Full text biomedical articles

Guiding dose adjustment of amlodipine after co-administration with ritonavir containing regimens using a physiologically-based pharmacokinetic/pharmacodynamic model

Dwaipayan Mukherjee, Jiuhong Zha, Rajeev M. Menon, Mohamad Shebley
J Pharmacokinet Pharmacodyn. 2018; 45(3): 443–456. Published online 2018 Feb 9. doi: 10.1007/s10928-018-9574-0


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Amlodipine induces vasodilation via Akt2/Sp1‐activated miR‐21 in smooth muscle cells

Qin Fang, Min Tian, Feng Wang, Zhihao Zhang, Tingyi Du, Wei Wang, Yong Yang, Xianqing Li, Guangzhi Chen, Lei Xiao, Haoran Wei, Yan Wang, Chen Chen, Dao Wen Wang
Br J Pharmacol. 2019 Jul; 176(13): 2306–2320. Published online 2019 May 20. doi: 10.1111/bph.14679


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Lipid emulsion inhibits the vasodilation induced by a toxic dose of amlodipine in isolated rat aortae

Seong-Ho Ok, Soo Hee Lee, Ji-Yoon Kim, Hyun-Jin Kim, Sung Il Bae, Yeran Hwang, Seongyeong Tak, Ju-Tae Sohn
Int J Med Sci. 2019; 16(12): 1621–1630. Published online 2019 Nov 9. doi: 10.7150/ijms.38502


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Effects of triptolide on pharmacokinetics of amlodipine in rats by using LC–MS/MS

Chengyin Zhang, Zhiqiang Gao, Lijuan Niu, Xuexun Chen
Pharm Biol. 2018; 56(1): 132–137. Published online 2018 Feb 1. doi: 10.1080/13880209.2018.1430835


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Pharmacogenomics of amlodipine and hydrochlorothiazide therapy and the quest for improved control of hypertension: a mini review

Rabia Johnson, Phiwayinkosi Dludla, Sihle Mabhida, Mongi Benjeddou, Johan Louw, Faghri February
Heart Fail Rev. 2019; 24(3): 343–357. Published online 2019 Jan 15. doi: 10.1007/s10741-018-09765-y


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No pharmacokinetic interactions between candesartan and amlodipine following multiple oral administrations in healthy subjects

Jung-Ryul Kim, Seokuee Kim, Wooseong Huh, Jae-Wook Ko
Drug Des Devel Ther. 2018; 12: 2475–2483. Published online 2018 Aug 10. doi: 10.2147/DDDT.S172568


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Quantitative model for the blood pressure‐lowering interaction of valsartan and amlodipine

Young‐A Heo, Nick Holford, Yukyung Kim, Mijeong Son, Kyungsoo Park
Br J Clin Pharmacol. 2016 Dec; 82(6): 1557–1567. Published online 2016 Oct 3. doi: 10.1111/bcp.13082


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Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects

Woo Youl Kang, Sook Jin Seong, Boram Ohk, Mi-Ri Gwon, Bo Kyung Kim, Sookie La, Hyun-Ju Kim, Seungil Cho, Young-Ran Yoon, Dong Heon Yang, Hae Won Lee
Drug Des Devel Ther. 2018; 12: 545–553. Published online 2018 Mar 14. doi: 10.2147/DDDT.S156492


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Comparisons of the pharmacokinetics and tolerability of fixed-dose combinations of amlodipine besylate/losartan and amlodipine camsylate/losartan in healthy subjects: a randomized, open-label, single-dose, two-period, two-sequence crossover study

YoonJung Choi, SeungHwan Lee, Sang-Min Cho, Won-Ho Kang, Kyu-Yeol Nam, In-Jin Jang, Kyung-Sang Yu
Drug Des Devel Ther. 2016; 10: 3021–3028. Published online 2016 Sep 20. doi: 10.2147/DDDT.S113891


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Efficacy and Safety of S-Amlodipine 2.5 and 5 mg/d in Hypertensive Patients Who Were Treatment-Naive or Previously Received Antihypertensive Monotherapy

Selçuk Şen, Meral Demir, Zerrin Yiğit, Ali Yağız Üresin
J Cardiovasc Pharmacol Ther. 2018 Jul; 23(4): 318–328. Published online 2018 Apr 12. doi: 10.1177/1074248418769054


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Effects of curcumin on the pharmacokinetics of amlodipine in rats and its potential mechanism

Na Jiang, Meicheng Zhang, Xiangzhi Meng, Bin Sun
Pharm Biol. 2020; 58(1): 465–468. Published online 2020 May 20. doi: 10.1080/13880209.2020.1764060


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Efficacy and safety of two fixed-dose combinations of S-amlodipine and telmisartan (CKD-828) versus S-amlodipine monotherapy in patients with hypertension inadequately controlled using S-amlodipine monotherapy: an 8-week, multicenter, randomized, double-blind, Phase III clinical study

Sang-Hyun Ihm, Hui-Kyung Jeon, Tae-Joon Cha, Taek-Jong Hong, Sang-Hyun Kim, Nae-Hee Lee, Jung Han Yoon, Namsik Yoon, Kyung-Kuk Hwang, Sang-Ho Jo, Ho-Joong Youn
Drug Des Devel Ther. 2016; 10: 3817–3826. Published online 2016 Nov 23. doi: 10.2147/DDDT.S116847


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Induction of store operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

Zhijun Liu, Yiju Wei, Lei Zhang, Patricia P. Yee, Martin Johnson, Xuexin Zhang, Melissa Gulley, Jennifer Xavier, Mohamed Trebak, Hong-Gang Wang, Wei Li
Oncogene. Author manuscript; available in PMC 2019 Feb 6.
Published in final edited form as: Oncogene. 2019 Jan; 38(1): 120–139. Published online 2018 Aug 6. doi: 10.1038/s41388-018-0425-7


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Amlodipine Ameliorates Ischemia-Induced Neovascularization in Diabetic Rats through Endothelial Progenitor Cell Mobilization

Jiayin Sun, Jun Xie, Lina Kang, Albert Ferro, Li Dong, Biao Xu
Biomed Res Int. 2016; 2016: 3182764. Published online 2016 May 8. doi: 10.1155/2016/3182764


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Development and Feasibility of a Porcine Model of Amlodipine Toxicity

Sean P. Boley, Rebecca B. Mackenzie, Jenna M. LeRoy, Kristin M. Engebretsen, Samuel J. Stellpflug
J Med Toxicol. 2020 Jan; 16(1): 61–66. Published online 2019 Aug 5. doi: 10.1007/s13181-019-00721-2


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Efficacy and safety of co‐administered telmisartan/amlodipine and rosuvastatin in subjects with hypertension and dyslipidemia

Xuan Jin, Moo Hyun Kim, Ki Hoon Han, Soon Jun Hong, Jeong‐Cheon Ahn, Jung‐Hoon Sung, Jin‐Man Cho, Han Cheol Lee, So‐Yeon Choi, Kyounghoon Lee, Woo‐Shik Kim, Moo‐Yong Rhee, Ju Han Kim, Seung Pyo Hong, Byung Su Yoo, Eun Joo Cho, Jae‐Hwan Lee, Pum‐Joon Kim, Chang‐Gyu Park, Min Su Hyon, Jin Ho Shin, Sang Hyun Lee, Ki Chul Sung, Jinyong Hwang, Kihwan Kwon, In‐Ho Chae, Jeong‐Sook Seo, Hyungseop Kim, Hana Lee, Yoonhwa Cho, Hyo‐Soo Kim
J Clin Hypertens (Greenwich) 2020 Oct; 22(10): 1835–1845. Published online 2020 Sep 16. doi: 10.1111/jch.13893


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Evaluation of pharmacokinetics and safety with bioequivalence of Amlodipine in healthy Chinese volunteers: Bioequivalence Study Findings

Tongtong Wang, Yannan Wang, Sisi Lin, Lu Fang, Sai Lou, Di Zhao, Jingjing Zhu, Qigang Yang, Ying Wang
J Clin Lab Anal. 2020 Jun; 34(6): e23228. Published online 2020 Feb 7. doi: 10.1002/jcla.23228


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Pharmacokinetic and Safety Profiles of a Fixed‐Dose Combination of Amlodipine, Valsartan, and Atorvastatin: A 3‐Period Replicate Crossover Study

Seokuee Kim, Jae‐Wook Ko, Jung‐Ryul Kim
Clin Pharmacol Drug Dev. 2020 Apr; 9(3): 386–394. Published online 2019 Aug 2. doi: 10.1002/cpdd.727


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Pharmacokinetic interactions between telmisartan/amlodipine and rosuvastatin after multiple oral administrations in healthy Korean male subjects

Seol Ju Moon, Ji-Young Jeon, Kyungho Jang, Kyung-Sang Yu, Yeji Lim, Min-Gul Kim
Drug Des Devel Ther. 2019; 13: 2533–2542. Published online 2019 Jul 25. doi: 10.2147/DDDT.S210364


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Pharmacokinetics of amlodipine besylate at delivery and during lactation

Jamie L. MORGAN, Benjamin K. KOGUTT, Claudia MEEK, Elizabeth K. STEHEL, Donald D. MCINTIRE, Jeanne S. SHEFFIELD, Scott W. ROBERTS
Pregnancy Hypertens. Author manuscript; available in PMC 2019 Jan 4.
Published in final edited form as: Pregnancy Hypertens. 2018 Jan; 11: 77–80. Published online 2018 Jan 4. doi: 10.1016/j.preghy.2018.01.002


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