DMAE: Benefits, Side Effects, Dosages, and Interactions


DMAE (also known as dimethylaminoethanol, dimethylethanolamine, or deanol) is a compound that is sometimes used as an ingredient in lotions, creams, and other skin care products. It is also available in the form of a dietary supplement.

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Health benefits

DMAE is believed to increase the production of acetylcholine (a chemical that helps nerve cells transmit signals). Since acetylcholine plays a key role in many brain functions, such as learning and memory, advocates argue that taking DMAE supplements can improve brain health by increasing acetylcholine levels .

Medications that increase acetylcholine have been used to treat Alzheimer's disease, so some studies have looked at AMD as a potential remedy for Alzheimer's disease. However, so far they have not shown encouraging results .

DMAE has been used to some extent to treat attention deficit / hyperactivity disorder (ADHD), but this use has only weak evidence. A 2011 study on nutritional therapy found that it "probably has little effect. "

Additionally, DMAE has been studied to improve athletic performance, improve mood, and relieve symptoms of depression .

The effects of DMAE are not scientifically documented at this time.

skin care products

DMAE creams, lotions, and other skin care products are believed to have anti-aging properties, reducing the appearance of wrinkles, dark circles, and sagging neck skin. While research on the effectiveness of DMAE is very limited, there is some evidence that using DMAE-based products can help improve skin.

For example, a review published in the American Journal of Clinical Dermatology suggests that DMAE may help improve skin firmness and reduce skin inflammation . In their analysis of previously published studies, the review authors found that DMAE can help reduce fine lines on the forehead and around the eyes and improve the overall appearance of aging skin. Additionally, the review authors noted that AMD does not appear to cause common side effects such as redness, peeling, and dryness.

In a preliminary study published in Pharmazie in 2009, the topical application of DMAE increased the thickness of the epidermal and dermal layers of the skin (in contrast, the application of formulations without DMAE increased the thickness of the epidermal layer only).

Cognitive function

In a study published in the Journal of Alzheimer's Disease in 2012, 242 people (all diagnosed with early-stage Alzheimer's) took a placebo or an oral extract of DMAE known as V0191 every day for 24 weeks. At the end of the study, there were no significant differences in cognitive function between the two groups.

The studies noted that there could be several problems in the study design, including the relatively short treatment period, the lack of effective measures to assess study participants, and problems assessing changes in cognitive function over time.

There is also no evidence that oral DMAE supplements can treat depression or improve athletic performance.

Possible side effects.

Very little is known about the safety of DMAE supplements. However, there are some concerns that DMAE may cause certain side effects, such as high blood pressure , upset stomach, headaches, muscle tension, drowsiness, confusion, and irritability.

Pregnant and lactating women, and women trying to conceive, should not take DMAE because of concerns that it may cause neural tube defects. Also, people with bipolar disorder or epilepsy should not use AMD. Here you can get tips on using nutritional supplements.

When applied topically, DMAE can cause skin irritation.

Dosage and preparation

There is insufficient scientific evidence to establish a safe or effective dose of DMAE.

The doses have been used in scientific studies. For example, in a study that examined the benefits of DMAE for athletic performance, study participants took 300 to 2,000 mg of deanol per day.

The safe and effective dose for you may depend on a variety of factors, including your age, gender, and medical history. Talk to your doctor for personalized advice.

What to look for

Currently, there is insufficient evidence to support the use of DMAE. If you are still considering trying it, be sure to follow the advice of health experts to buy the best product for you.

The National Institutes of Health (NIH) recommend that you look for the supplement label on the product you purchase. This label will contain vital information, including the amount of active ingredients per serving and other added ingredients (such as fillers, binders, and flavors).

Additionally, the organization invites you to search for a product that has a seal of approval from a third-party quality testing organization. These organizations include the United States Pharmacopeia,, and NSF International. A seal of approval from one of these organizations does not guarantee the safety or effectiveness of a product, but does provide assurance that the product has been manufactured correctly, contains the ingredients listed on the label, and does not contain harmful levels of contaminants.

If you need more help protecting your skin, consider using products that contain argan oil, shea butter, or green tea. It is also important to wear sunscreen to protect your skin from sun-related damage and reduce your risk of skin cancer.

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