Full text biomedical articles

A Novel Role of Irbesartan in Gastroprotection against Indomethacin-Induced Gastric Injury in Rats: Targeting DDAH/ADMA and EGFR/ERK Signaling

Nancy N. Shahin, Noha F. Abdelkader, Marwa M. Safar
Sci Rep. 2018; 8: 4280. Published online 2018 Mar 9. doi: 10.1038/s41598-018-22727-6


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Comparison of efficacy and safety between two different irbesartan, generic vs branded, in the treatment of Korean patients with mild-to-moderate hypertension: an 8-week, multicenter, randomized, open-label, Phase IV clinical study

Seung Hwan Han, Gyu Chul Oh, Hyuck Moon Kwon, Chang Gyu Park, In Jai Kim, Gyo-Seung Hwang, Byung Su Yoo, Seong Hoon Park, Kwang Je Lee, Hyo-soo Kim
Drug Des Devel Ther. 2018; 12: 4217–4229. Published online 2018 Dec 19. doi: 10.2147/DDDT.S172046


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Nanoparticle-Mediated Delivery of Irbesartan Induces Cardioprotection from Myocardial Ischemia-Reperfusion Injury by Antagonizing Monocyte-Mediated Inflammation

Yasuhiro Nakano, Tetsuya Matoba, Masaki Tokutome, Daiki Funamoto, Shunsuke Katsuki, Gentaro Ikeda, Kazuhiro Nagaoka, Ayako Ishikita, Kaku Nakano, Jun-ichiro Koga, Kenji Sunagawa, Kensuke Egashira
Sci Rep. 2016; 6: 29601. Published online 2016 Jul 11. doi: 10.1038/srep29601


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Suppressive Effects of Irbesartan on Inflammation and Apoptosis in Atherosclerotic Plaques of apoE−/− Mice: Molecular Imaging with 14C-FDG and 99mTc-Annexin A5

Yan Zhao, Ayahisa Watanabe, Songji Zhao, Tatsuo Kobayashi, Keita Fukao, Yoshikazu Tanaka, Toru Nakano, Tetsuya Yoshida, Hiroshi Takemoto, Nagara Tamaki, Yuji Kuge
PLoS One. 2014; 9(2): e89338. Published online 2014 Feb 19. doi: 10.1371/journal.pone.0089338


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AT1-receptor blockade: Protective effects of irbesartan in cardiomyocytes under hypoxic stress

Mariarosaria Boccellino, Marina Di Domenico, Maria Donniacuo, Giuseppe Bitti, Giulia Gritti, Pasqualina Ambrosio, Lucio Quagliuolo, Barbara Rinaldi
PLoS One. 2018; 13(10): e0202297. Published online 2018 Oct 24. doi: 10.1371/journal.pone.0202297


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Irbesartan prevents sodium channel remodeling in a canine model of atrial fibrillation

Xuewen Wang, Guangping Li
J Renin Angiotensin Aldosterone Syst. 2018 Jan-Mar; 19(1): 1470320318755269. Published online 2018 Jan 29. doi: 10.1177/1470320318755269


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Effects of Irbesartan Pretreatment on Pancreatic β-Cell Apoptosis in STZ-Induced Acute Prediabetic Mice

Cuihong Chen, Li Li, Haijing Qin, Zhenxing Huang, Jing Xian, Jinwei Cai, Yingfen Qin, Jie Zhang, Xinghuan Liang
Oxid Med Cell Longev. 2018; 2018: 8616194. Published online 2018 Dec 2. doi: 10.1155/2018/8616194


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Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial

Michael Mullen, Xu Yu Jin, Anne Child, A Graham Stuart, Matthew Dodd, José Antonio Aragon-Martin, David Gaze, Anatoli Kiotsekoglou, Li Yuan, Jiangting Hu, Claire Foley, Laura Van Dyck, Rosemary Knight, Tim Clayton, Lorna Swan, John D R Thomson, Guliz Erdem, David Crossman, Marcus Flather, AIMS Investigators
Lancet. 2019 Dec 21; 394(10216): 2263–2270. doi: 10.1016/S0140-6736(19)32518-8


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Effects of Ang II Receptor Blocker Irbesartan on Adipose Tissue Function in Mice with Metabolic Disorders

Akinobu Maeda, Kouichi Tamura, Hiromichi Wakui, Masato Ohsawa, Kengo Azushima, Kazushi Uneda, Ryu Kobayashi, Yuko Tsurumi-Ikeya, Tomohiko Kanaoka, Toru Dejima, Koji Ohki, Sona Haku, Akio Yamashita, Satoshi Umemura
Int J Med Sci. 2014; 11(6): 646–651. Published online 2014 Apr 27. doi: 10.7150/ijms.8577


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Effects of irbesartan on myocardial injury in diabetic rats: The role of NLRP3/ASC/Caspase-1 pathway

Li Rong, Shuo Sun, Feiyu Zhu, Qingmei Xu, Hui Li, Qin Gao, Wei Zhang, Bi Tang, Heng Zhang, Hongju Wang, Pinfang Kang
J Renin Angiotensin Aldosterone Syst. 2020 Apr-Jun; 21(2): 1470320320926049. Published online 2020 May 29. doi: 10.1177/1470320320926049


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Effect of Irbesartan on AGEs-RAGE and MMPs systems in rat type 2 diabetes myocardial-fibrosis model

Ye Hongwei, Cao Ruiping, Fang Yingyan, Zhang Guanjun, Hu Jie, Liu Xingyu, Tang Jie, Li Zhenghong, Gao Qin, Hu Junfeng, Zhang Heng
Exp Biol Med (Maywood) 2019 May; 244(7): 612–620. Published online 2019 Apr 26. doi: 10.1177/1535370219840981


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Efficacy of Zofenopril vs. Irbesartan in Combination with a Thiazide Diuretic in Hypertensive Patients with Multiple Risk Factors not Controlled by a Previous Monotherapy: A Review of the Double-Blind, Randomized “Z” Studies

Stefano Omboni, Ettore Malacco, Claudio Napoli, Pietro Amedeo Modesti, Athanasios Manolis, Gianfranco Parati, Enrico Agabiti-Rosei, Claudio Borghi
Adv Ther. 2017; 34(4): 784–798. Published online 2017 Mar 4. doi: 10.1007/s12325-017-0497-8


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Short-term treatment of irbesartan and hydrochlorothiazide decreases plasma N-terminal pro-brain natriuretic peptide levels in subjects with acute exacerbations of COPD

Gui-yun Jiang, Qun Li, Yun-xiang Lv
Int J Chron Obstruct Pulmon Dis. 2019; 14: 73–80. Published online 2018 Dec 20. doi: 10.2147/COPD.S186872


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Angiotensin II Receptor Blocker Ameliorates Stress-Induced Adipose Tissue Inflammation and Insulin Resistance

Motoharu Hayashi, Kyosuke Takeshita, Yasuhiro Uchida, Koji Yamamoto, Ryosuke Kikuchi, Takayuki Nakayama, Emiko Nomura, Xian Wu Cheng, Tadashi Matsushita, Shigeo Nakamura, Toyoaki Murohara
PLoS One. 2014; 9(12): e116163. Published online 2014 Dec 31. doi: 10.1371/journal.pone.0116163


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Zofenopril Plus Hydrochlorothiazide and Irbesartan Plus Hydrochlorothiazide in Previously Treated and Uncontrolled Diabetic and Non-diabetic Essential Hypertensive Patients

Enrico Agabiti-Rosei, Athanasios Manolis, Dario Zava, Stefano Omboni
Adv Ther. 2014; 31(2): 217–233. Published online 2014 Jan 11. doi: 10.1007/s12325-013-0090-8


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Irbesartan inhibits human T-lymphocyte activation through downregulation of activator protein-1

Shu-Meng Cheng, Shih-Ping Yang, Ling-Jun Ho, Tien-Ping Tsao, Deh-Ming Chang, Jenn-Haung Lai
Br J Pharmacol. 2004 Jul; 142(6): 933–942. Published online 2004 Jun 21. doi: 10.1038/sj.bjp.0705785


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Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression

Chizuru Yabumoto, Hiroshi Akazawa, Rie Yamamoto, Masamichi Yano, Yoko Kudo-Sakamoto, Tomokazu Sumida, Takehiro Kamo, Hiroki Yagi, Yu Shimizu, Akiko Saga-Kamo, Atsuhiko T. Naito, Toru Oka, Jong-Kook Lee, Jun-ichi Suzuki, Yasushi Sakata, Etsuko Uejima, Issei Komuro
Sci Rep. 2015; 5: 14453. Published online 2015 Sep 25. doi: 10.1038/srep14453


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The effects of age and gender on the pharmacokinetics of irbesartan

Nimish N Vachharajani, Wen Chyi Shyu, Robert A Smith, Douglas S Greene
Br J Clin Pharmacol. 1998 Dec; 46(6): 611–613. doi: 10.1046/j.1365-2125.1998.00837.x


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Fixed combination of irbesartan and hydrochlorothiazide in the management of hypertension

Peter Bramlage
Vasc Health Risk Manag. 2009; 5: 213–224. Published online 2009 Apr 8. doi: 10.2147/vhrm.s3302


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Cardiac and Renal Protective Effects of Irbesartan via Peroxisome Proliferator‐Activated Receptorγ–Hepatocyte Growth Factor Pathway Independent of Angiotensin II Type 1a Receptor Blockade in Mouse Model of Salt‐Sensitive Hypertension

Hiroshi Kusunoki, Yoshiaki Taniyama, Hiromi Rakugi, Ryuichi Morishita
J Am Heart Assoc. 2013 Apr; 2(2): e000103. Published online 2013 Apr 24. doi: 10.1161/JAHA.113.000103


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