Full text biomedical articles

Biosynthesis of medicinal tropane alkaloids in yeast

Prashanth Srinivasan, Christina D. Smolke
Nature. Author manuscript; available in PMC 2021 Mar 2.
Published in final edited form as: Nature. 2020 Sep; 585(7826): 614–619. Published online 2020 Sep 2. doi: 10.1038/s41586-020-2650-9


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Promoting the accumulation of scopolamine and hyoscyamine in Hyoscyamus niger L. through EMS based mutagenesis

Durdana Shah, Azra N. Kamili, Aijaz A. Wani, Umer Majeed, Zubair Ahmad Wani, Nasreena Sajjad, Parvaiz Ahmad
PLoS One. 2020; 15(5): e0231355. Published online 2020 May 21. doi: 10.1371/journal.pone.0231355


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Tropane alkaloids GC/MS analysis and low dose elicitors’ effects on hyoscyamine biosynthetic pathway in hairy roots of Algerian Datura species

Boualem Harfi, Lakhdar Khelifi, Majda Khelifi-Slaoui, Corinne Assaf-Ducrocq, Eric Gontier
Sci Rep. 2018; 8: 17951. Published online 2018 Dec 18. doi: 10.1038/s41598-018-36625-4


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Changes in Regioselectivity of H Atom Abstraction during the Hydroxylation and Cyclization Reactions Catalyzed by Hyoscyamine 6β-Hydroxylase

Richiro Ushimaru, Mark W. Ruszczycky, Hung-wen Liu
J Am Chem Soc. Author manuscript; available in PMC 2019 Jul 16.
Published in final edited form as: J Am Chem Soc. 2019 Jan 16; 141(2): 1062–1066. Published online 2018 Dec 28. doi: 10.1021/jacs.8b11585


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Optimization of the Culture Medium Composition to Improve the Production of Hyoscyamine in Elicited Datura stramonium L. Hairy Roots Using the Response Surface Methodology (RSM)

Amdoun Ryad, Khelifi Lakhdar, Khelifi-Slaoui Majda, Amroune Samia, Asch Mark, Assaf-Ducrocq Corinne, Gontier Eric
Int J Mol Sci. 2010; 11(11): 4726–4740. Published online 2010 Nov 18. doi: 10.3390/ijms11114726


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Antagonism of acetylcholine by (+)- and (—)-hyoscyamine

P. B. Marshall
Br J Pharmacol Chemother. 1955 Sep; 10(3): 354–355. doi: 10.1111/j.1476-5381.1955.tb00883.x


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Some pharmacological studies on the optically active isomers of hyoscine and hyoscyamine

W. R. Buckett, C. G. Haining
Br J Pharmacol Chemother. 1965 Feb; 24(1): 138–146. doi: 10.1111/j.1476-5381.1965.tb02088.x


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Interventions to slow progression of myopia in children

Jeffrey J Walline, Kristina B Lindsley, S. Swaroop Vedula, Susan A Cotter, Donald O Mutti, Sueko M Ng, J. Daniel Twelker, Cochrane Eyes and Vision Group
Cochrane Database Syst Rev. 2020 Jan; 2020(1): CD004916. Published online 2020 Jan 13. doi: 10.1002/14651858.CD004916.pub4


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Phenotypic Transformation Affects Associative Learning in the Desert Locust

Patrício M.V. Simões, Jeremy E. Niven, Swidbert R. Ott
Curr Biol. 2013 Dec 2; 23(23): 2407–2412. doi: 10.1016/j.cub.2013.10.016


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Update in myopia and treatment strategy of atropine use in myopia control

Pei-Chang Wu, Meng-Ni Chuang, Jessy Choi, Huan Chen, Grace Wu, Kyoko Ohno-Matsui, Jost B Jonas, Chui Ming Gemmy Cheung
Eye (Lond) 2019 Jan; 33(1): 3–13. Published online 2018 Jun 11. doi: 10.1038/s41433-018-0139-7


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Development of Atropa belladonna L. Plants with High-Yield Hyoscyamine and without Its Derivatives Using the CRISPR/Cas9 System

Lingjiang Zeng, Qiaozhuo Zhang, Chunxue Jiang, Yueyue Zheng, Youwei Zuo, Jianbo Qin, Zhihua Liao, Hongping Deng
Int J Mol Sci. 2021 Feb; 22(4): 1731. Published online 2021 Feb 9. doi: 10.3390/ijms22041731


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A STROBE-compliant case–control study: Effects of cumulative doses of topical atropine on intraocular pressure and myopia progression

Teng-Chieh Yu, Tzu-En Wu, Yuan-Shen Wang, Shen-Fu Cheng, Shiow-Wen Liou
Medicine (Baltimore) 2020 Nov 25; 99(48): e22745. Published online 2020 Nov 25. doi: 10.1097/MD.0000000000022745


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The selectivity of the (-)-and (+)-forms of hyoscine methiodide and of hyoscyamine camphorsulphonate for muscarinic (M2) receptors.

R. B. Barlow, S. Dawson
Br J Pharmacol. 1986 Oct; 89(2): 439–444. doi: 10.1111/j.1476-5381.1986.tb10278.x


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Low-Concentration Atropine Eye Drops for Myopia Progression

Fen Fen Li, Jason C. Yam
Asia Pac J Ophthalmol (Phila) 2019 Sep-Oct; 8(5): 360–365. Published online 2019 Oct 4. doi: 10.1097/APO.0000000000000256


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Tropane Alkaloids: Chemistry, Pharmacology, Biosynthesis and Production

Kathrin Laura Kohnen-Johannsen, Oliver Kayser
Molecules. 2019 Feb; 24(4): 796. Published online 2019 Feb 22. doi: 10.3390/molecules24040796


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Additive effect of atropine eye drops and short-term retinal defocus on choroidal thickness in children with myopia

Samuel T.-H. Chiang, Philip R. K. Turnbull, John R. Phillips
Sci Rep. 2020; 10: 18310. Published online 2020 Oct 27. doi: 10.1038/s41598-020-75342-9


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Interdigestive Gastric Secretion in Duodenal Ulcer

M. J. Riddell
Br Med J. 1951 Dec 22; 2(4746): 1498–1500. doi: 10.1136/bmj.2.4746.1498


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Efficacy of combined orthokeratology and 0.01% atropine solution for slowing axial elongation in children with myopia: a 2-year randomised trial

Nozomi Kinoshita, Yasuhiro Konno, Naoki Hamada, Yoshinobu Kanda, Machiko Shimmura-Tomita, Toshikatsu Kaburaki, Akihiro Kakehashi
Sci Rep. 2020; 10: 12750. Published online 2020 Jul 29. doi: 10.1038/s41598-020-69710-8


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Comparison of atropine and (--)-hyoscyamine on heart rate in man.

H Bagshaw, D A Chamberlain, P Turner
Br J Pharmacol. 1970 Nov; 40(3): 600P+.


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Short-term effects of low-concentration atropine eye drops on pupil size and accommodation in young adult subjects

Hakan Kaymak, Andreas Fricke, Yvonne Mauritz, Anne Löwinger, Karsten Klabe, Detlev Breyer, Achim Lagenbucher, Berthold Seitz, Frank Schaeffel
Graefes Arch Clin Exp Ophthalmol. 2018; 256(11): 2211–2217. Published online 2018 Aug 25. doi: 10.1007/s00417-018-4112-8


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