Clinical Trials
ALL2008 Protocol for Childhood Acute Lymphoblastic Leukemia Intermittent Versus Continuous PEG AsparaginaseCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: PEG Asparaginase at six weeks interval; Drug: PEG Asparaginase at two weeks interval Sponsors: Rigshospitalet, Denmark; Nordic Society for Pediatric Hematology and Oncology Completed Fri, 09 Jan 2009 12:00:00 EST Intravenous Erwinia Chrysanthemi Asparaginase in Patients With Newly Diagnosed Philadelphia Chromosome Negative Acute Lymphoblastic Leukemia Aged 60 Years or OlderConditions: Acute Lymphoblastic Leukemia (ALL); Newly Diagnosed Philadelphia Chromosome Negative; Aged 60 Years or OlderIntervention: Drug: Erwinia Chrysanthemi asparaginase Sponsors: Memorial Sloan Kettering Cancer Center; Jazz Pharmaceuticals Withdrawn Wed, 06 Jan 2016 12:00:00 EST Anti-PD-1 Antibody Combined With Peg-Asparaginase and Chidamide for the Early Stage of NK/T Cell LymphomaConditions: Immune Checkpoint Inhibitor; Chemotherapy Effect; Epigenetic Disorder; NK/T-cell Lymphoma of Nasal CavityIntervention: Drug: Anti-PD-1 antibody+Peg-Asparaginase+Chidamide Sponsor: Hunan Cancer Hospital Recruiting Thu, 04 Jun 2020 12:00:00 EDT L-asparaginase Encapsulated in Red Blood Cells (Eryaspase) for Treatment of Adult Patients With ALL or LBLConditions: Acute Lymphoblastic Leukemia; Lymphoblastic LymphomaIntervention: Drug: L-asparaginase encapsulated in RBC Sponsor: ERYtech Pharma Terminated Mon, 29 Jul 2013 12:00:00 EDT Erwinase Study in Patients With Acute Lymphoblastic LeukemiaCondition: LeukemiaIntervention: Drug: Erwinase Sponsor: M.D. Anderson Cancer Center Completed Wed, 25 Jul 2007 12:00:00 EDT GRASPA (Erythrocytes Encapsulating L-asparaginase) in Patients With Relapse of Acute Lymphoblastic LeukemiaCondition: Acute Lymphoblastic Leukemia, in RelapseInterventions: Drug: GRASPA; Drug: L-asparaginase Sponsor: ERYtech Pharma Completed Thu, 26 Jan 2012 12:00:00 EST L-asparaginase Monotherapy as Salvage Treatment in Patients With NK/T Cell LymphomaCondition: LymphomaIntervention: Drug: L-asparaginase Sponsor: Fudan University Completed Tue, 03 Mar 2009 12:00:00 EST Asparaginase Activity Monitoring (AAM) in Adult Patients With Acute Lymphoblastic Leukemia (ALL)Condition: Acute Lymphoblastic LeukemiaIntervention: Drug: Asparaginase Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto Recruiting Wed, 12 Sep 2018 12:00:00 EDT Expanded Access Program: Safety of Erythrocytes Encapsulating L-asparaginase (GRASPA®) in Combination With Polychemotherapy in Patients Under 55 Years Old With Acute Lymphoblastic Leukemia (ALL) at Risk to Receive Other Formulation of AsparaginaseCondition: Acute Lymphoblastic LeukemiaIntervention: Drug: suspension of erythrocytes encapsulating L-asparaginase Sponsor: ERYtech Pharma No longer available Wed, 23 Jul 2014 12:00:00 EDT 1336GCC: Study of Erwinaze for Treatment of Acute Myeloid Leukemia (AML)Condition: Acute Myeloid LeukemiaIntervention: Drug: Erwinase Sponsor: Ashkan Emadi Completed Wed, 05 Nov 2014 12:00:00 EST 
An Open-Label, Single-Arm, Multicenter Pharmacokinetic Study of Intramuscular Erwinaze® (Asparaginase Erwinia Chrysanthemi)/Erwinase® (Crisantaspase)Condition: Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL)Intervention: Drug: Erwinaze® (Asparaginase Erwinia Chrysanthemi)/Erwinase® (Crisantaspase) Sponsor: Jazz Pharmaceuticals Withdrawn Fri, 30 May 2014 12:00:00 EDT Erwinase Master Treatment ProtocolConditions: Leukemia, Acute Lymphoblastic; Acute Lymphoid LeukemiaIntervention: Drug: Erwinia L-asparaginase Sponsors: Phoenix Children's Hospital; Fisher Bioservices; Jazz Pharmaceuticals No longer available Fri, 11 Jan 2008 12:00:00 EST Efficacy and Safety of Recombinant Asparaginase in Infants With Previously Untreated Acute Lymphoid Leukemia (ALL)Condition: Acute Lymphoid LeukemiaIntervention: Drug: recombinant asparaginase Sponsor: medac GmbH Completed Wed, 23 Sep 2009 12:00:00 EDT Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Eukaemia During Therapy With L - Asparaginase.Condition: Acute Lymphoblastic LeukemiaIntervention: Other: Correlation of Polymorphisms of Lipoprotein Lipase (LpL) and Apolipoprotein E (Apo E) With Lipid Profile of Children With Acute Lymphoblastic Leukaemia During Therapy With L - Asparaginase Sponsor: Aristotle University Of Thessaloniki Recruiting Tue, 28 Apr 2020 12:00:00 EDT Comparative Efficacy and Safety of Two Asparaginase Preparations in Children With Previously Untreated Acute Lymphoblastic LeukaemiaCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: asparaginase; Drug: recombinant asparaginase Sponsor: medac GmbH Completed Sun, 02 Nov 2008 12:00:00 EDT JZP458 - Recombinant Erwinia Asparaginase for Treatment of ALL / LBL Patients With Hypersensitivity to E. Coli-derived AsparaginaseConditions: Acute Lymphoblastic Leukemia; Lymphoblastic LymphomaIntervention: Drug: Asparaginase Erwinia Chrysanthemi (recombinant) Sponsor: Jazz Pharmaceuticals Approved for marketing Tue, 29 Jun 2021 12:00:00 EDT The Association Between Asparaginase Enzyme Activity Levels and Toxicities in Childhood Acute Lymphoblastic Leukaemia in NOPHOALL 2008Condition: Acute Lymphoblastic LeukemiaIntervention: Drug: Asparaginase Sponsor: Aarhus University Hospital Completed Thu, 05 Dec 2019 12:00:00 EST A Study of Erwinaze Administered Intravenously in Patients Who Had an Allergy to Frontline Asparaginase TherapyConditions: Acute Lymphoblastic Leukemia; Lymphoblastic LymphomaIntervention: Drug: asparaginase Erwinia chrysanthemi Sponsor: Jazz Pharmaceuticals Completed Wed, 18 Jul 2012 12:00:00 EDT Intensified Post Remission Therapy Containing PEG-AsparaginaseCondition: Acute Lymphoblastic LeukemiaIntervention: Drug: Daunorubicin, Vincristine, Prednisone, Methotrexate, PEG-Asparaginase, 6-Mercaptopurine, Cytoxan, Cytosine Arabinoside, VM-26 and 6-Thioguanine Sponsor: University of Southern California Completed Fri, 16 Sep 2005 12:00:00 EDT Study of Sirolimus With PEG-Asparaginase in Acute Lymphoblastic Leukemia (ALL)Condition: Acute Lymphoblastic LeukemiaInterventions: Drug: Sirolimus; Drug: PEG-asparaginase Sponsor: Emory University Withdrawn Wed, 12 Aug 2009 12:00:00 EDT
Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment CoursesCondition: Acute Lymphoblastic LeukemiaIntervention: Drug: PEG-asparaginase Sponsors: Nordic Society for Pediatric Hematology and Oncology; Medac, Hamburg, Germany; Danish Child Cancer Foundation Unknown status Mon, 19 Sep 2005 12:00:00 EDT Erwinia Asparaginase After Allergy to PEG-Asparaginase in Treating Young Patients With Acute Lymphoblastic LeukemiaConditions: Adult Acute Lymphoblastic Leukemia; Childhood Acute Lymphoblastic LeukemiaInterventions: Drug: Asparaginase; Other: Laboratory Biomarker Analysis; Other: Pharmacological Study Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Fri, 28 Sep 2007 12:00:00 EDT A Pilot Study of Oncaspar® + Dexamethasone in Patients With Relapsed or Refractory T-Cell LymphomaConditions: T-Cell Lymphoma; Relapsed T-Cell Lymphoma; Refractory T-Cell LymphomaInterventions: Drug: PEG-L-asparaginase; Drug: Dexamethasone acetate Sponsors: Dana-Farber Cancer Institute; Leadiant Biosciences, Inc. Terminated Mon, 17 Jun 2013 12:00:00 EDT PK, PD, Safety and Immunogenicity of Spectrila in Adults With Acute B-cell Lymphoblastic LeukaemiaCondition: Acute B-Cell Lymphoblastic LeukaemiaIntervention: Drug: Spectrila® Sponsors: medac GmbH; Syneos Health Active, not recruiting Wed, 17 May 2017 12:00:00 EDT New Combination Regimen of L-asparaginase, Dexamethasone, Ifosfamide, Cisplatin and Etoposide in NK/T-Cell LymphomaCondition: LymphomaIntervention: Drug: L-asp, DXM, IFO, VP-16, DDP Sponsor: Fudan University Unknown status Tue, 07 Jul 2009 12:00:00 EDT Phase II Study of Fludarabine, Cytarabine (ARA-C) and Erwinase IV in Patients With Relapsed or Refractory Hematologic MalignanciesCondition: Hematologic MalignancyInterventions: Drug: Fludarabine; Drug: Cytarabine; Drug: Erwinase Sponsors: M.D. Anderson Cancer Center; Jazz Pharmaceuticals Withdrawn Thu, 24 Mar 2016 12:00:00 EDT Compassionate Use of Erwinase For Pediatric Patients With Acute Lymphoblastic Leukemia Or Non Hodgkins LymphomaConditions: Acute Lymphoblastic Leukemia; Non Hodgkins LymphomaIntervention: Drug: Erwinase Sponsors: St. Jude Children's Research Hospital; Jazz Pharmaceuticals; Parexel Completed Mon, 09 Jun 2008 12:00:00 EDT Thromboembolic Complications Related to Asparaginase in Children With Acute Lymphoblastic Leukemia (ALL) Treated According to NOPHO ALL 2008Conditions: Thromboembolism; Acute Lymphoblastic LeukemiaIntervention: Sponsor: Oslo University Hospital Unknown status Wed, 23 Sep 2009 12:00:00 EDT Efficacy and Safety of L-asparaginase Encapsulated in RBC Combined With Gemcitabine or FOLFOX in 2nd Line for Progressive Metastatic Pancreatic CarcinomaCondition: Pancreatic Adenocarcinoma MetastaticInterventions: Drug: ERY001; Drug: Gemcitabine; Drug: 5-fluoro-uracil/oxaliplatin/leucovorin (folfox) Sponsor: ERYtech Pharma Completed Mon, 21 Jul 2014 12:00:00 EDT Asparaginase Encapsulated in Erythrocytes for Patients With ALL and Hypersensitivity to PEG-asparaginaseCondition: Acute Lymphoblastic LeukemiaIntervention: Drug: GRASPA Sponsors: Birgitte Klug Albertsen; ERYtech Pharma Completed Wed, 30 Aug 2017 12:00:00 EDT
Methotrexate, Vincristine, Pegylated L-Asparaginase and Dexamethasone (MOAD) in Acute Lymphoblastic Leukemia (ALL) SalvageCondition: Leukemia, Lymphocytic, AcuteInterventions: Drug: Methotrexate; Drug: Vincristine; Drug: PEG-l-asparaginase; Drug: Dexamethasone; Drug: Rituximab Sponsors: M.D. Anderson Cancer Center; Leadiant Biosciences, Inc. Completed Wed, 20 May 2009 12:00:00 EDT Association of L-asparaginase-Methotrexate-Dexamethasone for Nasal and Nasal-type Natural Killer (NK)-T-cell LymphomaCondition: Lymphoma, Non-HodgkinInterventions: Drug: Kidrolase; Drug: Methotrexate; Drug: Dexamethasone; Drug: Erwinase Sponsor: University Hospital, Limoges Completed Tue, 31 Jan 2006 12:00:00 EST Administration of Allogenic Red Blood Cells Loaded L-asparaginase in Cases of Relapse of Acute Lymphoblastic LeukaemiaCondition: Acute Lymphoblastic LeukemiaInterventions: Biological: GRASPA; Drug: native L asparaginase Sponsors: ERYtech Pharma; Centre Leon Berard Completed Mon, 28 Jul 2008 12:00:00 EDT Nivolumab in Combination With GDP/ L-asparaginase in NK/ T-cell LymphomaCondition: NK/T Cell LymphomaInterventions: Drug: IV Nivolumab; Drug: IV Gemcitabine; Drug: IV Cisplatin; Drug: IV/PO Dexamethasone; Drug: IV L-asparaginase Sponsors: National Cancer Centre, Singapore; Bristol-Myers Squibb Withdrawn Sat, 18 Jan 2020 12:00:00 EST PEG-Asparaginase Associated Pancreatitis, Hepatotoxicity and Hyperlipidemia in Children With ALLConditions: Acute Lymphoblastic Leukemia; PancreatitisIntervention: Sponsors: Rigshospitalet, Denmark; Technical University of Denmark Completed Wed, 13 Jul 2011 12:00:00 EDT Combination Chemotherapy Including Cisplatin, Ifosfamide, Gemcitabine, L-asparaginase, Etoposide and Dexamethasone as Treatment of Newly Diagnosed and Relapsed/Refractory Peripheral T Cell LymphomasCondition: Peripheral T Cell LymphomaInterventions: Drug: cisplatin; Drug: ifosfamide; Drug: gemcitabine; Drug: L-asparaginase; Drug: etoposide; Drug: dexamethasone Sponsor: The University of Hong Kong Recruiting Tue, 07 Mar 2017 12:00:00 EST Outcome Following Truncation of AsparaginaseCondition: Relapse LeukemiaIntervention: Sponsor: Birgitte Klug Albertsen Unknown status Mon, 17 Jun 2019 12:00:00 EDT Vincristine, Dexamethasone, Doxorubicin, and PEG-asparaginase (VPLD) and Metformin for Relapsed Childhood Acute Lymphoblastic Leukemia (ALL)Condition: Acute Lymphoblastic LeukemiaInterventions: Drug: Metformin; Drug: Vincristine; Drug: Dexamethasone; Drug: PEG-asparaginase; Drug: Doxorubicin; Drug: Intrathecal chemotherapy Sponsors: H. Lee Moffitt Cancer Center and Research Institute; Pediatric Cancer Foundation Completed Mon, 28 Mar 2011 12:00:00 EDT VP-16, Ifosfamide, Dexamethasone, L-asparaginase Chemotherapy in Patients With Extranodal Natural Killer T Cell Lymphoma (VIDL+ASCT)Condition: Extranodal NK-T-Cell LymphomaInterventions: Drug: Etoposide; Drug: Ifosfamide; Drug: Dexamethasone; Drug: L-asparaginase; Drug: Busulfan; Drug: Melphalan Sponsor: Samsung Medical Center Recruiting Wed, 09 Sep 2015 12:00:00 EDT GRASPA Treatment for Patients With Acute Myeloblastic LeukemiaCondition: Acute Myeloid LeukemiaIntervention: Drug: GRASPA Sponsor: ERYtech Pharma Completed Wed, 13 Mar 2013 12:00:00 EDT
Etoposide, Prednisone, Vincristine Sulfate, Cyclophosphamide, and Doxorubicin Hydrochloride With Asparaginase in Treating Patients With Acute Lymphoblastic Leukemia or Lymphoblastic LymphomaConditions: B Acute Lymphoblastic Leukemia; B Lymphoblastic Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent B Lymphoblastic Lymphoma; Recurrent T Lymphoblastic Leukemia/Lymphoma; Refractory B Lymphoblastic Lymphoma; Refractory T Lymphoblastic Lymphoma; T Acute Lymphoblastic Leukemia; T Lymphoblastic LymphomaInterventions: Drug: Asparaginase; Drug: Cyclophosphamide; Drug: Doxorubicin Hydrochloride; Drug: Etoposide; Drug: Imatinib Mesylate; Other: Laboratory Biomarker Analysis; Drug: Prednisone; Biological: Rituximab; Drug: Vincristine Sulfate Sponsors: University of Washington; National Cancer Institute (NCI) Withdrawn Wed, 02 Sep 2015 12:00:00 EDT Phase II Study of Clinical Activity of Pegaspargase in Women With Relapsed or Refractory Epithelial Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal CancerConditions: Ovarian Neoplasms; Fallopian Tube Neoplasms; Primary Peritoneal NeoplasmsIntervention: Drug: Pegylated L-Asparaginase Sponsor: National Cancer Institute (NCI) Completed Fri, 11 Mar 2011 12:00:00 EST Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2008Condition: Childhood Acute Lymphoblastic LeukemiaInterventions: Drug: PEG-L-asparaginase ind; Drug: PEG-L-asparaginase cons; Drug: E.coli L-asparaginase; Drug: High-dose Methotrexate; Drug: Low-dose Methotrexate; Drug: Triple intrathecal therapy; Radiation: Cranial irradiation; Drug: Daunorubicin Sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology Active, not recruiting Tue, 01 Oct 2013 12:00:00 EDT Administration of GRASPA (Suspension of Erythrocytes Encapsulating L-asparaginase)in Patients With Pancreatic CancerCondition: Pancreatic CancerIntervention: Drug: GRASPA Sponsor: ERYtech Pharma Completed Wed, 01 Feb 2012 12:00:00 EST Pharmacogenomics of Asparaginase Induced HepatotoxicityCondition: Acute Lymphoblastic LeukemiaIntervention: Procedure: Biospecimen Collection Sponsors: University of Southern California; National Cancer Institute (NCI) Recruiting Tue, 26 Jun 2018 12:00:00 EDT Trial of Oncaspar® and Three Doses of Pegylated Recombinant Asparaginase in Adult Patients With Newly Diagnosed Acute Lymphoblastic LeukaemiaCondition: Acute Lymphoblastic LeukaemiaInterventions: Drug: Oncaspar; Drug: PEG-rASNase Sponsor: medac GmbH Terminated Thu, 02 Dec 2010 12:00:00 EST Erwinase for Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL) (IND 104224)Conditions: Relapsed Acute Lymphoblastic Leukemia; Allergy to PEG e.Coli Asparaginase; Allergy to Native e.Coli AsparaginaseInterventions: Drug: Erwinase; Drug: Vincristine; Drug: Dexamethasone; Drug: Doxorubicin; Drug: Cytarabine; Drug: Methotrexate; Drug: Triple Intrathecal Therapy; Drug: Dexrazoxane Sponsor: Therapeutic Advances in Childhood Leukemia Consortium Terminated Thu, 25 Jun 2009 12:00:00 EDT Social Media-based Active Self-report on Incidence and Outcomes of Adverse Events in NK/TCL PatientsCondition: Extranodal NK-T-Cell Lymphoma, Nasal TypeIntervention: Combination Product: L-Asparaginase or or Pegaspargase containing chemotherapy Sponsor: Rong Tao Completed Tue, 14 Mar 2017 12:00:00 EDT Levocarnitine and Vitamin B Complex in Treating PEG-Asparaginase or Inotuzumab Ozogamicin-Induced Hyperbilirubinemia in Patients With Acute Lymphoblastic LeukemiaConditions: Acute Lymphoblastic Leukemia; HyperbilirubinemiaInterventions: Dietary Supplement: Levocarnitine; Drug: Vitamin B Complex Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI) Recruiting Thu, 21 Jun 2018 12:00:00 EDT Administration of GRASPA (Suspension of Erythrocytes Encapsulating L-asparaginase) in Elderly Patients With First Line Acute Lymphoblastic LeukemiaCondition: Acute Lymphoblastic LeukemiaIntervention: Drug: GRASPA Sponsor: ERYtech Pharma Completed Wed, 01 Feb 2012 12:00:00 EST
A Safety and Tolerability Study of Clofarabine, Etoposide, Cyclophosphamide, PEG-asparaginase, and Vincristine in Pediatric Acute Lymphoblastic Leukemia (ALL)Condition: Lymphoblastic Leukemia, Acute, ChildhoodIntervention: Drug: Clofarabine incorporated into a 5-drug regimen Sponsor: Genzyme, a Sanofi Company Completed Wed, 07 Oct 2009 12:00:00 EDT Pharmacokinetics of Asparaginase and Antibody Formation in Interfant-06Condition: LeukemiaIntervention: Sponsor: Aarhus University Hospital Completed Fri, 04 Dec 2009 12:00:00 EST Study of CM4620 to Reduce the Severity of Pancreatitis Due to AsparaginaseCondition: Acute PancreatitisIntervention: Drug: CM4620 Sponsors: St. Jude Children's Research Hospital; CalciMedica, Inc. Recruiting Wed, 11 Dec 2019 12:00:00 EST Hemostasis During Asparaginase Treatment in Acute Lymphoblastic Leukemia(ALL)Condition: Acute Lymphoblastic LeukemiaIntervention: Sponsor: Aarhus University Hospital Completed Mon, 29 Mar 2010 12:00:00 EDT A Drug Monitoring Study on PEG-asparaginase Treatment in Children Diagnosed Acute Lymphoblastic LeukaemiaCondition: Acute Lymphoblastic LeukaemiaIntervention: Sponsor: Aarhus University Hospital Unknown status Fri, 07 Jan 2011 12:00:00 EST LAMPP Trial for Peripheral and Cutaneous T-Cell LymphomaCondition: T-Cell LymphomaIntervention: Drug: Doxil, Methotrexate, L-Asparaginase, Prednisone Sponsors: University of Medicine and Dentistry of New Jersey; Ortho Biotech, Inc. Terminated Mon, 12 Sep 2005 12:00:00 EDT TDM of Asparaginase in ALL2008Condition: Acute Lymphoblastic LeukemiaIntervention: Sponsor: Aarhus University Hospital Recruiting Tue, 13 Apr 2021 12:00:00 EDT Combination Chemotherapy and Alemtuzumab in Treating Patients With Relapsed or Refractory Acute Lymphoblastic LeukemiaCondition: Recurrent Adult Acute Lymphoblastic LeukemiaInterventions: Biological: alemtuzumab; Drug: asparaginase; Drug: methotrexate; Drug: dexamethasone; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: vincristine Sponsor: National Cancer Institute (NCI) Terminated Wed, 07 Dec 2005 12:00:00 EST MRD/Risk-oriented Therapy of Adult Ph- ALL Including Pegylated Asparaginase and Lineage-targeted MethotrexateConditions: Untreated Philadelphia Positive Acute Lymphoblastic Leukemia; De Novo; Secondary; Low-dose Corticosteroids PretreatmentInterventions: Drug: Prephase PDN + CY; Drug: Cycle 1 Induction; Drug: Cycle 2 Induction / Early consolidation; Drug: Cycle 3 Early consolidation; Drug: Cycle 4 Consolidation; Drug: Cycle 5 Consolidation; Drug: Cycle 6 Consolidation; Drug: Cycle 7 Consolidation; Drug: Cycle 8 Reinduction; Drug: Maintenance; Procedure: Allogeneic SCT or Autologous SCT Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto Completed Thu, 20 Feb 2014 12:00:00 EST SIMPLE Chemotherapy for NK Lymphoma/LeukaemiaConditions: Non-Hodgkin's Lymphoma, Relapsed; Non-Hodgkin T-cell Lymphoma; Natural Killer/T-Cell Lymphoma, Nasal and Nasal-TypeInterventions: Drug: Cisplatin; Drug: Gemcitabine; Drug: Etoposide (VP-16); Device: Ifosfamide; Drug: Dexamethasone; Drug: L-asparaginase Sponsor: The University of Hong Kong Unknown status Thu, 09 Aug 2018 12:00:00 EDT
Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic LeukemiaCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Prednisone, Vincristine, Daunorubicin, PEG-L-asparaginase, Erwinia L-asparaginase, Doxorubicin, Cyclophosphamide, Cytarabine, Thioguanine; Drug: Clofarabine, Methotrexate, Mercaptopurine, Dexamethasone, Etoposide, Dasatinib Sponsors: St. Jude Children's Research Hospital; National Cancer Institute (NCI); Enzon Pharmaceuticals, Inc.; National Institute of General Medical Sciences (NIGMS) Active, not recruiting Fri, 26 Oct 2007 12:00:00 EDT Combine GELOX With Concurrent Radiation Therapy for Patients With Stage IE/IIE ENKTLCondition: Lymphoma, Extranodal NK-T-CellInterventions: Drug: GELOX; Radiation: IFRT Sponsor: Sun Yat-sen University Unknown status Thu, 06 Mar 2014 12:00:00 EST Pharmacokinetics and Immunogenicity of the First Doses of PEG-Asparaginase -An ALLTogether Pilot StudyCondition: Acute Lymphoblastic LeukemiaIntervention: Sponsor: Aarhus University Hospital Recruiting Tue, 13 Apr 2021 12:00:00 EDT LSA4 Protocol for the Treatment of Advanced Pediatric and Adolescent Non-Hodgkins LymphomaCondition: Non-Hodgkin's LymphomaIntervention: Drug: LSA4, Cyclophosphamide, Methotrexate, Daunomycin, L-asparaginase, BCNU Sponsor: Memorial Sloan Kettering Cancer Center Completed Fri, 08 Feb 2008 12:00:00 EST SC-PEG Asparaginase vs. Oncaspar in Pediatric Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic LymphomaConditions: Acute Lymphoblastic Leukemia; Lymphoblastic LymphomaInterventions: Drug: SC-PEG; Drug: Oncaspar Sponsors: Dana-Farber Cancer Institute; Shire; National Cancer Institute (NCI) Active, not recruiting Tue, 10 Apr 2012 12:00:00 EDT A Study of the Safety and Effectiveness of Apixaban in Preventing Blood Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With AsparaginaseConditions: Lymphoma; Acute Lymphoblastic LeukemiaInterventions: Drug: Apixaban; Other: No systemic anticoagulant prophylaxis Sponsors: Bristol-Myers Squibb; Pfizer Recruiting Tue, 24 Feb 2015 12:00:00 EST Treatment of Acute Lymphoblastic Leukemia in ChildrenConditions: Drug/Agent Toxicity by Tissue/Organ; LeukemiaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: dexamethasone; Drug: dexrazoxane hydrochloride; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: methylprednisolone; Drug: pegaspargase; Drug: prednisolone; Drug: therapeutic hydrocortisone; Drug: vincristine sulfate; Radiation: radiation therapy Sponsors: Dana-Farber Cancer Institute; National Cancer Institute (NCI) Completed Fri, 17 Nov 2006 12:00:00 EST Total Therapy Study XIV for Newly Diagnosed Patients With Acute Lymphoblastic LeukemiaCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Prednisone, Dexamethasone, Vincristine, Daunorubicin, PEG-L-asparaginase; Drug: L-asparaginase, Methotrexate, Idarubicin, Etoposide, Cyclophosphamide, Cytarabine, Mercaptopurine Sponsor: St. Jude Children's Research Hospital Terminated Fri, 16 Sep 2005 12:00:00 EDT A Study in Adults With Untreated Acute Lymphoblastic LeukemiaCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: prednisone; Drug: doxorubicin; Drug: vincristine; Drug: methotrexate; Drug: asparaginase; Drug: dexamethasone; Radiation: cranial radiation; Drug: leucovorin; Drug: cytarabine; Drug: hydrocortisone; Drug: 6-mercaptopurine (6-MP); Drug: e. coli L-asparaginase Sponsors: Dana-Farber Cancer Institute; Brigham and Women's Hospital; Massachusetts General Hospital; Queen Elizabeth II Health Sciences Centre Active, not recruiting Mon, 29 Aug 2005 12:00:00 EDT NOPHO ALL-2008 Pilot Study on Consolidation Therapy for Children and Adolescents With Acute Lymphoblastic LeukemiaCondition: Leukemia, Lymphocytic, AcuteIntervention: Drug: 6-mercaptopurine Sponsor: Rigshospitalet, Denmark Completed Wed, 24 Oct 2007 12:00:00 EDT
ABT-751 With Chemotherapy for Relapsed Pediatric ALLConditions: Recurrent Pediatric ALL; Relapsed Pediatric ALL; Acute Lymphoblastic Leukemia; Refractory Pediatric ALLInterventions: Drug: ABT-751; Drug: Dexamethasone; Drug: PEG-asparaginase; Drug: Doxorubicin; Drug: Cytarabine; Drug: Methotrexate; Drug: Cyclophosphamide; Drug: 6-thioguanine Sponsors: Therapeutic Advances in Childhood Leukemia Consortium; Abbott Terminated Fri, 23 Feb 2007 12:00:00 EST Anlotinib for Advanced and Refractory Natural Killer /T-cell LymphomaCondition: Natural Killer/T-Cell Lymphoma, Nasal and Nasal-TypeIntervention: Drug: Anlotinib Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine Completed Tue, 07 Aug 2018 12:00:00 EDT Therapy for Pediatric Relapsed or Refractory Acute Lymphoblastic LeukemiaConditions: Acute Lymphoblastic Leukemia; Lymphoma, LymphoblasticInterventions: Drug: Etoposide, cytarabine, vincristine, dexamethasone; Drug: methotrexate, teniposide, PEG-asparaginase; Drug: mitoxantrone, cyclophosphamide, mercaptopurine, vinblastine; Drug: L-asparaginase, erwinia asparaginase; Procedure: chemotherapy, intrathecal chemotherapy, steroid therapy; Procedure: Hematopoietic Stem Cell Transplant; Procedure: Natural Killer (NK) Cell Transplant Sponsor: St. Jude Children's Research Hospital Completed Fri, 16 Sep 2005 12:00:00 EDT B-MAD Chemotherapy in Newly-diagnosed Extranodal NK/ T-cell LymphomaCondition: Extranodal NK/T-cell LymphomaIntervention: Drug: B-MAD chemotherapy Sponsors: The Thai Lymphoma Study Group; Takeda Recruiting Fri, 11 Aug 2017 12:00:00 EDT PO Ixazomib in Combination With Chemotherapy for Childhood Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic LymphomaConditions: ALL, Childhood; Lymphoblastic Lymphoma, Childhood; Lymphoblastic Leukemia, Acute, ChildhoodInterventions: Drug: Ixazomib; Drug: Vincristine; Drug: Dexamethasone; Drug: Asparaginase; Drug: Doxorubicin Sponsors: Therapeutic Advances in Childhood Leukemia Consortium; Takeda; Children's Hospital Los Angeles Recruiting Fri, 25 Jan 2019 12:00:00 EST MESA Versus ESA in the Treatment of Early Stage NK/T-cell LymphomaCondition: Extranodal NK/T-cell Lymphoma, Nasal TypeInterventions: Drug: Methotrexate; Drug: Etoposide; Drug: Dexamethasone; Drug: Pegaspargase; Radiation: Radiotherapy Sponsor: Ruijin Hospital Active, not recruiting Wed, 16 Dec 2015 12:00:00 EST Study of Eryaspase in Combination With Chemotherapy Versus Chemotherapy Alone as 2nd-Line Treatment in PACCondition: Pancreatic AdenocarcinomaInterventions: Drug: eryaspase; Drug: Gemcitabine plus Abraxane; Drug: Irinotecan plus 5-FU plus leucovorin Sponsor: ERYtech Pharma Active, not recruiting Tue, 11 Sep 2018 12:00:00 EDT Combination Chemotherapy in Patients With Newly Diagnosed BPDCNCondition: Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)Intervention: Drug: Chemotherapy Sponsors: Centre Hospitalier Universitaire de Besancon; UMR1098, EFS BFC, BESANCON; Centre Henri Becquerel; Maisonneuve-Rosemont Hospital; Centre Hospitalier Universitaire Dijon; Inserm CIC1431, CHU Besancon Recruiting Thu, 26 Jul 2018 12:00:00 EDT Study of Eryaspase in Combination With Chemotherapy Versus Chemotherapy Alone for the Treatment of TNBC (TRYbeCA-2)Condition: Triple Negative Breast CancerInterventions: Drug: eryaspase (L-asparaginase encapsulated in red blood cells); Drug: Gemcitabine; Drug: Carboplatin Sponsor: ERYtech Pharma Recruiting Mon, 17 Sep 2018 12:00:00 EDT NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic LymphomaCondition: Lymphoblastic LymphomaInterventions: Drug: Prednisone; Drug: Vincristine; Drug: Daunorubicin; Drug: PEG-asparaginase; Drug: Erwinia asparaginase; Drug: Doxorubicin; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Thioguanine; Drug: Clofarabine; Drug: Methotrexate; Drug: Mercaptopurine; Drug: Dexamethasone; Drug: Hydrocortisone; Drug: Etoposide Sponsors: St. Jude Children's Research Hospital; National University, Singapore Active, not recruiting Thu, 13 Oct 2011 12:00:00 EDT
Oncaspar/Doxil/Decadron in Patients With Refractory Lymphoid MalignanciesConditions: Non-hodgkins Lymphoma; Hodgkins Lymphoma; Multiple MyelomaIntervention: Drug: Oncaspar, Doxil, Decadron Sponsor: Milton S. Hershey Medical Center Terminated Thu, 05 Feb 2009 12:00:00 EST HCL Single Arm Pilot Study in Treatment of Hyperglycemia of Pediatric ALLCondition: High Risk Acute Lymphoblastic LeukemiaIntervention: Device: Hybrid Closed Loop System Sponsors: University of Colorado, Denver; Children's Hospital Colorado; DexCom, Inc.; Tandem Diabetes Care, Inc.; National Cancer Institute (NCI) Not yet recruiting Mon, 16 Aug 2021 12:00:00 EDT Safety and Efficacy of an Adult Acute Lymphoblastic Leukemia Chemotherapy for Adult Lymphoblastic LymphomaCondition: Lymphoblastic LymphomaInterventions: Drug: Prednisone, vincristine, daunorubicin , cyclophosphamide , L.-asparaginase, cytosine-arabinoside, methotrexate, etoposide; Procedure: hematopoietic stem cell allograft Sponsor: Centre Henri Becquerel Unknown status Tue, 20 Sep 2005 12:00:00 EDT Safety of Clofarabine With Multiagent Chemotherapy in Childhood Acute Lymphoblastic LeukemiaConditions: Acute Lymphoid Leukemia Relapse; Acute Lymphoid Leukemia Relapse After Bone Marrow TransplantIntervention: Drug: Clofarabine Sponsors: University Hospital, Lille; Centre Hospitalier Universitaire de Besancon; Saint-Louis Hospital, Paris, France; Assistance Publique - Hôpitaux de Paris; Hospices Civils de Lyon; University Hospital, Toulouse; Central Hospital, Nancy, France; University Hospital, Marseille; University Hospital, Bordeaux; Nantes University Hospital; Rennes University Hospital Completed Wed, 19 Jan 2011 12:00:00 EST Treatment of Patients With Newly Diagnosed Acute Myeloid Leukemia or MyelodysplasiaCondition: Leukemia, Myelocytic, AcuteInterventions: Drug: Cladribine, Cyclophosphamide, Cytarabine, Daunorubicin, Dexamethasone; Drug: Etoposide, Cytarabine, Gemtuzumab, L-asparaginase, Mercaptopurine, methotrexate, Mitoxantrone, Prednisone, Vincristine Sponsors: St. Jude Children's Research Hospital; National Cancer Institute (NCI) Completed Fri, 26 Aug 2005 12:00:00 EDT SWOG-9400 Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Previously Untreated Acute Lymphocytic LeukemiaConditions: Leukemia; Neutropenia; ThrombocytopeniaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisone; Drug: thioguanine; Drug: vincristine sulfate; Procedure: allogeneic bone marrow transplantation; Radiation: radiation therapy Sponsors: Southwest Oncology Group; National Cancer Institute (NCI) Completed Thu, 29 Jul 2004 12:00:00 EDT Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's LymphomaConditions: Leukemia; LymphomaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: methylprednisolone; Drug: mitoxantrone hydrochloride; Drug: prednisolone; Drug: therapeutic hydrocortisone; Drug: thioguanine; Drug: vincristine sulfate; Drug: vindesine; Procedure: allogeneic bone marrow transplantation; Procedure: peripheral blood stem cell transplantation Sponsor: European Organisation for Research and Treatment of Cancer - EORTC Unknown status Mon, 27 Jan 2003 12:00:00 EST Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) ICondition: Acute Lymphoblastic LeukemiaInterventions: Drug: ITMHA; Drug: Dexamethasone; Drug: Mitoxantrone; Drug: Pegaspargase; Drug: Asparaginase Erwinia Chrysanthemi; Drug: Bortezomib; Drug: Vorinostat; Drug: Cyclophosphamide; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Leucovorin Calcium; Drug: Cytarabine; Drug: Etoposide; Drug: Vincristine Sponsors: St. Jude Children's Research Hospital; Gateway for Cancer Research; Baylor College of Medicine Recruiting Thu, 17 Sep 2015 12:00:00 EDT Pegaspargase and Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: cyclophosphamide; Drug: cytarabine; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: imatinib mesylate; Drug: methotrexate; Drug: methylprednisolone; Drug: pegaspargase; Drug: vincristine sulfate Sponsors: OHSU Knight Cancer Institute; National Cancer Institute (NCI) Terminated Sun, 01 Nov 2009 12:00:00 EDT A Study of Children With Refractory or Relapsed ALLCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Topotecan, dexamethasone, vincristine; Drug: E. coli Asparaginase, PEG-L-asparaginase; Drug: erwinia asparaginase; Drug: fludarabine, methotrexate, mercaptopurine; Drug: idarubicin, etoposide, cytarbine, teniposide; Procedure: chemotherapy, intrathecal chemotherapy, steroid therapy Sponsor: St. Jude Children's Research Hospital Completed Fri, 16 Sep 2005 12:00:00 EDT
Pre-reinductive Decitabine and Vorinostat in Relapsed Lymphoblastic Lymphoma or Acute Lymphoblastic LeukemiaConditions: Leukemia; LymphomaInterventions: Drug: cytarabine; Drug: decitabine; Drug: doxorubicin hydrochloride; Drug: imatinib mesylate; Drug: methotrexate; Drug: pegaspargase; Drug: prednisone; Drug: vincristine sulfate; Drug: vorinostat Sponsor: Masonic Cancer Center, University of Minnesota Terminated Thu, 16 Apr 2009 12:00:00 EDT Bortezomib and Vorinostat in Younger Patients With Refractory or Relapsed MLL Rearranged Hematologic MalignanciesConditions: Mixed Lineage Acute Leukemia; Acute Myeloid Leukemia; Acute Lymphoid LeukemiaInterventions: Drug: Bortezomib; Drug: Vorinostat; Drug: Mitoxantrone; Drug: Cytarabine; Drug: Methotrexate; Drug: Hydrocortisone; Drug: Peg-L-Asparaginase; Drug: Erwinia L-Asparaginase; Drug: Dexamethasone; Drug: Mercaptopurine; Drug: Doxorubicin Sponsor: St. Jude Children's Research Hospital Terminated Fri, 17 Apr 2015 12:00:00 EDT EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL)Conditions: Lymphoblastic Leukemia, Acute; Lymphoblastic Leukemia, Acute, Childhood; Leukemia, Lymphoblastic, Acute, T Cell; Leukemia, Lymphoblastic, AcuteInterventions: Drug: EZN-3042; Drug: Cytarabine; Drug: Doxorubicin; Drug: Prednisone; Drug: Vincristine; Drug: PEG-asparaginase; Drug: Methotrexate; Drug: Hydrocortisone Sponsors: Therapeutic Advances in Childhood Leukemia Consortium; Enzon Pharmaceuticals, Inc. Terminated Mon, 23 Aug 2010 12:00:00 EDT An Open-Label Study of JZP-458 (RC-P) in Patients With Acute Lymphoblastic Leukemia (ALL)/Lymphoblastic Lymphoma (LBL)Conditions: Acute Lymphoblastic Leukemia; Lymphoblastic LeukemiaInterventions: Drug: IM JZP-458; Drug: IV JZP-458 Sponsors: Jazz Pharmaceuticals; Children's Oncology Group (COG) Recruiting Wed, 30 Oct 2019 12:00:00 EDT Multicenter Clinical Trial for Adult Ph-negative ALL. Non-intensive But Non-iterruptive TreatmentCondition: Ph-negative Adult Acute Lymphoblastic LeukemiaIntervention: Procedure: autologous HSCT Sponsor: National Research Center for Hematology, Russia Active, not recruiting Thu, 02 Sep 2010 12:00:00 EDT Treatment of Natural Killer/T Cell Lymphoma-Ⅲ/ⅣCondition: Nasal and Nasal-type NK/T-cell LymphomaInterventions: Drug: DDGP(cisplatin,dexamethasone,gemcitabine,pegaspargase); Drug: Modified SMILE （MTX，DEX，IFO，L-ASP，Etoposide，Mesna） Sponsors: Mingzhi Zhang; Second Hospital of Shanxi Medical University; Shanxi Province Cancer Hospital; Wuhan University; Wuhan TongJi Hospital; Wuhan Union Hospital, China; Qingdao University; Cancer Hospital of Guizhou Province; Xinyang Central Hospital; The First Affiliated Hospital of Henan University of Traditional Chinese Medicine Unknown status Thu, 29 Dec 2011 12:00:00 EST Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic Leukemia (Closed to Accrual 4-22-2011)Conditions: Acute Lymphoblastic Leukemia; Adult B Acute Lymphoblastic Leukemia; Childhood B Acute Lymphoblastic LeukemiaInterventions: Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Doxorubicin Hydrochloride; Other: Laboratory Biomarker Analysis; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Drug: Prednisone; Radiation: Prophylactic Cranial Irradiation; Drug: Thioguanine; Drug: Vincristine Sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Fri, 20 Mar 2009 12:00:00 EDT Re-Induction Therapy for Relapsed Pediatric T-Cell Acute Lymphoblastic Leukemia or LymphomaConditions: Acute Lymphoblastic Leukemia; Lymphoma, Non-Hodgkin's; Leukemia, T-Cell; Leukemia, B-CellInterventions: Drug: Dexamethasone; Drug: Panobinostat; Drug: Liposomal vincristine; Drug: Mitoxantrone; Drug: Peg-asparaginase; Drug: Bortezomib; Drug: Intrathecal Triples; Drug: High-dose methotrexate; Drug: 6-Mercaptopurine; Drug: High-dose cytarabine; Drug: Nelarabine; Drug: Cyclophosphamide; Drug: Etoposide; Drug: Clofarabine Sponsors: St. Jude Children's Research Hospital; Novartis Pharmaceuticals; Spectrum Pharmaceuticals, Inc Terminated Mon, 10 Aug 2015 12:00:00 EDT Calaspargase Pegol-Mnkl and Cobimetinib for the Treatment of Locally Advanced or Metastatic Pancreatic CancerConditions: Locally Advanced Pancreatic Adenocarcinoma; Metastatic Pancreatic Adenocarcinoma; Stage II Pancreatic Cancer AJCC v8; Stage IIA Pancreatic Cancer AJCC v8; Stage IIB Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8Interventions: Procedure: Biopsy; Drug: Calaspargase Pegol-mknl; Drug: Cobimetinib Sponsors: OHSU Knight Cancer Institute; Oregon Health and Science University; Genentech, Inc.; Servier Pharmaceuticals, LLC Not yet recruiting Sun, 05 Sep 2021 12:00:00 EDT Augmented Berlin-Frankfurt-Munster (BFM) Therapy for Adolescent/Young Adults With Acute Lymphoblastic Leukemia or Acute Lymphoblastic LymphomaConditions: Lymphoblastic Leukemia; Lymphoblastic LymphomaInterventions: Drug: Daunorubicin; Drug: Vincristine; Drug: PEG-asparaginase; Drug: Intrathecal Methotrexate; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Doxorubicin; Drug: Thioguanine Sponsor: M.D. Anderson Cancer Center Completed Fri, 20 Mar 2009 12:00:00 EDT
Calaspargase Pegol or Pegaspargase and Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed High-Risk Acute Lymphoblastic LeukemiaConditions: Acute Lymphoblastic Leukemia; Adult B Acute Lymphoblastic Leukemia; Childhood B Acute Lymphoblastic LeukemiaInterventions: Drug: Calaspargase Pegol-mknl; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Doxorubicin Hydrochloride; Other: Laboratory Biomarker Analysis; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Other: Pharmacological Study; Drug: Prednisone; Radiation: Radiation Therapy; Drug: Thioguanine; Drug: Vincristine Sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Fri, 02 May 2008 12:00:00 EDT MESA Treatment for NK/T Cell LymphomaCondition: Lymphoma, Extranodal NK-T-CellInterventions: Drug: MESA chemotherapy; Drug: MESA Sponsor: Air Force Military Medical University, China Unknown status Mon, 02 Sep 2013 12:00:00 EDT Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic SyndromesConditions: Childhood Acute Basophilic Leukemia; Childhood Acute Eosinophilic Leukemia; Childhood Acute Erythroleukemia (M6); Childhood Acute Megakaryocytic Leukemia (M7); Childhood Acute Minimally Differentiated Myeloid Leukemia (M0); Childhood Acute Monoblastic Leukemia (M5a); Childhood Acute Monocytic Leukemia (M5b); Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Myeloblastic Leukemia Without Maturation (M1); Childhood Acute Myelomonocytic Leukemia (M4); Childhood Myelodysplastic Syndromes; de Novo Myelodysplastic Syndromes; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid MalignanciesInterventions: Drug: asparaginase; Drug: daunorubicin hydrochloride; Drug: cytarabine; Drug: thioguanine; Drug: etoposide; Other: laboratory biomarker analysis Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Active, not recruiting Tue, 29 Aug 2006 12:00:00 EDT Radiotherapy Followed by Adjuvant Chemotherapy in NK/T-cell LymphomaCondition: Extranodal NK/T-cell Lymphoma, Nasal TypeIntervention: Drug: Radiotherapy followed by chemotherapy Sponsor: Fudan University Unknown status Fri, 17 Aug 2012 12:00:00 EDT Modified Hyper-CVAD (Cyclophosphamide, Vincristine, Adriamycin, and Dexamethasone) Program for Acute Lymphoblastic LeukemiaConditions: Leukemia; Acute Lymphoblastic LeukemiaInterventions: Drug: Rituximab; Drug: Cyclophosphamide (CTX); Drug: Doxorubicin; Drug: Vincristine; Drug: Dexamethasone; Drug: Methotrexate (MTX); Drug: Cytarabine; Drug: G-CSF; Drug: Mesna; Drug: Pegylated asparaginase; Drug: Pegfilgrastim; Drug: Solumedrol Sponsor: M.D. Anderson Cancer Center Completed Mon, 05 May 2008 12:00:00 EDT Mild-dose IMRT for Early-staged Extranodal Nasal-type NK/T-cell Lymphoma With CR Tumor After GELOX ChemotherapyConditions: Lymphoma,; Non-Hodgkin Lymphoma,; Extranodal NK/T-cell Lymphoma,Nasal-type,Intervention: Radiation: Mild-dose IMRT Sponsor: Sun Yat-sen University Unknown status Mon, 01 Sep 2014 12:00:00 EDT Monoclonal Antibody Plus Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic SyndromesConditions: Leukemia; Myelodysplastic SyndromesInterventions: Drug: asparaginase; Drug: cytarabine; Drug: gemtuzumab ozogamicin; Drug: mitoxantrone hydrochloride Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST Chemoimmunotherapy With Epratuzumab in Relapsed Acute Lymphoblastic Leukemia (ALL)Condition: Recurrent Childhood Acute Lymphoblastic LeukemiaInterventions: Drug: L-asparaginase; Drug: doxorubicin hydrochloride; Drug: therapeutic hydrocortisone; Drug: vincristine sulfate; Biological: epratuzumab; Drug: cytarabine; Drug: prednisone; Drug: pegaspargase; Drug: dexrazoxane hydrochloride; Drug: methotrexate; Drug: etoposide; Drug: cyclophosphamide; Drug: leucovorin calcium; Biological: filgrastim Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Thu, 09 Dec 2004 12:00:00 EST Bortezomib and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic LeukemiaConditions: B-cell Adult Acute Lymphoblastic Leukemia (ALL); Ph-positive Adult Acute Lymphoblastic Leukemia (ALL); Recurrent Adult Acute Lymphoblastic Leukemia (ALL); T-cell Adult Acute Lymphoblastic Leukemia (ALL)Interventions: Drug: Bortezomib; Drug: Doxorubicin hydrochloride (HCl); Drug: PEG-Asparaginase; Drug: Vincristine sulfate; Drug: Dexamethasone; Drug: Cytarabine; Drug: Methotrexate Sponsors: Stanford University; National Cancer Institute (NCI) Completed Wed, 16 Jan 2013 12:00:00 EST ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016Conditions: Down Syndrome; Acute Lymphoblastic Leukemia; Childhood CancerInterventions: Drug: Daunorubicin; Drug: Prednisolone; Drug: Vincristine; Drug: Epirubicin; Drug: E-coli L-asparaginase; Drug: 6-Mercaptopurine; Drug: Methotrexate; Drug: Hydrocortisone; Drug: Cytarabine; Drug: Cyclophosphamide Sponsor: National Hospital Organization Nagoya Medical Center Recruiting Mon, 18 Sep 2017 12:00:00 EDT
Phase 3 Trial of Blinatumomab vs Standard Chemotherapy in Pediatric Subjects With HIgh-Risk (HR) First Relapse B-precursor Acute Lymphoblastic Leukemia (ALL)Condition: Leukemia, Acute LymphoblasticInterventions: Drug: Blinatumomab; Drug: Dexamethasone; Drug: Vincrisitne; Drug: Daunorubicin; Drug: Methotrexate; Drug: Ifosfamide; Drug: PEG-asparaginase; Drug: Erwinia-asparaginase Sponsor: Amgen Active, not recruiting Fri, 20 Mar 2015 12:00:00 EDT Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down SyndromeConditions: Acute Myeloid Leukemia; Down Syndrome; Myelodysplastic Syndrome; Myeloid Leukemia Associated With Down Syndrome; Myeloproliferative NeoplasmInterventions: Drug: Asparaginase; Drug: Asparaginase Erwinia chrysanthemi; Drug: Cytarabine; Drug: Daunorubicin Hydrochloride; Drug: Etoposide; Other: Laboratory Biomarker Analysis; Drug: Mitoxantrone Hydrochloride; Drug: Thioguanine Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Recruiting Thu, 13 Aug 2015 12:00:00 EDT Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: dexamethasone; Drug: idarubicin; Drug: methotrexate; Drug: mitoxantrone hydrochloride; Drug: pegaspargase; Drug: vincristine sulfate Sponsor: Children's Cancer and Leukaemia Group Completed Thu, 27 Aug 2009 12:00:00 EDT Pentoxifylline In Pediatric Acute Lymphoblastic Leukemia During InductionCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Pentoxifylline Plus Chemotherapy; Drug: Placebo Plus Chemotherapy Sponsors: Ramón Óscar González-Ramella, Ph.D; Instituto de Investigacion en Cancer de la Infancia y la Adolescencia; Hospital Civil Juan I. Menchaca; Centro de Investigacion Biomedica de Occidente Unknown status Fri, 22 May 2015 12:00:00 EDT Combination Chemotherapy With or Without Gemtuzumab in Treating Young Patients With Newly Diagnosed Acute Myeloid LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: etoposide; Drug: gemtuzumab ozogamicin; Drug: mitoxantrone hydrochloride Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Thu, 07 Sep 2006 12:00:00 EDT CINJALL: Treatment for Children With Acute Lymphocytic LeukemiaCondition: Acute Lymphocytic LeukemiaInterventions: Drug: aminopterin; Drug: L-asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunomycin; Drug: dexamethasone; Drug: 6-mercaptopurine; Drug: methotrexate; Drug: 6-thioguanine; Drug: vincristine; Drug: Triple Intrathecal Therapy (MTX, Cytarabine, Hydrocortisone); Drug: Leucovorin Sponsors: Rutgers, The State University of New Jersey; National Cancer Institute (NCI) Completed Thu, 15 Sep 2005 12:00:00 EDT S0333 Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Biological: filgrastim; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin; Drug: dexamethasone; Drug: doxorubicin; Drug: leucovorin; Drug: mercaptopurine; Drug: methotrexate; Drug: mitoxantrone; Drug: Asparaginase; Drug: prednisone; Drug: thioguanine; Drug: vincristine; Radiation: radiation therapy; Drug: allopurinol; Drug: bactrim Sponsors: Southwest Oncology Group; National Cancer Institute (NCI) Completed Wed, 04 May 2005 12:00:00 EDT Chemotherapy in Treating Children With Down Syndrome and Myeloproliferative Disorder, Acute Myelogenous Leukemia, or Myelodysplastic SyndromeConditions: Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative NeoplasmsInterventions: Drug: asparaginase; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: methotrexate; Drug: therapeutic hydrocortisone; Drug: thioguanine Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST Bortezomib With Chemotherapy for Relapsed Pediatric Acute Lymphoblastic Leukemia (ALL)Condition: Acute Lymphoblastic LeukemiaInterventions: Drug: Bortezomib; Drug: Dexamethasone; Drug: PEG-asparaginase; Drug: Doxorubicin; Drug: Cytarabine; Drug: Methotrexate; Drug: Vincristine; Drug: Triple IT Therapy Sponsor: Therapeutic Advances in Childhood Leukemia Consortium Completed Tue, 27 Feb 2007 12:00:00 EST Pevonedistat With VXLD Chemotherapy for Adolescent/Young Adults With Relapsed/Refractory ALL or Lymphoblastic NHLConditions: Refractory Acute Lymphoblastic Leukemia; Relapsed Acute Lymphoblastic LeukemiaInterventions: Drug: Pevonedistat; Drug: Vincristine; Drug: Dexamethasone; Drug: PEG-asparaginase; Drug: Doxorubicin; Drug: Cytarabine; Drug: Methotrexate; Drug: Hydrocortisone Sponsors: Julio Barredo, MD; Takeda Recruiting Tue, 21 Nov 2017 12:00:00 EST
A Study to Evaluate the Efficacy and Safety of Daratumumab in Pediatric and Young Adult Participants Greater Than or Equal to (>=)1 and Less Than or Equal to (<=) 30 Years of Age With Relapsed/Refractory Precursor B-cell or T-cell Acute Lymphoblastic Leukemia or Lymphoblastic LymphomaCondition: Precursor Cell Lymphoblastic Leukemia-LymphomaInterventions: Drug: Daratumumab; Drug: Vincristine; Drug: Prednisone; Drug: Doxorubicin; Biological: Peg-asparaginase; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: 6-mercaptopurine; Drug: Methotrexate Sponsor: Janssen Research & Development, LLC Active, not recruiting Wed, 27 Dec 2017 12:00:00 EST Combination Chemotherapy in Treating Children With Acute Lymphocytic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: idarubicin; Drug: mercaptopurine; Drug: methotrexate; Drug: pegaspargase; Drug: prednisone; Drug: thioguanine; Drug: vincristine sulfate; Radiation: radiation therapy Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Mon, 24 Nov 2003 12:00:00 EST Ruxolitinib Plus LVP in Patients With R/R ETP-ALLCondition: Acute T Cell LeukemiaInterventions: Drug: Ruxolitinib; Drug: Vincristine; Drug: Prednisone Sponsor: Sichuan University Unknown status Fri, 03 Aug 2018 12:00:00 EDT GLIDE Regimen Followed by ASCT for Aggressive NK/T Cell LymphomaCondition: Lymphoma, Extranodal NK-T-CellIntervention: Drug: GLIDE Sponsor: Sichuan University Unknown status Tue, 16 May 2017 12:00:00 EDT Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic LeukemiaCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Cyclophosphamide; Drug: Doxorubicin; Drug: Vincristine; Drug: Dexamethasone; Drug: Cytarabine; Drug: Methotrexate; Drug: Rituximab; Drug: 6-Mercaptopurine; Drug: Prednisone; Drug: L-asparaginase Sponsor: Ruijin Hospital Completed Mon, 23 May 2011 12:00:00 EDT Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic LeukemiaConditions: Childhood Acute Lymphoblastic Leukemia; Philadelphia Chromosome, Ph^1^, Absent; B-cell Childhood Acute Lymphoblastic LeukemiaIntervention: Drug: Idarubicin(IDA) Sponsor: Chinese Academy of Medical Sciences Unknown status Thu, 21 Nov 2013 12:00:00 EST Concomitant Chemo-radiotherapy Followed by MIDLE Chemotherapy in Stage I/II Extranodal NK/T-cell LymphomaCondition: Extranodal NK-T-Cell Lymphoma, Nasal and Nasal-TypeIntervention: Radiation: CCRT+MIDLE chemotherapy Sponsors: Samsung Medical Center; Asan Medical Center; Yonsei University; Seoul National University; Chonnam National University Completed Wed, 10 Nov 2010 12:00:00 EST Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's LymphomaConditions: Cardiac Toxicity; Leukemia; LymphomaInterventions: Drug: asparaginase; Drug: cytarabine; Drug: dexrazoxane hydrochloride; Drug: doxorubicin hydrochloride; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisone; Drug: therapeutic hydrocortisone; Drug: vincristine sulfate; Radiation: radiation therapy Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Fri, 29 Oct 2010 12:00:00 EDT Treatment of Acute Lymphoblastic Leukemia in ChildrenCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: prednisone; Drug: dexamethasone; Drug: doxorubicin; Drug: E. coli asparaginase; Drug: vincristine; Drug: methotrexate; Drug: Leucovorin; Drug: Asparaginase; Drug: cytarabine; Drug: Methotrexate/Hydrocortisone Sponsors: Dana-Farber Cancer Institute; Boston Children's Hospital; University of Rochester; McMaster University; San Jorge Children's Hospital (Puerto Rico); St. Justine's Hospital; Maine Children's Cancer Program; Ochsner Health System; Tulane University School of Medicine; Laval University; Columbia University Completed Wed, 14 Sep 2005 12:00:00 EDT A Study of Venetoclax in Combination With Navitoclax and Chemotherapy in Subjects With Relapsed/Refractory Acute Lymphoblastic Leukemia or Relapsed/Refractory Lymphoblastic LymphomaConditions: Acute Lymphoblastic Leukemia (ALL); Lymphoblastic LymphomaInterventions: Drug: Navitoclax; Drug: Chemotherapy; Drug: Venetoclax Sponsor: AbbVie Completed Thu, 08 Jun 2017 12:00:00 EDT
Comparison of Liposomal Doxorubicin and Daunorubicin-containing VDCLD Regimen in the Treatment of Adult ALL PatientsCondition: Adult Acute Lymphoblastic LeukemiaInterventions: Drug: PLD; Drug: DNR Sponsor: CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Unknown status Mon, 05 Feb 2018 12:00:00 EST Biomarkers to Classify Young Patients With Acute Lymphoblastic Leukemia (ALL) and Remission Induction Therapy in Young Patients With B-Precursor ALLCondition: LeukemiaInterventions: Drug: SC-PEG E. coli L-asparaginase; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: methotrexate; Drug: pegaspargase; Drug: prednisone; Drug: vincristine sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Thu, 21 Oct 2010 12:00:00 EDT Augmented Berlin-Frankfurt-Munster Therapy Plus Ofatumumab for Young Adults With Acute Lymphoblastic Leukemia or Lymphoblastic LymphomaConditions: Leukemia; Precursor-B Acute Lymphoblastic Leukemia; Lymphoblastic Lymphoma; LymphomaInterventions: Drug: Cytarabine; Drug: Daunorubicin; Drug: Vincristine; Drug: Prednisone; Drug: PEG asparaginase; Drug: Ofatumumab; Drug: Rituximab; Drug: Methotrexate; Drug: Cyclophosphamide; Drug: Mercaptopurine; Drug: Doxorubicin; Drug: Dexamethasone acetate; Drug: Thioguanine Sponsors: M.D. Anderson Cancer Center; Jazz Pharmaceuticals Terminated Fri, 17 Apr 2015 12:00:00 EDT Comparison of Different Combination Chemotherapy Regimens in Treating Infants With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cytarabine; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisolone; Drug: vincristine sulfate Sponsor: Dutch Childhood Oncology Group Completed Mon, 27 Jan 2003 12:00:00 EST Study of Carfilzomib in Combination With Induction Chemotherapy in Children With Relapsed or Refractory Acute Lymphoblastic LeukemiaCondition: Acute Lymphoblastic Leukemia (ALL)Interventions: Drug: Carfilzomib; Drug: Dexamethasone; Drug: Mitoxantrone; Drug: PEG-asparaginase; Drug: Vincristine; Drug: Intrathecal (IT) Methotrexate; Drug: Intrathecal Triple Therapy (Intrathecal Cytarabine, Hydrocortisone, and Methotrexate); Drug: 6-Mercaptopurine; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin Sponsors: Amgen; Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) - Study Design & Execution Collaborator; Innovative Therapies For Children with Cancer Consortium Recruiting Mon, 01 Dec 2014 12:00:00 EST Optimization of Therapy in Adult Patients With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma by Individualised, Targeted and Intensified TreatmentConditions: Acute Lymphoblastic Leukemia; Lymphoblastic LymphomaInterventions: Drug: Rituximab; Drug: Nelarabine; Drug: PEG-Asparaginase; Procedure: Cranial irradiation; Drug: Imatinib; Drug: Idarubicin; Drug: Dexamethasone; Drug: Cyclophosphamide; Drug: Fludarabine; Drug: Vincristine; Drug: Mercaptopurine; Drug: VP16; Drug: Daunorubicin (DNR); Drug: Methotrexate; Procedure: Stem cell transplantation; Drug: Cytarabine; Drug: Vindesine; Drug: Adriamycin; Drug: Prednisolone Sponsor: Goethe University Recruiting Fri, 26 Aug 2016 12:00:00 EDT LBL-2016 for Children or Adolescents in ChinaCondition: Lymphoblastic LymphomaInterventions: Drug: Prednisone,Vincristine, Pegylated-asparaginase, Cytarabine, Cyclophosphamide, Daunorubicin, 6-mercaptopurine; Drug: 6-mercaptopurine,Methotrexate; Drug: Dexamethasone,Vincristine, Pegylated-asparaginase, Cytarabine, Cyclophosphamide, Doxorubicin, 6-mercaptopurine; Drug: Dexamethasone,Vincristine, Pegylated-asparaginase, Cytarabine, Cyclophosphamide, Methotrexate; Drug: Dexamethasone, Vindesine, Methotrexate, Ifosfamide, Daunorubicin, Pegylated-asparaginase; Drug: Dexamethasone, Cytarabine, Etoposide, Pegylated-asparaginase; Drug: Methotrexate, 6-mercaptopurine Sponsors: Children's Cancer Group, China; Shanghai Children's Medical Center; Tongji Hospital; West China Second University Hospital; Qilu Hospital of Shandong University; Tianjin Medical University Cancer Institute and Hospital; Children's Hospital Of Soochow University; Nanjing Children's Hospital; Xiangya Hospital of Central South University Recruiting Wed, 27 Jul 2016 12:00:00 EDT Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: dexamethasone; Drug: asparaginase; Drug: Asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin; Drug: doxorubicin; Drug: Etoposide; Drug: Ifosfamide; Drug: mercaptopurine; Drug: Methotrexate; Drug: prednisone; Drug: thioguanine; Drug: Vincristine; Drug: Vindesine Sponsor: Associazione Italiana Ematologia Oncologia Pediatrica Completed Wed, 13 Feb 2008 12:00:00 EST A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid LeukemiaConditions: Acute Myeloid Leukemia; Myelodysplastic SyndromesInterventions: Drug: Azacitidine; Drug: Decitabine; Drug: Cytarabine; Drug: Daunorubicin; Drug: Etoposide; Combination Product: ITMHA; Drug: Idarubicin; Drug: Fludarabine; Drug: Mitoxantrone; Drug: Erwinia asparaginase; Drug: Sorafenib; Drug: G-CSF; Drug: Dexrazoxane; Biological: Stem Cell Transplant Sponsor: St. Jude Children's Research Hospital Recruiting Tue, 23 May 2017 12:00:00 EDT A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and AdolescentsCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: pegaspargase 1250 IU/m2 x 2; Drug: pegaspargase 2500 IU/m2 x 1 Sponsors: Assistance Publique - Hôpitaux de Paris; Shire Recruiting Wed, 23 Mar 2016 12:00:00 EDT
Chemotherapy With Liposomal Cytarabine CNS Prophylaxis for Adult Acute Lymphoblastic Leukemia & Lymphoblastic LymphomaConditions: Acute Lymphocytic Leukemia; Adult Lymphoblastic LymphomaInterventions: Drug: DNR; Drug: VCR; Drug: PEG-asp; Drug: CTX; Drug: Prednisone; Drug: Liposomal AraC; Drug: MTX; Drug: LCV; Drug: AraC; Drug: Etoposide; Drug: Dasatinib; Drug: Rituximab; Drug: Hydrocortisone Sponsors: University of California, San Diego; Leadiant Biosciences, Inc. Active, not recruiting Thu, 23 Jan 2014 12:00:00 EST "Sandwich" Chemotherapy With Radiotherapy in Newly Diagnosed, Stage IE to IIE, ENKTLCondition: Treatment RefusalInterventions: Drug: P-CHOP; Radiation: Radiotherapy Sponsor: Sun Yat-sen University Terminated Tue, 11 Aug 2015 12:00:00 EDT Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: mercaptopurine; Drug: methotrexate; Drug: pegaspargase; Drug: prednisone; Drug: therapeutic hydrocortisone; Drug: thioguanine; Drug: vincristine sulfate; Radiation: low-LET cobalt-60 gamma ray therapy; Radiation: low-LET photon therapy Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Wed, 01 Sep 2004 12:00:00 EDT Fludarabine, Cytarabine, and Pegcrisantaspase for the Treament of Relapsed or Refractory LeukemiaConditions: Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent Acute Biphenotypic Leukemia; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent T-Cell Prolymphocytic Leukemia; Refractory Acute Biphenotypic Leukemia; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory T-Cell Prolymphocytic LeukemiaInterventions: Drug: Cytarabine; Drug: Fludarabine; Drug: Pegcrisantaspase Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI) Recruiting Wed, 26 Aug 2020 12:00:00 EDT Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic LymphomaCondition: LymphomaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisone; Drug: thioguanine; Drug: vincristine sulfate; Radiation: radiation therapy Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 MutationsCondition: Acute Myeloid LeukemiaInterventions: Procedure: Allogeneic Hematopoietic Stem Cell Transplantation; Drug: Asparaginase; Drug: Asparaginase Erwinia chrysanthemi; Behavioral: Cogstate Assessment Battery; Drug: Cytarabine; Drug: Daunorubicin Hydrochloride; Drug: Dexrazoxane Hydrochloride; Drug: Etoposide; Drug: Gemtuzumab Ozogamicin; Drug: Gilteritinib Fumarate; Drug: Liposome-encapsulated Daunorubicin-Cytarabine; Drug: Methotrexate; Drug: Mitoxantrone Hydrochloride; Drug: Therapeutic Hydrocortisone Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Recruiting Tue, 03 Mar 2020 12:00:00 EST Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic LymphomaConditions: T Acute Lymphoblastic Leukemia; T Lymphoblastic LymphomaInterventions: Drug: Asparaginase; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Doxorubicin Hydrochloride; Other: Laboratory Biomarker Analysis; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Nelarabine; Drug: Pegaspargase; Drug: Prednisone; Radiation: Radiation Therapy; Drug: Thioguanine; Drug: Vincristine Sulfate Sponsor: National Cancer Institute (NCI) Active, not recruiting Tue, 05 Dec 2006 12:00:00 EST Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and AdolescentsCondition: Acute Lymphoblastic Leukemia, PediatricInterventions: Drug: Pegaspargase; Drug: Erwinia asparaginase; Drug: Cyclophosphamide; Drug: CYTARABINE; Drug: DASATINIB; Drug: DEXAMETHASONE; Drug: Dexrazoxane; Drug: Doxorubicin; Drug: ETOPOSIDE; Drug: HYDROCORTISONE; Drug: LEUCOVORIN CALCIUM; Drug: MERCAPTOPURINE; Drug: METHOTREXATE; Drug: NELARABINE; Drug: Vincristine Sponsors: Dana-Farber Cancer Institute; Servier Recruiting Fri, 13 Jan 2017 12:00:00 EST Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017Condition: Acute Lymphoblastic Leukemia, PediatricInterventions: Drug: Blinatumomab; Drug: Bortezomib; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin; Drug: Myocet; Drug: Dexamethasone; Drug: Doxorubicin; Drug: Etoposide; Drug: Fludarabine Phosphate; Drug: Ifosfamide; Drug: 6-Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Drug: Prednisolone; Drug: Tioguanin; Drug: Vincristine; Drug: Vindesine; Drug: Erwinase Sponsors: Martin Schrappe; Deutsche Krebshilfe e.V., Bonn (Germany) Recruiting Wed, 22 Aug 2018 12:00:00 EDT Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and LymphomaConditions: Acute Lymphoblastic Leukemia; Acute Lymphoblastic LymphomaInterventions: Drug: Prednisone; Drug: Vincristine; Drug: Daunorubicin; Drug: Pegaspargase; Drug: Erwinase®; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Mercaptopurine; Drug: Dasatinib; Drug: Methotrexate; Drug: Blinatumomab; Drug: Ruxolitinib; Drug: Bortezomib; Drug: Dexamethasone; Drug: Doxorubicin; Drug: Etoposide; Drug: Clofarabine; Drug: Vorinostat; Drug: Idarubicin; Drug: Nelarabine; Drug: Thioguanine Sponsors: St. Jude Children's Research Hospital; Incyte Corporation; Amgen; Servier Recruiting Tue, 18 Apr 2017 12:00:00 EDT
A Novel "Pediatric-Inspired" Regimen With Reduced Myelosuppressive Drugs for Adults (Aged 18-60) With Newly Diagnosed Ph Negative Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: Daunorubicin; Drug: Vincristine; Drug: Prednisone; Drug: PEG-Asparaginase; Drug: Methotrexate; Drug: 6-MP (6-Mercaptopurine); Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Leucovorin; Drug: Dexamethasone; Other: Blood draw; Device: CT/PET scans Sponsors: Memorial Sloan Kettering Cancer Center; Shire; Duke University; Weill Medical College of Cornell University; Lehigh Valley Health Network Active, not recruiting Mon, 12 Aug 2013 12:00:00 EDT Rituximab+mVPDL for CD20(+) Adult Acute Lymphoblastic LeukemiaCondition: Precursor Cell Lymphoblastic Leukemia-LymphomaIntervention: Drug: Rituximab+mVPDL Sponsor: Asan Medical Center Unknown status Wed, 07 Sep 2011 12:00:00 EDT Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic LymphomaConditions: B-cell Adult Acute Lymphoblastic Leukemia; B-cell Childhood Acute Lymphoblastic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Lymphoblastic Lymphoma; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Childhood Acute Lymphoblastic LeukemiaInterventions: Drug: L-asparaginase; Drug: doxorubicin hydrochloride; Drug: therapeutic hydrocortisone; Drug: vincristine sulfate; Drug: cytarabine; Drug: prednisone; Drug: bortezomib; Drug: pegaspargase; Drug: methotrexate; Drug: etoposide phosphate; Drug: cyclophosphamide; Biological: filgrastim; Drug: leucovorin calcium; Other: laboratory biomarker analysis; Drug: High Dose MTX Sponsor: National Cancer Institute (NCI) Completed Wed, 01 Apr 2009 12:00:00 EDT Treatment for Patients With Stage III or IV Non-Hodgkin LymphomaCondition: Lymphoblastic LymphomaInterventions: Drug: Vincristine; Procedure: Radiation Therapy; Drug: Daunomycin; Drug: L-Asparaginase; Drug: Cytarabine; Drug: Methotrexate; Drug: Mercaptopurine; Drug: Etoposide; Drug: Cyclophosphamide; Drug: Prednisone; Drug: Dexamethasone Sponsor: St. Jude Children's Research Hospital Completed Fri, 16 Sep 2005 12:00:00 EDT Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic LeukemiaConditions: Childhood Acute Lymphoblastic Leukemia in Remission; Recurrent Childhood Acute Lymphoblastic LeukemiaInterventions: Biological: filgrastim; Drug: asparaginase; Drug: cyclophosphamide; Drug: cyclosporine; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: etoposide; Drug: ifosfamide; Drug: imatinib mesylate; Drug: leucovorin calcium; Drug: mercaptopurine tablet; Drug: methotrexate; Drug: pegaspargase; Drug: vincristine sulfate; Procedure: allogeneic bone marrow transplantation; Procedure: peripheral blood stem cell transplantation; Procedure: umbilical cord blood transplantation; Radiation: radiation therapy Sponsor: National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST Low-Dose or High-Dose Vincristine and Combination Chemotherapy in Treating Young Patients With Relapsed B-Cell Acute Lymphoblastic LeukemiaConditions: B-cell Childhood Acute Lymphoblastic Leukemia; L1 Childhood Acute Lymphoblastic Leukemia; L2 Childhood Acute Lymphoblastic Leukemia; Intermediate Risk Recurrent Childhood Acute Lymphoblastic LeukemiaInterventions: Drug: vincristine sulfate; Drug: prednisone; Drug: doxorubicin hydrochloride; Drug: pegaspargase; Drug: cytarabine; Drug: methotrexate; Drug: dexamethasone; Drug: etoposide; Drug: cyclophosphamide; Drug: leucovorin calcium; Biological: filgrastim; Drug: asparaginase; Drug: mercaptopurine Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Thu, 28 Sep 2006 12:00:00 EDT Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaConditions: T-cell Childhood Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic LeukemiaInterventions: Drug: prednisone; Drug: vincristine sulfate; Drug: daunorubicin hydrochloride; Drug: asparaginase; Drug: methotrexate; Drug: cyclophosphamide; Drug: cytarabine; Drug: mercaptopurine; Drug: leucovorin calcium; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: thioguanine; Radiation: radiation therapy; Drug: nelarabine; Drug: pegaspargase; Other: pharmacological study; Other: laboratory biomarker analysis Sponsor: National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST AflacLL1901 (CHOA-AML)Conditions: Acute Myeloid Leukemia; AML, ChildhoodInterventions: Drug: Cytarabine; Drug: Daunorubicin; Drug: Erwinase; Drug: Etoposide; Drug: Gemtuzumab ozogamicin; Procedure: Stem cell transplantation (SCT); Drug: Sorafenib Sponsor: Emory University Terminated Mon, 30 Mar 2020 12:00:00 EDT Combination Chemotherapy Followed by Melphalan and Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Acute Myeloid LeukemiaCondition: LeukemiaInterventions: Biological: filgrastim; Drug: asparaginase; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: melphalan; Drug: thioguanine; Procedure: peripheral blood stem cell transplantation Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Thu, 20 May 2004 12:00:00 EDT Concomitant Chemo-radiotherapy Plus VIDL Chemotherapy in NK/T-cell LymphomaCondition: NK/T-cell Lymphoma of Nasal CavityIntervention: Other: CCRT followed by VIDL chemotherapy Sponsors: Samsung Medical Center; Asan Medical Center; National Cancer Center, Korea; Severance Hospital Completed Wed, 04 Nov 2009 12:00:00 EST
Study for Treatment of Cancer in Children With Ataxia-telangiectasiaCondition: Ataxia-TelangiectasiaInterventions: Drug: vinblastine, vincristine, prednisone, daunorubicin; Drug: doxorubicin, methotrexate, cyclophosphamide, L-asparaginase; Drug: etoposide, cytarabine, mercaptopurine; Drug: dexamethasone, procarbazine; Procedure: chemotherapy, intrathecal chemotherapy, steroid therapy Sponsors: St. Jude Children's Research Hospital; Children's Hospital of Philadelphia; National Cancer Institute (NCI) Completed Fri, 16 Sep 2005 12:00:00 EDT Combination Chemotherapy in Treating Children With Newly Diagnosed Acute Lymphocytic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: thioguanine; Drug: vincristine sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Mon, 13 Sep 2004 12:00:00 EDT Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic LeukemiaCondition: Recurrent B Acute Lymphoblastic LeukemiaInterventions: Procedure: Allogeneic Hematopoietic Stem Cell Transplantation; Drug: Asparaginase; Biological: Blinatumomab; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Dexamethasone; Drug: Etoposide; Other: Laboratory Biomarker Analysis; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Mitoxantrone; Drug: Mitoxantrone Hydrochloride; Drug: Pegaspargase; Other: Pharmacological Study; Radiation: Radiation Therapy; Drug: Therapeutic Hydrocortisone; Drug: Thioguanine; Drug: Vincristine; Drug: Vincristine Sulfate Sponsor: National Cancer Institute (NCI) Active, not recruiting Wed, 02 Apr 2014 12:00:00 EDT Dasatinib and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaConditions: Acute Lymphoblastic Leukemia; Adult B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1; Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1Interventions: Drug: Asparaginase; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Dasatinib; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Etoposide; Biological: Filgrastim; Drug: Hydrocortisone Sodium Succinate; Drug: Ifosfamide; Other: Laboratory Biomarker Analysis; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Methylprednisolone; Drug: Pegaspargase; Drug: Prednisone; Radiation: Radiation Therapy; Drug: Vincristine Sulfate Sponsor: National Cancer Institute (NCI) Completed Tue, 22 Jul 2008 12:00:00 EDT Combination Chemotherapy in Treating Children With Very High Risk Acute Lymphocytic LeukemiaCondition: LeukemiaInterventions: Biological: filgrastim; Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: etoposide; Drug: idarubicin; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisone; Drug: vincristine sulfate; Radiation: radiation therapy Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Tue, 27 Apr 2004 12:00:00 EDT Combination Chemotherapy With or Without Lestaurtinib in Treating Younger Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaConditions: Acute Lymphoblastic Leukemia; Acute Undifferentiated Leukemia; Childhood T Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic LeukemiaInterventions: Drug: Asparaginase; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Etoposide; Biological: Filgrastim; Other: Laboratory Biomarker Analysis; Drug: Lestaurtinib; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Methylprednisolone; Drug: Pegaspargase; Other: Pharmacological Study; Drug: Prednisone; Drug: Therapeutic Hydrocortisone; Drug: Vincristine Sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Active, not recruiting Mon, 12 Nov 2007 12:00:00 EST Isatuximab in Combination With Chemotherapy in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia or Acute Myeloid LeukemiaConditions: Acute Lymphoblastic Leukemia; Acute Myeloid LeukemiaInterventions: Drug: Montelukast; Drug: Isatuximab; Drug: Dexamethasone; Drug: Fludarabine; Drug: Cytarabine; Drug: Liposomal daunorubicin; Drug: Daunorubicin; Drug: Idarubicin; Drug: Filgrastim; Drug: Mitoxantrone; Drug: Doxorubicin; Drug: Vincristine; Drug: PEG Asparaginase; Drug: Cyclophosphamide; Drug: Etoposide; Drug: Methotrexate; Drug: L - Asparginase; Drug: Hydroxyurea; Drug: L - Asparaginase (Erwinase); Drug: Tocilizumab Sponsor: Sanofi Recruiting Mon, 04 Mar 2019 12:00:00 EST Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic LeukemiaCondition: Acute Lymphobkastic LeukemiaInterventions: Drug: Vincristine; Drug: Daunorubicin; Drug: Prednisone; Drug: L-asparaginase; Drug: Ciclophosphamide; Drug: Metotrexate; Drug: ARA-C; Drug: Hidrocortisone; Drug: Mercaptopurine; Drug: VP-16; Drug: Dexametasone Sponsor: PETHEMA Foundation Completed Wed, 15 Jan 2014 12:00:00 EST A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic LeukemiaConditions: B Acute Lymphoblastic Leukemia; B Lymphoblastic Lymphoma; Down SyndromeInterventions: Drug: Asparaginase Erwinia chrysanthemi; Biological: Blinatumomab; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Dexamethasone; Drug: Doxorubicin Hydrochloride; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Mercaptopurine Oral Suspension; Drug: Methotrexate; Drug: Pegaspargase; Drug: Prednisolone; Drug: Prednisone; Radiation: Radiation Therapy; Drug: Thioguanine; Drug: Vincristine Sulfate Sponsor: National Cancer Institute (NCI) Recruiting Tue, 16 Apr 2019 12:00:00 EDT Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myelogenous Leukemia or Myelodysplastic SyndromeConditions: Childhood Acute Erythroleukemia (M6); Childhood Acute Megakaryocytic Leukemia (M7); Childhood Acute Monoblastic Leukemia (M5a); Childhood Acute Monocytic Leukemia (M5b); Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Myeloblastic Leukemia Without Maturation (M1); Childhood Acute Myelomonocytic Leukemia (M4); Childhood Myelodysplastic Syndromes; Chronic Myelomonocytic Leukemia; de Novo Myelodysplastic Syndromes; Refractory Anemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Excess Blasts in Transformation; Refractory Anemia With Ringed Sideroblasts; Secondary Myelodysplastic Syndromes; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid MalignanciesInterventions: Drug: asparaginase; Drug: daunorubicin hydrochloride; Drug: fludarabine phosphate; Drug: therapeutic hydrocortisone; Procedure: allogeneic bone marrow transplantation; Radiation: 3-dimensional conformal radiation therapy; Biological: filgrastim; Drug: cytarabine; Drug: idarubicin; Drug: dexamethasone; Drug: thioguanine; Drug: etoposide; Drug: methotrexate; Drug: cyclophosphamide; Biological: aldesleukin; Drug: busulfan Sponsor: National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST
ALL Adult Consortium Trial: Adult ALL TrialCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Doxorubicin; Drug: Cytarabine; Drug: Methotrexate; Drug: Vincristine; Drug: Cyclophosphamide; Drug: Methylprednisone; Drug: Hydrocortisone Sodium Succinate; Drug: Dexamethasone; Drug: 6-MP; Drug: PEG-Asparaginase; Drug: Imatinib; Drug: Etoposide; Procedure: Radiation Therapy; Drug: E. coli Asparaginase Sponsors: Dana-Farber Cancer Institute; Massachusetts General Hospital; Boston Children's Hospital; NCIC Clinical Trials Group Active, not recruiting Mon, 21 May 2007 12:00:00 EDT Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid LeukemiaConditions: Acute Myeloid Leukemia; Leukemia Cutis; Myeloid Neoplasm; Myeloid SarcomaInterventions: Drug: Asparaginase; Drug: Bortezomib; Drug: Cytarabine; Drug: Daunorubicin Hydrochloride; Drug: Etoposide; Other: Laboratory Biomarker Analysis; Drug: Mitoxantrone Hydrochloride; Other: Pharmacological Study; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Drug: Sorafenib Tosylate Sponsor: National Cancer Institute (NCI) Active, not recruiting Mon, 13 Jun 2011 12:00:00 EDT Clinical Study of Liposomal Mitoxantrone Hydrochloride Injection Combined With Pegaspargase in the Treatment of NKTCLCondition: Extranodal NK/T-cell Lymphoma, Nasal TypeInterventions: Drug: Part 1: Liposomal mitoxantrone hydrochloride and Pegaspargase; Drug: Part 2 (treatment-naïve patients): Liposomal mitoxantrone hydrochloride and Pegaspargase; Drug: Part 2 (relapsed or refractory patients): Liposomal mitoxantrone hydrochloride and Pegaspargase Sponsor: CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Not yet recruiting Wed, 12 Aug 2020 12:00:00 EDT Everolimus With Multiagent Re-Induction Chemotherapy in Pediatric Patients With ALLCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Everolimus; Drug: Prednisone; Drug: Vincristine; Drug: PEG-Asparaginase; Drug: Doxorubicin; Drug: Dexrazoxane Sponsors: Dana-Farber Cancer Institute; Novartis Completed Wed, 01 Feb 2012 12:00:00 EST Induction Chemotherapy Sequential Sintilimab Combined With Dual Epigenetic Drugs for ENKTL-HLHCondition: Safety and EfficacyInterventions: Drug: Sintilimab; Drug: Chidamide; Drug: Azacitidine; Drug: L-DEP Sponsor: Sun Yat-sen University Not yet recruiting Tue, 17 Aug 2021 12:00:00 EDT Personalized Therapy of Precursor Lymphoid NeoplasmsCondition: Precursor Lymphoid NeoplasmsIntervention: Other: Treatment strategy: induction, consolidation, HSCT, maintenance Sponsors: Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice; Polish Adult Leukemia Group Unknown status Wed, 15 Aug 2012 12:00:00 EDT Four Drug Reinduction With Bortezomib for Relapsed or Refractory ALL or LL in Children and Young AdultsConditions: Acute Lymphoblastic Leukemia; Lymphoblastic LymphomaInterventions: Drug: Velcade; Drug: Methotrexate; Drug: Methotrexate / Hydrocortisone / Cytarabine; Drug: Dexamethasone; Drug: Mitoxantrone; Drug: Vincristine; Drug: Pegaspargase Sponsors: Children's Mercy Hospital Kansas City; Millennium Pharmaceuticals, Inc. Terminated Mon, 31 Aug 2015 12:00:00 EDT Combination Chemotherapy in Treating Young Adult Patients With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: ifosfamide; Drug: mercaptopurine; Drug: methotrexate; Drug: methylprednisolone; Drug: prednisone; Drug: thioguanine; Drug: vincristine sulfate; Drug: vindesine Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto Completed Mon, 05 Jul 2010 12:00:00 EDT Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: ifosfamide; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisone; Drug: thioguanine; Drug: vincristine sulfate; Drug: vindesine Sponsor: University Hospital, Motol Unknown status Thu, 02 Oct 2008 12:00:00 EDT PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic LeukemiaCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Asparaginase; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin; Drug: Mercaptopurine; Drug: Prednisone; Drug: Vincristine; Drug: Methotrexate; Procedure: Intrathecally treatment Sponsor: PETHEMA Foundation Completed Mon, 02 Jul 2007 12:00:00 EDT
Chemotherapy With or Without Imatinib and/or Peripheral Stem Cell Transplant in Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: daunorubicin hydrochloride; Drug: etoposide; Drug: idarubicin; Drug: imatinib mesylate; Drug: mercaptopurine; Drug: methotrexate; Drug: methylprednisolone; Drug: mitoxantrone hydrochloride; Drug: prednisone; Drug: vincristine sulfate; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: autologous hematopoietic stem cell transplantation; Procedure: peripheral blood stem cell transplantation; Radiation: radiation therapy Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto Completed Wed, 11 Apr 2007 12:00:00 EDT Combination Chemotherapy Based on Risk of Relapse in Treating Young Patients With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: ifosfamide; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisone; Drug: thioguanine; Drug: vincristine sulfate; Drug: vindesine; Radiation: radiation therapy Sponsor: University Hospital Schleswig-Holstein Completed Thu, 01 Feb 2007 12:00:00 EST Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: mercaptopurine; Drug: methotrexate; Drug: pegaspargase; Drug: prednisolone; Drug: teniposide; Drug: thioguanine; Drug: vincristine sulfate; Radiation: radiation therapy Sponsor: Universitätsklinikum Hamburg-Eppendorf Unknown status Fri, 23 Jun 2006 12:00:00 EDT Prednisolone or Dexamethasone Combined With Chemotherapy in Treating Young Patients With Newly Diagnosed Lymphoblastic LymphomaCondition: LymphomaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisolone; Drug: thioguanine; Drug: vincristine sulfate; Procedure: radiation therapy Sponsors: Children's Cancer and Leukaemia Group; European Inter-group Cooperation on Childhood and Adolescent Non Hodgkin Lymphoma Terminated Wed, 11 Jan 2006 12:00:00 EST German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93)Condition: Adult Acute Lymphocytic LeukemiaInterventions: Drug: Asparaginase; Drug: Vincristine; Drug: Daunorubicin, Adriamycin; Drug: Cyclophosphamide; Drug: Ifosfamide; Drug: Cytarabine; Drug: Mitoxantrone; Drug: Methotrexate; Drug: 6-Mercaptopurine; Drug: 6-Thioguanine; Drug: VM26; Drug: Dexamethasone / Prednisolone; Procedure: CNS Irradiation; Procedure: Mediastinal Irradiation; Procedure: Stem Cell Transplantation Sponsors: Johann Wolfgang Goethe University Hospital; Deutsche Krebshilfe e.V., Bonn (Germany) Completed Tue, 20 Sep 2005 12:00:00 EDT Therapy for Newly Diagnosed Patients With Acute Lymphoblastic LeukemiaCondition: Lymphoblastic Leukemia, AcuteInterventions: Drug: Prednisone, Dexamethasone, Vincristine, Daunorubicin; Drug: Doxorubicin, L-asparaginase, PEG-L-asparaginase, Erwinia asparaginase; Drug: Methotrexate, Cyclophosphamide, Cytarabine, Etoposide; Drug: Mercaptopurine, Imatinib; Procedure: chemotherapy, intrathecal chemotherapy; Procedure: steroid therapy, hematopoietic stem cell transplantation Sponsors: St. Jude Children's Research Hospital; National Cancer Institute (NCI) Completed Mon, 29 Aug 2005 12:00:00 EDT Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003Condition: Acute Lymphoblastic LeukemiaInterventions: Other: Reduced intensification; Drug: Standard childhood UK ALL protocol; Drug: Intensified treatment including Capizzi maintenance Sponsors: University of Oxford; Medical Research Council Unknown status Thu, 22 Sep 2005 12:00:00 EDT Combination Chemotherapy in Treating Patients With Acute B-Lymphoblastic Leukemia or Non-Hodgkin's LymphomaConditions: Leukemia; LymphomaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: etoposide; Drug: leucovorin calcium; Drug: methotrexate; Drug: methylprednisolone; Drug: therapeutic hydrocortisone; Drug: thiotepa; Drug: vincristine sulfate Sponsor: Memorial Sloan Kettering Cancer Center Completed Mon, 30 Aug 2004 12:00:00 EDT Combination Chemotherapy in Treating Children With Relapsed Acute Lymphocytic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: methotrexate; Drug: prednisone; Drug: vincristine sulfate; Radiation: radiation therapy Sponsor: Grupo Argentino de Tratamiento de la Leucemia Aguda Unknown status Mon, 23 Aug 2004 12:00:00 EDT Different Therapies in Treating Infants With Newly Diagnosed Acute LeukemiaCondition: LeukemiaInterventions: Biological: anti-thymocyte globulin; Drug: asparaginase; Drug: busulfan; Drug: cyclophosphamide; Drug: cyclosporine; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: etoposide; Drug: leucovorin calcium; Drug: melphalan; Drug: mercaptopurine; Drug: methotrexate; Drug: mitoxantrone hydrochloride; Drug: pegaspargase; Drug: prednisolone; Drug: prednisone; Drug: therapeutic hydrocortisone; Drug: thioguanine; Drug: vincristine sulfate; Procedure: allogeneic bone marrow transplantation; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: umbilical cord blood transplantation Sponsors: Dutch Childhood Oncology Group; BFM Germany; CORS Monza Italy; Associazione Italiana Ematologia Oncologia Pediatrica; Australian and New Zealand Children's Oncology Group; BFM Austria; CLCG France Belgium Portugal; COALL Germany; CPH, Czech republic; DFCI consortium USA; FRALLE France; Hong Kong; MD Anderson USA; NOPHO Scandinavian countries; PINDA, Chile; PPLLSG Poland; Seattle USA; SJCRH USA; UKCCSG United Kingdom Unknown status Tue, 30 Oct 2007 12:00:00 EDT
Combination Chemotherapy in Treating Children With Non-Hodgkin's LymphomaCondition: LymphomaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: etoposide; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisolone; Drug: thioguanine; Drug: vincristine sulfate Sponsor: United Kingdom Children's Cancer Study Group Unknown status Thu, 20 May 2004 12:00:00 EDT Radiation Therapy to the Head or Intrathecal Chemotherapy Plus High Dose Cytarabine in Preventing CNS Disease in Children With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisone; Drug: therapeutic hydrocortisone; Drug: vincristine sulfate; Radiation: radiation therapy Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI) Withdrawn Fri, 27 Feb 2004 12:00:00 EST Combination Chemotherapy in Treating Adults With Acute Lymphocytic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: ifosfamide; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: mitoxantrone hydrochloride; Drug: prednisolone; Drug: teniposide; Drug: thioguanine; Drug: vincristine sulfate; Drug: vindesine; Procedure: allogeneic bone marrow transplantation; Procedure: peripheral blood stem cell transplantation; Radiation: radiation therapy Sponsor: Johann Wolfgang Goethe University Hospital Unknown status Mon, 16 Feb 2004 12:00:00 EST Gemtuzumab Ozogamicin in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Undergoing Remission Induction and Intensification TherapyCondition: LeukemiaInterventions: Drug: asparaginase; Drug: busulfan; Drug: cyclophosphamide; Drug: cyclosporine; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: etoposide; Drug: gemtuzumab ozogamicin; Drug: methotrexate; Drug: mitoxantrone hydrochloride; Procedure: allogeneic bone marrow transplantation Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Tue, 07 Oct 2003 12:00:00 EDT Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia and Diffuse Non-Hodgkin's LymphomaConditions: Leukemia; LymphomaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: ifosfamide; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisone; Drug: vincristine sulfate; Procedure: conventional surgery; Radiation: radiation therapy Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI) Completed Thu, 12 Jun 2003 12:00:00 EDT Combination Chemotherapy With or Without Donor Bone Marrow Transplantation in Treating Infants With Previously Untreated Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cyclosporine; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: mercaptopurine; Drug: methotrexate; Drug: methylprednisolone; Drug: pegaspargase; Drug: thioguanine; Drug: vincristine sulfate; Procedure: allogeneic bone marrow transplantation; Radiation: radiation therapy Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST Combination Chemotherapy in Treating Children With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisone; Drug: thioguanine; Drug: vincristine sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST Combination Chemotherapy in Treating Children With Non-Hodgkin's LymphomaCondition: LymphomaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: etoposide; Drug: mercaptopurine; Drug: methotrexate; Drug: methylprednisolone; Drug: mitoxantrone hydrochloride; Drug: prednisone; Drug: vincristine sulfate; Radiation: radiation therapy Sponsor: UNICANCER Completed Mon, 27 Jan 2003 12:00:00 EST Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: mercaptopurine; Drug: methotrexate; Drug: pegaspargase; Drug: prednisolone; Drug: thioguanine; Drug: vincristine sulfate; Radiation: radiation therapy Sponsor: Medical Research Council Unknown status Mon, 27 Jan 2003 12:00:00 EST Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic LeukemiaConditions: Leukemia; LymphomaInterventions: Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: mitoxantrone hydrochloride; Drug: prednisolone; Drug: prednisone; Drug: therapeutic hydrocortisone; Drug: vincristine sulfate; Procedure: allogeneic bone marrow transplantation; Procedure: autologous bone marrow transplantation; Radiation: radiation therapy Sponsors: European Organisation for Research and Treatment of Cancer - EORTC; Acute Leukemia French Association Completed Mon, 27 Jan 2003 12:00:00 EST
Efficacy of Acute Lymphoblastic Leukemia-Based Therapy in Treating Patients With Acute Leukemia of Ambiguous LineageCondition: Acute Leukemia of Ambiguous LineageInterventions: Drug: vincristine; Drug: daunorubicin; Drug: cyclophosphamide; Drug: L-Asparaginase; Drug: prednisone; Drug: mercaptopurine; Drug: methotrexate; Drug: dexamethasone; Drug: Tyrosine kinase inhibitor Sponsor: wang, jianxiang Not yet recruiting Fri, 19 Jun 2020 12:00:00 EDT Radiation Therapy and Chemotherapy in Treating Children With CNS Relapse From Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Biological: filgrastim; Drug: asparaginase; Drug: cyclophosphamide; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: etoposide; Drug: leucovorin calcium; Drug: liposomal cytarabine; Drug: mercaptopurine; Drug: mesna; Drug: methotrexate; Drug: therapeutic hydrocortisone; Drug: thiotepa; Drug: vincristine sulfate; Radiation: low-LET electron therapy; Radiation: low-LET photon therapy Sponsor: National Cancer Institute (NCI) Completed Thu, 01 Jul 2004 12:00:00 EDT Combination Chemotherapy in Treating Pediatric Patients With Stage III or IV Non-Hodgkin's LymphomaCondition: LymphomaInterventions: Biological: filgrastim; Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: etoposide; Drug: leucovorin calcium; Drug: mesna; Drug: methotrexate; Drug: vincristine sulfate Sponsor: Memorial Sloan Kettering Cancer Center Completed Thu, 01 Jul 2004 12:00:00 EDT Combination Chemotherapy, Bone Marrow Transplantation, and Radiation Therapy in Treating Infants With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Biological: filgrastim; Drug: asparaginase; Drug: cyclophosphamide; Drug: cyclosporine; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: etoposide; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: mesna; Drug: methotrexate; Drug: methylprednisolone; Drug: pegaspargase; Drug: prednisone; Drug: therapeutic hydrocortisone; Drug: vincristine sulfate; Procedure: allogeneic bone marrow transplantation; Radiation: low-LET cobalt-60 gamma ray therapy; Radiation: low-LET photon therapy Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Wed, 16 Jun 2004 12:00:00 EDT Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 StudyCondition: Acute Lymphoblastic Leukemia (ALL)Interventions: Drug: Prednisolone; Drug: Dexamethasone; Drug: L-Asparaginase; Drug: Vincristine; Drug: Methotrexate; Drug: Daunorubicin; Drug: Doxorubicin; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: 6-Mercaptopurine; Drug: Thioguanine; Drug: Fludarabine; Drug: Imatinib Sponsor: National University Hospital, Singapore Unknown status Fri, 09 Sep 2016 12:00:00 EDT Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Biological: G-CSF; Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisone; Drug: vincristine sulfate; Drug: Allopurinol Sponsors: Alliance for Clinical Trials in Oncology; National Cancer Institute (NCI) Completed Thu, 20 May 2004 12:00:00 EDT Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Lymphocytic LeukemiaCondition: LeukemiaInterventions: Biological: filgrastim; Drug: asparaginase; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: etoposide; Drug: idarubicin; Drug: ifosfamide; Drug: leucovorin calcium; Drug: methotrexate; Drug: prednisolone; Drug: vindesine Sponsor: Hannover Medical School Unknown status Mon, 16 Feb 2004 12:00:00 EST Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid LeukemiaConditions: Leukemia; Myelodysplastic SyndromesInterventions: Drug: amsacrine; Drug: asparaginase; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: etoposide; Drug: methotrexate; Drug: mitoxantrone hydrochloride; Drug: therapeutic hydrocortisone; Procedure: allogeneic bone marrow transplantation Sponsor: Medical Research Council Completed Wed, 30 Apr 2003 12:00:00 EDT Induction Intensification in Treating Infants With Newly Diagnosed Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Biological: filgrastim; Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: etoposide; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisone; Drug: therapeutic hydrocortisone; Drug: vincristine sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST Stem Cell Transplantation Compared With Standard Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia in First RemissionCondition: LeukemiaInterventions: Biological: sargramostim; Drug: asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: etoposide; Drug: imatinib mesylate; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisone; Drug: thioguanine; Drug: vincristine sulfate; Procedure: allogeneic bone marrow transplantation; Procedure: autologous bone marrow transplantation; Procedure: peripheral blood stem cell transplantation; Radiation: radiation therapy Sponsors: Eastern Cooperative Oncology Group; National Cancer Institute (NCI); Medical Research Council Completed Mon, 27 Jan 2003 12:00:00 EST
International Cooperative Treatment Protocol for Children and Adolescents With Lymphoblastic LymphomaCondition: Lymphoblastic Lymphoma, ChildhoodInterventions: Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Dexamethasone; Drug: Daunorubicin; Drug: Doxorubicin; Drug: Ifosfamide; Drug: 6-Mercaptopurine; Drug: Methotrexate; Drug: PEG asparaginase; Drug: Prednisone; Drug: Prednisolone; Drug: Thioguanine; Drug: Vincristine; Drug: Vindesine Sponsors: University Hospital Muenster; Deutsche Krebshilfe e.V., Bonn (Germany) Recruiting Fri, 02 Aug 2019 12:00:00 EDT A Phase 2 Study of Ruxolitinib With Chemotherapy in Children With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: Ruxolitinib; Drug: Asparaginase Erwinia Chrysanthemi; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Dexamethasone; Drug: Doxorubicin; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Drug: Prednisone; Drug: Thioguanine; Drug: Vincristine Sulfate Sponsors: Incyte Corporation; Children's Oncology Group Recruiting Thu, 31 Mar 2016 12:00:00 EDT German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in AdultsCondition: Lymphoma, LymphoblasticInterventions: Drug: Dexamethasone/Prednisolone; Drug: Cyclophosphamide; Drug: Vincristine; Drug: Daunorubicin; Drug: Asparaginase; Drug: G-CSF; Drug: Mercaptopurine; Drug: Cytarabine; Drug: Methotrexate; Drug: VP16; Drug: Vindesine; Drug: Adriamycin; Drug: Thioguanine; Drug: HDARAC; Procedure: CNS irradiation; Procedure: Mediastinal irradiation; Drug: Cladribine Sponsor: Johann Wolfgang Goethe University Hospital Completed Tue, 20 Sep 2005 12:00:00 EDT Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and RituximabCondition: Adult Acute Lymphocytic LeukemiaInterventions: Drug: Cyclophosphamide; Drug: Dexamethasone / Prednisolone; Drug: Vincristine; Drug: Daunorubicin; Drug: Asparaginase; Drug: Methotrexate; Drug: Cytarabine; Drug: Mercaptopurine; Drug: G-CSF; Drug: Vindesine; Drug: VP16; Drug: Adriamycin; Drug: Thioguanine; Drug: VM26; Drug: Rituximab; Procedure: CNS irradiation; Procedure: Mediastinal irradiation (if residual TU); Procedure: Stem cell transplantation Sponsor: Johann Wolfgang Goethe University Hospital Completed Tue, 20 Sep 2005 12:00:00 EDT German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003)Condition: Adult Acute Lymphocytic LeukemiaInterventions: Drug: Cyclophosphamide; Drug: Dexamethasone; Drug: Vincristine; Drug: daunorubicin; Drug: Asparaginase; Drug: Methotrexate; Drug: Cytarabine; Drug: Mercaptopurine; Drug: G-CSF; Drug: Vindesine; Drug: VP16; Drug: Prednisolone; Drug: Adriamycin; Drug: Thioguanine; Drug: VM26; Procedure: CNS irradiation; Procedure: Mediastinal Irradiation; Procedure: Stem cell transplantation; Drug: Idarubicin; Drug: Fludarabine; Drug: Cladribine Sponsors: Johann Wolfgang Goethe University Hospital; Deutsche Krebshilfe e.V., Bonn (Germany); German Federal Ministry of Education and Research Unknown status Tue, 20 Sep 2005 12:00:00 EDT German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99)Condition: Adult Acute Lymphocytic LeukemiaInterventions: Drug: Dexamethasone / Prednisolone; Drug: Cyclophosphamide; Drug: Methotrexate; Drug: Vincristine / Vindesine; Drug: Daunorubicin; Drug: Asparaginase; Drug: G-CSF; Drug: Cytarabine; Drug: 6-Mercaptopurine; Drug: VP16; Drug: Adriamycin; Drug: Thioguanine; Drug: VM26; Drug: Idarubicin; Drug: Fludarabine; Drug: Ifosfamide; Procedure: CNS irradiation; Procedure: Mediastinal irradiation (if residual tumor); Procedure: stem cell transplantation Sponsor: Johann Wolfgang Goethe University Hospital Completed Tue, 20 Sep 2005 12:00:00 EDT German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaCondition: Adult Acute Lymphocytic LeukemiaInterventions: Drug: Cyclophosphamide; Drug: Dexamethasone / Prednisolone; Drug: Cytarabine; Drug: Idarubicin; Drug: Granulocyte-Colony-Stimulating Factor; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Rituximab; Drug: HDARAC; Drug: Vincristine; Drug: Depocyte; Drug: Asparaginase Sponsor: Johann Wolfgang Goethe University Hospital Unknown status Tue, 20 Sep 2005 12:00:00 EDT International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: PEG-L-asparaginase; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: ifosfamide; Drug: mercaptopurine; Drug: methotrexate; Drug: prednisone; Drug: thioguanine; Drug: vincristine sulfate; Drug: vindesine; Drug: daunoxome; Drug: fludarabine; Radiation: Radiation Therapy Sponsors: University Hospital Schleswig-Holstein; Deutsche Krebshilfe e.V., Bonn (Germany) Active, not recruiting Wed, 05 May 2010 12:00:00 EDT Treatment of Older Adults With Acute Lymphoblastic LeukemiaCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Prednisone; Drug: Vincristine; Drug: Doxorubicin; Drug: PEG-asparaginase; Drug: Cytarabine; Drug: Methotrexate; Drug: Imatinib; Drug: Clofarabine; Drug: 6 Mercaptopurine Sponsors: Massachusetts General Hospital; Dana-Farber Cancer Institute; Beth Israel Deaconess Medical Center; Enzon Pharmaceuticals, Inc.; Genzyme, a Sanofi Company Completed Wed, 09 Sep 2009 12:00:00 EDT Alemtuzumab and Combination Chemotherapy in Treating Patients With Untreated Acute Lymphoblastic LeukemiaConditions: Acute Undifferentiated Leukemia; B-cell Adult Acute Lymphoblastic Leukemia; B-cell Childhood Acute Lymphoblastic Leukemia; L1 Adult Acute Lymphoblastic Leukemia; L1 Childhood Acute Lymphoblastic Leukemia; L2 Adult Acute Lymphoblastic Leukemia; L2 Childhood Acute Lymphoblastic Leukemia; Philadelphia Chromosome Negative Adult Precursor Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia; Philadelphia Chromosome Positive Childhood Precursor Acute Lymphoblastic Leukemia; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Childhood Acute Lymphoblastic Leukemia; Untreated Adult Acute Lymphoblastic Leukemia; Untreated Childhood Acute Lymphoblastic LeukemiaInterventions: Drug: allopurinol; Drug: cyclophosphamide; Drug: daunorubicin hydrochloride; Drug: vincristine sulfate; Drug: dexamethasone; Drug: asparaginase; Biological: filgrastim; Drug: imatinib mesylate; Drug: methotrexate; Drug: cytarabine; Drug: trimethoprim-sulfamethoxazole; Drug: mercaptopurine; Drug: leucovorin calcium; Biological: alemtuzumab; Drug: acyclovir; Other: laboratory biomarker analysis; Other: pharmacological study Sponsor: National Cancer Institute (NCI) Completed Fri, 06 Jun 2003 12:00:00 EDT
Combination Chemotherapy and Imatinib Mesylate in Treating Children With Relapsed Acute Lymphoblastic LeukemiaConditions: L1 Childhood Acute Lymphoblastic Leukemia; L2 Childhood Acute Lymphoblastic Leukemia; Non-T, Non-B Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; T-cell Childhood Acute Lymphoblastic LeukemiaInterventions: Drug: cytarabine; Drug: methotrexate; Drug: vincristine sulfate; Drug: prednisone; Drug: pegaspargase; Drug: doxorubicin hydrochloride; Drug: imatinib mesylate; Drug: cyclophosphamide; Drug: etoposide; Biological: filgrastim; Drug: leucovorin calcium; Drug: asparaginase; Drug: therapeutic hydrocortisone Sponsor: National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic LeukemiaCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Prednisolone; Drug: Daunorubicin; Drug: Vincristine; Drug: L-Asparaginase; Drug: Cyclophosphamide; Drug: Methotrexate; Drug: Cytosine Arabinoside Sponsor: PETHEMA Foundation Completed Mon, 10 Sep 2007 12:00:00 EDT LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia PositiveCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Vincristine; Drug: Daunorubicin; Drug: Prednisone; Drug: L-Asparaginase; Drug: Mitoxantrone; Drug: Cytosine Arabinoside; Drug: Hydrocortisone; Drug: Mercaptopurine; Drug: Cyclophosphamide; Drug: Dexamethasone Sponsor: PETHEMA Foundation Completed Mon, 10 Sep 2007 12:00:00 EDT LAL-BR/2001: Study Treatment to Low Risk ALLCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Prednisone; Drug: Vincristine; Drug: Daunorubicin; Drug: L-Asparaginase; Drug: Cyclophosphamide; Drug: Methotrexate; Drug: Cytosine Arabinoside; Drug: Mercaptopurine; Drug: VP-16 Sponsor: PETHEMA Foundation Completed Mon, 10 Sep 2007 12:00:00 EDT Blinatumomab Versus Standard of Care Chemotherapy in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)Condition: Relapsed/Refractory B-precursor Acute Lymphoblastic LeukemiaInterventions: Drug: Blinatumomab; Drug: Standard of Care Chemotherapy Sponsor: Amgen Terminated Tue, 17 Dec 2013 12:00:00 EST High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL)Condition: Lymphoblastic Leukemia, AcuteInterventions: Drug: Cyclophosphamide; Drug: Daunorubicin; Drug: Vincristine; Drug: Prednisolone; Drug: L-asparaginase; Drug: Cytarabine; Drug: Etoposide; Drug: Dexamethasone; Drug: Methotrexate; Drug: Mercaptopurine; Drug: Doxorubicin Sponsor: Japan Adult Leukemia Study Group Unknown status Wed, 17 Aug 2005 12:00:00 EDT Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic LeukemiaCondition: B Acute Lymphoblastic LeukemiaInterventions: Drug: Allopurinol; Drug: Cytarabine; Drug: Daunorubicin Hydrochloride; Drug: Vincristine Sulfate; Drug: Dexamethasone; Drug: Pegylated L-Asparaginase; Drug: Methotrexate; Procedure: Bone Marrow Aspiration and Biopsy; Drug: Cyclophosphamide; Drug: Mercaptopurine; Biological: Rituximab; Drug: Doxorubicin; Drug: Thioguanine; Biological: Inotuzumab Ozogamicin; Other: Laboratory Biomarker Analysis Sponsors: Alliance for Clinical Trials in Oncology; National Cancer Institute (NCI) Recruiting Fri, 12 May 2017 12:00:00 EDT Applying Pediatric Regimens to Younger Adult Patients With Acute Lymphoblastic Leukemia (ALL)Condition: Lymphoblastic Leukemia, AcuteInterventions: Drug: Methotrexate; Drug: Prednisolone; Drug: Dexamethasone; Drug: Vincristine; Drug: Pirarubicin; Drug: Cyclophosphamide; Drug: L-asparaginase; Drug: Cytarabine; Drug: Hydrocortisone; Drug: Mercaptopurine Sponsor: Japan Adult Leukemia Study Group Unknown status Wed, 17 Aug 2005 12:00:00 EDT Pegylated Liposomal Doxorubicin Versus Daunorubicin to Treat Acute Lymphoblastic Leukemia:Condition: Acute Lymphoblastic LeukemiaIntervention: Drug: VDCLD regimen Sponsors: Changzhou Jinyuan Pharmaceutical Manufacturing Co., Ltd.; CSPC ZhongQi Pharmaceutical Technology Co., Ltd. Unknown status Tue, 25 Feb 2014 12:00:00 EST Genomic Based Assignment of Therapy in Advanced Urothelial CarcinomaConditions: Urothelial Carcinoma; Bladder Cancer; Urinary Bladder NeoplasmsInterventions: Drug: 75 approved agents; Other: COXEN Sponsor: National Cancer Institute (NCI) Completed Thu, 02 Jun 2016 12:00:00 EDT
Induction Therapy With Cytarabine, High-Dose Mitoxantrone and Dasatinib for Patients With Philadelphia-Chromosome Positive (Ph+) Acute Lymphoblastic LeukemiaConditions: Leukemia; Acute Lymphoblastic LeukemiaIntervention: Drug: Dasatinib, Mitoxantrone, Cytarabine Sponsors: Memorial Sloan Kettering Cancer Center; Bristol-Myers Squibb Completed Thu, 16 Jul 2009 12:00:00 EDT Study of Iomab-B vs. Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid LeukemiaConditions: Acute Myeloid Leukemia; Leukemia, Acute Myeloid; Myeloid Leukemia, Acute; Leukemia, Myeloid, Acute; Acute Myelogenous Leukemia; Leukemia, Acute Myelogenous; Myelogenous Leukemia, Acute; AML; Bone Marrow TransplantInterventions: Drug: Iomab-B; Drug: Conventional Care; Procedure: HCT Sponsor: Actinium Pharmaceuticals Recruiting Wed, 27 Jan 2016 12:00:00 EST Peroneal Muscles Response to Expected and Unexpected Falls Among Young and Middle-aged Adults Before and After Neuromuscular TrainingCondition: Healthy ParticipantsIntervention: Other: Electromyograph Biofeedback training of the peroneal muscle Sponsor: Ariel University Recruiting Mon, 16 Aug 2021 12:00:00 EDT Vincristine Sulfate Liposome Injection (Marqibo®) in Combination With UK ALL R3 Induction Chemotherapy for Children, Adolescents, and Young Adults With Relapsed ALLConditions: ALL, Childhood; Lymphoblastic Leukemia, Acute, Childhood; Lymphoblastic Leukemia, AcuteIntervention: Drug: Marqibo Sponsors: Therapeutic Advances in Childhood Leukemia Consortium; Spectrum Pharmaceuticals, Inc Recruiting Fri, 26 Aug 2016 12:00:00 EDT Cladribine in Combination With GAP in Patients With Refractory/Relapsed Acute Lymphoblastic LeukemiaCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Cladribine; Drug: G-CSF; Drug: Cytarabine; Drug: Pegaspargase Sponsor: Sun Yat-sen University Unknown status Mon, 23 Oct 2017 12:00:00 EDT A Study of Ponatinib With Chemotherapy in Children, Teenagers, and Adults With Philadelphia Chromosome-Positive Acute Lymphoblastic LeukemiaConditions: Pediatric Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia (Ph+ALL); Ph+ Mixed Phenotype Acute Leukemia (MPAL); Philadelphia Chromosome-Like ALL (Ph-like ALL)Interventions: Drug: Ponatinib; Drug: Ponatinib AAF; Drug: Chemotherapy Agents Sponsor: Takeda Recruiting Thu, 06 Aug 2020 12:00:00 EDT Combination Chemotherapy in Treating Children With LymphomaCondition: LymphomaInterventions: Biological: filgrastim; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: leucovorin calcium; Drug: methotrexate; Drug: pegaspargase; Drug: prednisone; Drug: thioguanine; Drug: vincristine sulfate; Radiation: radiation therapy Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Thu, 29 Apr 2004 12:00:00 EDT A Pilot Study of Decitabine and Vorinostat With Chemotherapy for Relapsed ALLConditions: Acute Lymphoblastic Leukemia; Precursor B-Cell Lymphoblastic Leukemia; Precursor T-Cell Lymphoblastic LeukemiaInterventions: Drug: Decitabine; Drug: Vorinostat; Drug: Vincristine; Drug: Dexamethasone; Drug: Mitoxantrone; Drug: Pegaspargase; Drug: Methotrexate Sponsor: Therapeutic Advances in Childhood Leukemia Consortium Terminated Thu, 01 Dec 2011 12:00:00 EST Combination Chemotherapy in Treating Children With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: pegaspargase; Drug: thioguanine; Drug: vincristine sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST Comparison of Different Combination Chemotherapy Regimens in Treating Children With Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: mercaptopurine; Drug: methotrexate; Drug: pegaspargase; Drug: thioguanine; Drug: vincristine sulfate; Radiation: radiation therapy Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST
Study of Augmented Hyper-CVAD in Acute Lymphoblastic Leukemia SalvageCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Cyclophosphamide (CTX); Drug: Vincristine; Drug: Doxorubicin; Drug: Decadron; Drug: G-CSF; Drug: Methotrexate (MTX); Drug: Ara-C; Drug: Pegaspargase Sponsors: M.D. Anderson Cancer Center; Enzon Pharmaceuticals, Inc. Completed Thu, 30 Apr 2009 12:00:00 EDT Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and LymphomaConditions: Recurrent B-Cell Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood B-Lymphoblastic LymphomaInterventions: Drug: dexamethasone; Drug: vincristine sulfate; Biological: rituximab; Drug: clofarabine; Drug: cyclophosphamide; Drug: etoposide; Biological: aldesleukin; Drug: pegaspargase; Drug: methotrexate; Drug: mercaptopurine; Drug: cytarabine; Drug: mitoxantrone; Drug: teniposide; Drug: vinblastine; Biological: natural killer cell infusion; Other: laboratory biomarker analysis; Drug: therapeutic hydrocortisone; Procedure: allogeneic hematopoietic stem cell transplantation; Device: CliniMACS Sponsors: St. Jude Children's Research Hospital; Cookies for Kids' Cancer; Assisi Foundation Completed Thu, 04 Oct 2012 12:00:00 EDT Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLyConditions: B Acute Lymphoblastic Leukemia; B Lymphoblastic Lymphoma; Central Nervous System Leukemia; Mixed Phenotype Acute Leukemia; Testicular LeukemiaInterventions: Drug: Calaspargase Pegol-mknl; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Doxorubicin Hydrochloride; Biological: Inotuzumab Ozogamicin; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Drug: Prednisolone; Other: Questionnaire Administration; Radiation: Radiation Therapy; Drug: Thioguanine; Drug: Vincristine Sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Recruiting Wed, 22 May 2019 12:00:00 EDT Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin LymphomaConditions: Childhood B Acute Lymphoblastic Leukemia; Childhood T Acute Lymphoblastic Leukemia; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Lymphoblastic LymphomaInterventions: Drug: Dexamethasone; Other: Laboratory Biomarker Analysis; Drug: Methotrexate; Drug: Mitoxantrone Hydrochloride; Drug: Pegaspargase; Other: Pharmacological Study; Drug: Temsirolimus; Drug: Vincristine Sulfate Sponsor: National Cancer Institute (NCI) Completed Wed, 27 Jul 2011 12:00:00 EDT Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or TestesCondition: LeukemiaInterventions: Biological: filgrastim; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: dexamethasone; Drug: etoposide; Drug: leucovorin calcium; Drug: mercaptopurine; Drug: methotrexate; Drug: pegaspargase; Drug: therapeutic hydrocortisone; Drug: vincristine sulfate; Radiation: radiation therapy Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Tue, 09 Nov 2004 12:00:00 EST A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)Conditions: Down Syndrome; Recurrent B Acute Lymphoblastic LeukemiaInterventions: Radiation: 3-Dimensional Conformal Radiation Therapy; Biological: Blinatumomab; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Dexamethasone; Drug: Etoposide; Drug: Hydrocortisone Sodium Succinate; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Biological: Nivolumab; Drug: Pegaspargase; Drug: Thioguanine; Drug: Vincristine Sulfate Sponsor: National Cancer Institute (NCI) Recruiting Mon, 14 Sep 2020 12:00:00 EDT Low-Intensity Chemotherapy and Venetoclax in Treating Patients With Relapsed or Refractory B- or T-Cell Acute Lymphoblastic LeukemiaConditions: Recurrent B Acute Lymphoblastic Leukemia; Recurrent T Acute Lymphoblastic Leukemia; Refractory B Acute Lymphoblastic Leukemia; Refractory T Acute Lymphoblastic LeukemiaInterventions: Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Dexamethasone; Drug: Methotrexate; Drug: Nelarabine; Drug: Pegaspargase; Drug: Prednisone; Biological: Rituximab; Drug: Venetoclax; Drug: Vincristine Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI) Recruiting Thu, 17 Jan 2019 12:00:00 EST Imatinib Mesylate and Combination Chemotherapy in Treating Patients With Newly Diagnosed Philadelphia Chromosome Positive Acute Lymphoblastic LeukemiaConditions: Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia; Mixed Phenotype Acute Leukemia; T Acute Lymphoblastic LeukemiaInterventions: Procedure: Allogeneic Hematopoietic Stem Cell Transplantation; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Dexrazoxane Hydrochloride; Drug: Doxorubicin; Drug: Etoposide; Biological: Filgrastim; Drug: Ifosfamide; Drug: Imatinib Mesylate; Other: Laboratory Biomarker Analysis; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Methylprednisolone; Drug: Pegaspargase; Drug: Prednisolone; Other: Questionnaire Administration; Drug: Therapeutic Hydrocortisone; Drug: Thioguanine; Drug: Vincristine Sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI); EsPhALL network I-BFM Study Group Recruiting Mon, 02 Jan 2017 12:00:00 EST Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic LeukemiaConditions: Recurrent B Acute Lymphoblastic Leukemia; Recurrent B Lymphoblastic Lymphoma; Refractory B Acute Lymphoblastic Leukemia; Refractory B Lymphoblastic LymphomaInterventions: Drug: Cyclophosphamide; Drug: Cytarabine; Biological: Inotuzumab Ozogamicin; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Drug: Vincristine Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Recruiting Mon, 05 Dec 2016 12:00:00 EST Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive MutationsConditions: B Acute Lymphoblastic Leukemia; Central Nervous System Leukemia; Ph-Like Acute Lymphoblastic Leukemia; Testicular LeukemiaInterventions: Drug: Clofarabine; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Dasatinib; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Doxorubicin Hydrochloride; Drug: Etoposide; Drug: Hydrocortisone Sodium Succinate; Other: Laboratory Biomarker Analysis; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Drug: Prednisone; Radiation: Radiation Therapy; Drug: Thioguanine; Drug: Vincristine Sulfate Sponsor: National Cancer Institute (NCI) Active, not recruiting Tue, 30 Aug 2016 12:00:00 EDT
Azacitidine and Combination Chemotherapy in Treating Infants With Acute Lymphoblastic Leukemia and KMT2A Gene RearrangementConditions: Acute Leukemia of Ambiguous Lineage; B Acute Lymphoblastic Leukemia; Mixed Phenotype Acute LeukemiaInterventions: Drug: Azacitidine; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Hydrocortisone Sodium Succinate; Other: Laboratory Biomarker Analysis; Drug: Leucovorin; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Other: Pharmacological Study; Drug: Prednisolone; Drug: Thioguanine; Drug: Vincristine; Drug: Vincristine Sulfate Sponsor: National Cancer Institute (NCI) Active, not recruiting Mon, 11 Jul 2016 12:00:00 EDT Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic LymphomaConditions: Adult T Acute Lymphoblastic Leukemia; Ann Arbor Stage II Adult Lymphoblastic Lymphoma; Ann Arbor Stage II Childhood Lymphoblastic Lymphoma; Ann Arbor Stage III Adult Lymphoblastic Lymphoma; Ann Arbor Stage III Childhood Lymphoblastic Lymphoma; Ann Arbor Stage IV Adult Lymphoblastic Lymphoma; Ann Arbor Stage IV Childhood Lymphoblastic Lymphoma; Childhood T Acute Lymphoblastic LeukemiaInterventions: Drug: Bortezomib; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Doxorubicin; Drug: Doxorubicin Hydrochloride; Drug: Etoposide; Drug: Hydrocortisone Sodium Succinate; Drug: Ifosfamide; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Radiation: Radiation Therapy; Drug: Thioguanine; Drug: Vincristine; Drug: Vincristine Sulfate Sponsor: National Cancer Institute (NCI) Active, not recruiting Mon, 14 Apr 2014 12:00:00 EDT Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic LeukemiaConditions: Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia, Philadelphia Chromosome NegativeInterventions: Procedure: Allogeneic Hematopoietic Stem Cell Transplantation; Biological: Blinatumomab; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Etoposide; Other: Laboratory Biomarker Analysis; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Drug: Prednisone; Biological: Rituximab; Drug: Vincristine; Drug: Vincristine Sulfate Sponsors: National Cancer Institute (NCI); Canadian Cancer Trials Group Active, not recruiting Fri, 06 Dec 2013 12:00:00 EST Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic LymphomaConditions: Acute Lymphoblastic Leukemia; Adult B Lymphoblastic Lymphoma; Ann Arbor Stage I B Lymphoblastic Lymphoma; Ann Arbor Stage II B Lymphoblastic Lymphoma; Childhood B Acute Lymphoblastic Leukemia; Childhood B Acute Lymphoblastic Leukemia With t(9;22)(q34.1;q11.2); BCR-ABL1; Childhood B Lymphoblastic Lymphoma; Down Syndrome; Hypodiploid B Acute Lymphoblastic Leukemia; Philadelphia Chromosome PositiveInterventions: Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Dexamethasone; Drug: Doxorubicin Hydrochloride; Other: Laboratory Biomarker Analysis; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Drug: Thioguanine; Drug: Vincristine Sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Active, not recruiting Mon, 30 Aug 2010 12:00:00 EDT Combination Chemotherapy and Nelarabine in Treating Patients With T-cell Acute Lymphoblastic Leukemia or Lymphoblastic LymphomaConditions: T Acute Lymphoblastic Leukemia; T Lymphoblastic LymphomaInterventions: Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Dexamethasone; Drug: Doxorubicin Hydrochloride; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Nelarabine; Drug: Pegaspargase; Drug: Prednisone; Drug: Venetoclax; Drug: Vincristine Sulfate Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI) Recruiting Mon, 16 Jul 2007 12:00:00 EDT Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaConditions: Acute Lymphoblastic Leukemia; Childhood B Acute Lymphoblastic LeukemiaInterventions: Radiation: 3-Dimensional Conformal Radiation Therapy; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Dexamethasone; Drug: Doxorubicin Hydrochloride; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Drug: Thioguanine; Drug: Vincristine Sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Tue, 08 Feb 2005 12:00:00 EST Dexamethasone Compared With Prednisone During Induction Therapy and Methotrexate With or Without Leucovorin During Maintenance Therapy in Treating Patients With Newly Diagnosed High-Risk Acute Lymphoblastic LeukemiaConditions: Acute Lymphoblastic Leukemia; Adult B Acute Lymphoblastic Leukemia; Childhood B Acute Lymphoblastic LeukemiaInterventions: Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin Hydrochloride; Drug: Dexamethasone; Drug: Doxorubicin Hydrochloride; Drug: Leucovorin Calcium; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Pegaspargase; Drug: Prednisone; Radiation: Radiation Therapy; Drug: Thioguanine; Drug: Vincristine Sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Tue, 13 Jan 2004 12:00:00 EST Combination Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic LeukemiaCondition: LeukemiaInterventions: Drug: cytarabine; Drug: dexamethasone; Drug: etoposide; Drug: idarubicin; Drug: ifosfamide; Drug: leucovorin calcium; Drug: mesna; Drug: pegaspargase; Drug: therapeutic hydrocortisone; Drug: thioguanine; Drug: vincristine sulfate; Radiation: low-LET cobalt-60 gamma ray therapy; Radiation: low-LET electron therapy; Radiation: low-LET photon therapy; Drug: Methotrexate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Wed, 23 Jun 2004 12:00:00 EDT Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaCondition: LeukemiaIntervention: Drug: Nilotinib+mVPD Sponsor: Asan Medical Center Completed Mon, 16 Feb 2009 12:00:00 EST Modified BFM-95 Regimen as First-Line Chemotherapy in Adults With T- Lymphoblastic LymphomaCondition: Lymphoma, LymphoblasticInterventions: Drug: induction phase1; Drug: induction phase2; Drug: protocol M; Drug: maintenance therapy; Drug: reinduction phase1; Drug: reinduction phase2; Drug: Intrathecal (IT) Sponsor: Sun Yat-sen University Unknown status Tue, 24 Mar 2015 12:00:00 EDT
Treatment of Acute Lymphoblastic Leukemia HIGH RISK BCR / ABL NEGATIVE IN ADULTSCondition: Acute Lymphoblastic LeukemiaInterventions: Drug: Vincristine in induction; Drug: Daunorubicin in induction; Drug: Prednisone in induction; Drug: Metotrexato in induction; Drug: Cytarabine in induction; Drug: Hydrocortisone in induction; Drug: Idarubicin in induction-2; Drug: Fludarabine in induction-2; Drug: Ara-C in induction-2; Drug: G-CSF in induction-2; Drug: Dexamethasone in consolidation-1; Drug: Vincristrine in consolidation-1; Drug: Metotrexato in consolidation-1; Drug: PEG-ASP in consolidation-1; Drug: Dexamethasone in consolidation-2; Drug: ARA-C in consolidation-2; Drug: PEG-ASP in consolidation-2; Drug: Dexamethasone in consolidation-3; Drug: Vincristine in consolidation-3; Drug: Metotrexato in consolidation-3; Drug: PEG-ASP in consolidation-3; Procedure: allogeneic HSCT; Procedure: Allo HSCT with reduced-intensity conditioning Sponsor: PETHEMA Foundation Completed Wed, 29 Feb 2012 12:00:00 EST Treatment of Natural Killer/T Cell Lymphoma-I/IICondition: Nasal and Nasal-type NK/T-cell LymphomaInterventions: Other: DDGP(cisplatin,dexamethasone,gemcitabine,pegaspargase); Other: VIPD（cisplatin，Etoposide，Ifosfamide， dexamethasone，Mesna）; Other: gemcitabine,pegaspargase,cisplatin,dexamethasone; Other: cisplatin,Etoposide,Ifosfamide,dexamethasone,Mesna; Radiation: Radiotherapy Sponsors: Mingzhi Zhang; Second Hospital of Shanxi Medical University; Shanxi Province Cancer Hospital; Wuhan University; Wuhan TongJi Hospital; Wuhan Union Hospital, China; Qingdao University; Cancer Hospital of Guizhou Province; Xinyang Central Hospital; The First Affiliated Hospital of Henan University of Traditional Chinese Medicine Unknown status Thu, 29 Dec 2011 12:00:00 EST Clofarabine or High-Dose Cytarabine and Pegaspargase in Children With ALLCondition: LeukemiaInterventions: Drug: Amsacrine; Drug: Clofarabine; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: Daunorubicin hydrochloride; Drug: Dexamethasone; Drug: Doxorubicin hydrochloride; Drug: Etoposide phosphate; Drug: Mercaptopurine; Drug: Methotrexate; Drug: Methylprednisolone; Drug: Pegaspargase; Drug: Thioguanine; Drug: Vincristine sulfate; Radiation: Whole-brain radiation therapy Sponsor: Universitätsklinikum Hamburg-Eppendorf Active, not recruiting Tue, 26 Oct 2010 12:00:00 EDT Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2015 (ALL-MB 2015)Condition: Childhood Acute Lymphoblastic LeukemiaInterventions: Drug: Dexamethasone continuous; Drug: Dexamethasone intermittent; Drug: Dexamethasone; Drug: Methylprednisolone; Drug: Daunorubicin; Drug: Idarubicin; Drug: Bortezomib; Drug: Second phase of induction; Drug: Standard induction therapy; Drug: Standard consolidation therapy Sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology Recruiting Thu, 04 Jan 2018 12:00:00 EST |