References from scientific journals

Association Between Fexofenadine Use During Pregnancy and Fetal Outcomes.

Andersson NW, Torp-Pedersen C, Andersen JT. Andersson NW, et al. JAMA Pediatr. 2020 Aug 1;174(8):e201316. doi: 10.1001/jamapediatrics.2020.1316. Epub 2020 Aug 3. JAMA Pediatr. 2020. PMID: 32478810 Free PMC article.

IMPORTANCE: Fexofenadine hydrochloride is a frequently used drug for treatment of allergic conditions during pregnancy, but the fetal safety of fexofenadine use has not been well studied. ...Sensitivity analyses of the primary outcomes, including the comparisons of …
IMPORTANCE: Fexofenadine hydrochloride is a frequently used drug for treatment of allergic conditions during pregnancy, but the fetal …

Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review.

Devillier P, Roche N, Faisy C. Devillier P, et al. Clin Pharmacokinet. 2008;47(4):217-30. doi: 10.2165/00003088-200847040-00001. Clin Pharmacokinet. 2008. PMID: 18336052 Review.

When comparing the efficacy and safety profiles of the newest second-generation antihistamines - desloratadine, fexofenadine and levocetirizine - many pharmacological and clinical criteria must be considered. ...Desloratadine and fexofenadine do not impair cognitive …
When comparing the efficacy and safety profiles of the newest second-generation antihistamines - desloratadine, fexofenadine and levo …

Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials.

Huang CZ, Jiang ZH, Wang J, Luo Y, Peng H. Huang CZ, et al. BMC Pharmacol Toxicol. 2019 Nov 29;20(1):72. doi: 10.1186/s40360-019-0363-1. BMC Pharmacol Toxicol. 2019. PMID: 31783781 Free PMC article.

When compared with placebo, fexofenadine produced more significant antihistamine effects. CONCLUSIONS: Fexofenadine has a positive antihistamine effect, which is probably no worse than the second-generation antihistamines. ...Therefore, fexofenadine may be wo …
When compared with placebo, fexofenadine produced more significant antihistamine effects. CONCLUSIONS: Fexofenadine has a posi …

Comparison of efficacy, safety, and cost-effectiveness of montelukast-levocetirizine and montelukast-fexofenadine in patients of allergic rhinitis: A randomized, double-blind clinical trial.

Mahatme MS, Dakhale GN, Tadke K, Hiware SK, Dudhgaonkar SD, Wankhede S. Mahatme MS, et al. Indian J Pharmacol. 2016 Nov-Dec;48(6):649-653. doi: 10.4103/0253-7613.194854. Indian J Pharmacol. 2016. PMID: 28066101 Free PMC article. Clinical Trial.

The mean change of TNSS, i.e., 9.46 was significant (P fexofenadine group. The cost-effectiveness ratio was less in montelukast-levocetirizine group than in montelukast-fexofenadine group. CONCLUSION: The decrease in TNSS was more in montel

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The mean change of TNSS, i.e., 9.46 was significant (P fexofenadine group. The cost-effectiveness ratio was

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Fexofenadine.

Markham A, Wagstaff AJ. Markham A, et al. Drugs. 1998 Feb;55(2):269-74; discussion 275-6. doi: 10.2165/00003495-199855020-00012. Drugs. 1998. PMID: 9506246 Review.

Other double-blind clinical trials showed that fexofenadine 40 to 240mg twice daily was significantly more effective than placebo. Fexofenadine 180 or 240mg once daily was significantly more effective than placebo in patients with chronic idiopathic urticaria. ...
Other double-blind clinical trials showed that fexofenadine 40 to 240mg twice daily was significantly more effective than placebo. …

An update on the clinical pharmacokinetics of fexofenadine enantiomers.

Akamine Y, Miura M. Akamine Y, et al. Expert Opin Drug Metab Toxicol. 2018 Apr;14(4):429-434. doi: 10.1080/17425255.2018.1459565. Epub 2018 Apr 11. Expert Opin Drug Metab Toxicol. 2018. PMID: 29635947 Review.

Fexofenadine is administered as a racemic mixture of (R)- and (S)-enantiomers. The plasma concentrations of (R)-fexofenadine in humans are about 1.5-fold higher than those of the (S)-enantiomer. ...
Fexofenadine is administered as a racemic mixture of (R)- and (S)-enantiomers. The plasma concentrations of (R)-fexofenadine i …

[Determinants of the stereoselective pharmacokinetics of fexofenadine].

Akamine Y. Akamine Y. Yakugaku Zasshi. 2015;135(3):473-81. doi: 10.1248/yakushi.14-00218. Yakugaku Zasshi. 2015. PMID: 25759055 Free article. Review. Japanese.

This review focuses on the drug transporters contributing to the stereoselective pharmacokinetics of fexofenadine enantiomers in humans. Fexofenadine is administered clinically as a racemic mixture, and the plasma concentration of (R)-fexofenadine is about 1. …
This review focuses on the drug transporters contributing to the stereoselective pharmacokinetics of fexofenadine enantiomers in huma …

Clinical pharmacokinetics of fexofenadine enantiomers.

Miura M, Uno T. Miura M, et al. Expert Opin Drug Metab Toxicol. 2010 Jan;6(1):69-74. doi: 10.1517/17425250903382615. Expert Opin Drug Metab Toxicol. 2010. PMID: 19947891 Review.

This article reviews the pharmacokinetic differences between fexofenadine enantiomers in humans and summarizes the previous reports that co-administration of P-glycoprotein inhibitors has altered the stereoselective pharmacokinetics of fexofenadine enantiomers. ...T …
This article reviews the pharmacokinetic differences between fexofenadine enantiomers in humans and summarizes the previous reports t …

Efficacy of Fexofenadine in the Treatment of Chronic Idiopathic Urticaria.

Jahan H, Akhter F, Nandi AK. Jahan H, et al. Mymensingh Med J. 2020 Apr;29(2):414-419. Mymensingh Med J. 2020. PMID: 32506098

The primary purpose of this study is to find out the efficacy of fexofenadine in the treatment of chronic idiopathic urticaria patients among the Bangladeshi population. ...Total 100 patients of chronic idiopathic urticaria aged 18 years and above with exclusion and inclus …
The primary purpose of this study is to find out the efficacy of fexofenadine in the treatment of chronic idiopathic urticaria patien …

Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders.

Smith SM, Gums JG. Smith SM, et al. Expert Opin Drug Metab Toxicol. 2009 Jul;5(7):813-22. doi: 10.1517/17425250903044967. Expert Opin Drug Metab Toxicol. 2009. PMID: 19545214 Review.

OBJECTIVE: To review the pharmacology, efficacy and safety of fexofenadine and the attributes differentiating it from other H(1)-antihistamines. ...In addition, fexofenadine may offer cost savings over other selected H(1)-antihistamines owing to its recent availabil …
OBJECTIVE: To review the pharmacology, efficacy and safety of fexofenadine and the attributes differentiating it from other H(1)-anti …