References from scientific journals

Alitretinoin.

Cheer SM, Foster RH. Cheer SM, et al. Am J Clin Dermatol. 2000 Sep-Oct;1(5):307-14; discussion 315-6. doi: 10.2165/00128071-200001050-00005. Am J Clin Dermatol. 2000. PMID: 11702321 Review.

Alitretinoin is a retinoid receptor pan-agonist, which has been investigated in the treatment of Kaposi's sarcoma (KS). Binding with high affinity to all known retinoid receptors, alitretinoin is thought to regulate proliferation, differentiation, and apoptosis of K …
Alitretinoin is a retinoid receptor pan-agonist, which has been investigated in the treatment of Kaposi's sarcoma (KS). Binding with …

Alitretinoin: A Review in Severe Chronic Hand Eczema.

Blair HA, Scott LJ. Blair HA, et al. Drugs. 2016 Sep;76(13):1271-1279. doi: 10.1007/s40265-016-0621-0. Drugs. 2016. PMID: 27438290 Review.

This article updates an earlier review of alitretinoin in this indication, focusing on recently published data. ...Thus, oral alitretinoin is a useful treatment option for patients with severe chronic hand eczema unresponsive to potent topical corticosteroids....
This article updates an earlier review of alitretinoin in this indication, focusing on recently published data. ...Thus, oral alit …

[Alitretinoin (Toctino): Recent pharmacovigilance data].

Schmutz JL. Schmutz JL. Ann Dermatol Venereol. 2020 Apr;147(4):329-330. doi: 10.1016/j.annder.2020.01.002. Epub 2020 Mar 4. Ann Dermatol Venereol. 2020. PMID: 32145989 French. No abstract available.


Oral alitretinoin: a review of the clinical pharmacokinetics and pharmacodynamics.

Schmitt-Hoffmann AH, Roos B, Schoetzau A, Leese PT, Meyer I, van de Wetering J, Kovacs P. Schmitt-Hoffmann AH, et al. Expert Rev Clin Pharmacol. 2012 Jul;5(4):373-88. doi: 10.1586/ecp.12.26. Expert Rev Clin Pharmacol. 2012. PMID: 22943117 Review.

Alitretinoin is an endogenous retinoid related to vitamin A. Studies have shown that oral alitretinoin is effective and well tolerated in the treatment of severe chronic hand eczema. This review summarizes the clinical pharmacokinetic and pharmacodynamic data from a …
Alitretinoin is an endogenous retinoid related to vitamin A. Studies have shown that oral alitretinoin is effective and well t …

Alitretinoin: An Update of Real-World Evidence in The Management of Chronic Hand Dermatitis.

Gooderham MJ. Gooderham MJ. Skin Therapy Lett. 2018 Jul;23(4):1-4. Skin Therapy Lett. 2018. PMID: 30086182 Free article. Review.

Chronic hand dermatitis is a debilitating inflammatory dermatosis that has a significant impact on the quality of life of those affected. Alitretinoin is an oral retinoid which has proven efficacy and safety in the treatment of chronic hand dermatitis through randomized co …
Chronic hand dermatitis is a debilitating inflammatory dermatosis that has a significant impact on the quality of life of those affected. …

Alitretinoin: a comprehensive review.

Cheng C, Michaels J, Scheinfeld N. Cheng C, et al. Expert Opin Investig Drugs. 2008 Mar;17(3):437-43. doi: 10.1517/13543784.17.3.437. Expert Opin Investig Drugs. 2008. PMID: 18321241 Review.

RESULTS/CONCLUSIONS: Orally administered alitretinoin is a safe and effective treatment for chronic hand dermatitis. ...Despite these benefits, oral alitretinoin will face a difficult path attaining approval for use in the US....
RESULTS/CONCLUSIONS: Orally administered alitretinoin is a safe and effective treatment for chronic hand dermatitis. ...Despite these …

Alitretinoin for palmoplantar keratodermas: A novel case and review of the literature.

Balestri R, Magnano M, Savoia F, Patrizi A, Neri I. Balestri R, et al. Dermatol Ther. 2019 Mar;32(2):e12794. doi: 10.1111/dth.12794. Epub 2018 Dec 26. Dermatol Ther. 2019. PMID: 30515925 Review. No abstract available.


Oral Alitretinoin for Patients with Refractory Prurigo.

Chung BY, Um JY, Kang SY, Jung MJ, Kim JC, Kwak IS, Park CW, Kim HO. Chung BY, et al. Medicina (Kaunas). 2020 Nov 9;56(11):599. doi: 10.3390/medicina56110599. Medicina (Kaunas). 2020. PMID: 33182351 Free PMC article.

Conclusions: we suggest that oral alitretinoin may be an effective and well tolerated treatment option for patients with intractable prurigo. Further clinical studies are warranted to confirm the long-lasting efficacy and safety of alitretinoin for treating patients …
Conclusions: we suggest that oral alitretinoin may be an effective and well tolerated treatment option for patients with intractable …

[Alitretinoin (Toctino()): A French follow-up study of harmacovigilance].

Vrignaud L, Simon C, Agier MS, Théophile H, Gras-Champel V, Beau-Salinas F, Lengellé C, Jonville-Béra AP. Vrignaud L, et al. Therapie. 2019 Oct;74(5):513-519. doi: 10.1016/j.therap.2019.02.006. Epub 2019 Mar 31. Therapie. 2019. PMID: 31014976 French.

INTRODUCTION: The adverse reaction profile of alitretinoin, a retinoid indicated in severe topical corticosteroid-refractory chronic hand eczema, is similar to that of other oral retinoids, especially isotretinoin. The objective of this study was to detect new adverse effe …
INTRODUCTION: The adverse reaction profile of alitretinoin, a retinoid indicated in severe topical corticosteroid-refractory chronic …

Alitretinoin reduces erythema in inherited ichthyosis.

Onnis G, Chiaverini C, Hickman G, Dreyfus I, Fischer J, Bourrat E, Mazereeuw-Hautier J. Onnis G, et al. Orphanet J Rare Dis. 2018 Apr 4;13(1):46. doi: 10.1186/s13023-018-0783-9. Orphanet J Rare Dis. 2018. PMID: 29618363 Free PMC article.

Our objective is evaluation of the effects and tolerance of alitretinoin. An observational retrospective multicentric study was designed to analyse patients with inherited ichthyosis treated by alitretinoin. ...Starting dose was 10 mg/day, increased to 20 or 30 mg/d …
Our objective is evaluation of the effects and tolerance of alitretinoin. An observational retrospective multicentric study was desig …