Before taking Osteo Bi-Flex for osteoarthritis


Osteo Bi-Flex is a dietary supplement that helps maintain joint health. It is often recommended as an over-the-counter treatment for people with knee osteoarthritis and is one of the most prominent supplements in this category.

As with any supplement, you should speak with your doctor before taking Osteo Bi-Flex. Your medical history may indicate that it is not suitable for you and it may interact with other medications.

It is also helpful to know what this supplement contains and what scientific studies say about the effectiveness of its ingredients. Since Osteo Bi-Flex is an additive, it is not approved by the FDA. However, the components of the drug have been studied.

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Osteo Bi-Flex offers a variety of formulations that contain multiple ingredients; each one is slightly different. However, there are several ingredients that the brand is promoting as key ingredients. These include Joint Shield, UC-II Collagen, Glucosamine, Chondroitin Sulfate, and Methylsulfonylmethane (MSM).

Joint shield

Osteo Bi-Flex promotes "Joint Shield" as its main ingredient, a proprietary blend of compounds that includes 5-Loxin Advanced, a toothed boswellia extract enriched in a compound known as 3-O-acetyl-11-keto-beta- acid. Boswellian (AKBA) .

5-loxin has been reported to be helpful in the treatment of knee osteoarthritis. In one study, it reduced pain and improved physical function in osteoarthritis patients by controlling inflammation. While researchers say it's safe, they are wary of saying it can improve joint health.

"Joint Shield" is found in most Osteo Bi-Flex products, although they differ slightly in minor ingredients. Each of them has also been reported to have some degree of positive effect on osteoarthritis symptoms.


Along with chondroitin, glucosamine has long been recommended for the treatment of osteoarthritis . Its actual effectiveness is debated and may vary from one supplement manufacturer to another.

Glucosamine is a natural compound found in human cartilage and is responsible for the fluid around the joints. In supplements, glucosamine is made in the laboratory or from shellfish shells. For people with a shellfish allergy, glucosamine can be problematic. If you are concerned about this, it is important to read the labels carefully.


Another natural compound found in cartilage, chondroitin , helps retain water in the joints. In supplements, the most common source of chondroitin is animal cartilage.

Research on the effectiveness of glucosamine and chondroitin varies widely. Studies and trials by supplement manufacturers show positive results in terms of their efficacy in treating osteoarthritis. However, tests carried out by independent organizations have yielded virtually no results .

Collagen UC-II

It is undenatured type II collagen known to support joint health. It is found in various Osteo Bi-Flex products. In supplements, it is most often obtained from chicken breast cartilage. Collagen UC-II has shown positive results in independent studies of the treatment of osteoarthritis.

The study examined the effects of collagen UC-II in patients with moderate to severe knee osteoarthritis and found that patients taking collagen UC-II reported significant improvements in physical function, stiffness, and pain compared to patients receiving placebo. or a combination of glucosamine hydrochloride and chondroitin sulfate .


Methylsulfonylmethane (MSM) is often sold separately as a dietary supplement for a variety of conditions, including osteoarthritis. Some Osteo Bi-Flex products contain it and the packaging often says "with MSM."

MSM is a sulfur-containing compound that is required by the connective tissues of the body. It is believed to fight inflammation, although one study found its benefits to be minimal. It is also observed that the clinical importance of MSM and osteoarthritis is unknown .

Supplements containing only MSM are known to have side effects including an upset stomach and diarrhea. Also, it should not be taken with blood thinners. Please discuss this with your healthcare professional as the amount of MSM in a specific Osteo Bi-Flex product may not be suitable for you.

Warnings and cautions

Just because a dietary supplement is out of date and sold over the counter does not necessarily mean that it is safe for you. Talk to your doctor before taking Osteo Bi-Flex. There may be an ingredient in one of the different product formulas that you might be warned against, depending on your medical history. Note the following precautions:

  • Allergy Some Osteo Bi-Flex products cause an allergy to shellfish. Also, some people have allergic reactions to glucosamine (which can be obtained from shellfish) or chondroitin.
  • Pregnant or Lactating Women: Pregnant or lactating women are advised to consult their healthcare professional before taking any Osteo Bi-Flex product.
  • Drug Interactions : There seem to be several drug interactions to consider when taking Osteo Bi-Flex. Two anticoagulants , Coumadin (warfarin) and Miradon (anisindione), have been observed. If you are taking any medications, check with your doctor before taking Osteo Bi-Flex.

Get the word of drug information

Many people with osteoarthritis have found some relief with regular use of Osteo Bi-Flex. It is available in a variety of forms, with most requiring only one or two capsules a day.

The American College of Rheumatology notes that these products may not work for everyone and emphasizes that since these products are not FDA tested, they can have serious side effects.

While there is research to support the benefits of some of the ingredients found in Osteo Bi-Flex, the supplements themselves have not been tested. Now that you know what this supplement contains, you can discuss with your doctor whether they are suitable for you.

Frequently asked questions

  • Osteo Bi-Flex is a food supplement designed to improve joint health. It is primarily intended for people with knee osteoarthritis.

  • The main ingredient is a proprietary blend called Joint Shield, which contains a plant extract called 5-loxin, which can help reduce pain and improve joint mobility in people with knee osteoarthritis.

    Other compounds in Osteo Bi-Flex include glucosamine, chondroitin, collagen, and methylsulfonylmethane (MSM).

  • Possibly, but unlikely. Studies of the individual ingredients in Osteo Bi-Flex show that they may have beneficial effects on joint health, improve mobility, and reduce pain over time. However, there have been no clinical trials comparing before and after imaging studies (such as X-rays) to confirm that the compounds in Osteo Bi-Flex can reverse joint damage.

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