Allicin: benefits, side effects, dosage and interactions.


Allicin is a compound that can help relieve swelling and prevent free radicals from damaging cells and tissues in your body and causing disease.

Allin is an amino acid found in fresh garlic. An enzyme called allinase is released when a tooth is injured or damaged.

This enzyme converts the amino acid to allicin.

This compound is one of the main active components of garlic and gives it its special flavor and aroma.

Pure allicin remains stable only in freshly ground or minced garlic for a short time. But let it act for 10 minutes after chopping or cutting to increase its level.

The compound is also added to diet foods to maintain its effect.

In this article, we will discuss:

  • How Allicin Helps Maintain Good Health
  • What risks and side effects are known
  • What is the correct dose
  • How do you prepare
  • What to look for when choosing a product with their help.

Commonly known as

  • Allicin
  • Allium sativum
  • Garlic

Why is allicin used?

Allicin can help prevent health problems like heart disease and cancer.

It can also protect against health problems that affect your blood vessels and help reduce levels of:

Some studies have also shown that allicin can help your muscles recover faster after exercise.

This compound is believed to support immune health by protecting against disease-causing agents such as viruses and fungi.

Does allicin support health?

Many studies have shown that the allicin in garlic can support health in a number of ways.

Allicin May Support Blood Vessel Health

Research has shown that the allicin in garlic supports healthy blood vessels.

It can help improve blood pressure (BP) control and prevent a blood vessel disease known as atherosclerosis .

A review of 39 randomized controlled trials (RCTs) of compounds in garlic reduced the risk of heart attacks in adults in their 50s by nearly 40 percent.

It also helped reduce the level of "bad fats" in the blood when taken for at least two months. The tests showed that the adults who participated in the study had fewer:

A subsequent review of studies also supports these findings. The results of eight of the nine reviews showed marked reductions in total cholesterol.

Allicin helps control high blood pressure

Research shows that allicin can help lower blood pressure and keep it within the normal range.

In adults with high blood pressure, mean systolic blood pressure (SBP or higher value) was approximately 6 points lower and diastolic blood pressure (DBP or lower value) was almost 9 points lower.

A double-blind randomized controlled trial published in 2021 confirmed these results. The adults in the study received a placebo or two 400 mg garlic tablets daily for 15 weeks.

The authors noted a decrease in SBP by almost 8 points and DBP by more than 5 points at the end of the study.

All of the participants in this study lived with nonalcoholic fatty liver disease (NAFLD).

Along with high blood pressure, NAFLD is closely related to other health problems such as heart disease and metabolic syndrome .

NAFLD affects your liver in the long term, but it can contain disease and health problems associated with lifestyle habits like healthy eating.


Allicin can help you better control high blood pressure. Studies have observed a decrease in SBP and DBP from 2 to almost 9 mm Hg.

Allicin May Help Protect Against Certain Types of Cancer

The National Cancer Institute praised garlic for its ability to prevent and protect against cancer in 1990.

Since then, numerous studies have shown that allicin and other active compounds in garlic can protect against certain types of cancer and inhibit the spread of cancer cells.

Research has examined its role in fighting cancer:

What are the risks and side effects of allicin?

There are several side effects and health risks associated with the use of allicin. But be sure to talk to your doctor about how it fits into your plan of care before adding it to your regimen.

Discuss how this compound can affect your health or interact with the medications and medications you are taking, such as:

  • Prescription and Over-the-Counter (OTC) Drugs
  • Nutritional supplements
  • Herbal supplements
  • Essential oils

Using allicin carries risks:

Digestive problems

The connection can cause problems like:

  • Belching
  • Gas
  • Nausea
  • Diarrhea
  • Acidity

By taking it with meals, you can limit or prevent these problems.


Allicin can increase the risk of bleeding. This is because this and other compounds in garlic help prevent blood clots .

It is likely that part of your health plan includes avoiding certain foods and medications for a certain time before surgery. This includes foods like garlic and foods with garlic compounds.

Be sure to check with your doctor if you are also taking blood-thinning medications such as warfarin and other herbal and over-the-counter medications that can thin your blood, such as:

  • Aspirin
  • Ginkgo biloba
  • Vitamin E

Drug interactions and other unknown risks

If you have blood pressure or blood sugar problems and are taking medication to correct them, be sure to speak with your doctor before adding allicin to your health plan.

Concomitant use of allicin may cause a drop in blood pressure or blood sugar too low.

It is not known if it is safe for everyone to accept the connection. This includes people with special health needs such as:

  • Pregnant women
  • Breastfeeding mothers
  • Kids


Allicin causes little-known side effects and health risks. These can include digestive problems and risk of bleeding.

People with certain health problems and special needs should check with their doctor before adding the compound to their daily routine.

Get Drug Information / Anastasia Tretyak

How is allicin made and what dosage works best?

Products are sold in pill or tablet form and may have garlic or allicin on the label. They can also be in the form of a powder, oil, or extract.

There is no standard dosage for the compound. The dosage may vary depending on your health needs and the form of the product.

A clove of garlic contains 5 to 18 mg of allicin. The most commonly researched doses are between 300 and 1500 mg.

The highest daily doses are often divided into multiple doses. Dividing your doses can also help limit side effects.

Make sure to talk to your doctor about the right dose for you.

What to look for when choosing an allicin product?

Stomach acids can dissolve the tablets and enzymes in garlic before they take effect. Coated tablets can help prevent this.

But a 2018 review of garlic and allicin supplements found that enteric-coated tablets are no more bioavailable (can be used and absorbed by the body) than tablets without them.

The study also found that allicin from garlic powder supplements was as bioavailable as allicin from an equivalent amount of minced raw garlic when taken with food.

Make sure the product has been certified by one or more of these agencies, regardless of the product you choose to use:

  • Consumer laboratories
  • United States Pharmacopoeia Convention
  • NSF International


Allicin is one of the main active substances derived from garlic. It helps prevent certain types of cancer and can help decrease the amount of blood:

  • Lipids
  • Pressure
  • Sugar

It can help your muscles recover from exercise and prevent diseases caused by agents such as viruses and fungi.

Taking the compound carries several side effects and health risks. Most of them are associated with digestive problems or risk of bleeding.

Try to speak frankly with your doctor about these risks and side effects before adding the compound to your daily routine. Also discuss how it could improve or harm your health.

This is especially true since there is no standard dosage for allicin. Your healthcare professional can help you choose the correct dose based on:

  • Why would you like to use this?
  • What are your health needs and risks?
  • What form do you prefer to use?

Make sure the allicin product you choose is certified by one of the leading quality control agencies.

Frequently asked questions

  • Yes. But since allicin is formed after mincing garlic , you can increase its active amount by waiting at least 10 minutes before cooking. It is also best not to expose garlic to temperatures above 140 degrees. One way to do this is to add garlic in the later stages of cooking.

  • Some research suggests that garlic can help prevent or treat colds. But current research has not determined what that dose or dose range should be.

  • There is no clinical evidence that placing garlic in the vagina cures a yeast infection . Oral garlic tablets have been shown to have some effect on various laboratory strains of the fungus. But the practice of placing a nail in the vagina has not been proven by serious science. It is best not to insert any foreign object into the vagina other than the tampon or suppository prescribed by your healthcare professional.

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