Full text biomedical articles

Bioprocess development for L-asparaginase production by Streptomyces rochei, purification and in-vitro efficacy against various human carcinoma cell lines

Noura El-Ahmady El-Naggar, Nancy M. El-Shweihy
Sci Rep. 2020; 10: 7942. Published online 2020 May 14. doi: 10.1038/s41598-020-64052-x


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Purification and Characterization of Glutaminase Free Asparaginase from Enterobacter cloacae: In-Vitro Evaluation of Cytotoxic Potential against Human Myeloid Leukemia HL-60 Cells

Islam Husain, Anjana Sharma, Suresh Kumar, Fayaz Malik
PLoS One. 2016; 11(2): e0148877. Published online 2016 Feb 18. doi: 10.1371/journal.pone.0148877


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Purification, characterization and immunogenicity assessment of glutaminase free L-asparaginase from Streptomyces brollosae NEAE-115

Noura El-Ahmady El-Naggar, Sahar F. Deraz, Sara M. El-Ewasy, Ghada M. Suddek
BMC Pharmacol Toxicol. 2018; 19: 51. Published online 2018 Aug 23. doi: 10.1186/s40360-018-0242-1


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HAP1 loss confers l-asparaginase resistance in ALL by downregulating the calpain-1-Bid-caspase-3/12 pathway

Jung Kwon Lee, SungMyung Kang, Xidi Wang, Jesusa L. Rosales, Xu Gao, Hee-Guk Byun, Yan Jin, Songbin Fu, Jinghua Wang, Ki-Young Lee
Blood. 2019 May 16; 133(20): 2222–2232. Prepublished online 2019 Feb 28. doi: 10.1182/blood-2018-12-890236


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Asparagine levels in the cerebrospinal fluid of children with acute lymphoblastic leukemia treated with pegylated-asparaginase in the induction phase of the AIEOP-BFM ALL 2009 study

Carmelo Rizzari, Claudia Lanvers-Kaminsky, Maria Grazia Valsecchi, Andrea Ballerini, Cristina Matteo, Joachim Gerss, Gudrun Wuerthwein, Daniela Silvestri, Antonella Colombini, Valentino Conter, Andrea Biondi, Martin Schrappe, Anja Moericke, Martin Zimmermann, Arend von Stackelberg, Christin Linderkamp, Michael C. Frühwald, Sabine Legien, Andishe Attarbaschi, Bettina Reismüller, David Kasper, Petr Smisek, Jan Stary, Luciana Vinti, Elena Barisone, Rosanna Parasole, Concetta Micalizzi, Massimo Zucchetti, Joachim Boos
Haematologica. 2019 Sep; 104(9): 1812–1821. Prepublished online 2019 Jan 31. doi: 10.3324/haematol.2018.206433


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Thiol-maleimide poly(ethylene glycol) crosslinking of L-asparaginase subunits at recombinant cysteine residues introduced by mutagenesis

Josell Ramirez-Paz, Manoj Saxena, Louis J. Delinois, Freisa M. Joaquín-Ovalle, Shiru Lin, Zhongfang Chen, Virginia A. Rojas-Nieves, Kai Griebenow
PLoS One. 2018; 13(7): e0197643. Published online 2018 Jul 27. doi: 10.1371/journal.pone.0197643


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Effect of Premedications in a Murine Model of Asparaginase Hypersensitivity

Christian A. Fernandez, Colton Smith, Seth E. Karol, Laura B. Ramsey, Chengcheng Liu, Ching-Hon Pui, Sima Jeha, William E. Evans, Fred D. Finkelman, Mary V. Relling
J Pharmacol Exp Ther. 2015 Mar; 352(3): 541–551. Published online 2015 Mar. doi: 10.1124/jpet.114.220780


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Asparaginase-associated toxicity in children with acute lymphoblastic leukemia

Nobuko Hijiya, Inge M. van der Sluis
Leuk Lymphoma. 2016 Apr 2; 57(4): 748–757. Published online 2015 Nov 20. doi: 10.3109/10428194.2015.1101098


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Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

Laura Hinze, Maren Pfirrmann, Salmaan Karim, James Degar, Connor McGuckin, Divya Vinjamur, Joshua Sacher, Kristen E. Stevenson, Donna S. Neuberg, Esteban Orellana, Martin Stanulla, Richard I. Gregory, Daniel E. Bauer, Florence F. Wagner, Kimberly Stegmaier, Alejandro Gutierrez
Cancer Cell. Author manuscript; available in PMC 2020 Apr 15.
Published in final edited form as: Cancer Cell. 2019 Apr 15; 35(4): 664–676.e7. doi: 10.1016/j.ccell.2019.03.004


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Cloning and expression of L-asparaginase from Bacillus tequilensis PV9W and therapeutic efficacy of Solid Lipid Particle formulations against cancer

Ganeshan Shakambari, Rai Sameer Kumar, Balasubramaniem Ashokkumar, Venkatachalam Ganesh, Vairathevar Sivasamy Vasantha, Perumal Varalakshmi
Sci Rep. 2018; 8: 18013. Published online 2018 Dec 20. doi: 10.1038/s41598-018-36161-1


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Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation

Inge M. van der Sluis, Lynda M. Vrooman, Rob Pieters, Andre Baruchel, Gabriele Escherich, Nicholas Goulden, Veerle Mondelaers, Jose Sanchez de Toledo, Carmelo Rizzari, Lewis B. Silverman, James A. Whitlock
Haematologica. 2016 Mar; 101(3): 279–285. doi: 10.3324/haematol.2015.137380


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Metabolic reprogramming of glioblastoma cells by L-asparaginase sensitizes for apoptosis in vitro and in vivo

Georg Karpel-Massler, Doruntina Ramani, Chang Shu, Marc-Eric Halatsch, Mike-Andrew Westhoff, Jeffrey N. Bruce, Peter Canoll, Markus D. Siegelin
Oncotarget. 2016 Jun 7; 7(23): 33512–33528. Published online 2016 May 9. doi: 10.18632/oncotarget.9257


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Recombinant L-Asparaginase from Zymomonas mobilis: A Potential New Antileukemic Agent Produced in Escherichia coli

Karen Einsfeldt, Isis Cavalcante Baptista, Juliana Christina Castanheira Vicente Pereira, Isabele Campos Costa-Amaral, Elaine Sobral da Costa, Maria Cecília Menks Ribeiro, Marcelo Gerardin Poirot Land, Tito Lívio Moitinho Alves, Ariane Leites Larentis, Rodrigo Volcan Almeida
PLoS One. 2016; 11(6): e0156692. Published online 2016 Jun 2. doi: 10.1371/journal.pone.0156692


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A prospective study on drug monitoring of PEGasparaginase and Erwinia asparaginase and asparaginase antibodies in pediatric acute lymphoblastic leukemia

Wing H. Tong, Rob Pieters, Gertjan J. L. Kaspers, D. Maroeska W. M. te Loo, Marc B. Bierings, Cor van den Bos, Wouter J. W. Kollen, Wim C. J. Hop, Claudia Lanvers-Kaminsky, Mary V. Relling, Wim J. E. Tissing, Inge M. van der Sluis
Blood. 2014 Mar 27; 123(13): 2026–2033. Prepublished online 2014 Jan 21. doi: 10.1182/blood-2013-10-534347


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Purification, characterization, cytotoxicity and anticancer activities of L-asparaginase, anti-colon cancer protein, from the newly isolated alkaliphilic Streptomyces fradiae NEAE-82

Noura El-Ahmady El-Naggar, Sahar F. Deraz, Hoda M. Soliman, Nehal M. El-Deeb, Sara M. El-Ewasy
Sci Rep. 2016; 6: 32926. Published online 2016 Sep 8. doi: 10.1038/srep32926


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Plasma asparaginase activity and asparagine depletion in acute lymphoblastic leukemia patients treated with pegaspargase on Children’s Oncology Group AALL07P4

Reuven J Schore, Meenakshi Devidas, Archie Bleyer, Gregory H Reaman, Naomi Winick, Mignon L Loh, Elizabeth A Raetz, William L Carroll, Stephen P Hunger, Anne L Angiolillo
Leuk Lymphoma. Author manuscript; available in PMC 2020 Jul 1.
Published in final edited form as: Leuk Lymphoma. 2019 Jul; 60(7): 1740–1748. Published online 2019 Jan 10. doi: 10.1080/10428194.2018.1542146


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Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells

Ping Song, Li Ye, Jiajun Fan, Yubin Li, Xian Zeng, Ziyu Wang, Shaofei Wang, Guoping Zhang, Ping Yang, Zhonglian Cao, Dianwen Ju
Oncotarget. 2015 Feb; 6(6): 3861–3873. Published online 2015 Jan 8. doi: 10.18632/oncotarget.2869


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Best Practices in Adolescent and Young Adult Patients with Acute Lymphoblastic Leukemia: A Focus on Asparaginase

Nicolas Boissel, Leonard S. Sender
J Adolesc Young Adult Oncol. 2015 Sep 1; 4(3): 118–128. doi: 10.1089/jayao.2015.0014


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The role of autophagy in asparaginase-induced immune suppression of macrophages

Ping Song, Ziyu Wang, Xuyao Zhang, Jiajun Fan, Yubin Li, Qicheng Chen, Shaofei Wang, Peipei Liu, Jingyun Luan, Li Ye, Dianwen Ju
Cell Death Dis. 2017 Mar; 8(3): e2721. Published online 2017 Mar 30. doi: 10.1038/cddis.2017.144


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Use of PEG-asparaginase in newly diagnosed adults with standard-risk acute lymphoblastic leukemia compared with E. coli-asparaginase: a retrospective single-center study

Wen-jian Liu, Hua Wang, Wei-da Wang, Meng-yuan Zhu, Cheng-cheng Liu, Jing-hua Wang, Yue Lu
Sci Rep. 2016; 6: 39463. Published online 2016 Dec 21. doi: 10.1038/srep39463


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