References from scientific journals

Oral amoxicillin and amoxicillin-clavulanic acid: properties, indications and usage.

Huttner A, Bielicki J, Clements MN, Frimodt-Møller N, Muller AE, Paccaud JP, Mouton JW. Huttner A, et al. Clin Microbiol Infect. 2020 Jul;26(7):871-879. doi: 10.1016/j.cmi.2019.11.028. Epub 2019 Dec 4. Clin Microbiol Infect. 2020. PMID: 31811919 Free article. Review.

BACKGROUND: Amoxicillin has been in use since the 1970s; it is the most widely used penicillin both alone and in combination with the beta-lactamase clavulanic acid. ...IMPLICATIONS: Using available epidemiological and pharmacokinetic data, we provide guidance on in …
BACKGROUND: Amoxicillin has been in use since the 1970s; it is the most widely used penicillin both alone and in combination w …

A placebo-controlled trial of antimicrobial treatment for acute otitis media.

Tähtinen PA, Laine MK, Huovinen P, Jalava J, Ruuskanen O, Ruohola A. Tähtinen PA, et al. N Engl J Med. 2011 Jan 13;364(2):116-26. doi: 10.1056/NEJMoa1007174. N Engl J Med. 2011. PMID: 21226577 Free article. Clinical Trial.

RESULTS: Treatment failure occurred in 18.6% of the children who received amoxicillin-clavulanate, as compared with 44.9% of the children who received placebo (P<0.001). ...Analgesic or antipyretic agents were given to 84.2% and 85.9% of the children in the am …
RESULTS: Treatment failure occurred in 18.6% of the children who received amoxicillin-clavulanate, as compared with 44.9% of t …

Reply.

Sompornrattanaphan M, Pudchakan P, Wongsa C, Thongngarm T. Sompornrattanaphan M, et al. J Allergy Clin Immunol Pract. 2020 Jun;8(6):2123-2124. doi: 10.1016/j.jaip.2020.04.011. J Allergy Clin Immunol Pract. 2020. PMID: 32499044 No abstract available.


Does the use of amoxicillin/amoxicillin-clavulanic acid in third molar surgery reduce the risk of postoperative infection? A systematic review with meta-analysis.

Menon RK, Gopinath D, Li KY, Leung YY, Botelho MG. Menon RK, et al. Int J Oral Maxillofac Surg. 2019 Feb;48(2):263-273. doi: 10.1016/j.ijom.2018.08.002. Epub 2018 Aug 23. Int J Oral Maxillofac Surg. 2019. PMID: 30145064

The risk of adverse effects was significantly higher in the amoxicillin-clavulanic acid group (RR=4.12, P=0.023) than in the amoxicillin group (RR 1.57, P=0.405). In conclusion, amoxicillin-clavulanic acid and amoxicillin may significantly reduce the r …
The risk of adverse effects was significantly higher in the amoxicillin-clavulanic acid group (RR=4.12, P=0.023) than in the amoxi …

Crystalluria.

van Noord C, Wulkan RW, van den Dorpel MA. van Noord C, et al. Neth J Med. 2012 Mar;70(2):84, 87. Neth J Med. 2012. PMID: 22418755 Free article. No abstract available.


Amoxicillin mit Clavulansäure. Standardantibiotikum im allgemeinzahnärztlichen Alltag.

Rostetter C, Schenkel J, Rücker M, Lübbers HT. Rostetter C, et al. Swiss Dent J. 2017;127(7-8):654-655. Swiss Dent J. 2017. PMID: 28752505 Free article. German.

This script gives a pragmatic advice for general dentists on accurate use of amoxicillin with clavulanic acid considering current literature at acute inflammatory disease. ...Compared to clindamycin the concentration of amoxicillin in teeth and bone (Hallig 2014) is …
This script gives a pragmatic advice for general dentists on accurate use of amoxicillin with clavulanic acid considering current lit …

Proof of concept: performance testing in models.

Craig WA. Craig WA. Clin Microbiol Infect. 2004 Apr;10 Suppl 2:12-7. doi: 10.1111/j.1470-9465.2004.00865.x. Clin Microbiol Infect. 2004. PMID: 14759229 Free article. Review.

These principles indicate that for amoxicillin and amoxicillin/clavulanate, a time above MIC of 35-40% of the dosing interval is predictive of high bacterial efficacy. ...Following infection with S. pneumoniae strains with amoxicillin MICs of 8 mg/L, t …
These principles indicate that for amoxicillin and amoxicillin/clavulanate, a time above MIC of 35-40% of the dosing in …

Extended release amoxicillin/clavulanate: optimizing a product for respiratory infections based on pharmacodynamic principles.

Jacobs MR. Jacobs MR. Expert Rev Anti Infect Ther. 2005 Jun;3(3):353-60. doi: 10.1586/14787210.3.3.353. Expert Rev Anti Infect Ther. 2005. PMID: 15954852 Review.

In response to recent guidelines recommending higher dose amoxicillin to extend coverage to a higher percentage of S. pneumoniae, a new formulation of amoxicillin/clavulanic acid was developed. This formulation includes a higher amoxicillin dose, with part of …
In response to recent guidelines recommending higher dose amoxicillin to extend coverage to a higher percentage of S. pneumoniae, a n …

Impact of oral amoxicillin and amoxicillin/clavulanic acid treatment on bacterial diversity and beta-lactam resistance in the canine faecal microbiota.

Espinosa-Gongora C, Jessen LR, Kieler IN, Damborg P, Bjørnvad CR, Gudeta DD, Pires Dos Santos T, Sablier-Gallis F, Sayah-Jeanne S, Corbel T, Nevière A, Hugon P, Saint-Lu N, de Gunzburg J, Guardabassi L. Espinosa-Gongora C, et al. J Antimicrob Chemother. 2020 Feb 1;75(2):351-361. doi: 10.1093/jac/dkz458. J Antimicrob Chemother. 2020. PMID: 31778166

OBJECTIVES: To investigate changes in the faecal microbiota of dogs treated with amoxicillin or amoxicillin/clavulanic acid. METHODS: Faeces collected from 42 dogs (21 per treatment group) immediately before, during and 1 week after termination of oral treatment wit …
OBJECTIVES: To investigate changes in the faecal microbiota of dogs treated with amoxicillin or amoxicillin/clavulanic acid. M …

The stability of amoxicillin trihydrate and potassium clavulanate combination in aqueous solutions.

Jerzsele A, Nagy G. Jerzsele A, et al. Acta Vet Hung. 2009 Dec;57(4):485-93. doi: 10.1556/AVet.57.2009.4.3. Acta Vet Hung. 2009. PMID: 19897453

Increasing the water hardness decreased the stability of both substances, amoxicillin being more stable at each hardness value than clavulanate. ...The stability of the amoxicillin-clavulanic acid combination depends mainly on the less stable clavul …
Increasing the water hardness decreased the stability of both substances, amoxicillin being more stable at each hardness value than …