Cost of Tamoxifen vs. Aromatase Inhibitors


For women who have estrogen receptor-positive breast cancers, the cost of hormonal therapy is an important consideration. This type of therapy is usually recommended after primary treatment with surgery and possibly chemotherapy and/or radiation therapy. The two main choices of hormonal therapy are Tamoxifen (brand name Nolvadex or Soltamox) and aromatase inhibitors, including Arimidex (anastrozole), Femara (letrozole), and Aromasin (exemestane).

The costs can be very different, which may influence your decision. However, the cost isn’t the only factor to consider. If you’re having trouble paying for these drugs, options may be available to help you.


Hormone Therapy and Risk of Breast Cancer Recurrence

After primary treatment for breast cancer, there is a risk of recurrence. With estrogen receptor-positive tumors, late recurrences, several years or even decades after treatment, are more common than with other types of breast cancer. Hormone therapies have been shown to reduce the risk of recurrence and improve survival rates.

Basically, estrogen is fuel for this type of tumor, so both reducing the amount of estrogen in your bloodstream and blocking estrogen receptors can help protect you from growing new tumors.

While tamoxifen and aromatase inhibitors both prevent recurrence estrogen-receptor positive breast cancer, they do work in different ways and for different people.


  • Anti-estrogen and estrogen-like effects

  • For premenopausal women only

  • Reduces recurrence risk by about 50 percent

  • Older, less expensive drug

Aromatase Inhibitors

  • Anti-estrogen effects

  • For premenopausal and postmenopausal women

  • May be more effective than tamoxifen in premenopausal women

  • Newer and more expensive

Comparing Costs

Since tamoxifen is the oldest and most prescribed hormonal therapy, it tends to be one of the cheapest options.

Below are the pre-insurance, U.S. prices for a month’s supply of the brand name and generic versions of tamoxifen and aromatase inhibitors, as well as the lowest costs found using coupons or prescription-assistance programs.

  Nolvadex/Soltamox (tamoxifen) Arimidex (anastrozole) Femara Aromasin (exemestane)
Brand Name $70 $560 $750 $1,160
Average $70 $170 $310 $505
Generic $70 $140 No generic $95
Lowest $20 $8 $11 $95

Keep in mind that the lowest prices often come from coupons, which may come and go, or prescription programs that you may not qualify for.

Paying for Hormonal Therapy

The costs of these medications can vary considerably based on your insurance coverage. In addition, some insurance companies will cover one type of aromatase inhibitor and not another.

If you are having difficulty affording hormonal therapy, you have a few options.

Work With Your Healthcare Provider and Insurance Company

Your first step should be to talk to your healthcare provider. He or she may believe a more expensive drug is the best one for protecting your health. If not, ask for one that is more affordable. Also, be sure to ask about generics.

If the medication your healthcare provider thinks is best isn’t in your insurance company’s formulary, your healthcare provider may be able to complete a prior authorization so that it is covered.

Even if you do have private health insurance, look into your eligibility for Medicare Part D, or Medicaid.

If you need to work something out with your insurance company, it may be easier to talk in person than over the phone, if you have a local office or representative.

Prescription Assistance Programs

If you are still having difficulty paying for the prescription your healthcare provider feels is best, there are more options. Some of these include:

  • Patient assistance programs: Learn more about the different patient prescription assistance programs available, and check with drug manufacturers for further assistance and savings programs. 
  • Drug discount programs: You may be eligible for a prescription drug discount card.
  • Samples: Some oncologists are provided samples of aromatase inhibitors. It can’t hurt to ask.
  • Disability: If you are not yet 65 but can qualify for disability, you may be able to get your medication through Medicare.
  • Online pharmacies: You may find more affordable prices, but before you buy, learn about how to safely order drugs on the web.
  • State pharmaceutical assistance programs: Many U.S. states have discount or assistance programs. Check to see if your state offers coverage.
  • Non-profit assistance: Ask your healthcare provider or clinic about local organizations that provide assistance with the cost of prescriptions. You can also check with breast cancer advocacy organizations. Keep in mind that different organizations have different goals, which may or may not include helping patients afford treatment.

Keep Careful Records

With insurance changes often requiring greater contributions from those who are insured, keeping careful records is more important than ever. Many costs for cancer treatment are tax deductible, including the out-of-pocket cost of hormonal therapy.

A Word From Get Meds Info

Hormone therapy is recommended for a full five to 10 years after the primary treatment of breast cancer, so the cost of tamoxifen or your aromatase inhibitor is an important factor to consider. Never settle for paying the full retail price of a drug, though. With some effort exploring your options, you may be able to significantly lower your overall spend on treatment.

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2 Sources
Get Meds Info uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
  1. National Cancer Institute. Breast Cancer Treatment (PDQ)—Health Professional Version.

  2. Tjan-Hejinen V, Hellemond I, Peer P, et al. Extended Adjuvant Aromatase Inhibition After Sequential Endocrine Therapy (DATA): A Randomised, Phase 3 Trial. The Lancet Oncology. 2017. 18(11):1502-1511. doi: 10.1016/S1470-2045(17)30600-9

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