Facts about robaxin (methocarbamol) for arthritis

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Robaxin (methocarbamol) is indicated as an adjunct to rest, physical therapy , and other measures to relieve discomfort associated with acute painful conditions of the musculoskeletal system. The mechanism of action of methocarbamol is not clearly defined, but may be related to its sedative properties. Robaxin does not directly relax tense human skeletal muscles.

David Smart / Stoxy United

Contraindications

Robaxin is contraindicated in patients with hypersensitivity to methocarbamol or any of the components of the tablet.

Warnings

Since methocarbamol may have a general depressant effect on the central nervous system, patients receiving robaxin should be advised of the combined effects with alcohol and other CNS depressants.

The safe use of robaxin in relation to possible side effects on fetal development has not been established. There have been reports of intrauterine and fetal abnormalities after exposure to methocarbamol in utero. Therefore, Robaxin should not be used in women who are or may become pregnant, especially in early pregnancy, unless, in the opinion of the doctor, the potential benefits outweigh the possible dangers.

Robaxin can affect the mental and / or physical abilities necessary to perform dangerous tasks, such as operating machinery or driving a car.

Safety measures

Patients should be advised that robaxin may cause drowsiness or dizziness, which may affect their ability to drive vehicles or machinery. Since Robaxin may have a general depressant effect on the central nervous system, patients should be warned about the combined effects of alcohol and other CNS depressants.

Adverse reactions

Adverse reactions seen with methocarbamol include:

  • Body as a whole: anaphylactic reaction, angioedema, fever, headache.
  • Cardiovascular system: bradycardia, hyperemia, hypotension, fainting, thrombophlebitis.
  • Digestive system : dyspepsia, jaundice (including cholestatic jaundice), nausea and vomiting.
  • Hemic and lymphatic system: leukopenia.
  • Immune system : hypersensitivity reactions.
  • Nervous system: amnesia, confusion, diplopia, dizziness or lightheadedness, drowsiness, insomnia, mild muscle incoordination, nystagmus, sedation, seizures (including large ones), dizziness.
  • Skin and special senses: blurred vision, conjunctivitis, nasal congestion, metallic taste, itching, rash, hives.

Drug and laboratory interactions

Robaxin can inhibit the action of pyridostigmine bromide. Therefore, robaxin should be used with caution in patients with myasthenia gravis receiving anticholinesterase drugs.

Methocarbamol may cause color interference in some 5-hydroxyindoleacetic acid detection tests.

Carcinogenesis, mutagenesis, impaired fertility

Long-term studies have not been performed to evaluate the carcinogenic potential of Robaxin. No studies have been conducted to evaluate the effect of robaxin on mutagenesis or its ability to affect fertility.

The pregnancy

Animal reproduction studies have not been conducted with methocarbamol. It is also not known whether methocarbamol can harm the fetus when administered to a pregnant woman or if it can affect fertility. Robaxin should be prescribed to a pregnant woman only if absolutely necessary.

The safe use of robaxin in relation to possible side effects on fetal development has not been established. There have been reports of intrauterine and fetal abnormalities after exposure to methocarbamol in utero. Therefore, Robaxin should not be used in women who are or may become pregnant, especially in early pregnancy, unless, in the opinion of the doctor, the potential benefits outweigh the possible dangers.

Breastfeeding mothers

Methocarbamol and / or its metabolites are excreted in the milk of dogs; however, it is not known whether methocarbamol or its metabolites are excreted in human milk. Since many drugs are excreted in human milk, caution should be exercised when administering robaxin to a nursing woman.

Pediatric use

The safety and efficacy of robaxin in children younger than 16 years have not been established.

Overdose

Limited information is available on the acute toxicity of methocarbamol. A methocarbamol overdose is often combined with alcohol or other CNS depressants and includes the following symptoms:

  • Nausea
  • Drowsiness
  • Blurry vision
  • Hypotension
  • Seizures
  • Eat

In post-marketing experience, deaths have been reported with methocarbamol overdose alone or in the presence of other CNS depressants, alcohol, or psychotropic drugs. Treatment of overdose includes symptomatic and supportive treatment.

Store Robaxin at controlled room temperature, 68 to 77 F.

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