Leaky gut syndrome (intestinal permeability)


In alternative medicine, a condition called leaky gut syndrome (or leaky gut) affects the lining of the intestines, leading to symptoms such as persistent muscle or joint pain, poor concentration, indigestion, gas, mood swings, nervousness, rashes. skin …, recurrent bladder or yeast infections, constipation or anxiety.

However, there is no scientific evidence in humans that increased intestinal permeability, resulting in increased intestinal permeability, causes symptoms outside of the gastrointestinal tract.

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Leaky gut syndrome / Leaky gut symptoms

In alternative medicine, symptoms include abdominal pain, asthma, chronic joint pain, chronic muscle pain, confusion, gas , upset stomach, mood swings, nervousness, frequent colds, recurrent vaginal infections, skin rashes, diarrhea, recurrent infections of the bladder. memory, shortness of breath, constipation, bloating, anxiety, irritability and fatigue.


The lining of the intestine creates a barrier that generally allows only properly digested fats, proteins, and starch to pass through and enter the bloodstream. This allows substances to travel multiple paths.

Chloride, potassium, magnesium, sodium, and free fatty acids diffuse through intestinal cells. Amino acids, fatty acids, glucose, minerals, and vitamins also travel through cells, but they do so through another mechanism called active transport.

There is a third way of penetrating substances. The spaces between the cells that line the intestines are usually closed. These tight junctions are called desmosomes. When the intestinal lining becomes irritated, the compounds break down and allow larger unwanted molecules in the intestine to pass into the bloodstream. The immune system perceives these unwanted substances as foreign (because they are not normally found in the blood). This triggers an antibody response.

When the intestinal lining is further damaged, even larger substances such as disease-causing bacteria, undigested food particles, and toxins pass directly through the damaged cells. Again, the immune system receives an alarm and antibodies and substances called cytokines are released. Cytokines make white blood cells fight particles. This fight produces oxidants that cause irritation and inflammation throughout the body.

Causes attributed by alternative medicine to leaky gut syndrome include:

  • Chronic stress
  • Intestinal infections
  • Bacteria overgrowth in the small intestine
  • Environmental pollution
  • Excess alcohol
  • Poor nutrition
  • Non-steroidal anti-inflammatory drugs (NSAIDs) and other medications.

Alternative doctors sometimes associate leaky gut syndrome with the following conditions:

  • Autoimmune disease
  • Celiac Disease
  • Crohn's disease
  • Environmental disease
  • Urticaria
  • Acne
  • Allergies
  • Inflammatory joint disease / arthritis
  • Intestinal infections
  • Pancreatic insufficiency
  • Ulcerative colitis
  • Giardia (intestinal parasitic infection)
  • Chronic Fatigue Syndrome
  • Eczema
  • Psoriasis
  • Food allergies and sensitivities
  • Liver dysfunction
  • Rheumatoid arthritis
  • Irritable bowel syndrome


The standard test for leaky gut syndrome is the mannitol and lactulose test. Both are water-soluble molecules that the body cannot use. Mannitol is easily absorbed by people with a healthy intestinal lining. Lactulose is a larger molecule that is only slightly absorbed.

For the test, the person drinks a solution that contains both mannitol and lactulose. Urine is collected for six hours and the amount present in the urine reflects how much of each has been absorbed by the body. The health test shows high levels of mannitol and low levels of lactulose. If high levels of both molecules are found, this indicates a leaky gut. If low levels of both molecules are found, this indicates a general malabsorption of all nutrients.

Get the word of drug information

It is important to remember that research on leaky gut syndrome is limited. It is also important to note that self-medication for a disease and avoiding or delaying standard treatment can have serious consequences. If you have any symptoms or are concerned about your health, be sure to check with your doctor.

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