Full text biomedical articles

Immunomodulatory Effects of Azithromycin Revisited: Potential Applications to COVID-19

Vincent J. Venditto, Dalia Haydar, Ahmed Abdel-Latif, John C. Gensel, Michael I. Anstead, Michelle G. Pitts, Jarrod Creameans, Timothy J. Kopper, Chi Peng, David J. Feola
Front Immunol. 2021; 12: 574425. Published online 2021 Feb 12. doi: 10.3389/fimmu.2021.574425

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Retargeting azithromycin analogues to have dual-modality antimalarial activity

Amy L. Burns, Brad E. Sleebs, Ghizal Siddiqui, Amanda E. De Paoli, Dovile Anderson, Benjamin Liffner, Richard Harvey, James G. Beeson, Darren J. Creek, Christopher D. Goodman, Geoffrey I. McFadden, Danny W. Wilson
BMC Biol. 2020; 18: 133. Published online 2020 Sep 29. doi: 10.1186/s12915-020-00859-4

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Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo

Xinran Qiao, Xiaofei Wang, Yue Shang, Yi Li, Shu-zhen Chen
Cancer Commun (Lond) 2018; 38: 43. Published online 2018 Jul 3. doi: 10.1186/s40880-018-0309-9

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Rationale for azithromycin in COVID-19: an overview of existing evidence

Iwein Gyselinck, Wim Janssens, Peter Verhamme, Robin Vos
BMJ Open Respir Res. 2021; 8(1): e000806. Published online 2021 Jan 13. doi: 10.1136/bmjresp-2020-000806

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Protective Effects of Carvedilol and Vitamin C against Azithromycin-Induced Cardiotoxicity in Rats via Decreasing ROS, IL1-β, and TNF-α Production and Inhibiting NF-κB and Caspase-3 Expression

Nagla A. El-Shitany, Karema El-Desoky
Oxid Med Cell Longev. 2016; 2016: 1874762. Published online 2016 May 5. doi: 10.1155/2016/1874762

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Combination of Hydroxychloroquine Plus Azithromycin As Potential Treatment for COVID-19 Patients: Safety Profile, Drug Interactions, and Management of Toxicity

Guillaume Hache, Jean Marc Rolain, Philippe Gautret, Jean-Claude Deharo, Philippe Brouqui, Didier Raoult, Stéphane Honoré
Microb Drug Resist. March 2021; 27(3): 281–290. Published online 2021 Mar 12. doi: 10.1089/mdr.2020.0232

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Physico-Chemical Properties, Aerosolization and Dissolution of Co-Spray Dried Azithromycin Particles with L-Leucine for Inhalation

Sharad Mangal, Haichen Nie, Rongkun Xu, Rui Guo, Alex Cavallaro, Dmitry Zemlyanov, Qi (Tony) Zhou
Pharm Res. Author manuscript; available in PMC 2018 Apr 26.
Published in final edited form as: Pharm Res. 2018 Jan 8; 35(2): 28. Published online 2018 Jan 8. doi: 10.1007/s11095-017-2334-9

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Molecular mechanism of azithromycin resistance among typhoidal Salmonella strains in Bangladesh identified through passive pediatric surveillance

Yogesh Hooda, Mohammad S. I. Sajib, Hafizur Rahman, Stephen P. Luby, Joseph Bondy-Denomy, Mathuram Santosham, Jason R. Andrews, Samir K. Saha, Senjuti Saha
PLoS Negl Trop Dis. 2019 Nov; 13(11): e0007868. Published online 2019 Nov 15. doi: 10.1371/journal.pntd.0007868

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Azithromycin decreases NALP3 mRNA stability in monocytes to limit inflammasome-dependent inflammation

Elizabeth A. Lendermon, Tiffany A. Coon, Joseph S. Bednash, Nathaniel M. Weathington, John F. McDyer, Rama K. Mallampalli
Respir Res. 2017; 18: 131. Published online 2017 Jun 28. doi: 10.1186/s12931-017-0608-8

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Measurement of tissue azithromycin levels in self-collected vaginal swabs post treatment using liquid chromatography and tandem mass spectrometry (LC-MS/MS)

Lenka A. Vodstrcil, Thusitha W. T. Rupasinghe, Fabian Y. S. Kong, Dedreia Tull, Karen Worthington, Marcus Y. Chen, Wilhelmina M. Huston, Peter Timms, Malcolm J. McConville, Christopher K. Fairley, Catriona S. Bradshaw, Sepehr N. Tabrizi, Jane S. Hocking
PLoS One. 2017; 12(5): e0177615. Published online 2017 May 12. doi: 10.1371/journal.pone.0177615

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Azithromycin in COVID-19 Patients: Pharmacological Mechanism, Clinical Evidence and Prescribing Guidelines

Janet Sultana, Paola Maria Cutroneo, Salvatore Crisafulli, Gabriele Puglisi, Gaetano Caramori, Gianluca Trifirò
Drug Saf. 2020 Jul 21 : 1–8. doi: 10.1007/s40264-020-00976-7 [Epub ahead of print]

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Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum

Danny W Wilson, Christopher D Goodman, Brad E Sleebs, Greta E Weiss, Nienke WM de Jong, Fiona Angrisano, Christine Langer, Jake Baum, Brendan S Crabb, Paul R Gilson, Geoffrey I McFadden, James G Beeson
BMC Biol. 2015; 13: 52. Published online 2015 Jul 18. doi: 10.1186/s12915-015-0162-0

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Azithromycin induces anti-viral effects in cultured bronchial epithelial cells from COPD patients

Mandy Menzel, Hamid Akbarshahi, Leif Bjermer, Lena Uller
Sci Rep. 2016; 6: 28698. Published online 2016 Jun 28. doi: 10.1038/srep28698

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Azithromycin polarizes macrophages to an M2 phenotype via inhibition of the STAT1 and NF-κB signaling pathways

Dalia Haydar, Theodore J. Cory, Susan E. Birket, Brian S. Murphy, Keith R. Pennypacker, Anthony P. Sinai, David J. Feola
J Immunol. Author manuscript; available in PMC 2020 Aug 15.
Published in final edited form as: J Immunol. 2019 Aug 15; 203(4): 1021–1030. Published online 2019 Jul 1. doi: 10.4049/jimmunol.1801228

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Azithromycin: The First Broad-spectrum Therapeutic

Anton Firth, Praveen Prathapan
Eur J Med Chem. 2020 Dec 1; 207: 112739. Published online 2020 Aug 19. doi: 10.1016/j.ejmech.2020.112739

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Chronic Azithromycin Use in Cystic Fibrosis and Risk of Treatment-Emergent Respiratory Pathogens

Jonathan D. Cogen, Frankline Onchiri, Julia Emerson, Ronald L. Gibson, Lucas R. Hoffman, David P. Nichols, Margaret Rosenfeld
Ann Am Thorac Soc. 2018 Jun; 15(6): 702–709. doi: 10.1513/AnnalsATS.201801-012OC

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Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

Bela Ozsvari, John R. Nuttall, Federica Sotgia, Michael P. Lisanti
Aging (Albany NY) 2018 Nov; 10(11): 3294–3307. Published online 2018 Nov 14. doi: 10.18632/aging.101633

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Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infection Model

Celina Jin, Malick M. Gibani, Shaun H. Pennington, Xinxue Liu, Alison Ardrey, Ghaith Aljayyoussi, Maria Moore, Brian Angus, Christopher M. Parry, Giancarlo A. Biagini, Nicholas A. Feasey, Andrew J. Pollard
PLoS Negl Trop Dis. 2019 Dec; 13(12): e0007955. Published online 2019 Dec 26. doi: 10.1371/journal.pntd.0007955

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Effect of Mass Treatment with Azithromycin on Causes of Death in Children in Malawi: Secondary Analysis from the MORDOR Trial

John D. Hart, Khumbo Kalua, Jeremy D. Keenan, Thomas M. Lietman, Robin L. Bailey
Am J Trop Med Hyg. 2020 Sep; 103(3): 1319–1328. Published online 2020 Apr 27. doi: 10.4269/ajtmh.19-0613

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Macrolides and viral infections: focus on azithromycin in COVID-19 pathology

Arianna Pani, Marinella Lauriola, Alessandra Romandini, Francesco Scaglione
Int J Antimicrob Agents. 2020 Aug; 56(2): 106053. Published online 2020 Jun 10. doi: 10.1016/j.ijantimicag.2020.106053

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