Antigenic drift and displacement with influenza virus


Influenza voltages are constantly mutated. A small change is known to the genetic composition of the Influenza strains as drift antigen , and a significant change is called antigenic change .While these designations are mainly relevant to scientists, they help explain why it can reduce the flu more than once, and why the flu vaccine changes annually (and may be less effective in some Seasons).


Drift from the antigen

Minor change in the virus Influenza is known as an antigen drift.Both influenza A and B viruses are exposed to antigenic drift.

These mutations in gene genes can cause changes in their surface gemaglutinin proteins (GA) and non-neurinamenamic (NA).Known as antigens, they are recognized as an immune system that encourages an immunological response that can lead to a disease and promote immunity in the future.

As viral replicas, these changes in the drift of the antigen are constantly produced. With time, these small changes accumulate and lead to a New strain that is not recognized by the immune system.The antibodies created in response to the presence of influenza in the past can not protect against this new version.

The antigenous drift is the reason why new flu vaccines are developed each year, and the reason why it can get sick of influenza, even if you had it before.

Antigenic change

Antigenic change is a more serious change in the influenza virus.This change usually occurs when the influenza virus is baptized with the flu virus, which usually attacks animals (such as birds or pigs).

When Muta Virus, they will create a new subtype, which differs from anyone from anyone.who has seen people. Previously.

can happen in three ways: UL>

  • Human Influenza Virus Infects Animal , For example, the pork this pork is also infected with the flu virus of another animal, like a duck.Two influenza viruses are mixed and mutated, creating a completely new type of influenza virus, which can then spread to people.
  • A strain of avian flu goes to people without spending any kind of genetic change.
  • A strain of avian flu goes to another type of animal (for example, a pig) and then transmits to people, not in genetic change.
  • , when there is an important antigenic change, as happens, very few people have some kind of immunity to a new or ‘novel’, ‘influenza virus’.

    In pandemic influenza occurred in recent history, they were associated with an antigenic change. They soon as this example is Covid-19, the Boronavirus disease of 2019 .Fortunately, these turns arise only occasionally, causing only the handful of the actual influenza pandemic in the last century.

    The main antigenic change only with influenza virus occurs only with virus of influenza.The flu viruses B only pass the drift from the antigen.

    Drifts, craves and flu vaccine

    Drives and antigenic changes make that the fun of the entertainment vaccine and medications,That they will treat influenza infections.Researchers hope to develop an effective vaccine that will be directed to a part of the virus, which does not depend on these changes that lead to the universal flu vaccine , which sometimes will be faster and not all years. . of influenza.

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