Full text biomedical articles

Imiquimod suppresses respiratory syncytial virus (RSV) replication via PKA pathway and reduces RSV induced-inflammation and viral load in mice lungs

Franco Maximiliano Salinas, Antonela Díaz Nebreda, Luciana Vázquez, María Virginia Gentilini, Victoria Marini, Martina Benedetti, Mercedes Soledad Nabaes Jodar, Mariana Viegas, Carina Shayo, Carlos Alberto Bueno
Antiviral Res. 2020 Jul; 179: 104817. Published online 2020 May 6. doi: 10.1016/j.antiviral.2020.104817

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Imiquimod‐induced apoptosis of melanoma cells is mediated by ER stress‐dependent Noxa induction and enhanced by NF‐κB inhibition

Abdelouahid El‐Khattouti, Denis Selimovic, Matthias Hannig, Erin B. Taylor, Zakaria Y. Abd Elmageed, Sofie Y. Hassan, Youssef Haikel, Emad Kandil, Martin Leverkus, Robert T. Brodell, Mosaad Megahed, Mohamed Hassan
J Cell Mol Med. 2016 Feb; 20(2): 266–286. Published online 2015 Nov 18. doi: 10.1111/jcmm.12718

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The effect of imiquimod on taste bud calcium transients and transmitter secretion

Anthony Y Huang, Sandy Y Wu
Br J Pharmacol. 2016 Nov; 173(21): 3121–3133. Published online 2016 Sep 6. doi: 10.1111/bph.13567

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The Immunomodulatory Small Molecule Imiquimod Induces Apoptosis in Devil Facial Tumour Cell Lines

Amanda L. Patchett, Jocelyn M. Darby, Cesar Tovar, A. Bruce Lyons, Gregory M. Woods
PLoS One. 2016; 11(12): e0168068. Published online 2016 Dec 9. doi: 10.1371/journal.pone.0168068

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EAPB0503: An Imiquimod analog with potent in vitro activity against cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica

Rana El Hajj, Hanady Bou Youness, Laurence Lachaud, Patrick Bastien, Carine Masquefa, Pierre-Antoine Bonnet, Hiba El Hajj, Ibrahim Khalifeh
PLoS Negl Trop Dis. 2018 Nov; 12(11): e0006854. Published online 2018 Nov 21. doi: 10.1371/journal.pntd.0006854

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Imiquimod - A toll like receptor 7 agonist - Is an ideal option for management of COVID 19

Athina Angelopoulou, Nikos Alexandris, Evangelia Konstantinou, Konstantinos Mesiakaris, Charilaos Zanidis, Konstantinos Farsalinos, Konstantinos Poulas
Environ Res. 2020 Sep; 188: 109858. Published online 2020 Jun 23. doi: 10.1016/j.envres.2020.109858

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Intranasal and epicutaneous administration of Toll-like receptor 7 (TLR7) agonists provides protection against influenza A virus-induced morbidity in mice

Eunice E. To, Jonathan Erlich, Felicia Liong, Raymond Luong, Stella Liong, Steven Bozinovski, Huei Jiunn Seow, John J. O’Leary, Doug A. Brooks, Ross Vlahos, Stavros Selemidis
Sci Rep. 2019; 9: 2366. Published online 2019 Feb 20. doi: 10.1038/s41598-019-38864-5

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Imiquimod - Its role in the treatment of cutaneous malignancies

Aditya Kumar Bubna
Indian J Pharmacol. 2015 Jul-Aug; 47(4): 354–359. doi: 10.4103/0253-7613.161249

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Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia

Theresa A Lawrie, Andy Nordin, Manas Chakrabarti, Andrew Bryant, Sonali Kaushik, Litha Pepas, Cochrane Gynaecological, Neuro‐oncology and Orphan Cancer Group
Cochrane Database Syst Rev. 2016 Jan; 2016(1): CD011837. Published online 2016 Jan 5. doi: 10.1002/14651858.CD011837.pub2

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Imiquimod Induces Apoptosis of Squamous Cell Carcinoma (SCC) Cells via Regulation of A20

Kyung-Cheol Sohn, Zheng Jun Li, Dae-Kyoung Choi, Tiejun Zhang, Jae Woo Lim, In-Kyu Chang, Gang Min Hur, Myung Im, Young Lee, Young-Joon Seo, Jeung-Hoon Lee, Chang Deok Kim
PLoS One. 2014; 9(4): e95337. Published online 2014 Apr 17. doi: 10.1371/journal.pone.0095337

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Genital warts treatment: Beyond imiquimod

Jianwei Yuan, Guoying Ni, Tianfang Wang, Kate Mounsey, Shelley Cavezza, Xuan Pan, Xiaosong Liu
Hum Vaccin Immunother. 2018; 14(7): 1815–1819. Published online 2018 Apr 9. doi: 10.1080/21645515.2018.1445947

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Medical interventions for high‐grade vulval intraepithelial neoplasia

Litha Pepas, Sonali Kaushik, Andy Nordin, Andrew Bryant, Theresa A Lawrie, Cochrane Gynaecological, Neuro‐oncology and Orphan Cancer Group
Cochrane Database Syst Rev. 2015 Aug; 2015(8): CD007924. Published online 2015 Aug 18. doi: 10.1002/14651858.CD007924.pub3

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TLR2 Deficiency Exacerbates Imiquimod-Induced Psoriasis-Like Skin Inflammation through Decrease in Regulatory T Cells and Impaired IL-10 Production

Momoko Nakao, Makoto Sugaya, Hideki Fujita, Tomomitsu Miyagaki, Sohshi Morimura, Sayaka Shibata, Yoshihide Asano, Shinichi Sato
Int J Mol Sci. 2020 Nov; 21(22): 8560. Published online 2020 Nov 13. doi: 10.3390/ijms21228560

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Transcriptomic profiles conducive to immune-mediated tumor rejection in human breast cancer skin metastases treated with Imiquimod

Mariya Rozenblit, Wouter Hendrickx, Adriana Heguy, Luis Chiriboga, Cynthia Loomis, Karina Ray, Farbod Darvishian, Mikala Egeblad, Sandra Demaria, Francesco M. Marincola, Davide Bedognetti, Sylvia Adams
Sci Rep. 2019; 9: 8572. Published online 2019 Jun 12. doi: 10.1038/s41598-019-42784-9

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The functional and inflammatory response of brain endothelial cells to Toll-Like Receptor agonists

Rebecca H. Johnson, Dan T. Kho, Simon J. O’ Carroll, Catherine E. Angel, E. Scott Graham
Sci Rep. 2018; 8: 10102. Published online 2018 Jul 4. doi: 10.1038/s41598-018-28518-3

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Efficacy of Imiquimod-Based Transcutaneous Immunization Using a Nano-Dispersed Emulsion Gel Formulation

Pamela Stein, Karsten Gogoll, Stefan Tenzer, Hansjörg Schild, Stefan Stevanovic, Peter Langguth, Markus P. Radsak
PLoS One. 2014; 9(7): e102664. Published online 2014 Jul 15. doi: 10.1371/journal.pone.0102664

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Toll like receptor agonist imiquimod facilitates antigen-specific CD8+ T cell accumulation in the genital tract leading to tumor control through interferon-γ

Ruey-Shyang Soong, Liwen Song, Janson Trieu, Jayne Knoff, Liangmei He, Ya-Chea Tsai, Warner Huh, Yung-Nien Chang, Wen-Fang Cheng, Richard B.S. Roden, T.-C. Wu, Chien-Fu Hung
Clin Cancer Res. Author manuscript; available in PMC 2015 Nov 1.
Published in final edited form as: Clin Cancer Res. 2014 Nov 1; 20(21): 5456–5467. Published online 2014 Jun 3. doi: 10.1158/1078-0432.CCR-14-0344

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Topical treatment of melanoma metastases with imiquimod, plus administration of a cancer vaccine, promotes immune signatures in the metastases

Ileana S. Mauldin, Nolan A. Wages, Anne M. Stowman, Ena Wang, Walter C. Olson, Donna H. Deacon, Kelly T. Smith, Nadedja Galeassi, Jessica E. Teague, Mark E. Smolkin, Kimberly A. Chianese-Bullock, Rachael A. Clark, Gina R. Petroni, Francesco M. Marincola, David W. Mullins, Craig L. Slingluff, Jr
Cancer Immunol Immunother. Author manuscript; available in PMC 2017 Oct 1.
Published in final edited form as: Cancer Immunol Immunother. 2016 Oct; 65(10): 1201–1212. Published online 2016 Aug 13. doi: 10.1007/s00262-016-1880-z

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Using Imiquimod-Induced Psoriasis-Like Skin as a Model to Measure the Skin Penetration of Anti-Psoriatic Drugs

Yin-Ku Lin, Sien-Hung Yang, Chin-Chuan Chen, Hsiao-Ching Kao, Jia-You Fang
PLoS One. 2015; 10(9): e0137890. Published online 2015 Sep 10. doi: 10.1371/journal.pone.0137890

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Interventions for cutaneous molluscum contagiosum

Johannes C van der Wouden, Renske van der Sande, Emma J Kruithof, Annet Sollie, Lisette WA van Suijlekom‐Smit, Sander Koning, Cochrane Skin Group
Cochrane Database Syst Rev. 2017 May; 2017(5): CD004767. Published online 2017 May 17. doi: 10.1002/14651858.CD004767.pub4

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