Clinical Trials

ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia Intermittent Versus Continuous PEG Asparaginase

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: PEG Asparaginase at six weeks interval;   Drug: PEG Asparaginase at two weeks interval
Sponsors:   Rigshospitalet, Denmark;   Nordic Society for Pediatric Hematology and Oncology
Completed

Fri, 09 Jan 2009 12:00:00 EST

Intravenous Erwinia Chrysanthemi Asparaginase in Patients With Newly Diagnosed Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Aged 60 Years or Older

Conditions:   Acute Lymphoblastic Leukemia (ALL);   Newly Diagnosed Philadelphia Chromosome Negative;   Aged 60 Years or Older
Intervention:   Drug: Erwinia Chrysanthemi asparaginase
Sponsors:   Memorial Sloan Kettering Cancer Center;   Jazz Pharmaceuticals
Withdrawn

Wed, 06 Jan 2016 12:00:00 EST

Anti-PD-1 Antibody Combined With Peg-Asparaginase and Chidamide for the Early Stage of NK/T Cell Lymphoma

Conditions:   Immune Checkpoint Inhibitor;   Chemotherapy Effect;   Epigenetic Disorder;   NK/T-cell Lymphoma of Nasal Cavity
Intervention:   Drug: Anti-PD-1 antibody+Peg-Asparaginase+Chidamide
Sponsor:   Hunan Cancer Hospital
Recruiting

Thu, 04 Jun 2020 12:00:00 EDT

L-asparaginase Encapsulated in Red Blood Cells (Eryaspase) for Treatment of Adult Patients With ALL or LBL

Conditions:   Acute Lymphoblastic Leukemia;   Lymphoblastic Lymphoma
Intervention:   Drug: L-asparaginase encapsulated in RBC
Sponsor:   ERYtech Pharma
Terminated

Mon, 29 Jul 2013 12:00:00 EDT

Erwinase Study in Patients With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Intervention:   Drug: Erwinase
Sponsor:   M.D. Anderson Cancer Center
Completed

Wed, 25 Jul 2007 12:00:00 EDT

GRASPA (Erythrocytes Encapsulating L-asparaginase) in Patients With Relapse of Acute Lymphoblastic Leukemia

Condition:   Acute Lymphoblastic Leukemia, in Relapse
Interventions:   Drug: GRASPA;   Drug: L-asparaginase
Sponsor:   ERYtech Pharma
Completed

Thu, 26 Jan 2012 12:00:00 EST

L-asparaginase Monotherapy as Salvage Treatment in Patients With NK/T Cell Lymphoma

Condition:   Lymphoma
Intervention:   Drug: L-asparaginase
Sponsor:   Fudan University
Completed

Tue, 03 Mar 2009 12:00:00 EST

Asparaginase Activity Monitoring (AAM) in Adult Patients With Acute Lymphoblastic Leukemia (ALL)

Condition:   Acute Lymphoblastic Leukemia
Intervention:   Drug: Asparaginase
Sponsor:   Gruppo Italiano Malattie EMatologiche dell'Adulto
Recruiting

Wed, 12 Sep 2018 12:00:00 EDT

Expanded Access Program: Safety of Erythrocytes Encapsulating L-asparaginase (GRASPA®) in Combination With Polychemotherapy in Patients Under 55 Years Old With Acute Lymphoblastic Leukemia (ALL) at Risk to Receive Other Formulation of Asparaginase

Condition:   Acute Lymphoblastic Leukemia
Intervention:   Drug: suspension of erythrocytes encapsulating L-asparaginase
Sponsor:   ERYtech Pharma
No longer available

Wed, 23 Jul 2014 12:00:00 EDT

1336GCC: Study of Erwinaze for Treatment of Acute Myeloid Leukemia (AML)

Condition:   Acute Myeloid Leukemia
Intervention:   Drug: Erwinase
Sponsor:   Ashkan Emadi
Completed

Wed, 05 Nov 2014 12:00:00 EST

An Open-Label, Single-Arm, Multicenter Pharmacokinetic Study of Intramuscular Erwinaze® (Asparaginase Erwinia Chrysanthemi)/Erwinase® (Crisantaspase)

Condition:   Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL)
Intervention:   Drug: Erwinaze® (Asparaginase Erwinia Chrysanthemi)/Erwinase® (Crisantaspase)
Sponsor:   Jazz Pharmaceuticals
Withdrawn

Fri, 30 May 2014 12:00:00 EDT

Erwinase Master Treatment Protocol

Conditions:   Leukemia, Acute Lymphoblastic;   Acute Lymphoid Leukemia
Intervention:   Drug: Erwinia L-asparaginase
Sponsors:   Phoenix Children's Hospital;   Fisher Bioservices;   Jazz Pharmaceuticals
No longer available

Fri, 11 Jan 2008 12:00:00 EST

Efficacy and Safety of Recombinant Asparaginase in Infants With Previously Untreated Acute Lymphoid Leukemia (ALL)

Condition:   Acute Lymphoid Leukemia
Intervention:   Drug: recombinant asparaginase
Sponsor:   medac GmbH
Completed

Wed, 23 Sep 2009 12:00:00 EDT

Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase.

Condition:   Acute Lymphoblastic Leukemia
Intervention:   Other: Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Leukaemia During Therapy With L - Asparaginase
Sponsor:   Aristotle University Of Thessaloniki
Recruiting

Tue, 28 Apr 2020 12:00:00 EDT

Comparative Efficacy and Safety of Two Asparaginase Preparations in Children With Previously Untreated Acute Lymphoblastic Leukaemia

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: asparaginase;   Drug: recombinant asparaginase
Sponsor:   medac GmbH
Completed

Sun, 02 Nov 2008 12:00:00 EDT

JZP458 - Recombinant Erwinia Asparaginase for Treatment of ALL / LBL Patients With Hypersensitivity to E. Coli-derived Asparaginase

Conditions:   Acute Lymphoblastic Leukemia;   Lymphoblastic Lymphoma
Intervention:   Drug: Asparaginase Erwinia Chrysanthemi (recombinant)
Sponsor:   Jazz Pharmaceuticals
Approved for marketing

Tue, 29 Jun 2021 12:00:00 EDT

The Association Between Asparaginase Enzyme Activity Levels and Toxicities in Childhood Acute Lymphoblastic Leukaemia in NOPHOALL 2008

Condition:   Acute Lymphoblastic Leukemia
Intervention:   Drug: Asparaginase
Sponsor:   Aarhus University Hospital
Completed

Thu, 05 Dec 2019 12:00:00 EST

A Study of Erwinaze Administered Intravenously in Patients Who Had an Allergy to Frontline Asparaginase Therapy

Conditions:   Acute Lymphoblastic Leukemia;   Lymphoblastic Lymphoma
Intervention:   Drug: asparaginase Erwinia chrysanthemi
Sponsor:   Jazz Pharmaceuticals
Completed

Wed, 18 Jul 2012 12:00:00 EDT

Intensified Post Remission Therapy Containing PEG-Asparaginase

Condition:   Acute Lymphoblastic Leukemia
Intervention:   Drug: Daunorubicin, Vincristine, Prednisone, Methotrexate, PEG-Asparaginase, 6-Mercaptopurine, Cytoxan, Cytosine Arabinoside, VM-26 and 6-Thioguanine
Sponsor:   University of Southern California
Completed

Fri, 16 Sep 2005 12:00:00 EDT

Study of Sirolimus With PEG-Asparaginase in Acute Lymphoblastic Leukemia (ALL)

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Sirolimus;   Drug: PEG-asparaginase
Sponsor:   Emory University
Withdrawn

Wed, 12 Aug 2009 12:00:00 EDT

Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses

Condition:   Acute Lymphoblastic Leukemia
Intervention:   Drug: PEG-asparaginase
Sponsors:   Nordic Society for Pediatric Hematology and Oncology;   Medac, Hamburg, Germany;   Danish Child Cancer Foundation
Unknown status

Mon, 19 Sep 2005 12:00:00 EDT

Erwinia Asparaginase After Allergy to PEG-Asparaginase in Treating Young Patients With Acute Lymphoblastic Leukemia

Conditions:   Adult Acute Lymphoblastic Leukemia;   Childhood Acute Lymphoblastic Leukemia
Interventions:   Drug: Asparaginase;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Fri, 28 Sep 2007 12:00:00 EDT

A Pilot Study of Oncaspar® + Dexamethasone in Patients With Relapsed or Refractory T-Cell Lymphoma

Conditions:   T-Cell Lymphoma;   Relapsed T-Cell Lymphoma;   Refractory T-Cell Lymphoma
Interventions:   Drug: PEG-L-asparaginase;   Drug: Dexamethasone acetate
Sponsors:   Dana-Farber Cancer Institute;   Leadiant Biosciences, Inc.
Terminated

Mon, 17 Jun 2013 12:00:00 EDT

PK, PD, Safety and Immunogenicity of Spectrila in Adults With Acute B-cell Lymphoblastic Leukaemia

Condition:   Acute B-Cell Lymphoblastic Leukaemia
Intervention:   Drug: Spectrila®
Sponsors:   medac GmbH;   Syneos Health
Active, not recruiting

Wed, 17 May 2017 12:00:00 EDT

New Combination Regimen of L-asparaginase, Dexamethasone, Ifosfamide, Cisplatin and Etoposide in NK/T-Cell Lymphoma

Condition:   Lymphoma
Intervention:   Drug: L-asp, DXM, IFO, VP-16, DDP
Sponsor:   Fudan University
Unknown status

Tue, 07 Jul 2009 12:00:00 EDT

Phase II Study of Fludarabine, Cytarabine (ARA-C) and Erwinase IV in Patients With Relapsed or Refractory Hematologic Malignancies

Condition:   Hematologic Malignancy
Interventions:   Drug: Fludarabine;   Drug: Cytarabine;   Drug: Erwinase
Sponsors:   M.D. Anderson Cancer Center;   Jazz Pharmaceuticals
Withdrawn

Thu, 24 Mar 2016 12:00:00 EDT

Compassionate Use of Erwinase For Pediatric Patients With Acute Lymphoblastic Leukemia Or Non Hodgkins Lymphoma

Conditions:   Acute Lymphoblastic Leukemia;   Non Hodgkins Lymphoma
Intervention:   Drug: Erwinase
Sponsors:   St. Jude Children's Research Hospital;   Jazz Pharmaceuticals;   Parexel
Completed

Mon, 09 Jun 2008 12:00:00 EDT

Thromboembolic Complications Related to Asparaginase in Children With Acute Lymphoblastic Leukemia (ALL) Treated According to NOPHO ALL 2008

Conditions:   Thromboembolism;   Acute Lymphoblastic Leukemia
Intervention:  
Sponsor:   Oslo University Hospital
Unknown status

Wed, 23 Sep 2009 12:00:00 EDT

Efficacy and Safety of L-asparaginase Encapsulated in RBC Combined With Gemcitabine or FOLFOX in 2nd Line for Progressive Metastatic Pancreatic Carcinoma

Condition:   Pancreatic Adenocarcinoma Metastatic
Interventions:   Drug: ERY001;   Drug: Gemcitabine;   Drug: 5-fluoro-uracil/oxaliplatin/leucovorin (folfox)
Sponsor:   ERYtech Pharma
Completed

Mon, 21 Jul 2014 12:00:00 EDT

Asparaginase Encapsulated in Erythrocytes for Patients With ALL and Hypersensitivity to PEG-asparaginase

Condition:   Acute Lymphoblastic Leukemia
Intervention:   Drug: GRASPA
Sponsors:   Birgitte Klug Albertsen;   ERYtech Pharma
Completed

Wed, 30 Aug 2017 12:00:00 EDT

Methotrexate, Vincristine, Pegylated L-Asparaginase and Dexamethasone (MOAD) in Acute Lymphoblastic Leukemia (ALL) Salvage

Condition:   Leukemia, Lymphocytic, Acute
Interventions:   Drug: Methotrexate;   Drug: Vincristine;   Drug: PEG-l-asparaginase;   Drug: Dexamethasone;   Drug: Rituximab
Sponsors:   M.D. Anderson Cancer Center;   Leadiant Biosciences, Inc.
Completed

Wed, 20 May 2009 12:00:00 EDT

Association of L-asparaginase-Methotrexate-Dexamethasone for Nasal and Nasal-type Natural Killer (NK)-T-cell Lymphoma

Condition:   Lymphoma, Non-Hodgkin
Interventions:   Drug: Kidrolase;   Drug: Methotrexate;   Drug: Dexamethasone;   Drug: Erwinase
Sponsor:   University Hospital, Limoges
Completed

Tue, 31 Jan 2006 12:00:00 EST

Administration of Allogenic Red Blood Cells Loaded L-asparaginase in Cases of Relapse of Acute Lymphoblastic Leukaemia

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Biological: GRASPA;   Drug: native L asparaginase
Sponsors:   ERYtech Pharma;   Centre Leon Berard
Completed

Mon, 28 Jul 2008 12:00:00 EDT

Nivolumab in Combination With GDP/ L-asparaginase in NK/ T-cell Lymphoma

Condition:   NK/T Cell Lymphoma
Interventions:   Drug: IV Nivolumab;   Drug: IV Gemcitabine;   Drug: IV Cisplatin;   Drug: IV/PO Dexamethasone;   Drug: IV L-asparaginase
Sponsors:   National Cancer Centre, Singapore;   Bristol-Myers Squibb
Withdrawn

Sat, 18 Jan 2020 12:00:00 EST

PEG-Asparaginase Associated Pancreatitis, Hepatotoxicity and Hyperlipidemia in Children With ALL

Conditions:   Acute Lymphoblastic Leukemia;   Pancreatitis
Intervention:  
Sponsors:   Rigshospitalet, Denmark;   Technical University of Denmark
Completed

Wed, 13 Jul 2011 12:00:00 EDT

Combination Chemotherapy Including Cisplatin, Ifosfamide, Gemcitabine, L-asparaginase, Etoposide and Dexamethasone as Treatment of Newly Diagnosed and Relapsed/Refractory Peripheral T Cell Lymphomas

Condition:   Peripheral T Cell Lymphoma
Interventions:   Drug: cisplatin;   Drug: ifosfamide;   Drug: gemcitabine;   Drug: L-asparaginase;   Drug: etoposide;   Drug: dexamethasone
Sponsor:   The University of Hong Kong
Recruiting

Tue, 07 Mar 2017 12:00:00 EST

Outcome Following Truncation of Asparaginase

Condition:   Relapse Leukemia
Intervention:  
Sponsor:   Birgitte Klug Albertsen
Unknown status

Mon, 17 Jun 2019 12:00:00 EDT

Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL)

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Metformin;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: PEG-asparaginase;   Drug: Doxorubicin;   Drug: Intrathecal chemotherapy
Sponsors:   H. Lee Moffitt Cancer Center and Research Institute;   Pediatric Cancer Foundation
Completed

Mon, 28 Mar 2011 12:00:00 EDT

VP-16, Ifosfamide, Dexamethasone, L-asparaginase Chemotherapy in Patients With Extranodal Natural Killer T Cell Lymphoma (VIDL+ASCT)

Condition:   Extranodal NK-T-Cell Lymphoma
Interventions:   Drug: Etoposide;   Drug: Ifosfamide;   Drug: Dexamethasone;   Drug: L-asparaginase;   Drug: Busulfan;   Drug: Melphalan
Sponsor:   Samsung Medical Center
Recruiting

Wed, 09 Sep 2015 12:00:00 EDT

GRASPA Treatment for Patients With Acute Myeloblastic Leukemia

Condition:   Acute Myeloid Leukemia
Intervention:   Drug: GRASPA
Sponsor:   ERYtech Pharma
Completed

Wed, 13 Mar 2013 12:00:00 EDT

Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin Hydrochloride With Asparaginase in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Conditions:   B Acute Lymphoblastic Leukemia;   B Lymphoblastic Lymphoma;   Recurrent Adult Acute Lymphoblastic Leukemia;   Recurrent B Lymphoblastic Lymphoma;   Recurrent T Lymphoblastic Leukemia/Lymphoma;   Refractory B Lymphoblastic Lymphoma;   Refractory T Lymphoblastic Lymphoma;   T Acute Lymphoblastic Leukemia;   T Lymphoblastic Lymphoma
Interventions:   Drug: Asparaginase;   Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Drug: Imatinib Mesylate;   Other: Laboratory Biomarker Analysis;   Drug: Prednisone;   Biological: Rituximab;   Drug: Vincristine Sulfate
Sponsors:   University of Washington;   National Cancer Institute (NCI)
Withdrawn

Wed, 02 Sep 2015 12:00:00 EDT

Phase II Study of Clinical Activity of Pegaspargase in Women With Relapsed or Refractory Epithelial Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer

Conditions:   Ovarian Neoplasms;   Fallopian Tube Neoplasms;   Primary Peritoneal Neoplasms
Intervention:   Drug: Pegylated L-Asparaginase
Sponsor:   National Cancer Institute (NCI)
Completed

Fri, 11 Mar 2011 12:00:00 EST

Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2008

Condition:   Childhood Acute Lymphoblastic Leukemia
Interventions:   Drug: PEG-L-asparaginase ind;   Drug: PEG-L-asparaginase cons;   Drug: E.coli L-asparaginase;   Drug: High-dose Methotrexate;   Drug: Low-dose Methotrexate;   Drug: Triple intrathecal therapy;   Radiation: Cranial irradiation;   Drug: Daunorubicin
Sponsor:   Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Active, not recruiting

Tue, 01 Oct 2013 12:00:00 EDT

Administration of GRASPA (Suspension of Erythrocytes Encapsulating L-asparaginase)in Patients With Pancreatic Cancer

Condition:   Pancreatic Cancer
Intervention:   Drug: GRASPA
Sponsor:   ERYtech Pharma
Completed

Wed, 01 Feb 2012 12:00:00 EST

Pharmacogenomics of Asparaginase Induced Hepatotoxicity

Condition:   Acute Lymphoblastic Leukemia
Intervention:   Procedure: Biospecimen Collection
Sponsors:   University of Southern California;   National Cancer Institute (NCI)
Recruiting

Tue, 26 Jun 2018 12:00:00 EDT

Trial of Oncaspar® and Three Doses of Pegylated Recombinant Asparaginase in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukaemia

Condition:   Acute Lymphoblastic Leukaemia
Interventions:   Drug: Oncaspar;   Drug: PEG-rASNase
Sponsor:   medac GmbH
Terminated

Thu, 02 Dec 2010 12:00:00 EST

Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224)

Conditions:   Relapsed Acute Lymphoblastic Leukemia;   Allergy to PEG e.Coli Asparaginase;   Allergy to Native e.Coli Asparaginase
Interventions:   Drug: Erwinase;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: Doxorubicin;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Triple Intrathecal Therapy;   Drug: Dexrazoxane
Sponsor:   Therapeutic Advances in Childhood Leukemia Consortium
Terminated

Thu, 25 Jun 2009 12:00:00 EDT

Social Media-based Active Self-report on Incidence and Outcomes of Adverse Events in NK/TCL Patients

Condition:   Extranodal NK-T-Cell Lymphoma, Nasal Type
Intervention:   Combination Product: L-Asparaginase or or Pegaspargase containing chemotherapy
Sponsor:   Rong Tao
Completed

Tue, 14 Mar 2017 12:00:00 EDT

Levocarnitine and Vitamin B Complex in Treating PEG-Asparaginase or Inotuzumab Ozogamicin-Induced Hyperbilirubinemia in Patients With Acute Lymphoblastic Leukemia

Conditions:   Acute Lymphoblastic Leukemia;   Hyperbilirubinemia
Interventions:   Dietary Supplement: Levocarnitine;   Drug: Vitamin B Complex
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Recruiting

Thu, 21 Jun 2018 12:00:00 EDT

Administration of GRASPA (Suspension of Erythrocytes Encapsulating L-asparaginase) in Elderly Patients With First Line Acute Lymphoblastic Leukemia

Condition:   Acute Lymphoblastic Leukemia
Intervention:   Drug: GRASPA
Sponsor:   ERYtech Pharma
Completed

Wed, 01 Feb 2012 12:00:00 EST

A Safety and Tolerability Study of Clofarabine, Etoposide, Cyclophosphamide, PEG-asparaginase, and Vincristine in Pediatric Acute Lymphoblastic Leukemia (ALL)

Condition:   Lymphoblastic Leukemia, Acute, Childhood
Intervention:   Drug: Clofarabine incorporated into a 5-drug regimen
Sponsor:   Genzyme, a Sanofi Company
Completed

Wed, 07 Oct 2009 12:00:00 EDT

Pharmacokinetics of Asparaginase and Antibody Formation in Interfant-06

Condition:   Leukemia
Intervention:  
Sponsor:   Aarhus University Hospital
Completed

Fri, 04 Dec 2009 12:00:00 EST

Study of CM4620 to Reduce the Severity of Pancreatitis Due to Asparaginase

Condition:   Acute Pancreatitis
Intervention:   Drug: CM4620
Sponsors:   St. Jude Children's Research Hospital;   CalciMedica, Inc.
Recruiting

Wed, 11 Dec 2019 12:00:00 EST

Hemostasis During Asparaginase Treatment in Acute Lymphoblastic Leukemia(ALL)

Condition:   Acute Lymphoblastic Leukemia
Intervention:  
Sponsor:   Aarhus University Hospital
Completed

Mon, 29 Mar 2010 12:00:00 EDT

A Drug Monitoring Study on PEG-asparaginase Treatment in Children Diagnosed Acute Lymphoblastic Leukaemia

Condition:   Acute Lymphoblastic Leukaemia
Intervention:  
Sponsor:   Aarhus University Hospital
Unknown status

Fri, 07 Jan 2011 12:00:00 EST

LAMPP Trial for Peripheral and Cutaneous T-Cell Lymphoma

Condition:   T-Cell Lymphoma
Intervention:   Drug: Doxil, Methotrexate, L-Asparaginase, Prednisone
Sponsors:   University of Medicine and Dentistry of New Jersey;   Ortho Biotech, Inc.
Terminated

Mon, 12 Sep 2005 12:00:00 EDT

TDM of Asparaginase in ALL2008

Condition:   Acute Lymphoblastic Leukemia
Intervention:  
Sponsor:   Aarhus University Hospital
Recruiting

Tue, 13 Apr 2021 12:00:00 EDT

Combination Chemotherapy and Alemtuzumab in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia

Condition:   Recurrent Adult Acute Lymphoblastic Leukemia
Interventions:   Biological: alemtuzumab;   Drug: asparaginase;   Drug: methotrexate;   Drug: dexamethasone;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: vincristine
Sponsor:   National Cancer Institute (NCI)
Terminated

Wed, 07 Dec 2005 12:00:00 EST

MRD/Risk-oriented Therapy of Adult Ph- ALL Including Pegylated Asparaginase and Lineage-targeted Methotrexate

Conditions:   Untreated Philadelphia Positive Acute Lymphoblastic Leukemia;   De Novo;   Secondary;   Low-dose Corticosteroids Pretreatment
Interventions:   Drug: Prephase PDN + CY;   Drug: Cycle 1 Induction;   Drug: Cycle 2 Induction / Early consolidation;   Drug: Cycle 3 Early consolidation;   Drug: Cycle 4 Consolidation;   Drug: Cycle 5 Consolidation;   Drug: Cycle 6 Consolidation;   Drug: Cycle 7 Consolidation;   Drug: Cycle 8 Reinduction;   Drug: Maintenance;   Procedure: Allogeneic SCT or Autologous SCT
Sponsor:   Gruppo Italiano Malattie EMatologiche dell'Adulto
Completed

Thu, 20 Feb 2014 12:00:00 EST

SIMPLE Chemotherapy for NK Lymphoma/Leukaemia

Conditions:   Non-Hodgkin's Lymphoma, Relapsed;   Non-Hodgkin T-cell Lymphoma;   Natural Killer/T-Cell Lymphoma, Nasal and Nasal-Type
Interventions:   Drug: Cisplatin;   Drug: Gemcitabine;   Drug: Etoposide (VP-16);   Device: Ifosfamide;   Drug: Dexamethasone;   Drug: L-asparaginase
Sponsor:   The University of Hong Kong
Unknown status

Thu, 09 Aug 2018 12:00:00 EDT

Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Prednisone, Vincristine, Daunorubicin, PEG-L-asparaginase, Erwinia L-asparaginase, Doxorubicin, Cyclophosphamide, Cytarabine, Thioguanine;   Drug: Clofarabine, Methotrexate, Mercaptopurine, Dexamethasone, Etoposide, Dasatinib
Sponsors:   St. Jude Children's Research Hospital;   National Cancer Institute (NCI);   Enzon Pharmaceuticals, Inc.;   National Institute of General Medical Sciences (NIGMS)
Active, not recruiting

Fri, 26 Oct 2007 12:00:00 EDT

Combine GELOX With Concurrent Radiation Therapy for Patients With Stage IE/IIE ENKTL

Condition:   Lymphoma, Extranodal NK-T-Cell
Interventions:   Drug: GELOX;   Radiation: IFRT
Sponsor:   Sun Yat-sen University
Unknown status

Thu, 06 Mar 2014 12:00:00 EST

Pharmacokinetics and Immunogenicity of the First Doses of PEG-Asparaginase -An ALLTogether Pilot Study

Condition:   Acute Lymphoblastic Leukemia
Intervention:  
Sponsor:   Aarhus University Hospital
Recruiting

Tue, 13 Apr 2021 12:00:00 EDT

LSA4 Protocol for the Treatment of Advanced Pediatric and Adolescent Non-Hodgkins Lymphoma

Condition:   Non-Hodgkin's Lymphoma
Intervention:   Drug: LSA4, Cyclophosphamide, Methotrexate, Daunomycin, L-asparaginase, BCNU
Sponsor:   Memorial Sloan Kettering Cancer Center
Completed

Fri, 08 Feb 2008 12:00:00 EST

SC-PEG Asparaginase vs. Oncaspar in Pediatric Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma

Conditions:   Acute Lymphoblastic Leukemia;   Lymphoblastic Lymphoma
Interventions:   Drug: SC-PEG;   Drug: Oncaspar
Sponsors:   Dana-Farber Cancer Institute;   Shire;   National Cancer Institute (NCI)
Active, not recruiting

Tue, 10 Apr 2012 12:00:00 EDT

A Study of the Safety and Effectiveness of Apixaban in Preventing Blood Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With Asparaginase

Conditions:   Lymphoma;   Acute Lymphoblastic Leukemia
Interventions:   Drug: Apixaban;   Other: No systemic anticoagulant prophylaxis
Sponsors:   Bristol-Myers Squibb;   Pfizer
Recruiting

Tue, 24 Feb 2015 12:00:00 EST

Treatment of Acute Lymphoblastic Leukemia in Children

Conditions:   Drug/Agent Toxicity by Tissue/Organ;   Leukemia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: dexamethasone;   Drug: dexrazoxane hydrochloride;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: methylprednisolone;   Drug: pegaspargase;   Drug: prednisolone;   Drug: therapeutic hydrocortisone;   Drug: vincristine sulfate;   Radiation: radiation therapy
Sponsors:   Dana-Farber Cancer Institute;   National Cancer Institute (NCI)
Completed

Fri, 17 Nov 2006 12:00:00 EST

Total Therapy Study XIV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Prednisone, Dexamethasone, Vincristine, Daunorubicin, PEG-L-asparaginase;   Drug: L-asparaginase, Methotrexate, Idarubicin, Etoposide, Cyclophosphamide, Cytarabine, Mercaptopurine
Sponsor:   St. Jude Children's Research Hospital
Terminated

Fri, 16 Sep 2005 12:00:00 EDT

A Study in Adults With Untreated Acute Lymphoblastic Leukemia

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: prednisone;   Drug: doxorubicin;   Drug: vincristine;   Drug: methotrexate;   Drug: asparaginase;   Drug: dexamethasone;   Radiation: cranial radiation;   Drug: leucovorin;   Drug: cytarabine;   Drug: hydrocortisone;   Drug: 6-mercaptopurine (6-MP);   Drug: e. coli L-asparaginase
Sponsors:   Dana-Farber Cancer Institute;   Brigham and Women's Hospital;   Massachusetts General Hospital;   Queen Elizabeth II Health Sciences Centre
Active, not recruiting

Mon, 29 Aug 2005 12:00:00 EDT

NOPHO ALL-2008 Pilot Study on Consolidation Therapy for Children and Adolescents With Acute Lymphoblastic Leukemia

Condition:   Leukemia, Lymphocytic, Acute
Intervention:   Drug: 6-mercaptopurine
Sponsor:   Rigshospitalet, Denmark
Completed

Wed, 24 Oct 2007 12:00:00 EDT

ABT-751 With Chemotherapy for Relapsed Pediatric ALL

Conditions:   Recurrent Pediatric ALL;   Relapsed Pediatric ALL;   Acute Lymphoblastic Leukemia;   Refractory Pediatric ALL
Interventions:   Drug: ABT-751;   Drug: Dexamethasone;   Drug: PEG-asparaginase;   Drug: Doxorubicin;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Cyclophosphamide;   Drug: 6-thioguanine
Sponsors:   Therapeutic Advances in Childhood Leukemia Consortium;   Abbott
Terminated

Fri, 23 Feb 2007 12:00:00 EST

Anlotinib for Advanced and Refractory Natural Killer /T-cell Lymphoma

Condition:   Natural Killer/T-Cell Lymphoma, Nasal and Nasal-Type
Intervention:   Drug: Anlotinib
Sponsor:   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Completed

Tue, 07 Aug 2018 12:00:00 EDT

Therapy for Pediatric Relapsed or Refractory Acute Lymphoblastic Leukemia

Conditions:   Acute Lymphoblastic Leukemia;   Lymphoma, Lymphoblastic
Interventions:   Drug: Etoposide, cytarabine, vincristine, dexamethasone;   Drug: methotrexate, teniposide, PEG-asparaginase;   Drug: mitoxantrone, cyclophosphamide, mercaptopurine, vinblastine;   Drug: L-asparaginase, erwinia asparaginase;   Procedure: chemotherapy, intrathecal chemotherapy, steroid therapy;   Procedure: Hematopoietic Stem Cell Transplant;   Procedure: Natural Killer (NK) Cell Transplant
Sponsor:   St. Jude Children's Research Hospital
Completed

Fri, 16 Sep 2005 12:00:00 EDT

B-MAD Chemotherapy in Newly-diagnosed Extranodal NK/ T-cell Lymphoma

Condition:   Extranodal NK/T-cell Lymphoma
Intervention:   Drug: B-MAD chemotherapy
Sponsors:   The Thai Lymphoma Study Group;   Takeda
Recruiting

Fri, 11 Aug 2017 12:00:00 EDT

PO Ixazomib in Combination With Chemotherapy for Childhood Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

Conditions:   ALL, Childhood;   Lymphoblastic Lymphoma, Childhood;   Lymphoblastic Leukemia, Acute, Childhood
Interventions:   Drug: Ixazomib;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: Asparaginase;   Drug: Doxorubicin
Sponsors:   Therapeutic Advances in Childhood Leukemia Consortium;   Takeda;   Children's Hospital Los Angeles
Recruiting

Fri, 25 Jan 2019 12:00:00 EST

MESA Versus ESA in the Treatment of Early Stage NK/T-cell Lymphoma

Condition:   Extranodal NK/T-cell Lymphoma, Nasal Type
Interventions:   Drug: Methotrexate;   Drug: Etoposide;   Drug: Dexamethasone;   Drug: Pegaspargase;   Radiation: Radiotherapy
Sponsor:   Ruijin Hospital
Active, not recruiting

Wed, 16 Dec 2015 12:00:00 EST

Study of Eryaspase in Combination With Chemotherapy Versus Chemotherapy Alone as 2nd-Line Treatment in PAC

Condition:   Pancreatic Adenocarcinoma
Interventions:   Drug: eryaspase;   Drug: Gemcitabine plus Abraxane;   Drug: Irinotecan plus 5-FU plus leucovorin
Sponsor:   ERYtech Pharma
Active, not recruiting

Tue, 11 Sep 2018 12:00:00 EDT

Combination Chemotherapy in Patients With Newly Diagnosed BPDCN

Condition:   Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)
Intervention:   Drug: Chemotherapy
Sponsors:   Centre Hospitalier Universitaire de Besancon;   UMR1098, EFS BFC, BESANCON;   Centre Henri Becquerel;   Maisonneuve-Rosemont Hospital;   Centre Hospitalier Universitaire Dijon;   Inserm CIC1431, CHU Besancon
Recruiting

Thu, 26 Jul 2018 12:00:00 EDT

Study of Eryaspase in Combination With Chemotherapy Versus Chemotherapy Alone for the Treatment of TNBC (TRYbeCA-2)

Condition:   Triple Negative Breast Cancer
Interventions:   Drug: eryaspase (L-asparaginase encapsulated in red blood cells);   Drug: Gemcitabine;   Drug: Carboplatin
Sponsor:   ERYtech Pharma
Recruiting

Mon, 17 Sep 2018 12:00:00 EDT

NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic Lymphoma

Condition:   Lymphoblastic Lymphoma
Interventions:   Drug: Prednisone;   Drug: Vincristine;   Drug: Daunorubicin;   Drug: PEG-asparaginase;   Drug: Erwinia asparaginase;   Drug: Doxorubicin;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Thioguanine;   Drug: Clofarabine;   Drug: Methotrexate;   Drug: Mercaptopurine;   Drug: Dexamethasone;   Drug: Hydrocortisone;   Drug: Etoposide
Sponsors:   St. Jude Children's Research Hospital;   National University, Singapore
Active, not recruiting

Thu, 13 Oct 2011 12:00:00 EDT

Oncaspar/Doxil/Decadron in Patients With Refractory Lymphoid Malignancies

Conditions:   Non-hodgkins Lymphoma;   Hodgkins Lymphoma;   Multiple Myeloma
Intervention:   Drug: Oncaspar, Doxil, Decadron
Sponsor:   Milton S. Hershey Medical Center
Terminated

Thu, 05 Feb 2009 12:00:00 EST

HCL Single Arm Pilot Study in Treatment of Hyperglycemia of Pediatric ALL

Condition:   High Risk Acute Lymphoblastic Leukemia
Intervention:   Device: Hybrid Closed Loop System
Sponsors:   University of Colorado, Denver;   Children's Hospital Colorado;   DexCom, Inc.;   Tandem Diabetes Care, Inc.;   National Cancer Institute (NCI)
Not yet recruiting

Mon, 16 Aug 2021 12:00:00 EDT

Safety and Efficacy of an Adult Acute Lymphoblastic Leukemia Chemotherapy for Adult Lymphoblastic Lymphoma

Condition:   Lymphoblastic Lymphoma
Interventions:   Drug: Prednisone, vincristine, daunorubicin , cyclophosphamide , L.-asparaginase, cytosine-arabinoside, methotrexate, etoposide;   Procedure: hematopoietic stem cell allograft
Sponsor:   Centre Henri Becquerel
Unknown status

Tue, 20 Sep 2005 12:00:00 EDT

Safety of Clofarabine With Multiagent Chemotherapy in Childhood Acute Lymphoblastic Leukemia

Conditions:   Acute Lymphoid Leukemia Relapse;   Acute Lymphoid Leukemia Relapse After Bone Marrow Transplant
Intervention:   Drug: Clofarabine
Sponsors:   University Hospital, Lille;   Centre Hospitalier Universitaire de Besancon;   Saint-Louis Hospital, Paris, France;   Assistance Publique - Hôpitaux de Paris;   Hospices Civils de Lyon;   University Hospital, Toulouse;   Central Hospital, Nancy, France;   University Hospital, Marseille;   University Hospital, Bordeaux;   Nantes University Hospital;   Rennes University Hospital
Completed

Wed, 19 Jan 2011 12:00:00 EST

Treatment of Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplasia

Condition:   Leukemia, Myelocytic, Acute
Interventions:   Drug: Cladribine, Cyclophosphamide, Cytarabine, Daunorubicin, Dexamethasone;   Drug: Etoposide, Cytarabine, Gemtuzumab, L-asparaginase, Mercaptopurine, methotrexate, Mitoxantrone, Prednisone, Vincristine
Sponsors:   St. Jude Children's Research Hospital;   National Cancer Institute (NCI)
Completed

Fri, 26 Aug 2005 12:00:00 EDT

SWOG-9400 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Previously Untreated Acute Lymphocytic Leukemia

Conditions:   Leukemia;   Neutropenia;   Thrombocytopenia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Procedure: allogeneic bone marrow transplantation;   Radiation: radiation therapy
Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
Completed

Thu, 29 Jul 2004 12:00:00 EDT

Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma

Conditions:   Leukemia;   Lymphoma
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: methylprednisolone;   Drug: mitoxantrone hydrochloride;   Drug: prednisolone;   Drug: therapeutic hydrocortisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Drug: vindesine;   Procedure: allogeneic bone marrow transplantation;   Procedure: peripheral blood stem cell transplantation
Sponsor:   European Organisation for Research and Treatment of Cancer - EORTC
Unknown status

Mon, 27 Jan 2003 12:00:00 EST

Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) I

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: ITMHA;   Drug: Dexamethasone;   Drug: Mitoxantrone;   Drug: Pegaspargase;   Drug: Asparaginase Erwinia Chrysanthemi;   Drug: Bortezomib;   Drug: Vorinostat;   Drug: Cyclophosphamide;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Leucovorin Calcium;   Drug: Cytarabine;   Drug: Etoposide;   Drug: Vincristine
Sponsors:   St. Jude Children's Research Hospital;   Gateway for Cancer Research;   Baylor College of Medicine
Recruiting

Thu, 17 Sep 2015 12:00:00 EDT

Pegaspargase and Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: imatinib mesylate;   Drug: methotrexate;   Drug: methylprednisolone;   Drug: pegaspargase;   Drug: vincristine sulfate
Sponsors:   OHSU Knight Cancer Institute;   National Cancer Institute (NCI)
Terminated

Sun, 01 Nov 2009 12:00:00 EDT

A Study of Children With Refractory or Relapsed ALL

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Topotecan, dexamethasone, vincristine;   Drug: E. coli Asparaginase, PEG-L-asparaginase;   Drug: erwinia asparaginase;   Drug: fludarabine, methotrexate, mercaptopurine;   Drug: idarubicin, etoposide, cytarbine, teniposide;   Procedure: chemotherapy, intrathecal chemotherapy, steroid therapy
Sponsor:   St. Jude Children's Research Hospital
Completed

Fri, 16 Sep 2005 12:00:00 EDT

Pre-reinductive Decitabine and Vorinostat in Relapsed Lymphoblastic Lymphoma or Acute Lymphoblastic Leukemia

Conditions:   Leukemia;   Lymphoma
Interventions:   Drug: cytarabine;   Drug: decitabine;   Drug: doxorubicin hydrochloride;   Drug: imatinib mesylate;   Drug: methotrexate;   Drug: pegaspargase;   Drug: prednisone;   Drug: vincristine sulfate;   Drug: vorinostat
Sponsor:   Masonic Cancer Center, University of Minnesota
Terminated

Thu, 16 Apr 2009 12:00:00 EDT

Bortezomib and Vorinostat in Younger Patients With Refractory or Relapsed MLL Rearranged Hematologic Malignancies

Conditions:   Mixed Lineage Acute Leukemia;   Acute Myeloid Leukemia;   Acute Lymphoid Leukemia
Interventions:   Drug: Bortezomib;   Drug: Vorinostat;   Drug: Mitoxantrone;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Hydrocortisone;   Drug: Peg-L-Asparaginase;   Drug: Erwinia L-Asparaginase;   Drug: Dexamethasone;   Drug: Mercaptopurine;   Drug: Doxorubicin
Sponsor:   St. Jude Children's Research Hospital
Terminated

Fri, 17 Apr 2015 12:00:00 EDT

EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL)

Conditions:   Lymphoblastic Leukemia, Acute;   Lymphoblastic Leukemia, Acute, Childhood;   Leukemia, Lymphoblastic, Acute, T Cell;   Leukemia, Lymphoblastic, Acute
Interventions:   Drug: EZN-3042;   Drug: Cytarabine;   Drug: Doxorubicin;   Drug: Prednisone;   Drug: Vincristine;   Drug: PEG-asparaginase;   Drug: Methotrexate;   Drug: Hydrocortisone
Sponsors:   Therapeutic Advances in Childhood Leukemia Consortium;   Enzon Pharmaceuticals, Inc.
Terminated

Mon, 23 Aug 2010 12:00:00 EDT

An Open-Label Study of JZP-458 (RC-P) in Patients With Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL)

Conditions:   Acute Lymphoblastic Leukemia;   Lymphoblastic Leukemia
Interventions:   Drug: IM JZP-458;   Drug: IV JZP-458
Sponsors:   Jazz Pharmaceuticals;   Children's Oncology Group (COG)
Recruiting

Wed, 30 Oct 2019 12:00:00 EDT

Multicenter Clinical Trial for Adult Ph-negative ALL. Non-intensive But Non-iterruptive Treatment

Condition:   Ph-negative Adult Acute Lymphoblastic Leukemia
Intervention:   Procedure: autologous HSCT
Sponsor:   National Research Center for Hematology, Russia
Active, not recruiting

Thu, 02 Sep 2010 12:00:00 EDT

Treatment of Natural Killer/T Cell Lymphoma-Ⅲ/Ⅳ

Condition:   Nasal and Nasal-type NK/T-cell Lymphoma
Interventions:   Drug: DDGP(cisplatin,dexamethasone,gemcitabine,pegaspargase);   Drug: Modified SMILE (MTX,DEX,IFO,L-ASP,Etoposide,Mesna)
Sponsors:   Mingzhi Zhang;   Second Hospital of Shanxi Medical University;   Shanxi Province Cancer Hospital;   Wuhan University;   Wuhan TongJi Hospital;   Wuhan Union Hospital, China;   Qingdao University;   Cancer Hospital of Guizhou Province;   Xinyang Central Hospital;   The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
Unknown status

Thu, 29 Dec 2011 12:00:00 EST

Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011)

Conditions:   Acute Lymphoblastic Leukemia;   Adult B Acute Lymphoblastic Leukemia;   Childhood B Acute Lymphoblastic Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisone;   Radiation: Prophylactic Cranial Irradiation;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Fri, 20 Mar 2009 12:00:00 EDT

Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or Lymphoma

Conditions:   Acute Lymphoblastic Leukemia;   Lymphoma, Non-Hodgkin's;   Leukemia, T-Cell;   Leukemia, B-Cell
Interventions:   Drug: Dexamethasone;   Drug: Panobinostat;   Drug: Liposomal vincristine;   Drug: Mitoxantrone;   Drug: Peg-asparaginase;   Drug: Bortezomib;   Drug: Intrathecal Triples;   Drug: High-dose methotrexate;   Drug: 6-Mercaptopurine;   Drug: High-dose cytarabine;   Drug: Nelarabine;   Drug: Cyclophosphamide;   Drug: Etoposide;   Drug: Clofarabine
Sponsors:   St. Jude Children's Research Hospital;   Novartis Pharmaceuticals;   Spectrum Pharmaceuticals, Inc
Terminated

Mon, 10 Aug 2015 12:00:00 EDT

Calaspargase Pegol-Mnkl and Cobimetinib for the Treatment of Locally Advanced or Metastatic Pancreatic Cancer

Conditions:   Locally Advanced Pancreatic Adenocarcinoma;   Metastatic Pancreatic Adenocarcinoma;   Stage II Pancreatic Cancer AJCC v8;   Stage IIA Pancreatic Cancer AJCC v8;   Stage IIB Pancreatic Cancer AJCC v8;   Stage III Pancreatic Cancer AJCC v8;   Stage IV Pancreatic Cancer AJCC v8
Interventions:   Procedure: Biopsy;   Drug: Calaspargase Pegol-mknl;   Drug: Cobimetinib
Sponsors:   OHSU Knight Cancer Institute;   Oregon Health and Science University;   Genentech, Inc.;   Servier Pharmaceuticals, LLC
Not yet recruiting

Sun, 05 Sep 2021 12:00:00 EDT

Augmented Berlin-Frankfurt-Munster (BFM) Therapy for Adolescent/Young Adults With Acute Lymphoblastic Leukemia or Acute Lymphoblastic Lymphoma

Conditions:   Lymphoblastic Leukemia;   Lymphoblastic Lymphoma
Interventions:   Drug: Daunorubicin;   Drug: Vincristine;   Drug: PEG-asparaginase;   Drug: Intrathecal Methotrexate;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Doxorubicin;   Drug: Thioguanine
Sponsor:   M.D. Anderson Cancer Center
Completed

Fri, 20 Mar 2009 12:00:00 EDT

Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia

Conditions:   Acute Lymphoblastic Leukemia;   Adult B Acute Lymphoblastic Leukemia;   Childhood B Acute Lymphoblastic Leukemia
Interventions:   Drug: Calaspargase Pegol-mknl;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Other: Pharmacological Study;   Drug: Prednisone;   Radiation: Radiation Therapy;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Fri, 02 May 2008 12:00:00 EDT

MESA Treatment for NK/T Cell Lymphoma

Condition:   Lymphoma, Extranodal NK-T-Cell
Interventions:   Drug: MESA chemotherapy;   Drug: MESA
Sponsor:   Air Force Military Medical University, China
Unknown status

Mon, 02 Sep 2013 12:00:00 EDT

Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes

Conditions:   Childhood Acute Basophilic Leukemia;   Childhood Acute Eosinophilic Leukemia;   Childhood Acute Erythroleukemia (M6);   Childhood Acute Megakaryocytic Leukemia (M7);   Childhood Acute Minimally Differentiated Myeloid Leukemia (M0);   Childhood Acute Monoblastic Leukemia (M5a);   Childhood Acute Monocytic Leukemia (M5b);   Childhood Acute Myeloblastic Leukemia With Maturation (M2);   Childhood Acute Myeloblastic Leukemia Without Maturation (M1);   Childhood Acute Myelomonocytic Leukemia (M4);   Childhood Myelodysplastic Syndromes;   de Novo Myelodysplastic Syndromes;   Secondary Acute Myeloid Leukemia;   Secondary Myelodysplastic Syndromes;   Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Interventions:   Drug: asparaginase;   Drug: daunorubicin hydrochloride;   Drug: cytarabine;   Drug: thioguanine;   Drug: etoposide;   Other: laboratory biomarker analysis
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Active, not recruiting

Tue, 29 Aug 2006 12:00:00 EDT

Radiotherapy Followed by Adjuvant Chemotherapy in NK/T-cell Lymphoma

Condition:   Extranodal NK/T-cell Lymphoma, Nasal Type
Intervention:   Drug: Radiotherapy followed by chemotherapy
Sponsor:   Fudan University
Unknown status

Fri, 17 Aug 2012 12:00:00 EDT

Modified Hyper-CVAD (Cyclophosphamide, Vincristine, Adriamycin, and Dexamethasone) Program for Acute Lymphoblastic Leukemia

Conditions:   Leukemia;   Acute Lymphoblastic Leukemia
Interventions:   Drug: Rituximab;   Drug: Cyclophosphamide (CTX);   Drug: Doxorubicin;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: Methotrexate (MTX);   Drug: Cytarabine;   Drug: G-CSF;   Drug: Mesna;   Drug: Pegylated asparaginase;   Drug: Pegfilgrastim;   Drug: Solumedrol
Sponsor:   M.D. Anderson Cancer Center
Completed

Mon, 05 May 2008 12:00:00 EDT

Mild-dose IMRT for Early-staged Extranodal Nasal-type NK/T-cell Lymphoma With CR Tumor After GELOX Chemotherapy

Conditions:   Lymphoma,;   Non-Hodgkin Lymphoma,;   Extranodal NK/T-cell Lymphoma,Nasal-type,
Intervention:   Radiation: Mild-dose IMRT
Sponsor:   Sun Yat-sen University
Unknown status

Mon, 01 Sep 2014 12:00:00 EDT

Monoclonal Antibody Plus Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndromes

Conditions:   Leukemia;   Myelodysplastic Syndromes
Interventions:   Drug: asparaginase;   Drug: cytarabine;   Drug: gemtuzumab ozogamicin;   Drug: mitoxantrone hydrochloride
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

Chemoimmunotherapy With Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL)

Condition:   Recurrent Childhood Acute Lymphoblastic Leukemia
Interventions:   Drug: L-asparaginase;   Drug: doxorubicin hydrochloride;   Drug: therapeutic hydrocortisone;   Drug: vincristine sulfate;   Biological: epratuzumab;   Drug: cytarabine;   Drug: prednisone;   Drug: pegaspargase;   Drug: dexrazoxane hydrochloride;   Drug: methotrexate;   Drug: etoposide;   Drug: cyclophosphamide;   Drug: leucovorin calcium;   Biological: filgrastim
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Thu, 09 Dec 2004 12:00:00 EST

Bortezomib and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia

Conditions:   B-cell Adult Acute Lymphoblastic Leukemia (ALL);   Ph-positive Adult Acute Lymphoblastic Leukemia (ALL);   Recurrent Adult Acute Lymphoblastic Leukemia (ALL);   T-cell Adult Acute Lymphoblastic Leukemia (ALL)
Interventions:   Drug: Bortezomib;   Drug: Doxorubicin hydrochloride (HCl);   Drug: PEG-Asparaginase;   Drug: Vincristine sulfate;   Drug: Dexamethasone;   Drug: Cytarabine;   Drug: Methotrexate
Sponsors:   Stanford University;   National Cancer Institute (NCI)
Completed

Wed, 16 Jan 2013 12:00:00 EST

ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016

Conditions:   Down Syndrome;   Acute Lymphoblastic Leukemia;   Childhood Cancer
Interventions:   Drug: Daunorubicin;   Drug: Prednisolone;   Drug: Vincristine;   Drug: Epirubicin;   Drug: E-coli L-asparaginase;   Drug: 6-Mercaptopurine;   Drug: Methotrexate;   Drug: Hydrocortisone;   Drug: Cytarabine;   Drug: Cyclophosphamide
Sponsor:   National Hospital Organization Nagoya Medical Center
Recruiting

Mon, 18 Sep 2017 12:00:00 EDT

Phase 3 Trial of Blinatumomab vs Standard Chemotherapy in Pediatric Subjects With HIgh-Risk (HR) First Relapse B-precursor Acute Lymphoblastic Leukemia (ALL)

Condition:   Leukemia, Acute Lymphoblastic
Interventions:   Drug: Blinatumomab;   Drug: Dexamethasone;   Drug: Vincrisitne;   Drug: Daunorubicin;   Drug: Methotrexate;   Drug: Ifosfamide;   Drug: PEG-asparaginase;   Drug: Erwinia-asparaginase
Sponsor:   Amgen
Active, not recruiting

Fri, 20 Mar 2015 12:00:00 EDT

Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome

Conditions:   Acute Myeloid Leukemia;   Down Syndrome;   Myelodysplastic Syndrome;   Myeloid Leukemia Associated With Down Syndrome;   Myeloproliferative Neoplasm
Interventions:   Drug: Asparaginase;   Drug: Asparaginase Erwinia chrysanthemi;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Drug: Mitoxantrone Hydrochloride;   Drug: Thioguanine
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Recruiting

Thu, 13 Aug 2015 12:00:00 EDT

Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: dexamethasone;   Drug: idarubicin;   Drug: methotrexate;   Drug: mitoxantrone hydrochloride;   Drug: pegaspargase;   Drug: vincristine sulfate
Sponsor:   Children's Cancer and Leukaemia Group
Completed

Thu, 27 Aug 2009 12:00:00 EDT

Pentoxifylline In Pediatric Acute Lymphoblastic Leukemia During Induction

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Pentoxifylline Plus Chemotherapy;   Drug: Placebo Plus Chemotherapy
Sponsors:   Ramón Óscar González-Ramella, Ph.D;   Instituto de Investigacion en Cancer de la Infancia y la Adolescencia;   Hospital Civil Juan I. Menchaca;   Centro de Investigacion Biomedica de Occidente
Unknown status

Fri, 22 May 2015 12:00:00 EDT

Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: etoposide;   Drug: gemtuzumab ozogamicin;   Drug: mitoxantrone hydrochloride
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Thu, 07 Sep 2006 12:00:00 EDT

CINJALL: Treatment for Children With Acute Lymphocytic Leukemia

Condition:   Acute Lymphocytic Leukemia
Interventions:   Drug: aminopterin;   Drug: L-asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunomycin;   Drug: dexamethasone;   Drug: 6-mercaptopurine;   Drug: methotrexate;   Drug: 6-thioguanine;   Drug: vincristine;   Drug: Triple Intrathecal Therapy (MTX, Cytarabine, Hydrocortisone);   Drug: Leucovorin
Sponsors:   Rutgers, The State University of New Jersey;   National Cancer Institute (NCI)
Completed

Thu, 15 Sep 2005 12:00:00 EDT

S0333 Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Biological: filgrastim;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin;   Drug: dexamethasone;   Drug: doxorubicin;   Drug: leucovorin;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: mitoxantrone;   Drug: Asparaginase;   Drug: prednisone;   Drug: thioguanine;   Drug: vincristine;   Radiation: radiation therapy;   Drug: allopurinol;   Drug: bactrim
Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
Completed

Wed, 04 May 2005 12:00:00 EDT

Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic Syndrome

Conditions:   Leukemia;   Myelodysplastic Syndromes;   Myelodysplastic/Myeloproliferative Neoplasms
Interventions:   Drug: asparaginase;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: methotrexate;   Drug: therapeutic hydrocortisone;   Drug: thioguanine
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

Bortezomib With Chemotherapy for Relapsed Pediatric Acute Lymphoblastic Leukemia (ALL)

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Bortezomib;   Drug: Dexamethasone;   Drug: PEG-asparaginase;   Drug: Doxorubicin;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Vincristine;   Drug: Triple IT Therapy
Sponsor:   Therapeutic Advances in Childhood Leukemia Consortium
Completed

Tue, 27 Feb 2007 12:00:00 EST

Pevonedistat With VXLD Chemotherapy for Adolescent/Young Adults With Relapsed/Refractory ALL or Lymphoblastic NHL

Conditions:   Refractory Acute Lymphoblastic Leukemia;   Relapsed Acute Lymphoblastic Leukemia
Interventions:   Drug: Pevonedistat;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: PEG-asparaginase;   Drug: Doxorubicin;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Hydrocortisone
Sponsors:   Julio Barredo, MD;   Takeda
Recruiting

Tue, 21 Nov 2017 12:00:00 EST

A Study to Evaluate the Efficacy and Safety of Daratumumab in Pediatric and Young Adult Participants Greater Than or Equal to (>=)1 and Less Than or Equal to (<=) 30 Years of Age With Relapsed/Refractory Precursor B-cell or T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Condition:   Precursor Cell Lymphoblastic Leukemia-Lymphoma
Interventions:   Drug: Daratumumab;   Drug: Vincristine;   Drug: Prednisone;   Drug: Doxorubicin;   Biological: Peg-asparaginase;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: 6-mercaptopurine;   Drug: Methotrexate
Sponsor:   Janssen Research & Development, LLC
Active, not recruiting

Wed, 27 Dec 2017 12:00:00 EST

Combination Chemotherapy in Treating Children With Acute Lymphocytic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: idarubicin;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: pegaspargase;   Drug: prednisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Radiation: radiation therapy
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Mon, 24 Nov 2003 12:00:00 EST

Ruxolitinib Plus LVP in Patients With R/R ETP-ALL

Condition:   Acute T Cell Leukemia
Interventions:   Drug: Ruxolitinib;   Drug: Vincristine;   Drug: Prednisone
Sponsor:   Sichuan University
Unknown status

Fri, 03 Aug 2018 12:00:00 EDT

GLIDE Regimen Followed by ASCT for Aggressive NK/T Cell Lymphoma

Condition:   Lymphoma, Extranodal NK-T-Cell
Intervention:   Drug: GLIDE
Sponsor:   Sichuan University
Unknown status

Tue, 16 May 2017 12:00:00 EDT

Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Doxorubicin;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Rituximab;   Drug: 6-Mercaptopurine;   Drug: Prednisone;   Drug: L-asparaginase
Sponsor:   Ruijin Hospital
Completed

Mon, 23 May 2011 12:00:00 EDT

Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia

Conditions:   Childhood Acute Lymphoblastic Leukemia;   Philadelphia Chromosome, Ph^1^, Absent;   B-cell Childhood Acute Lymphoblastic Leukemia
Intervention:   Drug: Idarubicin(IDA)
Sponsor:   Chinese Academy of Medical Sciences
Unknown status

Thu, 21 Nov 2013 12:00:00 EST

Concomitant Chemo-radiotherapy Followed by MIDLE Chemotherapy in Stage I/II Extranodal NK/T-cell Lymphoma

Condition:   Extranodal NK-T-Cell Lymphoma, Nasal and Nasal-Type
Intervention:   Radiation: CCRT+MIDLE chemotherapy
Sponsors:   Samsung Medical Center;   Asan Medical Center;   Yonsei University;   Seoul National University;   Chonnam National University
Completed

Wed, 10 Nov 2010 12:00:00 EST

Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma

Conditions:   Cardiac Toxicity;   Leukemia;   Lymphoma
Interventions:   Drug: asparaginase;   Drug: cytarabine;   Drug: dexrazoxane hydrochloride;   Drug: doxorubicin hydrochloride;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisone;   Drug: therapeutic hydrocortisone;   Drug: vincristine sulfate;   Radiation: radiation therapy
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Fri, 29 Oct 2010 12:00:00 EDT

Treatment of Acute Lymphoblastic Leukemia in Children

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: prednisone;   Drug: dexamethasone;   Drug: doxorubicin;   Drug: E. coli asparaginase;   Drug: vincristine;   Drug: methotrexate;   Drug: Leucovorin;   Drug: Asparaginase;   Drug: cytarabine;   Drug: Methotrexate/Hydrocortisone
Sponsors:   Dana-Farber Cancer Institute;   Boston Children's Hospital;   University of Rochester;   McMaster University;   San Jorge Children's Hospital (Puerto Rico);   St. Justine's Hospital;   Maine Children's Cancer Program;   Ochsner Health System;   Tulane University School of Medicine;   Laval University;   Columbia University
Completed

Wed, 14 Sep 2005 12:00:00 EDT

A Study of Venetoclax in Combination With Navitoclax and Chemotherapy in Subjects With Relapsed/Refractory Acute Lymphoblastic Leukemia or Relapsed/Refractory Lymphoblastic Lymphoma

Conditions:   Acute Lymphoblastic Leukemia (ALL);   Lymphoblastic Lymphoma
Interventions:   Drug: Navitoclax;   Drug: Chemotherapy;   Drug: Venetoclax
Sponsor:   AbbVie
Completed

Thu, 08 Jun 2017 12:00:00 EDT

Comparison of Liposomal Doxorubicin and Daunorubicin-containing VDCLD Regimen in the Treatment of Adult ALL Patients

Condition:   Adult Acute Lymphoblastic Leukemia
Interventions:   Drug: PLD;   Drug: DNR
Sponsor:   CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Unknown status

Mon, 05 Feb 2018 12:00:00 EST

Biomarkers to Classify Young Patients With Acute Lymphoblastic Leukemia (ALL) and Remission Induction Therapy in Young Patients With B-Precursor ALL

Condition:   Leukemia
Interventions:   Drug: SC-PEG E. coli L-asparaginase;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: methotrexate;   Drug: pegaspargase;   Drug: prednisone;   Drug: vincristine sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Thu, 21 Oct 2010 12:00:00 EDT

Augmented Berlin-Frankfurt-Munster Therapy Plus Ofatumumab for Young Adults With Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Conditions:   Leukemia;   Precursor-B Acute Lymphoblastic Leukemia;   Lymphoblastic Lymphoma;   Lymphoma
Interventions:   Drug: Cytarabine;   Drug: Daunorubicin;   Drug: Vincristine;   Drug: Prednisone;   Drug: PEG asparaginase;   Drug: Ofatumumab;   Drug: Rituximab;   Drug: Methotrexate;   Drug: Cyclophosphamide;   Drug: Mercaptopurine;   Drug: Doxorubicin;   Drug: Dexamethasone acetate;   Drug: Thioguanine
Sponsors:   M.D. Anderson Cancer Center;   Jazz Pharmaceuticals
Terminated

Fri, 17 Apr 2015 12:00:00 EDT

Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cytarabine;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisolone;   Drug: vincristine sulfate
Sponsor:   Dutch Childhood Oncology Group
Completed

Mon, 27 Jan 2003 12:00:00 EST

Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic Leukemia

Condition:   Acute Lymphoblastic Leukemia (ALL)
Interventions:   Drug: Carfilzomib;   Drug: Dexamethasone;   Drug: Mitoxantrone;   Drug: PEG-asparaginase;   Drug: Vincristine;   Drug: Intrathecal (IT) Methotrexate;   Drug: Intrathecal Triple Therapy (Intrathecal Cytarabine, Hydrocortisone, and Methotrexate);   Drug: 6-Mercaptopurine;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin
Sponsors:   Amgen;   Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) - Study Design & Execution Collaborator;   Innovative Therapies For Children with Cancer Consortium
Recruiting

Mon, 01 Dec 2014 12:00:00 EST

Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified Treatment

Conditions:   Acute Lymphoblastic Leukemia;   Lymphoblastic Lymphoma
Interventions:   Drug: Rituximab;   Drug: Nelarabine;   Drug: PEG-Asparaginase;   Procedure: Cranial irradiation;   Drug: Imatinib;   Drug: Idarubicin;   Drug: Dexamethasone;   Drug: Cyclophosphamide;   Drug: Fludarabine;   Drug: Vincristine;   Drug: Mercaptopurine;   Drug: VP16;   Drug: Daunorubicin (DNR);   Drug: Methotrexate;   Procedure: Stem cell transplantation;   Drug: Cytarabine;   Drug: Vindesine;   Drug: Adriamycin;   Drug: Prednisolone
Sponsor:   Goethe University
Recruiting

Fri, 26 Aug 2016 12:00:00 EDT

LBL-2016 for Children or Adolescents in China

Condition:   Lymphoblastic Lymphoma
Interventions:   Drug: Prednisone,Vincristine, Pegylated-asparaginase, Cytarabine, Cyclophosphamide, Daunorubicin, 6-mercaptopurine;   Drug: 6-mercaptopurine,Methotrexate;   Drug: Dexamethasone,Vincristine, Pegylated-asparaginase, Cytarabine, Cyclophosphamide, Doxorubicin, 6-mercaptopurine;   Drug: Dexamethasone,Vincristine, Pegylated-asparaginase, Cytarabine, Cyclophosphamide, Methotrexate;   Drug: Dexamethasone, Vindesine, Methotrexate, Ifosfamide, Daunorubicin, Pegylated-asparaginase;   Drug: Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase;   Drug: Methotrexate, 6-mercaptopurine
Sponsors:   Children's Cancer Group, China;   Shanghai Children's Medical Center;   Tongji Hospital;   West China Second University Hospital;   Qilu Hospital of Shandong University;   Tianjin Medical University Cancer Institute and Hospital;   Children's Hospital Of Soochow University;   Nanjing Children's Hospital;   Xiangya Hospital of Central South University
Recruiting

Wed, 27 Jul 2016 12:00:00 EDT

Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: dexamethasone;   Drug: asparaginase;   Drug: Asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin;   Drug: doxorubicin;   Drug: Etoposide;   Drug: Ifosfamide;   Drug: mercaptopurine;   Drug: Methotrexate;   Drug: prednisone;   Drug: thioguanine;   Drug: Vincristine;   Drug: Vindesine
Sponsor:   Associazione Italiana Ematologia Oncologia Pediatrica
Completed

Wed, 13 Feb 2008 12:00:00 EST

A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia

Conditions:   Acute Myeloid Leukemia;   Myelodysplastic Syndromes
Interventions:   Drug: Azacitidine;   Drug: Decitabine;   Drug: Cytarabine;   Drug: Daunorubicin;   Drug: Etoposide;   Combination Product: ITMHA;   Drug: Idarubicin;   Drug: Fludarabine;   Drug: Mitoxantrone;   Drug: Erwinia asparaginase;   Drug: Sorafenib;   Drug: G-CSF;   Drug: Dexrazoxane;   Biological: Stem Cell Transplant
Sponsor:   St. Jude Children's Research Hospital
Recruiting

Tue, 23 May 2017 12:00:00 EDT

A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: pegaspargase 1250 IU/m2 x 2;   Drug: pegaspargase 2500 IU/m2 x 1
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Shire
Recruiting

Wed, 23 Mar 2016 12:00:00 EDT

Chemotherapy With Liposomal Cytarabine CNS Prophylaxis for Adult Acute Lymphoblastic Leukemia & Lymphoblastic Lymphoma

Conditions:   Acute Lymphocytic Leukemia;   Adult Lymphoblastic Lymphoma
Interventions:   Drug: DNR;   Drug: VCR;   Drug: PEG-asp;   Drug: CTX;   Drug: Prednisone;   Drug: Liposomal AraC;   Drug: MTX;   Drug: LCV;   Drug: AraC;   Drug: Etoposide;   Drug: Dasatinib;   Drug: Rituximab;   Drug: Hydrocortisone
Sponsors:   University of California, San Diego;   Leadiant Biosciences, Inc.
Active, not recruiting

Thu, 23 Jan 2014 12:00:00 EST

"Sandwich" Chemotherapy With Radiotherapy in Newly Diagnosed, Stage IE to IIE, ENKTL

Condition:   Treatment Refusal
Interventions:   Drug: P-CHOP;   Radiation: Radiotherapy
Sponsor:   Sun Yat-sen University
Terminated

Tue, 11 Aug 2015 12:00:00 EDT

Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: pegaspargase;   Drug: prednisone;   Drug: therapeutic hydrocortisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Radiation: low-LET cobalt-60 gamma ray therapy;   Radiation: low-LET photon therapy
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Wed, 01 Sep 2004 12:00:00 EDT

Fludarabine, Cytarabine, and Pegcrisantaspase for the Treament of Relapsed or Refractory Leukemia

Conditions:   Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Recurrent Acute Biphenotypic Leukemia;   Recurrent Acute Lymphoblastic Leukemia;   Recurrent Acute Myeloid Leukemia;   Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Recurrent T-Cell Prolymphocytic Leukemia;   Refractory Acute Biphenotypic Leukemia;   Refractory Acute Lymphoblastic Leukemia;   Refractory Acute Myeloid Leukemia;   Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Refractory T-Cell Prolymphocytic Leukemia
Interventions:   Drug: Cytarabine;   Drug: Fludarabine;   Drug: Pegcrisantaspase
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Recruiting

Wed, 26 Aug 2020 12:00:00 EDT

Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic Lymphoma

Condition:   Lymphoma
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Radiation: radiation therapy
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

Condition:   Acute Myeloid Leukemia
Interventions:   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Drug: Asparaginase;   Drug: Asparaginase Erwinia chrysanthemi;   Behavioral: Cogstate Assessment Battery;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Dexrazoxane Hydrochloride;   Drug: Etoposide;   Drug: Gemtuzumab Ozogamicin;   Drug: Gilteritinib Fumarate;   Drug: Liposome-encapsulated Daunorubicin-Cytarabine;   Drug: Methotrexate;   Drug: Mitoxantrone Hydrochloride;   Drug: Therapeutic Hydrocortisone
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Recruiting

Tue, 03 Mar 2020 12:00:00 EST

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma

Conditions:   T Acute Lymphoblastic Leukemia;   T Lymphoblastic Lymphoma
Interventions:   Drug: Asparaginase;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Nelarabine;   Drug: Pegaspargase;   Drug: Prednisone;   Radiation: Radiation Therapy;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Tue, 05 Dec 2006 12:00:00 EST

Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents

Condition:   Acute Lymphoblastic Leukemia, Pediatric
Interventions:   Drug: Pegaspargase;   Drug: Erwinia asparaginase;   Drug: Cyclophosphamide;   Drug: CYTARABINE;   Drug: DASATINIB;   Drug: DEXAMETHASONE;   Drug: Dexrazoxane;   Drug: Doxorubicin;   Drug: ETOPOSIDE;   Drug: HYDROCORTISONE;   Drug: LEUCOVORIN CALCIUM;   Drug: MERCAPTOPURINE;   Drug: METHOTREXATE;   Drug: NELARABINE;   Drug: Vincristine
Sponsors:   Dana-Farber Cancer Institute;   Servier
Recruiting

Fri, 13 Jan 2017 12:00:00 EST

Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017

Condition:   Acute Lymphoblastic Leukemia, Pediatric
Interventions:   Drug: Blinatumomab;   Drug: Bortezomib;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin;   Drug: Myocet;   Drug: Dexamethasone;   Drug: Doxorubicin;   Drug: Etoposide;   Drug: Fludarabine Phosphate;   Drug: Ifosfamide;   Drug: 6-Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisolone;   Drug: Tioguanin;   Drug: Vincristine;   Drug: Vindesine;   Drug: Erwinase
Sponsors:   Martin Schrappe;   Deutsche Krebshilfe e.V., Bonn (Germany)
Recruiting

Wed, 22 Aug 2018 12:00:00 EDT

Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

Conditions:   Acute Lymphoblastic Leukemia;   Acute Lymphoblastic Lymphoma
Interventions:   Drug: Prednisone;   Drug: Vincristine;   Drug: Daunorubicin;   Drug: Pegaspargase;   Drug: Erwinase®;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Mercaptopurine;   Drug: Dasatinib;   Drug: Methotrexate;   Drug: Blinatumomab;   Drug: Ruxolitinib;   Drug: Bortezomib;   Drug: Dexamethasone;   Drug: Doxorubicin;   Drug: Etoposide;   Drug: Clofarabine;   Drug: Vorinostat;   Drug: Idarubicin;   Drug: Nelarabine;   Drug: Thioguanine
Sponsors:   St. Jude Children's Research Hospital;   Incyte Corporation;   Amgen;   Servier
Recruiting

Tue, 18 Apr 2017 12:00:00 EDT

A Novel "Pediatric-Inspired" Regimen With Reduced Myelosuppressive Drugs for Adults (Aged 18-60) With Newly Diagnosed Ph Negative Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: Daunorubicin;   Drug: Vincristine;   Drug: Prednisone;   Drug: PEG-Asparaginase;   Drug: Methotrexate;   Drug: 6-MP (6-Mercaptopurine);   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Leucovorin;   Drug: Dexamethasone;   Other: Blood draw;   Device: CT/PET scans
Sponsors:   Memorial Sloan Kettering Cancer Center;   Shire;   Duke University;   Weill Medical College of Cornell University;   Lehigh Valley Health Network
Active, not recruiting

Mon, 12 Aug 2013 12:00:00 EDT

Rituximab+mVPDL for CD20(+) Adult Acute Lymphoblastic Leukemia

Condition:   Precursor Cell Lymphoblastic Leukemia-Lymphoma
Intervention:   Drug: Rituximab+mVPDL
Sponsor:   Asan Medical Center
Unknown status

Wed, 07 Sep 2011 12:00:00 EDT

Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Conditions:   B-cell Adult Acute Lymphoblastic Leukemia;   B-cell Childhood Acute Lymphoblastic Leukemia;   Recurrent Adult Acute Lymphoblastic Leukemia;   Recurrent Adult Lymphoblastic Lymphoma;   Recurrent Childhood Acute Lymphoblastic Leukemia;   Recurrent Childhood Lymphoblastic Lymphoma;   T-cell Adult Acute Lymphoblastic Leukemia;   T-cell Childhood Acute Lymphoblastic Leukemia
Interventions:   Drug: L-asparaginase;   Drug: doxorubicin hydrochloride;   Drug: therapeutic hydrocortisone;   Drug: vincristine sulfate;   Drug: cytarabine;   Drug: prednisone;   Drug: bortezomib;   Drug: pegaspargase;   Drug: methotrexate;   Drug: etoposide phosphate;   Drug: cyclophosphamide;   Biological: filgrastim;   Drug: leucovorin calcium;   Other: laboratory biomarker analysis;   Drug: High Dose MTX
Sponsor:   National Cancer Institute (NCI)
Completed

Wed, 01 Apr 2009 12:00:00 EDT

Treatment for Patients With Stage III or IV Non-Hodgkin Lymphoma

Condition:   Lymphoblastic Lymphoma
Interventions:   Drug: Vincristine;   Procedure: Radiation Therapy;   Drug: Daunomycin;   Drug: L-Asparaginase;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Mercaptopurine;   Drug: Etoposide;   Drug: Cyclophosphamide;   Drug: Prednisone;   Drug: Dexamethasone
Sponsor:   St. Jude Children's Research Hospital
Completed

Fri, 16 Sep 2005 12:00:00 EDT

Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia

Conditions:   Childhood Acute Lymphoblastic Leukemia in Remission;   Recurrent Childhood Acute Lymphoblastic Leukemia
Interventions:   Biological: filgrastim;   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: etoposide;   Drug: ifosfamide;   Drug: imatinib mesylate;   Drug: leucovorin calcium;   Drug: mercaptopurine tablet;   Drug: methotrexate;   Drug: pegaspargase;   Drug: vincristine sulfate;   Procedure: allogeneic bone marrow transplantation;   Procedure: peripheral blood stem cell transplantation;   Procedure: umbilical cord blood transplantation;   Radiation: radiation therapy
Sponsor:   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic Leukemia

Conditions:   B-cell Childhood Acute Lymphoblastic Leukemia;   L1 Childhood Acute Lymphoblastic Leukemia;   L2 Childhood Acute Lymphoblastic Leukemia;   Intermediate Risk Recurrent Childhood Acute Lymphoblastic Leukemia
Interventions:   Drug: vincristine sulfate;   Drug: prednisone;   Drug: doxorubicin hydrochloride;   Drug: pegaspargase;   Drug: cytarabine;   Drug: methotrexate;   Drug: dexamethasone;   Drug: etoposide;   Drug: cyclophosphamide;   Drug: leucovorin calcium;   Biological: filgrastim;   Drug: asparaginase;   Drug: mercaptopurine
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Thu, 28 Sep 2006 12:00:00 EDT

Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Conditions:   T-cell Childhood Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions:   Drug: prednisone;   Drug: vincristine sulfate;   Drug: daunorubicin hydrochloride;   Drug: asparaginase;   Drug: methotrexate;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: mercaptopurine;   Drug: leucovorin calcium;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: thioguanine;   Radiation: radiation therapy;   Drug: nelarabine;   Drug: pegaspargase;   Other: pharmacological study;   Other: laboratory biomarker analysis
Sponsor:   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

AflacLL1901 (CHOA-AML)

Conditions:   Acute Myeloid Leukemia;   AML, Childhood
Interventions:   Drug: Cytarabine;   Drug: Daunorubicin;   Drug: Erwinase;   Drug: Etoposide;   Drug: Gemtuzumab ozogamicin;   Procedure: Stem cell transplantation (SCT);   Drug: Sorafenib
Sponsor:   Emory University
Terminated

Mon, 30 Mar 2020 12:00:00 EDT

Combination Chemotherapy Followed by Melphalan and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Acute Myeloid Leukemia

Condition:   Leukemia
Interventions:   Biological: filgrastim;   Drug: asparaginase;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: melphalan;   Drug: thioguanine;   Procedure: peripheral blood stem cell transplantation
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Thu, 20 May 2004 12:00:00 EDT

Concomitant Chemo-radiotherapy Plus VIDL Chemotherapy in NK/T-cell Lymphoma

Condition:   NK/T-cell Lymphoma of Nasal Cavity
Intervention:   Other: CCRT followed by VIDL chemotherapy
Sponsors:   Samsung Medical Center;   Asan Medical Center;   National Cancer Center, Korea;   Severance Hospital
Completed

Wed, 04 Nov 2009 12:00:00 EST

Study for Treatment of Cancer in Children With Ataxia-telangiectasia

Condition:   Ataxia-Telangiectasia
Interventions:   Drug: vinblastine, vincristine, prednisone, daunorubicin;   Drug: doxorubicin, methotrexate, cyclophosphamide, L-asparaginase;   Drug: etoposide, cytarabine, mercaptopurine;   Drug: dexamethasone, procarbazine;   Procedure: chemotherapy, intrathecal chemotherapy, steroid therapy
Sponsors:   St. Jude Children's Research Hospital;   Children's Hospital of Philadelphia;   National Cancer Institute (NCI)
Completed

Fri, 16 Sep 2005 12:00:00 EDT

Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphocytic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: thioguanine;   Drug: vincristine sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Mon, 13 Sep 2004 12:00:00 EDT

Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia

Condition:   Recurrent B Acute Lymphoblastic Leukemia
Interventions:   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Drug: Asparaginase;   Biological: Blinatumomab;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Mitoxantrone;   Drug: Mitoxantrone Hydrochloride;   Drug: Pegaspargase;   Other: Pharmacological Study;   Radiation: Radiation Therapy;   Drug: Therapeutic Hydrocortisone;   Drug: Thioguanine;   Drug: Vincristine;   Drug: Vincristine Sulfate
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Wed, 02 Apr 2014 12:00:00 EDT

Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Conditions:   Acute Lymphoblastic Leukemia;   Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1;   Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1
Interventions:   Drug: Asparaginase;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dasatinib;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Etoposide;   Biological: Filgrastim;   Drug: Hydrocortisone Sodium Succinate;   Drug: Ifosfamide;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Methylprednisolone;   Drug: Pegaspargase;   Drug: Prednisone;   Radiation: Radiation Therapy;   Drug: Vincristine Sulfate
Sponsor:   National Cancer Institute (NCI)
Completed

Tue, 22 Jul 2008 12:00:00 EDT

Combination Chemotherapy in Treating Children With Very High Risk Acute Lymphocytic Leukemia

Condition:   Leukemia
Interventions:   Biological: filgrastim;   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: etoposide;   Drug: idarubicin;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisone;   Drug: vincristine sulfate;   Radiation: radiation therapy
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Tue, 27 Apr 2004 12:00:00 EDT

Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Conditions:   Acute Lymphoblastic Leukemia;   Acute Undifferentiated Leukemia;   Childhood T Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions:   Drug: Asparaginase;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Etoposide;   Biological: Filgrastim;   Other: Laboratory Biomarker Analysis;   Drug: Lestaurtinib;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Methylprednisolone;   Drug: Pegaspargase;   Other: Pharmacological Study;   Drug: Prednisone;   Drug: Therapeutic Hydrocortisone;   Drug: Vincristine Sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Active, not recruiting

Mon, 12 Nov 2007 12:00:00 EST

Isatuximab in Combination With Chemotherapy in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia or Acute Myeloid Leukemia

Conditions:   Acute Lymphoblastic Leukemia;   Acute Myeloid Leukemia
Interventions:   Drug: Montelukast;   Drug: Isatuximab;   Drug: Dexamethasone;   Drug: Fludarabine;   Drug: Cytarabine;   Drug: Liposomal daunorubicin;   Drug: Daunorubicin;   Drug: Idarubicin;   Drug: Filgrastim;   Drug: Mitoxantrone;   Drug: Doxorubicin;   Drug: Vincristine;   Drug: PEG Asparaginase;   Drug: Cyclophosphamide;   Drug: Etoposide;   Drug: Methotrexate;   Drug: L - Asparginase;   Drug: Hydroxyurea;   Drug: L - Asparaginase (Erwinase);   Drug: Tocilizumab
Sponsor:   Sanofi
Recruiting

Mon, 04 Mar 2019 12:00:00 EST

Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia

Condition:   Acute Lymphobkastic Leukemia
Interventions:   Drug: Vincristine;   Drug: Daunorubicin;   Drug: Prednisone;   Drug: L-asparaginase;   Drug: Ciclophosphamide;   Drug: Metotrexate;   Drug: ARA-C;   Drug: Hidrocortisone;   Drug: Mercaptopurine;   Drug: VP-16;   Drug: Dexametasone
Sponsor:   PETHEMA Foundation
Completed

Wed, 15 Jan 2014 12:00:00 EST

A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

Conditions:   B Acute Lymphoblastic Leukemia;   B Lymphoblastic Lymphoma;   Down Syndrome
Interventions:   Drug: Asparaginase Erwinia chrysanthemi;   Biological: Blinatumomab;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Mercaptopurine Oral Suspension;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisolone;   Drug: Prednisone;   Radiation: Radiation Therapy;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsor:   National Cancer Institute (NCI)
Recruiting

Tue, 16 Apr 2019 12:00:00 EDT

Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic Syndrome

Conditions:   Childhood Acute Erythroleukemia (M6);   Childhood Acute Megakaryocytic Leukemia (M7);   Childhood Acute Monoblastic Leukemia (M5a);   Childhood Acute Monocytic Leukemia (M5b);   Childhood Acute Myeloblastic Leukemia With Maturation (M2);   Childhood Acute Myeloblastic Leukemia Without Maturation (M1);   Childhood Acute Myelomonocytic Leukemia (M4);   Childhood Myelodysplastic Syndromes;   Chronic Myelomonocytic Leukemia;   de Novo Myelodysplastic Syndromes;   Refractory Anemia;   Refractory Anemia With Excess Blasts;   Refractory Anemia With Excess Blasts in Transformation;   Refractory Anemia With Ringed Sideroblasts;   Secondary Myelodysplastic Syndromes;   Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Interventions:   Drug: asparaginase;   Drug: daunorubicin hydrochloride;   Drug: fludarabine phosphate;   Drug: therapeutic hydrocortisone;   Procedure: allogeneic bone marrow transplantation;   Radiation: 3-dimensional conformal radiation therapy;   Biological: filgrastim;   Drug: cytarabine;   Drug: idarubicin;   Drug: dexamethasone;   Drug: thioguanine;   Drug: etoposide;   Drug: methotrexate;   Drug: cyclophosphamide;   Biological: aldesleukin;   Drug: busulfan
Sponsor:   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

ALL Adult Consortium Trial: Adult ALL Trial

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Doxorubicin;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Vincristine;   Drug: Cyclophosphamide;   Drug: Methylprednisone;   Drug: Hydrocortisone Sodium Succinate;   Drug: Dexamethasone;   Drug: 6-MP;   Drug: PEG-Asparaginase;   Drug: Imatinib;   Drug: Etoposide;   Procedure: Radiation Therapy;   Drug: E. coli Asparaginase
Sponsors:   Dana-Farber Cancer Institute;   Massachusetts General Hospital;   Boston Children's Hospital;   NCIC Clinical Trials Group
Active, not recruiting

Mon, 21 May 2007 12:00:00 EDT

Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

Conditions:   Acute Myeloid Leukemia;   Leukemia Cutis;   Myeloid Neoplasm;   Myeloid Sarcoma
Interventions:   Drug: Asparaginase;   Drug: Bortezomib;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Drug: Mitoxantrone Hydrochloride;   Other: Pharmacological Study;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Drug: Sorafenib Tosylate
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Mon, 13 Jun 2011 12:00:00 EDT

Clinical Study of Liposomal Mitoxantrone Hydrochloride Injection Combined With Pegaspargase in the Treatment of NKTCL

Condition:   Extranodal NK/T-cell Lymphoma, Nasal Type
Interventions:   Drug: Part 1: Liposomal mitoxantrone hydrochloride and Pegaspargase;   Drug: Part 2 (treatment-naïve patients): Liposomal mitoxantrone hydrochloride and Pegaspargase;   Drug: Part 2 (relapsed or refractory patients): Liposomal mitoxantrone hydrochloride and Pegaspargase
Sponsor:   CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Not yet recruiting

Wed, 12 Aug 2020 12:00:00 EDT

Everolimus With Multiagent Re-Induction Chemotherapy in Pediatric Patients With ALL

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Everolimus;   Drug: Prednisone;   Drug: Vincristine;   Drug: PEG-Asparaginase;   Drug: Doxorubicin;   Drug: Dexrazoxane
Sponsors:   Dana-Farber Cancer Institute;   Novartis
Completed

Wed, 01 Feb 2012 12:00:00 EST

Induction Chemotherapy Sequential Sintilimab Combined With Dual Epigenetic Drugs for ENKTL-HLH

Condition:   Safety and Efficacy
Interventions:   Drug: Sintilimab;   Drug: Chidamide;   Drug: Azacitidine;   Drug: L-DEP
Sponsor:   Sun Yat-sen University
Not yet recruiting

Tue, 17 Aug 2021 12:00:00 EDT

Personalized Therapy of Precursor Lymphoid Neoplasms

Condition:   Precursor Lymphoid Neoplasms
Intervention:   Other: Treatment strategy: induction, consolidation, HSCT, maintenance
Sponsors:   Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice;   Polish Adult Leukemia Group
Unknown status

Wed, 15 Aug 2012 12:00:00 EDT

Four Drug Reinduction With Bortezomib for Relapsed or Refractory ALL or LL in Children and Young Adults

Conditions:   Acute Lymphoblastic Leukemia;   Lymphoblastic Lymphoma
Interventions:   Drug: Velcade;   Drug: Methotrexate;   Drug: Methotrexate / Hydrocortisone / Cytarabine;   Drug: Dexamethasone;   Drug: Mitoxantrone;   Drug: Vincristine;   Drug: Pegaspargase
Sponsors:   Children's Mercy Hospital Kansas City;   Millennium Pharmaceuticals, Inc.
Terminated

Mon, 31 Aug 2015 12:00:00 EDT

Combination Chemotherapy in Treating Young Adult Patients With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: ifosfamide;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: methylprednisolone;   Drug: prednisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Drug: vindesine
Sponsor:   Gruppo Italiano Malattie EMatologiche dell'Adulto
Completed

Mon, 05 Jul 2010 12:00:00 EDT

Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: ifosfamide;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Drug: vindesine
Sponsor:   University Hospital, Motol
Unknown status

Thu, 02 Oct 2008 12:00:00 EDT

PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Asparaginase;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin;   Drug: Mercaptopurine;   Drug: Prednisone;   Drug: Vincristine;   Drug: Methotrexate;   Procedure: Intrathecally treatment
Sponsor:   PETHEMA Foundation
Completed

Mon, 02 Jul 2007 12:00:00 EDT

Chemotherapy With or Without Imatinib and/or Peripheral Stem Cell Transplant in Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: daunorubicin hydrochloride;   Drug: etoposide;   Drug: idarubicin;   Drug: imatinib mesylate;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: methylprednisolone;   Drug: mitoxantrone hydrochloride;   Drug: prednisone;   Drug: vincristine sulfate;   Procedure: allogeneic hematopoietic stem cell transplantation;   Procedure: autologous hematopoietic stem cell transplantation;   Procedure: peripheral blood stem cell transplantation;   Radiation: radiation therapy
Sponsor:   Gruppo Italiano Malattie EMatologiche dell'Adulto
Completed

Wed, 11 Apr 2007 12:00:00 EDT

Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: ifosfamide;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Drug: vindesine;   Radiation: radiation therapy
Sponsor:   University Hospital Schleswig-Holstein
Completed

Thu, 01 Feb 2007 12:00:00 EST

Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: pegaspargase;   Drug: prednisolone;   Drug: teniposide;   Drug: thioguanine;   Drug: vincristine sulfate;   Radiation: radiation therapy
Sponsor:   Universitätsklinikum Hamburg-Eppendorf
Unknown status

Fri, 23 Jun 2006 12:00:00 EDT

Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic Lymphoma

Condition:   Lymphoma
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisolone;   Drug: thioguanine;   Drug: vincristine sulfate;   Procedure: radiation therapy
Sponsors:   Children's Cancer and Leukaemia Group;   European Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma
Terminated

Wed, 11 Jan 2006 12:00:00 EST

German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93)

Condition:   Adult Acute Lymphocytic Leukemia
Interventions:   Drug: Asparaginase;   Drug: Vincristine;   Drug: Daunorubicin, Adriamycin;   Drug: Cyclophosphamide;   Drug: Ifosfamide;   Drug: Cytarabine;   Drug: Mitoxantrone;   Drug: Methotrexate;   Drug: 6-Mercaptopurine;   Drug: 6-Thioguanine;   Drug: VM26;   Drug: Dexamethasone / Prednisolone;   Procedure: CNS Irradiation;   Procedure: Mediastinal Irradiation;   Procedure: Stem Cell Transplantation
Sponsors:   Johann Wolfgang Goethe University Hospital;   Deutsche Krebshilfe e.V., Bonn (Germany)
Completed

Tue, 20 Sep 2005 12:00:00 EDT

Therapy for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia

Condition:   Lymphoblastic Leukemia, Acute
Interventions:   Drug: Prednisone, Dexamethasone, Vincristine, Daunorubicin;   Drug: Doxorubicin, L-asparaginase, PEG-L-asparaginase, Erwinia asparaginase;   Drug: Methotrexate, Cyclophosphamide, Cytarabine, Etoposide;   Drug: Mercaptopurine, Imatinib;   Procedure: chemotherapy, intrathecal chemotherapy;   Procedure: steroid therapy, hematopoietic stem cell transplantation
Sponsors:   St. Jude Children's Research Hospital;   National Cancer Institute (NCI)
Completed

Mon, 29 Aug 2005 12:00:00 EDT

Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Other: Reduced intensification;   Drug: Standard childhood UK ALL protocol;   Drug: Intensified treatment including Capizzi maintenance
Sponsors:   University of Oxford;   Medical Research Council
Unknown status

Thu, 22 Sep 2005 12:00:00 EDT

Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's Lymphoma

Conditions:   Leukemia;   Lymphoma
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: etoposide;   Drug: leucovorin calcium;   Drug: methotrexate;   Drug: methylprednisolone;   Drug: therapeutic hydrocortisone;   Drug: thiotepa;   Drug: vincristine sulfate
Sponsor:   Memorial Sloan Kettering Cancer Center
Completed

Mon, 30 Aug 2004 12:00:00 EDT

Combination Chemotherapy in Treating Children With Relapsed Acute Lymphocytic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: methotrexate;   Drug: prednisone;   Drug: vincristine sulfate;   Radiation: radiation therapy
Sponsor:   Grupo Argentino de Tratamiento de la Leucemia Aguda
Unknown status

Mon, 23 Aug 2004 12:00:00 EDT

Different Therapies in Treating Infants With Newly Diagnosed Acute Leukemia

Condition:   Leukemia
Interventions:   Biological: anti-thymocyte globulin;   Drug: asparaginase;   Drug: busulfan;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: etoposide;   Drug: leucovorin calcium;   Drug: melphalan;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: mitoxantrone hydrochloride;   Drug: pegaspargase;   Drug: prednisolone;   Drug: prednisone;   Drug: therapeutic hydrocortisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Procedure: allogeneic bone marrow transplantation;   Procedure: allogeneic hematopoietic stem cell transplantation;   Procedure: umbilical cord blood transplantation
Sponsors:   Dutch Childhood Oncology Group;   BFM Germany;   CORS Monza Italy;   Associazione Italiana Ematologia Oncologia Pediatrica;   Australian and New Zealand Children's Oncology Group;   BFM Austria;   CLCG France Belgium Portugal;   COALL Germany;   CPH, Czech republic;   DFCI consortium USA;   FRALLE France;   Hong Kong;   MD Anderson USA;   NOPHO Scandinavian countries;   PINDA, Chile;   PPLLSG Poland;   Seattle USA;   SJCRH USA;   UKCCSG United Kingdom
Unknown status

Tue, 30 Oct 2007 12:00:00 EDT

Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma

Condition:   Lymphoma
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: etoposide;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisolone;   Drug: thioguanine;   Drug: vincristine sulfate
Sponsor:   United Kingdom Children's Cancer Study Group
Unknown status

Thu, 20 May 2004 12:00:00 EDT

Radiation Therapy to the Head or Intrathecal Chemotherapy Plus High Dose Cytarabine in Preventing CNS Disease in Children With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisone;   Drug: therapeutic hydrocortisone;   Drug: vincristine sulfate;   Radiation: radiation therapy
Sponsors:   National Institutes of Health Clinical Center (CC);   National Cancer Institute (NCI)
Withdrawn

Fri, 27 Feb 2004 12:00:00 EST

Combination Chemotherapy in Treating Adults With Acute Lymphocytic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: ifosfamide;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: mitoxantrone hydrochloride;   Drug: prednisolone;   Drug: teniposide;   Drug: thioguanine;   Drug: vincristine sulfate;   Drug: vindesine;   Procedure: allogeneic bone marrow transplantation;   Procedure: peripheral blood stem cell transplantation;   Radiation: radiation therapy
Sponsor:   Johann Wolfgang Goethe University Hospital
Unknown status

Mon, 16 Feb 2004 12:00:00 EST

Gemtuzumab Ozogamicin in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Undergoing Remission Induction and Intensification Therapy

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: busulfan;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: etoposide;   Drug: gemtuzumab ozogamicin;   Drug: methotrexate;   Drug: mitoxantrone hydrochloride;   Procedure: allogeneic bone marrow transplantation
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Tue, 07 Oct 2003 12:00:00 EDT

Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia and Diffuse Non-Hodgkin's Lymphoma

Conditions:   Leukemia;   Lymphoma
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: ifosfamide;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisone;   Drug: vincristine sulfate;   Procedure: conventional surgery;   Radiation: radiation therapy
Sponsors:   National Institutes of Health Clinical Center (CC);   National Cancer Institute (NCI)
Completed

Thu, 12 Jun 2003 12:00:00 EDT

Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: methylprednisolone;   Drug: pegaspargase;   Drug: thioguanine;   Drug: vincristine sulfate;   Procedure: allogeneic bone marrow transplantation;   Radiation: radiation therapy
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisone;   Drug: thioguanine;   Drug: vincristine sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma

Condition:   Lymphoma
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: etoposide;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: methylprednisolone;   Drug: mitoxantrone hydrochloride;   Drug: prednisone;   Drug: vincristine sulfate;   Radiation: radiation therapy
Sponsor:   UNICANCER
Completed

Mon, 27 Jan 2003 12:00:00 EST

Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: pegaspargase;   Drug: prednisolone;   Drug: thioguanine;   Drug: vincristine sulfate;   Radiation: radiation therapy
Sponsor:   Medical Research Council
Unknown status

Mon, 27 Jan 2003 12:00:00 EST

Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia

Conditions:   Leukemia;   Lymphoma
Interventions:   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: mitoxantrone hydrochloride;   Drug: prednisolone;   Drug: prednisone;   Drug: therapeutic hydrocortisone;   Drug: vincristine sulfate;   Procedure: allogeneic bone marrow transplantation;   Procedure: autologous bone marrow transplantation;   Radiation: radiation therapy
Sponsors:   European Organisation for Research and Treatment of Cancer - EORTC;   Acute Leukemia French Association
Completed

Mon, 27 Jan 2003 12:00:00 EST

Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous Lineage

Condition:   Acute Leukemia of Ambiguous Lineage
Interventions:   Drug: vincristine;   Drug: daunorubicin;   Drug: cyclophosphamide;   Drug: L-Asparaginase;   Drug: prednisone;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: dexamethasone;   Drug: Tyrosine kinase inhibitor
Sponsor:   wang, jianxiang
Not yet recruiting

Fri, 19 Jun 2020 12:00:00 EDT

Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Biological: filgrastim;   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: etoposide;   Drug: leucovorin calcium;   Drug: liposomal cytarabine;   Drug: mercaptopurine;   Drug: mesna;   Drug: methotrexate;   Drug: therapeutic hydrocortisone;   Drug: thiotepa;   Drug: vincristine sulfate;   Radiation: low-LET electron therapy;   Radiation: low-LET photon therapy
Sponsor:   National Cancer Institute (NCI)
Completed

Thu, 01 Jul 2004 12:00:00 EDT

Combination Chemotherapy in Treating Pediatric Patients With Stage III or IV Non-Hodgkin's Lymphoma

Condition:   Lymphoma
Interventions:   Biological: filgrastim;   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: etoposide;   Drug: leucovorin calcium;   Drug: mesna;   Drug: methotrexate;   Drug: vincristine sulfate
Sponsor:   Memorial Sloan Kettering Cancer Center
Completed

Thu, 01 Jul 2004 12:00:00 EDT

Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Biological: filgrastim;   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cyclosporine;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: etoposide;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: mesna;   Drug: methotrexate;   Drug: methylprednisolone;   Drug: pegaspargase;   Drug: prednisone;   Drug: therapeutic hydrocortisone;   Drug: vincristine sulfate;   Procedure: allogeneic bone marrow transplantation;   Radiation: low-LET cobalt-60 gamma ray therapy;   Radiation: low-LET photon therapy
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Wed, 16 Jun 2004 12:00:00 EDT

Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study

Condition:   Acute Lymphoblastic Leukemia (ALL)
Interventions:   Drug: Prednisolone;   Drug: Dexamethasone;   Drug: L-Asparaginase;   Drug: Vincristine;   Drug: Methotrexate;   Drug: Daunorubicin;   Drug: Doxorubicin;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: 6-Mercaptopurine;   Drug: Thioguanine;   Drug: Fludarabine;   Drug: Imatinib
Sponsor:   National University Hospital, Singapore
Unknown status

Fri, 09 Sep 2016 12:00:00 EDT

Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Biological: G-CSF;   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisone;   Drug: vincristine sulfate;   Drug: Allopurinol
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Completed

Thu, 20 May 2004 12:00:00 EDT

Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic Leukemia

Condition:   Leukemia
Interventions:   Biological: filgrastim;   Drug: asparaginase;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: etoposide;   Drug: idarubicin;   Drug: ifosfamide;   Drug: leucovorin calcium;   Drug: methotrexate;   Drug: prednisolone;   Drug: vindesine
Sponsor:   Hannover Medical School
Unknown status

Mon, 16 Feb 2004 12:00:00 EST

Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia

Conditions:   Leukemia;   Myelodysplastic Syndromes
Interventions:   Drug: amsacrine;   Drug: asparaginase;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: etoposide;   Drug: methotrexate;   Drug: mitoxantrone hydrochloride;   Drug: therapeutic hydrocortisone;   Procedure: allogeneic bone marrow transplantation
Sponsor:   Medical Research Council
Completed

Wed, 30 Apr 2003 12:00:00 EDT

Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Biological: filgrastim;   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: etoposide;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisone;   Drug: therapeutic hydrocortisone;   Drug: vincristine sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

Stem Cell Transplantation Compared With Standard Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia in First Remission

Condition:   Leukemia
Interventions:   Biological: sargramostim;   Drug: asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: etoposide;   Drug: imatinib mesylate;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Procedure: allogeneic bone marrow transplantation;   Procedure: autologous bone marrow transplantation;   Procedure: peripheral blood stem cell transplantation;   Radiation: radiation therapy
Sponsors:   Eastern Cooperative Oncology Group;   National Cancer Institute (NCI);   Medical Research Council
Completed

Mon, 27 Jan 2003 12:00:00 EST

International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic Lymphoma

Condition:   Lymphoblastic Lymphoma, Childhood
Interventions:   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Daunorubicin;   Drug: Doxorubicin;   Drug: Ifosfamide;   Drug: 6-Mercaptopurine;   Drug: Methotrexate;   Drug: PEG asparaginase;   Drug: Prednisone;   Drug: Prednisolone;   Drug: Thioguanine;   Drug: Vincristine;   Drug: Vindesine
Sponsors:   University Hospital Muenster;   Deutsche Krebshilfe e.V., Bonn (Germany)
Recruiting

Fri, 02 Aug 2019 12:00:00 EDT

A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: Ruxolitinib;   Drug: Asparaginase Erwinia Chrysanthemi;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Doxorubicin;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisone;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsors:   Incyte Corporation;   Children's Oncology Group
Recruiting

Thu, 31 Mar 2016 12:00:00 EDT

German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults

Condition:   Lymphoma, Lymphoblastic
Interventions:   Drug: Dexamethasone/Prednisolone;   Drug: Cyclophosphamide;   Drug: Vincristine;   Drug: Daunorubicin;   Drug: Asparaginase;   Drug: G-CSF;   Drug: Mercaptopurine;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: VP16;   Drug: Vindesine;   Drug: Adriamycin;   Drug: Thioguanine;   Drug: HDARAC;   Procedure: CNS irradiation;   Procedure: Mediastinal irradiation;   Drug: Cladribine
Sponsor:   Johann Wolfgang Goethe University Hospital
Completed

Tue, 20 Sep 2005 12:00:00 EDT

Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab

Condition:   Adult Acute Lymphocytic Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Dexamethasone / Prednisolone;   Drug: Vincristine;   Drug: Daunorubicin;   Drug: Asparaginase;   Drug: Methotrexate;   Drug: Cytarabine;   Drug: Mercaptopurine;   Drug: G-CSF;   Drug: Vindesine;   Drug: VP16;   Drug: Adriamycin;   Drug: Thioguanine;   Drug: VM26;   Drug: Rituximab;   Procedure: CNS irradiation;   Procedure: Mediastinal irradiation (if residual TU);   Procedure: Stem cell transplantation
Sponsor:   Johann Wolfgang Goethe University Hospital
Completed

Tue, 20 Sep 2005 12:00:00 EDT

German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003)

Condition:   Adult Acute Lymphocytic Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Dexamethasone;   Drug: Vincristine;   Drug: daunorubicin;   Drug: Asparaginase;   Drug: Methotrexate;   Drug: Cytarabine;   Drug: Mercaptopurine;   Drug: G-CSF;   Drug: Vindesine;   Drug: VP16;   Drug: Prednisolone;   Drug: Adriamycin;   Drug: Thioguanine;   Drug: VM26;   Procedure: CNS irradiation;   Procedure: Mediastinal Irradiation;   Procedure: Stem cell transplantation;   Drug: Idarubicin;   Drug: Fludarabine;   Drug: Cladribine
Sponsors:   Johann Wolfgang Goethe University Hospital;   Deutsche Krebshilfe e.V., Bonn (Germany);   German Federal Ministry of Education and Research
Unknown status

Tue, 20 Sep 2005 12:00:00 EDT

German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99)

Condition:   Adult Acute Lymphocytic Leukemia
Interventions:   Drug: Dexamethasone / Prednisolone;   Drug: Cyclophosphamide;   Drug: Methotrexate;   Drug: Vincristine / Vindesine;   Drug: Daunorubicin;   Drug: Asparaginase;   Drug: G-CSF;   Drug: Cytarabine;   Drug: 6-Mercaptopurine;   Drug: VP16;   Drug: Adriamycin;   Drug: Thioguanine;   Drug: VM26;   Drug: Idarubicin;   Drug: Fludarabine;   Drug: Ifosfamide;   Procedure: CNS irradiation;   Procedure: Mediastinal irradiation (if residual tumor);   Procedure: stem cell transplantation
Sponsor:   Johann Wolfgang Goethe University Hospital
Completed

Tue, 20 Sep 2005 12:00:00 EDT

German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Condition:   Adult Acute Lymphocytic Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Dexamethasone / Prednisolone;   Drug: Cytarabine;   Drug: Idarubicin;   Drug: Granulocyte-Colony-Stimulating Factor;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Rituximab;   Drug: HDARAC;   Drug: Vincristine;   Drug: Depocyte;   Drug: Asparaginase
Sponsor:   Johann Wolfgang Goethe University Hospital
Unknown status

Tue, 20 Sep 2005 12:00:00 EDT

International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: PEG-L-asparaginase;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: ifosfamide;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: prednisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Drug: vindesine;   Drug: daunoxome;   Drug: fludarabine;   Radiation: Radiation Therapy
Sponsors:   University Hospital Schleswig-Holstein;   Deutsche Krebshilfe e.V., Bonn (Germany)
Active, not recruiting

Wed, 05 May 2010 12:00:00 EDT

Treatment of Older Adults With Acute Lymphoblastic Leukemia

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Prednisone;   Drug: Vincristine;   Drug: Doxorubicin;   Drug: PEG-asparaginase;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Imatinib;   Drug: Clofarabine;   Drug: 6 Mercaptopurine
Sponsors:   Massachusetts General Hospital;   Dana-Farber Cancer Institute;   Beth Israel Deaconess Medical Center;   Enzon Pharmaceuticals, Inc.;   Genzyme, a Sanofi Company
Completed

Wed, 09 Sep 2009 12:00:00 EDT

Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic Leukemia

Conditions:   Acute Undifferentiated Leukemia;   B-cell Adult Acute Lymphoblastic Leukemia;   B-cell Childhood Acute Lymphoblastic Leukemia;   L1 Adult Acute Lymphoblastic Leukemia;   L1 Childhood Acute Lymphoblastic Leukemia;   L2 Adult Acute Lymphoblastic Leukemia;   L2 Childhood Acute Lymphoblastic Leukemia;   Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia;   Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia;   Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia;   T-cell Adult Acute Lymphoblastic Leukemia;   T-cell Childhood Acute Lymphoblastic Leukemia;   Untreated Adult Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions:   Drug: allopurinol;   Drug: cyclophosphamide;   Drug: daunorubicin hydrochloride;   Drug: vincristine sulfate;   Drug: dexamethasone;   Drug: asparaginase;   Biological: filgrastim;   Drug: imatinib mesylate;   Drug: methotrexate;   Drug: cytarabine;   Drug: trimethoprim-sulfamethoxazole;   Drug: mercaptopurine;   Drug: leucovorin calcium;   Biological: alemtuzumab;   Drug: acyclovir;   Other: laboratory biomarker analysis;   Other: pharmacological study
Sponsor:   National Cancer Institute (NCI)
Completed

Fri, 06 Jun 2003 12:00:00 EDT

Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic Leukemia

Conditions:   L1 Childhood Acute Lymphoblastic Leukemia;   L2 Childhood Acute Lymphoblastic Leukemia;   Non-T, Non-B Childhood Acute Lymphoblastic Leukemia;   Recurrent Childhood Acute Lymphoblastic Leukemia;   T-cell Childhood Acute Lymphoblastic Leukemia
Interventions:   Drug: cytarabine;   Drug: methotrexate;   Drug: vincristine sulfate;   Drug: prednisone;   Drug: pegaspargase;   Drug: doxorubicin hydrochloride;   Drug: imatinib mesylate;   Drug: cyclophosphamide;   Drug: etoposide;   Biological: filgrastim;   Drug: leucovorin calcium;   Drug: asparaginase;   Drug: therapeutic hydrocortisone
Sponsor:   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Prednisolone;   Drug: Daunorubicin;   Drug: Vincristine;   Drug: L-Asparaginase;   Drug: Cyclophosphamide;   Drug: Methotrexate;   Drug: Cytosine Arabinoside
Sponsor:   PETHEMA Foundation
Completed

Mon, 10 Sep 2007 12:00:00 EDT

LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Vincristine;   Drug: Daunorubicin;   Drug: Prednisone;   Drug: L-Asparaginase;   Drug: Mitoxantrone;   Drug: Cytosine Arabinoside;   Drug: Hydrocortisone;   Drug: Mercaptopurine;   Drug: Cyclophosphamide;   Drug: Dexamethasone
Sponsor:   PETHEMA Foundation
Completed

Mon, 10 Sep 2007 12:00:00 EDT

LAL-BR/2001: Study Treatment to Low Risk ALL

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Prednisone;   Drug: Vincristine;   Drug: Daunorubicin;   Drug: L-Asparaginase;   Drug: Cyclophosphamide;   Drug: Methotrexate;   Drug: Cytosine Arabinoside;   Drug: Mercaptopurine;   Drug: VP-16
Sponsor:   PETHEMA Foundation
Completed

Mon, 10 Sep 2007 12:00:00 EDT

Blinatumomab Versus Standard of Care Chemotherapy in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)

Condition:   Relapsed/Refractory B-precursor Acute Lymphoblastic Leukemia
Interventions:   Drug: Blinatumomab;   Drug: Standard of Care Chemotherapy
Sponsor:   Amgen
Terminated

Tue, 17 Dec 2013 12:00:00 EST

High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL)

Condition:   Lymphoblastic Leukemia, Acute
Interventions:   Drug: Cyclophosphamide;   Drug: Daunorubicin;   Drug: Vincristine;   Drug: Prednisolone;   Drug: L-asparaginase;   Drug: Cytarabine;   Drug: Etoposide;   Drug: Dexamethasone;   Drug: Methotrexate;   Drug: Mercaptopurine;   Drug: Doxorubicin
Sponsor:   Japan Adult Leukemia Study Group
Unknown status

Wed, 17 Aug 2005 12:00:00 EDT

Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia

Condition:   B Acute Lymphoblastic Leukemia
Interventions:   Drug: Allopurinol;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Vincristine Sulfate;   Drug: Dexamethasone;   Drug: Pegylated L-Asparaginase;   Drug: Methotrexate;   Procedure: Bone Marrow Aspiration and Biopsy;   Drug: Cyclophosphamide;   Drug: Mercaptopurine;   Biological: Rituximab;   Drug: Doxorubicin;   Drug: Thioguanine;   Biological: Inotuzumab Ozogamicin;   Other: Laboratory Biomarker Analysis
Sponsors:   Alliance for Clinical Trials in Oncology;   National Cancer Institute (NCI)
Recruiting

Fri, 12 May 2017 12:00:00 EDT

Applying Pediatric Regimens to Younger Adult Patients With Acute Lymphoblastic Leukemia (ALL)

Condition:   Lymphoblastic Leukemia, Acute
Interventions:   Drug: Methotrexate;   Drug: Prednisolone;   Drug: Dexamethasone;   Drug: Vincristine;   Drug: Pirarubicin;   Drug: Cyclophosphamide;   Drug: L-asparaginase;   Drug: Cytarabine;   Drug: Hydrocortisone;   Drug: Mercaptopurine
Sponsor:   Japan Adult Leukemia Study Group
Unknown status

Wed, 17 Aug 2005 12:00:00 EDT

Pegylated Liposomal Doxorubicin Versus Daunorubicin to Treat Acute Lymphoblastic Leukemia:

Condition:   Acute Lymphoblastic Leukemia
Intervention:   Drug: VDCLD regimen
Sponsors:   Changzhou Jinyuan Pharmaceutical Manufacturing Co., Ltd.;   CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Unknown status

Tue, 25 Feb 2014 12:00:00 EST

Genomic Based Assignment of Therapy in Advanced Urothelial Carcinoma

Conditions:   Urothelial Carcinoma;   Bladder Cancer;   Urinary Bladder Neoplasms
Interventions:   Drug: 75 approved agents;   Other: COXEN
Sponsor:   National Cancer Institute (NCI)
Completed

Thu, 02 Jun 2016 12:00:00 EDT

Induction Therapy With Cytarabine, High-Dose Mitoxantrone and Dasatinib for Patients With Philadelphia-Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia

Conditions:   Leukemia;   Acute Lymphoblastic Leukemia
Intervention:   Drug: Dasatinib, Mitoxantrone, Cytarabine
Sponsors:   Memorial Sloan Kettering Cancer Center;   Bristol-Myers Squibb
Completed

Thu, 16 Jul 2009 12:00:00 EDT

Study of Iomab-B vs. Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia

Conditions:   Acute Myeloid Leukemia;   Leukemia, Acute Myeloid;   Myeloid Leukemia, Acute;   Leukemia, Myeloid, Acute;   Acute Myelogenous Leukemia;   Leukemia, Acute Myelogenous;   Myelogenous Leukemia, Acute;   AML;   Bone Marrow Transplant
Interventions:   Drug: Iomab-B;   Drug: Conventional Care;   Procedure: HCT
Sponsor:   Actinium Pharmaceuticals
Recruiting

Wed, 27 Jan 2016 12:00:00 EST

Peroneal Muscles Response to Expected and Unexpected Falls Among Young and Middle-aged Adults Before and After Neuromuscular Training

Condition:   Healthy Participants
Intervention:   Other: Electromyograph Biofeedback training of the peroneal muscle
Sponsor:   Ariel University
Recruiting

Mon, 16 Aug 2021 12:00:00 EDT

Vincristine Sulfate Liposome Injection (Marqibo®) in Combination With UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults With Relapsed ALL

Conditions:   ALL, Childhood;   Lymphoblastic Leukemia, Acute, Childhood;   Lymphoblastic Leukemia, Acute
Intervention:   Drug: Marqibo
Sponsors:   Therapeutic Advances in Childhood Leukemia Consortium;   Spectrum Pharmaceuticals, Inc
Recruiting

Fri, 26 Aug 2016 12:00:00 EDT

Cladribine in Combination With GAP in Patients With Refractory/Relapsed Acute Lymphoblastic Leukemia

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Cladribine;   Drug: G-CSF;   Drug: Cytarabine;   Drug: Pegaspargase
Sponsor:   Sun Yat-sen University
Unknown status

Mon, 23 Oct 2017 12:00:00 EDT

A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Conditions:   Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL);   Ph+ Mixed Phenotype Acute Leukemia (MPAL);   Philadelphia Chromosome-Like ALL (Ph-like ALL)
Interventions:   Drug: Ponatinib;   Drug: Ponatinib AAF;   Drug: Chemotherapy Agents
Sponsor:   Takeda
Recruiting

Thu, 06 Aug 2020 12:00:00 EDT

Combination Chemotherapy in Treating Children With Lymphoma

Condition:   Lymphoma
Interventions:   Biological: filgrastim;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: leucovorin calcium;   Drug: methotrexate;   Drug: pegaspargase;   Drug: prednisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Radiation: radiation therapy
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Thu, 29 Apr 2004 12:00:00 EDT

A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALL

Conditions:   Acute Lymphoblastic Leukemia;   Precursor B-Cell Lymphoblastic Leukemia;   Precursor T-Cell Lymphoblastic Leukemia
Interventions:   Drug: Decitabine;   Drug: Vorinostat;   Drug: Vincristine;   Drug: Dexamethasone;   Drug: Mitoxantrone;   Drug: Pegaspargase;   Drug: Methotrexate
Sponsor:   Therapeutic Advances in Childhood Leukemia Consortium
Terminated

Thu, 01 Dec 2011 12:00:00 EST

Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: pegaspargase;   Drug: thioguanine;   Drug: vincristine sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: doxorubicin hydrochloride;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: pegaspargase;   Drug: thioguanine;   Drug: vincristine sulfate;   Radiation: radiation therapy
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

Study of Augmented Hyper-CVAD in Acute Lymphoblastic Leukemia Salvage

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Cyclophosphamide (CTX);   Drug: Vincristine;   Drug: Doxorubicin;   Drug: Decadron;   Drug: G-CSF;   Drug: Methotrexate (MTX);   Drug: Ara-C;   Drug: Pegaspargase
Sponsors:   M.D. Anderson Cancer Center;   Enzon Pharmaceuticals, Inc.
Completed

Thu, 30 Apr 2009 12:00:00 EDT

Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and Lymphoma

Conditions:   Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia;   Recurrent Childhood B-Lymphoblastic Lymphoma
Interventions:   Drug: dexamethasone;   Drug: vincristine sulfate;   Biological: rituximab;   Drug: clofarabine;   Drug: cyclophosphamide;   Drug: etoposide;   Biological: aldesleukin;   Drug: pegaspargase;   Drug: methotrexate;   Drug: mercaptopurine;   Drug: cytarabine;   Drug: mitoxantrone;   Drug: teniposide;   Drug: vinblastine;   Biological: natural killer cell infusion;   Other: laboratory biomarker analysis;   Drug: therapeutic hydrocortisone;   Procedure: allogeneic hematopoietic stem cell transplantation;   Device: CliniMACS
Sponsors:   St. Jude Children's Research Hospital;   Cookies for Kids' Cancer;   Assisi Foundation
Completed

Thu, 04 Oct 2012 12:00:00 EDT

Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

Conditions:   B Acute Lymphoblastic Leukemia;   B Lymphoblastic Lymphoma;   Central Nervous System Leukemia;   Mixed Phenotype Acute Leukemia;   Testicular Leukemia
Interventions:   Drug: Calaspargase Pegol-mknl;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Biological: Inotuzumab Ozogamicin;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisolone;   Other: Questionnaire Administration;   Radiation: Radiation Therapy;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Recruiting

Wed, 22 May 2019 12:00:00 EDT

Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma

Conditions:   Childhood B Acute Lymphoblastic Leukemia;   Childhood T Acute Lymphoblastic Leukemia;   Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma;   Recurrent Childhood Acute Lymphoblastic Leukemia;   Recurrent Childhood Lymphoblastic Lymphoma
Interventions:   Drug: Dexamethasone;   Other: Laboratory Biomarker Analysis;   Drug: Methotrexate;   Drug: Mitoxantrone Hydrochloride;   Drug: Pegaspargase;   Other: Pharmacological Study;   Drug: Temsirolimus;   Drug: Vincristine Sulfate
Sponsor:   National Cancer Institute (NCI)
Completed

Wed, 27 Jul 2011 12:00:00 EDT

Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or Testes

Condition:   Leukemia
Interventions:   Biological: filgrastim;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: dexamethasone;   Drug: etoposide;   Drug: leucovorin calcium;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: pegaspargase;   Drug: therapeutic hydrocortisone;   Drug: vincristine sulfate;   Radiation: radiation therapy
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Tue, 09 Nov 2004 12:00:00 EST

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Conditions:   Down Syndrome;   Recurrent B Acute Lymphoblastic Leukemia
Interventions:   Radiation: 3-Dimensional Conformal Radiation Therapy;   Biological: Blinatumomab;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Etoposide;   Drug: Hydrocortisone Sodium Succinate;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Biological: Nivolumab;   Drug: Pegaspargase;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsor:   National Cancer Institute (NCI)
Recruiting

Mon, 14 Sep 2020 12:00:00 EDT

Low-Intensity Chemotherapy and Venetoclax in Treating Patients With Relapsed or Refractory B- or T-Cell Acute Lymphoblastic Leukemia

Conditions:   Recurrent B Acute Lymphoblastic Leukemia;   Recurrent T Acute Lymphoblastic Leukemia;   Refractory B Acute Lymphoblastic Leukemia;   Refractory T Acute Lymphoblastic Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Methotrexate;   Drug: Nelarabine;   Drug: Pegaspargase;   Drug: Prednisone;   Biological: Rituximab;   Drug: Venetoclax;   Drug: Vincristine
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Recruiting

Thu, 17 Jan 2019 12:00:00 EST

Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Conditions:   Acute Lymphoblastic Leukemia;   B Acute Lymphoblastic Leukemia;   Mixed Phenotype Acute Leukemia;   T Acute Lymphoblastic Leukemia
Interventions:   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Dexrazoxane Hydrochloride;   Drug: Doxorubicin;   Drug: Etoposide;   Biological: Filgrastim;   Drug: Ifosfamide;   Drug: Imatinib Mesylate;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Methylprednisolone;   Drug: Pegaspargase;   Drug: Prednisolone;   Other: Questionnaire Administration;   Drug: Therapeutic Hydrocortisone;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI);   EsPhALL network I-BFM Study Group
Recruiting

Mon, 02 Jan 2017 12:00:00 EST

Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia

Conditions:   Recurrent B Acute Lymphoblastic Leukemia;   Recurrent B Lymphoblastic Lymphoma;   Refractory B Acute Lymphoblastic Leukemia;   Refractory B Lymphoblastic Lymphoma
Interventions:   Drug: Cyclophosphamide;   Drug: Cytarabine;   Biological: Inotuzumab Ozogamicin;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Vincristine
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Recruiting

Mon, 05 Dec 2016 12:00:00 EST

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations

Conditions:   B Acute Lymphoblastic Leukemia;   Central Nervous System Leukemia;   Ph-Like Acute Lymphoblastic Leukemia;   Testicular Leukemia
Interventions:   Drug: Clofarabine;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dasatinib;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Drug: Hydrocortisone Sodium Succinate;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisone;   Radiation: Radiation Therapy;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Tue, 30 Aug 2016 12:00:00 EDT

Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene Rearrangement

Conditions:   Acute Leukemia of Ambiguous Lineage;   B Acute Lymphoblastic Leukemia;   Mixed Phenotype Acute Leukemia
Interventions:   Drug: Azacitidine;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Hydrocortisone Sodium Succinate;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Other: Pharmacological Study;   Drug: Prednisolone;   Drug: Thioguanine;   Drug: Vincristine;   Drug: Vincristine Sulfate
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Mon, 11 Jul 2016 12:00:00 EDT

Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma

Conditions:   Adult T Acute Lymphoblastic Leukemia;   Ann Arbor Stage II Adult Lymphoblastic Lymphoma;   Ann Arbor Stage II Childhood Lymphoblastic Lymphoma;   Ann Arbor Stage III Adult Lymphoblastic Lymphoma;   Ann Arbor Stage III Childhood Lymphoblastic Lymphoma;   Ann Arbor Stage IV Adult Lymphoblastic Lymphoma;   Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma;   Childhood T Acute Lymphoblastic Leukemia
Interventions:   Drug: Bortezomib;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Doxorubicin;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Drug: Hydrocortisone Sodium Succinate;   Drug: Ifosfamide;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Radiation: Radiation Therapy;   Drug: Thioguanine;   Drug: Vincristine;   Drug: Vincristine Sulfate
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Mon, 14 Apr 2014 12:00:00 EDT

Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia

Conditions:   Acute Lymphoblastic Leukemia;   B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
Interventions:   Procedure: Allogeneic Hematopoietic Stem Cell Transplantation;   Biological: Blinatumomab;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Etoposide;   Other: Laboratory Biomarker Analysis;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisone;   Biological: Rituximab;   Drug: Vincristine;   Drug: Vincristine Sulfate
Sponsors:   National Cancer Institute (NCI);   Canadian Cancer Trials Group
Active, not recruiting

Fri, 06 Dec 2013 12:00:00 EST

Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma

Conditions:   Acute Lymphoblastic Leukemia;   Adult B Lymphoblastic Lymphoma;   Ann Arbor Stage I B Lymphoblastic Lymphoma;   Ann Arbor Stage II B Lymphoblastic Lymphoma;   Childhood B Acute Lymphoblastic Leukemia;   Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1;   Childhood B Lymphoblastic Lymphoma;   Down Syndrome;   Hypodiploid B Acute Lymphoblastic Leukemia;   Philadelphia Chromosome Positive
Interventions:   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Other: Laboratory Biomarker Analysis;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Active, not recruiting

Mon, 30 Aug 2010 12:00:00 EDT

Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

Conditions:   T Acute Lymphoblastic Leukemia;   T Lymphoblastic Lymphoma
Interventions:   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Nelarabine;   Drug: Pegaspargase;   Drug: Prednisone;   Drug: Venetoclax;   Drug: Vincristine Sulfate
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Recruiting

Mon, 16 Jul 2007 12:00:00 EDT

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Conditions:   Acute Lymphoblastic Leukemia;   Childhood B Acute Lymphoblastic Leukemia
Interventions:   Radiation: 3-Dimensional Conformal Radiation Therapy;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Tue, 08 Feb 2005 12:00:00 EST

Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia

Conditions:   Acute Lymphoblastic Leukemia;   Adult B Acute Lymphoblastic Leukemia;   Childhood B Acute Lymphoblastic Leukemia
Interventions:   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin Hydrochloride;   Drug: Dexamethasone;   Drug: Doxorubicin Hydrochloride;   Drug: Leucovorin Calcium;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Pegaspargase;   Drug: Prednisone;   Radiation: Radiation Therapy;   Drug: Thioguanine;   Drug: Vincristine Sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Tue, 13 Jan 2004 12:00:00 EST

Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia

Condition:   Leukemia
Interventions:   Drug: cytarabine;   Drug: dexamethasone;   Drug: etoposide;   Drug: idarubicin;   Drug: ifosfamide;   Drug: leucovorin calcium;   Drug: mesna;   Drug: pegaspargase;   Drug: therapeutic hydrocortisone;   Drug: thioguanine;   Drug: vincristine sulfate;   Radiation: low-LET cobalt-60 gamma ray therapy;   Radiation: low-LET electron therapy;   Radiation: low-LET photon therapy;   Drug: Methotrexate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Wed, 23 Jun 2004 12:00:00 EDT

Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

Condition:   Leukemia
Intervention:   Drug: Nilotinib+mVPD
Sponsor:   Asan Medical Center
Completed

Mon, 16 Feb 2009 12:00:00 EST

Modified BFM-95 Regimen as First-Line Chemotherapy in Adults With T- Lymphoblastic Lymphoma

Condition:   Lymphoma, Lymphoblastic
Interventions:   Drug: induction phase1;   Drug: induction phase2;   Drug: protocol M;   Drug: maintenance therapy;   Drug: reinduction phase1;   Drug: reinduction phase2;   Drug: Intrathecal (IT)
Sponsor:   Sun Yat-sen University
Unknown status

Tue, 24 Mar 2015 12:00:00 EDT

Treatment of Acute Lymphoblastic Leukemia HIGH RISK BCR / ABL NEGATIVE IN ADULTS

Condition:   Acute Lymphoblastic Leukemia
Interventions:   Drug: Vincristine in induction;   Drug: Daunorubicin in induction;   Drug: Prednisone in induction;   Drug: Metotrexato in induction;   Drug: Cytarabine in induction;   Drug: Hydrocortisone in induction;   Drug: Idarubicin in induction-2;   Drug: Fludarabine in induction-2;   Drug: Ara-C in induction-2;   Drug: G-CSF in induction-2;   Drug: Dexamethasone in consolidation-1;   Drug: Vincristrine in consolidation-1;   Drug: Metotrexato in consolidation-1;   Drug: PEG-ASP in consolidation-1;   Drug: Dexamethasone in consolidation-2;   Drug: ARA-C in consolidation-2;   Drug: PEG-ASP in consolidation-2;   Drug: Dexamethasone in consolidation-3;   Drug: Vincristine in consolidation-3;   Drug: Metotrexato in consolidation-3;   Drug: PEG-ASP in consolidation-3;   Procedure: allogeneic HSCT;   Procedure: Allo HSCT with reduced-intensity conditioning
Sponsor:   PETHEMA Foundation
Completed

Wed, 29 Feb 2012 12:00:00 EST

Treatment of Natural Killer/T Cell Lymphoma-I/II

Condition:   Nasal and Nasal-type NK/T-cell Lymphoma
Interventions:   Other: DDGP(cisplatin,dexamethasone,gemcitabine,pegaspargase);   Other: VIPD(cisplatin,Etoposide,Ifosfamide, dexamethasone,Mesna);   Other: gemcitabine,pegaspargase,cisplatin,dexamethasone;   Other: cisplatin,Etoposide,Ifosfamide,dexamethasone,Mesna;   Radiation: Radiotherapy
Sponsors:   Mingzhi Zhang;   Second Hospital of Shanxi Medical University;   Shanxi Province Cancer Hospital;   Wuhan University;   Wuhan TongJi Hospital;   Wuhan Union Hospital, China;   Qingdao University;   Cancer Hospital of Guizhou Province;   Xinyang Central Hospital;   The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
Unknown status

Thu, 29 Dec 2011 12:00:00 EST

Clofarabine or High-Dose Cytarabine and Pegaspargase in Children With ALL

Condition:   Leukemia
Interventions:   Drug: Amsacrine;   Drug: Clofarabine;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: Daunorubicin hydrochloride;   Drug: Dexamethasone;   Drug: Doxorubicin hydrochloride;   Drug: Etoposide phosphate;   Drug: Mercaptopurine;   Drug: Methotrexate;   Drug: Methylprednisolone;   Drug: Pegaspargase;   Drug: Thioguanine;   Drug: Vincristine sulfate;   Radiation: Whole-brain radiation therapy
Sponsor:   Universitätsklinikum Hamburg-Eppendorf
Active, not recruiting

Tue, 26 Oct 2010 12:00:00 EDT

Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2015 (ALL-MB 2015)

Condition:   Childhood Acute Lymphoblastic Leukemia
Interventions:   Drug: Dexamethasone continuous;   Drug: Dexamethasone intermittent;   Drug: Dexamethasone;   Drug: Methylprednisolone;   Drug: Daunorubicin;   Drug: Idarubicin;   Drug: Bortezomib;   Drug: Second phase of induction;   Drug: Standard induction therapy;   Drug: Standard consolidation therapy
Sponsor:   Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Recruiting

Thu, 04 Jan 2018 12:00:00 EST