References from scientific journals

Asparaginase pharmacokinetics and implications of therapeutic drug monitoring.

Asselin B, Rizzari C. Asselin B, et al. Leuk Lymphoma. 2015;56(8):2273-80. doi: 10.3109/10428194.2014.1003056. Epub 2015 Mar 11. Leuk Lymphoma. 2015. PMID: 25586605 Free PMC article. Review.

However, pronounced interpatient variability, differences in pharmacokinetic properties between asparaginases and the formation of asparaginase antibodies make it difficult to predict the degree of asparagine depletion that will result from a given dose of aspara …
However, pronounced interpatient variability, differences in pharmacokinetic properties between asparaginases and the formation of …

A Comprehensive Review on L-Asparaginase and Its Applications.

Batool T, Makky EA, Jalal M, Yusoff MM. Batool T, et al. Appl Biochem Biotechnol. 2016 Mar;178(5):900-23. doi: 10.1007/s12010-015-1917-3. Epub 2015 Nov 7. Appl Biochem Biotechnol. 2016. PMID: 26547852 Review.

L-asparaginase (LA) catalyzes the degradation of asparagine, an essential amino acid for leukemic cells, into ammonia and aspartate. ...Pieces of information about the three-dimensional structure of L-asparaginase from Escherichia coli and Erwinia sp. have identifie …
L-asparaginase (LA) catalyzes the degradation of asparagine, an essential amino acid for leukemic cells, into ammonia and aspartate. …

What makes a good new therapeutic L-asparaginase?

Beckett A, Gervais D. Beckett A, et al. World J Microbiol Biotechnol. 2019 Sep 24;35(10):152. doi: 10.1007/s11274-019-2731-9. World J Microbiol Biotechnol. 2019. PMID: 31552479 Review.

L-asparaginase is a critical part of the treatment of acute lymphoblastic leukaemia in children and adolescents, and has contributed to the improvement in patient outcomes over the last 40 years. The main products used in clinical treatment are L-asparaginase enzyme …
L-asparaginase is a critical part of the treatment of acute lymphoblastic leukaemia in children and adolescents, and has contributed …

PEG-asparaginase.

Fu CH, Sakamoto KM. Fu CH, et al. Expert Opin Pharmacother. 2007 Aug;8(12):1977-84. doi: 10.1517/14656566.8.12.1977. Expert Opin Pharmacother. 2007. PMID: 17696798 Review.

L-asparaginases have been established components in the treatment of acute leukemias for nearly 40 years. ...PEG-asparaginase, a form of Escherichia coli L-asparaginase covalently linked to polyethylene glycol, was rationally synthesized to decrease immunogen …
L-asparaginases have been established components in the treatment of acute leukemias for nearly 40 years. ...PEG-asparaginase, …

Microbial L-asparaginase: purification, characterization and applications.

Muneer F, Siddique MH, Azeem F, Rasul I, Muzammil S, Zubair M, Afzal M, Nadeem H. Muneer F, et al. Arch Microbiol. 2020 Jul;202(5):967-981. doi: 10.1007/s00203-020-01814-1. Epub 2020 Feb 12. Arch Microbiol. 2020. PMID: 32052094 Review.

L-asparaginases have an optimum pH range between 6 and 10 and an optimum temperature between 37 and 85 C. ...This review is an attempt to summarize most of the available sources, their phylogenetic relationships, purification methods, data regarding different physiochemica …
L-asparaginases have an optimum pH range between 6 and 10 and an optimum temperature between 37 and 85 C. ...This review is an attemp …

L-asparaginase treatment in acute lymphoblastic leukemia: a focus on Erwinia asparaginase.

Pieters R, Hunger SP, Boos J, Rizzari C, Silverman L, Baruchel A, Goekbuget N, Schrappe M, Pui CH. Pieters R, et al. Cancer. 2011 Jan 15;117(2):238-49. doi: 10.1002/cncr.25489. Epub 2010 Sep 7. Cancer. 2011. PMID: 20824725 Free PMC article. Review.

Extensive clinical data have shown that intensive asparaginase treatment improves clinical outcomes in childhood ALL. Three asparaginase preparations are available: the native asparaginase derived from Escherichia coli (E. coli asparaginase), a pegylat …
Extensive clinical data have shown that intensive asparaginase treatment improves clinical outcomes in childhood ALL. Three aspara …

Recent Strategies and Applications for l-Asparaginase Confinement.

Nunes JCF, Cristóvão RO, Freire MG, Santos-Ebinuma VC, Faria JL, Silva CG, Tavares APM. Nunes JCF, et al. Molecules. 2020 Dec 10;25(24):5827. doi: 10.3390/molecules25245827. Molecules. 2020. PMID: 33321857 Free PMC article. Review.

l-asparaginase (ASNase, EC 3.5.1.1) is an aminohydrolase enzyme with important uses in the therapeutic/pharmaceutical and food industries. ...
l-asparaginase (ASNase, EC 3.5.1.1) is an aminohydrolase enzyme with important uses in the therapeutic/pharmaceutical and food indust …

L-asparaginase.

Whitecar JP Jr, Bodey GP, Harris JE, Freireich EJ. Whitecar JP Jr, et al. N Engl J Med. 1970 Mar 26;282(13):732-4. doi: 10.1056/NEJM197003262821307. N Engl J Med. 1970. PMID: 4906449 Review. No abstract available.


L-asparaginase.

Capizzi RL, Bertino JR, Handschumacher RE. Capizzi RL, et al. Annu Rev Med. 1970;21:433-44. doi: 10.1146/annurev.me.21.020170.002245. Annu Rev Med. 1970. PMID: 4913953 Review. No abstract available.


A comprehensive review on microbial l-asparaginase: Bioprocessing, characterization, and industrial applications.

Chand S, Mahajan RV, Prasad JP, Sahoo DK, Mihooliya KN, Dhar MS, Sharma G. Chand S, et al. Biotechnol Appl Biochem. 2020 Jul;67(4):619-647. doi: 10.1002/bab.1888. Epub 2020 Feb 18. Biotechnol Appl Biochem. 2020. PMID: 31954377 Review.

l-Asparaginase (E.C.3.5.1.1.) is a vital enzyme that hydrolyzes l-asparagine to l-aspartic acid and ammonia. This property of l-asparaginase inhibits the protein synthesis in cancer cells, making l-asparaginase a mainstay of pediatric chemotherapy practices t …
l-Asparaginase (E.C.3.5.1.1.) is a vital enzyme that hydrolyzes l-asparagine to l-aspartic acid and ammonia. This property of l-as …