Alfa-ketoglutarian acid: advantages, side effects, dose.

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Alpha-ketoglutaric acid is a biological connection that is naturally found in the human body. Touch a key role in the Krebs cycle a series of chemical reactions used to release stored energy.It is said that alpha-ketoglutaric acid offers various health benefits, including advanced sports features and improved metabolism.

Alpha-glutaric acid can not be obtained from food.Rather, it is synthesized by insignificant amino acids that the body produces its own cells. It is also available in the form of a food additive.

Many of the statements about the advantages of alpha-ketoglutarian acid are based on how it works in the body, including its role in the regulation of the immune system and the development of bones.But when taking alpha-ketoglutarian acid in the form of a supplement, it can increase these biological functions, it is not sure at best.

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  • Alfa ketoglutarat
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  • 2-oxoglutarate
  • 2-oxoglutaric acid

What is alpha? Ketogolutarized acid?

heart surgery , alpha-acidKetoglutaric is sometimes delivered intravenously (in Vienna) to reduce the damage to the heart muscle due to the reduction of blood. It can also improve the flow of blood to the kidneys after surgery.

its use as an additive is much less than defined.Alternative practices believe that alpha-acidKetoglutaric can be treated or prevented a wide range of health states, including:

due to its role in the release of stored energy, alpha ketoglutarized acid is often sold as an additional supplement of sports products.Complete supporters even affirm that the antioxidant effects of additives can slow aging.

, as often happens in the case of additives, they argue with respect to several unrelated conditions, the evidence confirms these claims; An incredible border.For example, approvals on the ‘anti-aging’ properties of additives are mainly based on the 2014 research with the participation of nematode worms.

With this, several early studies insinuated the possible advantages of alpha-ketoglutaric acid. This is what some of the current studies say; Additional studies are necessary.

Chronic kidney disease

Alfa-Kebetoglutaric acid used since the end of 1990 – X years to help break and absorb protein in people in hemodialisis , which requires a low voltage diet.The creation of evidence suggests that it can also stop the need for dialysis in people with advanced chronic kidney disease (CKD).

In the 2017 study, published in the Plos One Journal, scientific researchers were identified and followed 1,483 people with advanced ECD, which used alpha-ketoglutaric acid, called Keosterina .The average duration of the observation was 1.57 years.

Compared to an assigned set of people who did not accept the supplement, those who had less likely to take long-term dialysis.The advantages extend only to those who took more than 5.5 tablets per day pointing to the effects. Another investigation would have to explore this.

Gastrointestinal health

Alfetoglutarin additives are considered anti-catabolic, which means that slowly or prevent catabolism (Breakdown of the tissue).

Study in 2012 in Italian magazine Italian reported that alpha-ceetogurtural acid prevented the destruction of the intestine in laboratory rats, fueled a protein diet for 14 days.Instead of experiencing damage to the finger, similar to the fingers Villi of the intestine of the expected result and what happened in non-priming acid, Fed-Alpha-Ketoglutaric, did not have visible intestinal damage.

In addition, rats, provided that the additives could maintain normal growth, despite the general absence of proteins. Higher doses assigned even to the best results.The conclusions apparently support the anti-catabolic effects of alpha-ketogolithic acid.In addition to its use in chronic kidney disease, renal alpha-ketoglutaric acid can also help people with intestinal toxemia and malabsortium disorders, such as <> celiacs . More research is needed.

Sports features

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Opposite, alpha-ketoglutaric anticatabolic effects The acid apparently falls when it comes to the growth of muscles and sports features.

According to the 2012 study in the Magazine of the International Society of Sports Nutrition, Alfa-ketoglutarized acid did not have a tangible effect on muscle strength or resistance in 16 people of Resistance to training.

The study participated both with trained men and without preparation. Half gave him 3000 milligrams (mg) alpha-ketoglutarian acid, while the Another half received placebo 45 minutes before making a label and press press press.

After performing this procedure for seven days in a row, men gave the opposite drug to precede their training in the next seven days.

Sports performance was based on a total load exercise (TLV) performed on tandem from heart rate before and after exercise.On the basis of the conclusions of alpha-ketoglutarian acid, there was no statistical improvement in the resistance of the upper or lower part of the body, nor the aerobic capacity of the athletes.

What shows these results is the lack of a catabolic response, this is not the same as anabolic (tissue construction).

Possible side effects

Alpha-ketoglutaric acid is considered safe and well tolerable.Studies that investigate the influence of alpha-ketoglutarian acid reported several negative symptoms after three years of use.

As a compound made of insignificant amino acids, alpha-ketoglutaric acid is not a substance in which it can easily overdose.Any excess in the body will be displayed in the urine or will be divided into basic blocks of amino acid construction for other purposes.

With what she said, the safety of alpha-ketogolutaric acid, which represents women, mothers and children of nursing.It has not been established. This includes children with rare metabolic disorders, such as deficiency of alpha-ketogluta dehydrogenase, in which alpha-ketoglutaric acid levels are not normalized.

Be sure, always talk to your doctor, pediatrician or ob / gyn before using alpha-ketoglutarian acid or any other nutritional supplement.

It is unknown if alpha-ketoguarty acids can interact with other medications.

Get information Meds / Anastasia Tretiak

Dosage and Preparation

alpha-The additives to ketic acids are available on tablets, capsules and powder shapes and can be easily found on the Internet or in specialized stores in dietary additives.

There are no universal guidelines for the proper use of alpha-ketoglitarian acids. Accessories are generally sold at doses of 300 to 1000 mg, facts once a day with or without food.The doses of up to 3000 mg were used in studies without side effects.

As a general rule, it never exceeds the dose on the product label.

What to look for

Nutritional supplements in the United States are not strictly adjustable.To ensure quality and safety, select the marks that are voluntarily represented in testing an independent certification body, such as US Pharmacopeus. Pharmacopeia (USP), Thumblab or NSF International.Therefore, you can be sure that the additives contain the ingredients listed on the product label.

In addition, mark the label to add ingredients or fillings, especially if you are allergic to wheat or other general allergens.If I doubt, look for marked marks with ‘hypoallergenic’. ‘

Most additives for alpha-ketoglutic acids can be stored at room temperature for 12 months or more if stored in the original hermetic container.Never use the addition to your expiration date.

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