virus-specific CTL clones infused into severe combined immunodeficient foals: lack of correlation between in vitro activity and in vivo efficacy

Robert H. Mealey, Matt H. Littke, Steven R. Leib, William C. Davis, Travis C. McGuire
Vet Immunol Immunopathol. Author manuscript; available in PMC 2010 Nov 1.
Published in final edited form as: Vet Immunol Immunopathol. 2008 Jan 15; 121(1-2): 8–22. Published online 2007 Jul 25. doi: 10.1016/j.vetimm.2007.07.011


Article   |   PubReader   |   PDF–1.0M   |   Cite

The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes

Eleonora Seelig, James Howlett, Linsey Porter, Lucy Truman, James Heywood, Jane Kennet, Emma L. Arbon, Katerina Anselmiova, Neil M. Walker, Ravinder Atkar, Marcin L. Pekalski, Ed Rytina, Mark Evans, Linda S. Wicker, John A. Todd, Adrian P. Mander, Simon Bond, Frank Waldron-Lynch
JCI Insight. 2018 Oct 4; 3(19): e99306. Published online 2018 Oct 4. doi: 10.1172/jci.insight.99306


Article   |   PubReader   |   PDF–1.2M   |   Cite

The High-Dose Aldesleukin “Select” Trial: A Trial to Prospectively Validate Predictive Models of Response Treatment in Patients with Metastatic Renal Cell Carcinoma

David F. McDermott, Su-Chun Cheng, Sabina Signoretti, Kim A. Margolin, Joseph I. Clark, Jeffrey A. Sosman, Janice P. Dutcher, Theodore F. Logan, Brendan D. Curti, Marc S. Ernstoff, Leonard Appleman, Michael K.K. Wong, Nikhil I. Khushalani, Leslie Oleksowicz, Ulka N. Vaishampayan, James W. Mier, David J. Panka, Rupal S. Bhatt, Alexandra S. Bailey, Bradley C. Leibovich, Eugene D. Kwon, Fairooz F. Kabbinavar, Arie S. Belldegrun, Robert A. Figlin, Allan J. Pantuck, Meredith M. Regan, Michael B. Atkins
Clin Cancer Res. Author manuscript; available in PMC 2016 Feb 1.
Published in final edited form as: Clin Cancer Res. 2015 Feb 1; 21(3): 561–568. Published online 2014 Nov 25. doi: 10.1158/1078-0432.CCR-14-1520


Article   |   PubReader   |   PDF–698K   |   Cite

Molecular insights on the peripheral and intra-tumoral effects of systemic high dose rIL-2 (Aldesleukin) administration for the treatment of metastatic melanoma

Geoffrey R. Weiss, William W. Grosh, Kimberly A. Chianese-Bullock, Yingdong Zhao, Hui Liu, Craig L. Slingluff, Jr, Francesco M Marincola, Ena Wang
Clin Cancer Res. Author manuscript; available in PMC 2012 Dec 1.
Published in final edited form as: Clin Cancer Res. 2011 Dec 1; 17(23): 7440–7450. Published online 2011 Oct 5. doi: 10.1158/1078-0432.CCR-11-1650


Article   |   PubReader   |   PDF–2.0M   |   Cite

FCGR Polymorphisms Influence Response to IL-2 in Metastatic Renal Cell Carcinoma

Amy K Erbe, Wei Wang, Jacob Goldberg, Mikayla Gallenberger, KyungMann Kim, Lakeesha Carmichael, Dustin Hess, Eneida A Mendonca, Yiqiang Song, Jacquelyn A Hank, Su-Chun Cheng, Sabina Signoretti, Michael Atkins, Alexander Carlson, James Mier, David Panka, David F McDermott, Paul M Sondel
Clin Cancer Res. Author manuscript; available in PMC 2018 May 1.
Published in final edited form as: Clin Cancer Res. 2017 May 1; 23(9): 2159–2168. Published online 2016 Oct 14. doi: 10.1158/1078-0432.CCR-16-1874


Article   |   PubReader   |   PDF–1.1M   |   Cite

Low-dose interleukin-2 in patients with stable ischaemic heart disease and acute coronary syndromes (LILACS): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase I/II clinical trial

Tian Xiao Zhao, Michalis Kostapanos, Charmaine Griffiths, Emma L Arbon, Annette Hubsch, Fotini Kaloyirou, Joanna Helmy, Stephen P Hoole, James H F Rudd, Graham Wood, Keith Burling, Simon Bond, Joseph Cheriyan, Ziad Mallat
BMJ Open. 2018; 8(9): e022452. Published online 2018 Sep 17. doi: 10.1136/bmjopen-2018-022452


Article   |   PubReader   |   PDF–983K   |   Cite

Thrombotic Microangiopathy In Metastatic Melanoma Patients Treated with Adoptive Cell Therapy and Total Body Irradiation

Jennifer Tseng, Deborah E. Citrin, Meryl Waldman, Donald E. White, Steven A. Rosenberg, James C. Yang
Cancer. Author manuscript; available in PMC 2015 May 1.
Published in final edited form as: Cancer. 2014 May 1; 120(9): 1426–1432. Published online 2014 Jan 28. doi: 10.1002/cncr.28547


Article   |   PubReader   |   PDF–482K   |   Cite

Clinical and Immunologic Effects of Intranodal Autologous Tumor Lysate-Dendritic Cell Vaccine with Aldesleukin (Interleukin 2) and IFN-α2a Therapy in Metastatic Renal Cell Carcinoma Patients

Thomas Schwaab, Adrian Schwarzer, Benita Wolf, Todd S. Crocenzi, John D. Seigne, Nancy A. Crosby, Bernard F. Cole, Jan L. Fisher, Jill C. Uhlenhake, Diane Mellinger, Cathy Foster, Zbigniew M. Szczepiorkowski, Susan M. Webber, Alan R. Schned, Robert D. Harris, Richard J. Barth, Jr., John A. Heaney, Randolph J. Noelle, Marc S. Ernstoff
Clin Cancer Res. Author manuscript; available in PMC 2013 Sep 17.
Published in final edited form as: Clin Cancer Res. 2009 Aug 1; 15(15): 4986–4992. Published online 2009 Jul 21. doi: 10.1158/1078-0432.CCR-08-3240


Article   |   PubReader   |   PDF–759K   |   Cite

Thyroid Dysfunction from Antineoplastic Agents

Ole-Petter Riksfjord Hamnvik, P. Reed Larsen, Ellen Marqusee
J Natl Cancer Inst. 2011 Nov 2; 103(21): 1572–1587. Published online 2011 Oct 18. doi: 10.1093/jnci/djr373


Article   |   PubReader   |   PDF–772K   |   Cite

Humanized Mouse as a Tool to Predict Immunotoxicity of Human Biologics

Kylie Su Mei Yong, Zhisheng Her, Sue Yee Tan, Wilson Wei Sheng Tan, Min Liu, Fritz Lai, Shi Min Heng, Yong Fan, Kenneth Tou En Chang, Cheng-I Wang, Jerry Kok Yen Chan, Jianzhu Chen, Qingfeng Chen
Front Immunol. 2020; 11: 553362. Published online 2020 Oct 15. doi: 10.3389/fimmu.2020.553362


Article   |   PubReader   |   PDF–1.9M   |   Cite

Long-Term Effects of Intermittent IL-2 in HIV Infection: Extended Follow-Up of the INSIGHT STALWART Study

Norman Markowitz, Gustavo Lopardo, Deborah Wentworth, Daniela Gey, Abdel Babiker, Lawrence Fox, Jorge Tavel, STALWART Study Group
PLoS One. 2012; 7(10): e47506. Published online 2012 Oct 17. doi: 10.1371/journal.pone.0047506


Article   |   PubReader   |   PDF–507K   |   Cite

Low‐dose interleukin‐2 promotes STAT‐5 phosphorylation, Treg survival and CTLA‐4‐dependent function in autoimmune liver diseases

H. C. Jeffery, L. E. Jeffery, P. Lutz, M. Corrigan, G. J. Webb, G. M. Hirschfield, D. H. Adams, Y. H. Oo
Clin Exp Immunol. 2017 Jun; 188(3): 394–411. Published online 2017 Mar 20. doi: 10.1111/cei.12940


Article   |   PubReader   |   PDF–1.0M   |   Cite

Impact of Sequencing Targeted Therapies With High-dose Interleukin-2 Immunotherapy: An Analysis of Outcome and Survival of Patients With Metastatic Renal Cell Carcinoma From an On-going Observational IL-2 Clinical Trial: PROCLAIMSM

Joseph I. Clark, Michael K.K. Wong, Howard L. Kaufman, Gregory A. Daniels, Michael A. Morse, David F. McDermott, Sanjiv S. Agarwala, Lionel D. Lewis, John H. Stewart, Ulka Vaishampayan, Brendan Curti, René Gonzalez, Jose Lutzky, Venkatesh Rudraptna, Lee D. Cranmer, Joanne M. Jeter, Ralph J. Hauke, Gerald Miletello, Mohammed M. Milhem, Asim Amin, John M. Richart, Mayer Fishman, Sigrun Hallmeyer, Sapna P. Patel, Peter Van Veldhuizen, Neeraj Agarwal, Bret Taback, Jonathan S. Treisman, Marc S. Ernstoff, Jessica C. Perritt, Hong Hua, Tharak B. Rao, Janice P. Dutcher, Sandra Aung
Clin Genitourin Cancer. Author manuscript; available in PMC 2019 Nov 25.
Published in final edited form as: Clin Genitourin Cancer. 2017 Feb; 15(1): 31–41.e4. Published online 2016 Oct 29. doi: 10.1016/j.clgc.2016.10.008


Article   |   PubReader   |   PDF–868K   |   Cite

Differential Gene Expression in Response to Adjunctive Recombinant Human Interleukin-2 Immunotherapy in Multidrug-Resistant Tuberculosis Patients

Barbara J. Johnson, Iris Estrada, Zhu Shen, Stan Ress, Paul Willcox, M. Joseph Colston, Gilla Kaplan
Infect Immun. 1998 Jun; 66(6): 2426–2433.


Article   |   PubReader   |   PDF–739K   |   Cite

Locoregional IL-2 low dose applications for gastrointestinal tumors

Zachary Krastev, V Koltchakov, R Tomova, S Deredjian, A Alexiev, D Popov, B Tomov, Jan-Willem Koten, John Jacobs, Willem Den Otter
World J Gastroenterol. 2005 Sep 21; 11(35): 5525–5529. Published online 2005 Sep 21. doi: 10.3748/wjg.v11.i35.5525


Article   |   PubReader   |   PDF–329K   |   Cite

Interleukin-2 Therapy Induces CD4 Downregulation, Which Decreases Circulating CD4 T Cell Counts, in African Green Monkeys

Joseph C. Mudd, Molly R. Perkins, Sarah R. DiNapoli, Vanessa M. Hirsch, Jason M. Brenchley
J Virol. 2016 Jun 15; 90(12): 5750–5758. Prepublished online 2016 Apr 6. Published online 2016 May 27. doi: 10.1128/JVI.00057-16


Article   |   PubReader   |   PDF–2.3M   |   Cite

NK cell expression of natural cytotoxicity receptors may determine relapse risk in older AML patients undergoing immunotherapy for remission maintenance

Anna Martner, Anna Rydström, Rebecca E. Riise, Johan Aurelius, Mats Brune, Robin Foà, Kristoffer Hellstrand, Fredrik B. Thorén
Oncotarget. 2015 Dec 15; 6(40): 42569–42574. Published online 2015 Oct 30. doi: 10.18632/oncotarget.5559


Article   |   PubReader   |   PDF–1.9M   |   Cite

Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells

Charles J.M. Bell, Yongliang Sun, Urszula M. Nowak, Jan Clark, Sarah Howlett, Marcin L. Pekalski, Xin Yang, Oliver Ast, Inja Waldhauer, Anne Freimoser-Grundschober, Ekkehard Moessner, Pablo Umana, Christian Klein, Ralf J. Hosse, Linda S. Wicker, Laurence B. Peterson
J Autoimmun. 2015 Jan; 56: 66–80. doi: 10.1016/j.jaut.2014.10.002


Article   |   PubReader   |   PDF–1.8M   |   Cite

Antibiotic Agents Separated from the Root of Lace-leaved Leptotaenia

H. J. Carlson, H. G. Douglas
J Bacteriol. 1948 May; 55(5): 615–621.


Summary   |   Page Browse   |   PDF–770K   |   Cite