Full text biomedical articles

Preparation and in Vivo Evaluation of a Dutasteride-Loaded Solid-Supersaturatable Self-Microemulsifying Drug Delivery System

Min-Soo Kim, Eun-Sol Ha, Gwang-Ho Choo, In-Hwan Baek
Int J Mol Sci. 2015 May; 16(5): 10821–10833. Published online 2015 May 13. doi: 10.3390/ijms160510821

Article   |   PubReader   |   PDF–1.6M   |   Cite

Opposing Effects of Cyclooxygenase-2 (COX-2) on Estrogen Receptor β (ERβ) Response to 5α-Reductase Inhibition in Prostate Epithelial Cells

Teresa T. Liu, Melanie J. Grubisha, Krystle A. Frahm, Stacy G. Wendell, Jiayan Liu, William A. Ricke, Richard J. Auchus, Donald B. DeFranco
J Biol Chem. 2016 Jul 8; 291(28): 14747–14760. Published online 2016 May 13. doi: 10.1074/jbc.M115.711515

Article   |   PubReader   |   PDF–1.2M   |   Cite

Dutasteride reduces alcohol's sedative effects in men in a human laboratory setting and reduces drinking in the natural environment

Jonathan Covault, Timothy Pond, Richard Feinn, Albert J. Arias, Cheryl Oncken, Henry R. Kranzler
Psychopharmacology (Berl) Author manuscript; available in PMC 2015 Sep 1.
Published in final edited form as: Psychopharmacology (Berl). 2014 Sep; 231(17): 3609–3618. Published online 2014 Feb 21. doi: 10.1007/s00213-014-3487-4

Article   |   PubReader   |   PDF–1.3M   |   Cite

Formulation of a film-coated dutasteride tablet bioequivalent to a soft gelatin capsule (Avodart®): Effect of γ-cyclodextrin and solubilizers

Mi-Hong Min, Jin-Hyong Park, Mi-Ran Choi, Jong-Hyun Hur, Byung-Nak Ahn, Dae-Duk Kim
Asian J Pharm Sci. 2019 May; 14(3): 313–320. Published online 2018 Oct 5. doi: 10.1016/j.ajps.2018.08.007

Article   |   PubReader   |   PDF–946K   |   Cite

Design of a gelatin microparticle-containing self-microemulsifying formulation for enhanced oral bioavailability of dutasteride

In-hwan Baek, Eun-Sol Ha, Jin-Wook Yoo, Yunjin Jung, Min-Soo Kim
Drug Des Devel Ther. 2015; 9: 3231–3238. Published online 2015 Jun 23. doi: 10.2147/DDDT.S86458

Article   |   PubReader   |   PDF–1.9M   |   Cite

Identification of New Epididymal Luminal Fluid Proteins Involved in Sperm Maturation in Infertile Rats Treated by Dutasteride Using iTRAQ

Shu-Wu Xie, Guo-Ting Li, Li-Juan Qu, Yang Cao, Qian Wang, Jie-Yun Zhou, Rui-Hua Zhong, Xiang-Jie Guo, Yan Zhu
Molecules. 2016 May; 21(5): 602. Published online 2016 May 11. doi: 10.3390/molecules21050602

Article   |   PubReader   |   PDF–956K   |   Cite

MRI findings in men on active surveillance for prostate cancer: does dutasteride make MRI visible lesions less conspicuous? Results from a placebo-controlled, randomised clinical trial

Francesco Giganti, Caroline M. Moore, Nicola L. Robertson, Neil McCartan, Charles Jameson, Simon R. J. Bott, Mathias Winkler, Giulio Gambarota, Brandon Whitcher, Ramiro Castro, Mark Emberton, Clare Allen, Alex Kirkham
Eur Radiol. 2017; 27(11): 4767–4774. Published online 2017 May 18. doi: 10.1007/s00330-017-4858-0

Article   |   PubReader   |   PDF–1.3M   |   Cite

A cost effective analysis of fixed-dose combination of dutasteride and tamsulosin compared with dutasteride monotherapy for benign prostatic hyperplasia in Nigeria: a middle income perspective; using an interactive Markov model

Emeka I. Udeh, Chimaobi G. Ofoha, David A. Adewole, Ikenna I. Nnabugwu
BMC Cancer. 2016; 16: 405. Published online 2016 Jul 7. doi: 10.1186/s12885-016-2431-x

Article   |   PubReader   |   PDF–1.0M   |   Cite

Rates of prostate surgery and acute urinary retention for benign prostatic hyperplasia in men treated with dutasteride or finasteride

Josephina G. Kuiper, Irene D. Bezemer, Maurice T. Driessen, Averyan Vasylyev, Claus G. Roehrborn, Fernie J. A. Penning-van Beest, Ron M. C. Herings
BMC Urol. 2016; 16(1): 53. Published online 2016 Aug 31. doi: 10.1186/s12894-016-0170-6

Article   |   PubReader   |   PDF–540K   |   Cite

Combination therapy with dutasteride and tamsulosin for the treatment of symptomatic enlarged prostate

J Miller, TH Tarter
Clin Interv Aging. 2009; 4: 251–258. Published online 2009 Jun 9. doi: 10.2147/cia.s4102

Article   |   PubReader   |   PDF–190K   |   Cite

Role of Hepatic Glucocorticoid Receptor in Metabolism in Models of 5αR1 Deficiency in Male Mice

Tracy C S Mak, Dawn E W Livingstone, Mark Nixon, Brian R Walker, Ruth Andrew
Endocrinology. 2019 Sep; 160(9): 2061–2073. Published online 2019 Jun 14. doi: 10.1210/en.2019-00236

Article   |   PubReader   |   Cite

The corpus cavernosum after treatment with dutasteride or finasteride: A histomorphometric study in a benign prostatic hyperplasia rodent model

Marcello H A Da Silva, Waldemar S Costa, Francisco J B Sampaio, Diogo B De Souza
Asian J Androl. 2018 Sep-Oct; 20(5): 505–510. Published online 2018 Jun 8. doi: 10.4103/aja.aja_28_18

Article   |   PubReader   |   PDF–1.4M   |   Cite

A 52‐week multicenter randomized controlled study of the efficacy and safety of add‐on dutasteride and imidafenacin to tamsulosin in patients with benign prostatic hyperplasia with remaining overactive bladder symptoms (DIrecT study)

Tomonori Yamanishi, Hirotaka Asakura, Narihito Seki, Shoji Tokunaga
Low Urin Tract Symptoms. 2019 May; 11(3): 115–121. Published online 2018 Oct 24. doi: 10.1111/luts.12243

Article   |   PubReader   |   PDF–653K   |   Cite

Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia

Arang Rhie, Ho-Young Son, Soo Jung Kwak, Seungbok Lee, Dong Young Kim, Bark-Lynn Lew, Woo-Young Sim, Jeong-Sun Seo, Ohsang Kwon, Jong-Il Kim, Seong Jin Jo
PLoS One. 2019; 14(9): e0222533. Published online 2019 Sep 16. doi: 10.1371/journal.pone.0222533

Article   |   PubReader   |   PDF–1.1M   |   Cite

5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder

Pedro E Martinez, David R Rubinow, Lynnette K Nieman, Deloris E Koziol, A Leslie Morrow, Crystal E Schiller, Dahima Cintron, Karla D Thompson, Khursheed K Khine, Peter J Schmidt
Neuropsychopharmacology. 2016 Mar; 41(4): 1093–1102. Prepublished online 2013 Aug 14. Published online 2015 Sep 9. doi: 10.1038/npp.2015.246

Article   |   PubReader   |   PDF–465K   |   Cite

Controlled Release of Dutasteride from Biodegradable Microspheres: In Vitro and In Vivo Studies

Xiangyang Xie, Yanfang Yang, Qiang Chi, ZhiPing Li, Hui Zhang, Ying Li, Yang Yang
PLoS One. 2014; 9(12): e114835. Published online 2014 Dec 26. doi: 10.1371/journal.pone.0114835

Article   |   PubReader   |   PDF–1.0M   |   Cite

Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man

Jonathan M. Hazlehurst, Andrei I. Oprescu, Nikolaos Nikolaou, Riccardo Di Guida, Annabel E. K. Grinbergs, Nigel P. Davies, Robert B. Flintham, Matthew J. Armstrong, Angela E. Taylor, Beverly A. Hughes, Jinglei Yu, Leanne Hodson, Warwick B. Dunn, Jeremy W. Tomlinson
J Clin Endocrinol Metab. 2016 Jan; 101(1): 103–113. Published online 2015 Nov 17. doi: 10.1210/jc.2015-2928

Article   |   PubReader   |   Cite

Significance of intraprostatic architecture and regrowth velocity for considering discontinuation of dutasteride after combination therapy with an alpha blocker: A prospective, pilot study

Tetsuya Shindo, Kohei Hashimoto, Takashi Shimizu, Naoki Itoh, Naoya Masumori
Korean J Urol. 2015 Apr; 56(4): 305–309. Published online 2015 Mar 27. doi: 10.4111/kju.2015.56.4.305

Article   |   PubReader   |   PDF–2.7M   |   Cite

A population-based study of the risk of osteoporosis and fracture with dutasteride and finasteride

Tony Antoniou, Erin M. Macdonald, Zhan Yao, Tara Gomes, Mina Tadrous, Joanne M.-W. Ho, Muhammad M. Mamdani, David N. Juurlink, for the Canadian Drug Safety and Effectiveness Research Network
BMC Musculoskelet Disord. 2018; 19: 160. Published online 2018 May 22. doi: 10.1186/s12891-018-2076-9

Article   |   PubReader   |   PDF–549K   |   Cite

Early dutasteride monotherapy in men with detectable serum prostate-specific antigen levels following radical prostatectomy: A prospective trial

Yu Seob Shin, Jea Whan Lee, Myung Ki Kim, Young Beom Jeong, Seung Chol Park
Investig Clin Urol. 2017 Mar; 58(2): 98–102. Published online 2017 Feb 15. doi: 10.4111/icu.2017.58.2.98

Article   |   PubReader   |   PDF–2.9M   |   Cite