Full text biomedical articles

Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children

Amy McTague, Timothy Martland, Richard Appleton, Cochrane Epilepsy Group
Cochrane Database Syst Rev. 2018 Jan; 2018(1): CD001905. Published online 2018 Jan 10. doi: 10.1002/14651858.CD001905.pub3


Article   |   PubReader   |   PDF–941K   |   Cite

Population Pharmacokinetics and Exploratory Pharmacodynamics of Lorazepam in Pediatric Status Epilepticus

Daniel Gonzalez, James M. Chamberlain, Jeffrey T. Guptill, Michael Cohen-Wolkowiez, Barrie Harper, Jian Zhao, Edmund V. Capparelli
Clin Pharmacokinet. Author manuscript; available in PMC 2018 Aug 1.
Published in final edited form as: Clin Pharmacokinet. 2017 Aug; 56(8): 941–951. doi: 10.1007/s40262-016-0486-0


Article   |   PubReader   |   PDF–744K   |   Cite

GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations

Karol Ramirez, Anzela Niraula, John F. Sheridan
Brain Behav Immun. Author manuscript; available in PMC 2017 Jan 1.
Published in final edited form as: Brain Behav Immun. 2016 Jan; 51: 154–168. Published online 2015 Sep 3. doi: 10.1016/j.bbi.2015.08.011


Article   |   PubReader   |   PDF–661K   |   Cite

Effects of lorazepam and baclofen on short‐ and long‐latency afferent inhibition

Claudia V. Turco, Jenin El‐Sayes, Mitchell B. Locke, Robert Chen, Steven Baker, Aimee J. Nelson
J Physiol. 2018 Nov 1; 596(21): 5267–5280. Published online 2018 Oct 3. doi: 10.1113/JP276710


Article   |   PubReader   |   PDF–1.3M   |   Cite

Drug therapy for delirium in terminally ill adults

Anne M Finucane, Louise Jones, Baptiste Leurent, Elizabeth L Sampson, Patrick Stone, Adrian Tookman, Bridget Candy, Cochrane Pain, Palliative and Supportive Care Group
Cochrane Database Syst Rev. 2020 Jan; 2020(1): CD004770. Published online 2020 Jan 21. doi: 10.1002/14651858.CD004770.pub3


Article   |   PubReader   |   PDF–861K   |   Cite

Adverse performance effects of acute lorazepam administration in elderly long-term users: pharmacokinetic and clinical predictors

Nunzio Pomara, Sang Han Lee, Davide Bruno, Timothy Silber, David J. Greenblatt, Eva Petkova, John J. Sidtis
Prog Neuropsychopharmacol Biol Psychiatry. Author manuscript; available in PMC 2016 Jan 2.
Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2; 0: 129–135. Published online 2014 Sep 6. doi: 10.1016/j.pnpbp.2014.08.014


Article   |   PubReader   |   PDF–487K   |   Cite

Anticonvulsant therapy for status epilepticus

Manya Prasad, Pudukode R Krishnan, Reginald Sequeira, Khaldoon Al‐Roomi, Cochrane Epilepsy Group
Cochrane Database Syst Rev. 2014 Sep; 2014(9): CD003723. Published online 2014 Sep 10. doi: 10.1002/14651858.CD003723.pub3


Article   |   PubReader   |   PDF–631K   |   Cite

Potential prediction of formulation performance in paediatric patients using biopharmaceutical tools and simulation of clinically relevant administration scenarios of nifedipine and lorazepam

Anna C. Van der Vossen, Lidwien M. Hanff, Arnold G. Vulto, Nikoletta Fotaki
Br J Clin Pharmacol. 2019 Aug; 85(8): 1728–1739. Published online 2019 Jun 18. doi: 10.1111/bcp.13956


Article   |   PubReader   |   PDF–1.3M   |   Cite

The central nervous system effects of the partial GABA-Aα2,3-selective receptor modulator AZD7325 in comparison with lorazepam in healthy males

Xia Chen, Gabriël Jacobs, Marieke de Kam, Judith Jaeger, Jaakko Lappalainen, Paul Maruff, Mark A Smith, Alan J Cross, Adam Cohen, Joop van Gerven
Br J Clin Pharmacol. 2014 Dec; 78(6): 1298–1314. Published online 2014 Nov 20. doi: 10.1111/bcp.12413


Article   |   PubReader   |   PDF–2.9M   |   Cite

Effect of Lorazepam With Haloperidol vs Haloperidol Alone on Agitated Delirium in Patients With Advanced Cancer Receiving Palliative Care: A Randomized Clinical Trial

David Hui, Susan Frisbee-Hume, Annie Wilson, Seyedeh S. Dibaj, Thuc Nguyen, Maxine De La Cruz, Paul Walker, Donna S. Zhukovsky, Marvin Delgado-Guay, Marieberta Vidal, Daniel Epner, Akhila Reddy, Kimerson Tanco, Janet Williams, Stacy Hall, Diane Liu, Kenneth Hess, Sapna Amin, William Breitbart, Eduardo Bruera
JAMA. Author manuscript; available in PMC 2017 Oct 30.
Published in final edited form as: JAMA. 2017 Sep 19; 318(11): 1047–1056. doi: 10.1001/jama.2017.11468


Article   |   PubReader   |   PDF–424K   |   Cite

Formulation and Optimization of Polymeric Nanoparticles for Intranasal Delivery of Lorazepam Using Box-Behnken Design: In Vitro and In Vivo Evaluation

Deepak Sharma, Dipika Maheshwari, Gilphy Philip, Ravish Rana, Shanu Bhatia, Manisha Singh, Reema Gabrani, Sanjeev K. Sharma, Javed Ali, Rakesh Kumar Sharma, Shweta Dang
Biomed Res Int. 2014; 2014: 156010. Published online 2014 Jul 14. doi: 10.1155/2014/156010


Article   |   PubReader   |   PDF–2.6M   |   Cite

Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit

Yan Li, Jun Ma, Yinghui Jin, Nan Li, Rui Zheng, Wei Mu, Jiaying Wang, Jin Hua Si, Jing Chen, Hong Cai Shang, Cochrane Dementia and Cognitive Improvement Group
Cochrane Database Syst Rev. 2020 Feb; 2020(2): CD012670. Published online 2020 Feb 28. doi: 10.1002/14651858.CD012670.pub2


Article   |   PubReader   |   PDF–519K   |   Cite

Lorazepam challenge for individuals at varying genetic risk for Alzheimer’s disease

Cynthia M. Stonnington, Brian Harel, Dona E.C. Locke, Joseph G. Hentz, Nan Zhang, Paul Maruff, Richard J. Caselli
Alzheimer Dis Assoc Disord. Author manuscript; available in PMC 2018 Oct 1.
Published in final edited form as: Alzheimer Dis Assoc Disord. 2017 Oct-Dec; 31(4): 271–277. doi: 10.1097/WAD.0000000000000200


Article   |   PubReader   |   PDF–387K   |   Cite

Pharmacokinetic Evaluation of Intranasally Administered Vinyl Polymer-Coated Lorazepam Microparticles in Rabbits

Yanjun Zhao, Marc B. Brown, Rajeshree H. Khengar, Matthew J. Traynor, Pedro Barata, Stuart A. Jones
AAPS J. 2012 Jun; 14(2): 218–224. Published online 2012 Mar 1. doi: 10.1208/s12248-012-9325-x


Article   |   PubReader   |   PDF–145K   |   Cite

Dissociated effects of diazepam and lorazepam on short-latency afferent inhibition

Vincenzo Di Lazzaro, Fabio Pilato, Michele Dileone, Pietro A Tonali, Ulf Ziemann
J Physiol. 2005 Nov 15; 569(Pt 1): 315–323. Published online 2005 Sep 1. doi: 10.1113/jphysiol.2005.092155


Article   |   PubReader   |   PDF–181K   |   Cite

Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients

Eleonora L Swart, Klaas P Zuideveld, Joost de Jongh, Meindert Danhof, Lambertus G Thijs, Robert M J Strack van Schijndel
Br J Clin Pharmacol. 2004 Feb; 57(2): 135–145. doi: 10.1046/j.1365-2125.2003.01957.x


Article   |   PubReader   |   PDF–231K   |   Cite

Effects of lorazepam on short latency afferent inhibition and short latency intracortical inhibition in humans

V Di Lazzaro, A Oliviero, E Saturno, M Dileone, F Pilato, R Nardone, F Ranieri, G Musumeci, T Fiorilla, P Tonali
J Physiol. 2005 Apr 15; 564(Pt 2): 661–668. Published online 2005 Feb 17. doi: 10.1113/jphysiol.2004.061747


Article   |   PubReader   |   PDF–147K   |   Cite

Haloperidol plus promethazine for psychosis‐induced aggression

Gisele Huf, Jacob Alexander, Pinky Gandhi, Michael H Allen, Cochrane Schizophrenia Group
Cochrane Database Syst Rev. 2016 Nov; 2016(11): CD005146. Published online 2016 Nov 25. doi: 10.1002/14651858.CD005146.pub3


Article   |   PubReader   |   PDF–1.2M   |   Cite

Pharmacokinetic-pharmacodynamic analysis of mnesic effects of lorazepam in healthy volunteers

O Blin, A Jacquet, S Callamand, E Jouve, M Habib, D Gayraud, A Durand, B Bruguerolle, P Pisano
Br J Clin Pharmacol. 1999 Oct; 48(4): 510–512. doi: 10.1046/j.1365-2125.1999.00047.x


Article   |   PubReader   |   PDF–128K   |   Cite

The pharmacokinetics of intravenous lorazepam in pediatric patients with and without status epilepticus

James M. Chamberlain, Edmund V. Capparelli, Kathleen M. Brown, Cheryl W. Vance, Kathleen Lillis, Prashant Mahajan, Richard Lichenstein, Rachel M. Stanley, Colleen O. Davis, Stephen Gordon, Jill M. Baren, John N. van den Anker
J Pediatr. Author manuscript; available in PMC 2013 Apr 1.
Published in final edited form as: J Pediatr. 2012 Apr; 160(4): 667–672.e2. Published online 2011 Nov 1. doi: 10.1016/j.jpeds.2011.09.048


Article   |   PubReader   |   PDF–605K   |   Cite