References from scientific journals

[Aspirin: Indications and use during pregnancy].

Belhomme N, Doudnikoff C, Polard E, Henriot B, Isly H, Jego P. Belhomme N, et al. Rev Med Interne. 2017 Dec;38(12):825-832. doi: 10.1016/j.revmed.2017.10.419. Epub 2017 Nov 10. Rev Med Interne. 2017. PMID: 29129461 Review. French.

Aspirin (acetylsalicylic acid) has been used ever since the Antiquity for its painkilling and anti-inflammatory effects. Its antiplatelet properties have then extended its indications to the field of coronaropathy and vascular cerebral disease, and finally to vascular plac …
Aspirin (acetylsalicylic acid) has been used ever since the Antiquity for its painkilling and anti-inflammatory effects. Its antiplat …

Aspirin and its pleiotropic application.

Hybiak J, Broniarek I, Kiryczyński G, Los LD, Rosik J, Machaj F, Sławiński H, Jankowska K, Urasińska E. Hybiak J, et al. Eur J Pharmacol. 2020 Jan 5;866:172762. doi: 10.1016/j.ejphar.2019.172762. Epub 2019 Oct 26. Eur J Pharmacol. 2020. PMID: 31669590 Review.

It is important to always consider both the risks and benefits of aspirin's application. This is especially important for proposed use in the prevention and treatment of neurologic ailments like Alzheimer's disease, or in the prophylaxis of myocardial infarct …
It is important to always consider both the risks and benefits of aspirin's application. This is especially important for prop …

Aspirin challenge and desensitization: how, when and why.

Cortellini G, Caruso C, Romano A. Cortellini G, et al. Curr Opin Allergy Clin Immunol. 2017 Aug;17(4):247-254. doi: 10.1097/ACI.0000000000000374. Curr Opin Allergy Clin Immunol. 2017. PMID: 28590311 Review.

SUMMARY: The use of aspirin has proven to reduce morbidity and mortality associated with CAD. There is a general consensus on aspirin's effectiveness in secondary prevention of CAD. Therefore, aspirin desensitization is necessary in patients with CAD a …
SUMMARY: The use of aspirin has proven to reduce morbidity and mortality associated with CAD. There is a general consensus on aspi …

Aspirin for primary prevention: Is this the end of the road?

Singal AK, Karthikeyan G. Singal AK, et al. Indian Heart J. 2019 Mar-Apr;71(2):113-117. doi: 10.1016/j.ihj.2019.04.001. Epub 2019 May 2. Indian Heart J. 2019. PMID: 31280821 Free PMC article. Review.

Aspirin is one of the oldest and most commonly used cardiovascular drugs. ...Three major trials were published in 2018, which supplement the existing data on aspirin's role in primary prevention and provide further guidance on this contentious issue. ...
Aspirin is one of the oldest and most commonly used cardiovascular drugs. ...Three major trials were published in 2018, which supplem …

Aspirin for Primary Cardiovascular Risk Prevention and Beyond in Diabetes Mellitus.

Capodanno D, Angiolillo DJ. Capodanno D, et al. Circulation. 2016 Nov 15;134(20):1579-1594. doi: 10.1161/CIRCULATIONAHA.116.023164. Epub 2016 Oct 11. Circulation. 2016. PMID: 27729421

Daily administration of low-dose aspirin has proved to be beneficial in preventing recurrent cardiovascular events. ...Diabetes mellitus has been associated with a substantially increased risk of both first and recurrent atherothrombotic events, which makes aspirin …
Daily administration of low-dose aspirin has proved to be beneficial in preventing recurrent cardiovascular events. ...Diabetes melli …

Aspirin dosing frequency in the primary and secondary prevention of cardiovascular events.

Kim J, Becker RC. Kim J, et al. J Thromb Thrombolysis. 2016 Apr;41(3):493-504. doi: 10.1007/s11239-015-1307-2. J Thromb Thrombolysis. 2016. PMID: 26739313 Review.

Despite the popularity of aspirin and its wide use, the proper dosing and frequency of aspirin has yet to be determined. ...This difference in aspirin response necessitates a personalized, tailored aspirin therapy. ...
Despite the popularity of aspirin and its wide use, the proper dosing and frequency of aspirin has yet to be determined. ...Th …

Complex roles of the old drug aspirin in cancer chemoprevention and therapy.

Hua H, Zhang H, Kong Q, Wang J, Jiang Y. Hua H, et al. Med Res Rev. 2019 Jan;39(1):114-145. doi: 10.1002/med.21514. Epub 2018 Jun 1. Med Res Rev. 2019. PMID: 29855050 Review.

In addition, epidemiologic evidences reveal that aspirin may prevent a variety of human cancers, while data on the association between aspirin and some kinds of cancer are conflicting. ...We also discuss mechanisms of aspirin resistance and describe some deri …
In addition, epidemiologic evidences reveal that aspirin may prevent a variety of human cancers, while data on the association betwee …

The role of aspirin and inflammation on reproduction: the EAGeR trial (1).

Levine LD, Holland TL, Kim K, Sjaarda LA, Mumford SL, Schisterman EF. Levine LD, et al. Can J Physiol Pharmacol. 2019 Mar;97(3):187-192. doi: 10.1139/cjpp-2018-0368. Epub 2018 Dec 18. Can J Physiol Pharmacol. 2019. PMID: 30562044 Free PMC article. Review.

Therefore, the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial was designed to elucidate whether preconception-initiated daily low-dose aspirin would increase the live birth rate in women with 1-2 prior pregnancy losses and no infertility diagnosis an …
Therefore, the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial was designed to elucidate whether preconception-initiat …

Aspirin in Primary Prevention of Cardiovascular Events.

Soodi D, VanWormer JJ, Rezkalla SH. Soodi D, et al. Clin Med Res. 2020 Aug;18(2-3):89-94. doi: 10.3121/cmr.2020.1548. Epub 2020 Jun 24. Clin Med Res. 2020. PMID: 32580960 Free PMC article. Review.

Aspirin has demonstrated a clear benefit in secondary prevention of coronary syndrome, while aspirin's effect in primary prevention is unclear. ...A thoughtful discussion between patients and their doctors should be conducted before beginning aspirin u …
Aspirin has demonstrated a clear benefit in secondary prevention of coronary syndrome, while aspirin's effect in primar …

Aspirin resistance.

Howard PA. Howard PA. Ann Pharmacother. 2002 Oct;36(10):1620-4. doi: 10.1345/aph.1C013. Ann Pharmacother. 2002. PMID: 12243613 Review.

Key search terms included aspirin, resistance, resistant, failure, tolerance, and nonresponder. ...The studies to date have failed to demonstrate consistent relationships between aspirin's platelet-inhibiting effects, the impact of dosage escalation, and clin …
Key search terms included aspirin, resistance, resistant, failure, tolerance, and nonresponder. ...The studies to date have failed to …