Clinical Trials

Catatonia in Nodding Syndrome and Lorazepam Treatment

Conditions:   Catatonia;   Nodding Syndrome
Intervention:   Drug: Lorazepam
Sponsors:   Makerere University;   University of Mississippi Medical Center

Wed, 03 Jun 2015 12:00:00 EDT

Phenobarbital vs Ativan for Alcohol Withdrawal in the Intensive Care Unit

Conditions:   Alcohol Withdrawal;   Alcohol Withdrawal Delirium
Interventions:   Drug: Phenobarbital;   Drug: Lorazepam
Sponsor:   OSF Healthcare System

Thu, 07 Nov 2019 12:00:00 EST

Lorazepam for the Treatment of Status Epilepticus or Repetitive Status Epilepticus in Japan

Condition:   Status Epilepticus
Intervention:   Drug: Lorazepam
Sponsor:   Pfizer

Fri, 12 Sep 2014 12:00:00 EDT

The Cognitive Effects of Lorazepam in Healthy Older Individuals With TOMM40 Variable-length Polymorphisms

Condition:   Alzheimer's Disease (AD)
Intervention:   Drug: lorazepam
Sponsor:   Mayo Clinic

Thu, 31 Jan 2013 12:00:00 EST

Inhaled Loxapine vs Intramuscular (IM) Haloperidol + Lorazepam for Agitation

Conditions:   Agitation,Psychomotor;   Haloperidol Causing Adverse Effects in Therapeutic Use;   Lorazepam Causing Adverse Effects in Therapeutic Use;   Loxapine Causing Adverse Effects in Therapeutic Use
Interventions:   Drug: Haloperidol + lorazepam;   Drug: Loxapine
Sponsors:   University of Arkansas;   Mount Sinai Hospital, Chicago

Wed, 12 Apr 2017 12:00:00 EDT

Benzodiazepines for the Reduction of Distress and Pain During and After Emergency Department Care

Condition:   Acute Pain
Interventions:   Drug: Placebos;   Drug: Lorazepam
Sponsors:   Maria Pacella;   University of Pittsburgh Physicians;   The UPMC Mercy Emergency Medicine Fund

Wed, 28 Nov 2018 12:00:00 EST

Lorazepam Effects on Neuroimaging Measures

Conditions:   Lorazepam;   Neuroimaging
Interventions:   Drug: Lorazepam 1Mg Tablet;   Drug: Placebo
Sponsor:   Northwell Health
Not yet recruiting

Thu, 17 Dec 2020 12:00:00 EST

Effects of Pentazocine Versus Lorazepam on Manic Symptoms

Conditions:   Bipolar Disorder;   Schizoaffective Disorder;   Manic Disorder;   Mania;   Manic State
Interventions:   Drug: Pentazocine;   Drug: Lorazepam
Sponsors:   Mclean Hospital;   Stanley Medical Research Institute

Mon, 05 Feb 2007 12:00:00 EST

Efficacy and Safety Study Comparing Lorazepam and Diazepam for Children in the Emergency Department With Seizures (Status 2)

Condition:   Status Epilepticus
Intervention:   Drug: lorazepam or diazepam
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Fri, 22 Feb 2008 12:00:00 EST

Effect of A Single Dose of Lorazepam on Salivary Cortisol Response in Children Undergoing Digestive Endoscopy:

Condition:   Anxiety
Interventions:   Drug: Lorazepam;   Other: Placebo
Sponsor:   St. Justine's Hospital

Thu, 08 Jun 2017 12:00:00 EDT

Fasting Study of Lorazepam Tablets 2 mg and Ativan Tablets 2 mg

Condition:   Healthy
Interventions:   Drug: Lorazepam Tablets 2 mg;   Drug: Ativan Tablets 2 mg
Sponsor:   Mylan Pharmaceuticals

Tue, 01 Apr 2008 12:00:00 EDT

Lorazepam Sedation for Critically Ill Children

Condition:   Critical Illness
Interventions:   Drug: Lorazepam;   Drug: Midazolam;   Drug: Lorazepam CI
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   Case Western Reserve University;   The Emmes Company, LLC

Thu, 28 Apr 2005 12:00:00 EDT

Intramuscular (IM) Olanzapine Versus IM Haloperidol Plus Lorazepam for Acute Agitation in Schizophrenia

Conditions:   Schizophrenia;   Schizoaffective Disorder;   Agitation
Interventions:   Drug: IM olanzapine;   Drug: IM haloperidol plus lorazepam
Sponsors:   National Taiwan University Hospital;   Yu-Li Hospital

Tue, 25 Nov 2008 12:00:00 EST

Disulfiram Combined With Lorazepam for Alcohol Dependence and Anxiety Disorder

Conditions:   Alcohol Dependence;   Anxiety Disorder
Intervention:   Drug: disulfiram plus lorazepam
Sponsors:   University of New Mexico;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Thu, 24 Jul 2008 12:00:00 EDT

Lorazepam for the Analgosedation of Pediatric Patients in Mechanical Ventilation.

Condition:   Analgesia
Intervention:   Drug: Lorazepam 4 mg/ml
Sponsors:   Bambino Gesù Hospital and Research Institute;   Ministero della Salute, Italy;   University College, London
Not yet recruiting

Fri, 27 Nov 2020 12:00:00 EST

GHB Withdrawal Symptoms and Effectiveness of Treatment With Lorazepam Versus Pentobarbital - 1

Condition:   Substance-Related Disorders
Interventions:   Drug: Lorazepam;   Drug: Pentobarbital
Sponsors:   University of California, Los Angeles;   National Institute on Drug Abuse (NIDA)

Mon, 25 Jul 2005 12:00:00 EDT

Effect of Additive Lorazepam on Patient Satisfaction as a Premedication in Diagnostic Flexible Bronchoscopy

Condition:   Patient Satisfaction for Bronchoscopy
Interventions:   Drug: Lorazepam;   Drug: Control
Sponsor:   Seoul National University Hospital
Unknown status

Wed, 12 May 2010 12:00:00 EDT

Treatment of Alcohol Withdrawal in Hospital Patients

Condition:   Alcohol Withdrawal Syndrome
Interventions:   Drug: Lorazepam (drug);   Drug: Lorazepam
Sponsors:   Virginia Commonwealth University;   National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Mon, 07 Nov 2005 12:00:00 EST

LORA-PITA IV General Investigation

Condition:   Status Epilepticus
Intervention:   Drug: Lorazepam
Sponsor:   Pfizer

Fri, 05 Apr 2019 12:00:00 EDT

Phase 1 Study to Characterize the Safety and Pharmacokinetics of Single Intravenous Dose of Lorazepam in Healthy Japanese Adult Subjects

Condition:   Healthy
Interventions:   Drug: Lorazepam;   Drug: Placebo
Sponsor:   Pfizer

Tue, 26 Nov 2013 12:00:00 EST

Effects of Oxytocin and Lorazepam on Fear-related Intra-amygdalar Activity

Condition:   Oxytocin, Lorazepam, Anti-Anxiety Agents, Physiological Effects of Drugs
Interventions:   Drug: Oxytocin;   Drug: Lorazepam 1 mg;   Drug: Placebo nasalspray;   Drug: Placebo Oral Tablet
Sponsor:   University Hospital, Bonn

Mon, 04 Feb 2019 12:00:00 EST

Nasal Versus Venous Lorazepam for Control of Acute Seizures in Children

Conditions:   Status Epilepticus;   Seizures
Intervention:   Drug: Lorazepam
Sponsor:   All India Institute of Medical Sciences, New Delhi

Fri, 15 Aug 2008 12:00:00 EDT

Seizure Therapy With Intravenous Levetiracetam and Lorazepam

Condition:   Seizures
Interventions:   Drug: Levetiracetam 1 g IV + Lorazepam 2 mg IV;   Drug: Placebo + Lorazepam 3 mg IV
Sponsors:   Massachusetts General Hospital;   UCB Pharma

Tue, 24 Apr 2007 12:00:00 EDT

A Study of the Effect of LY2216684 on Lorazepam

Condition:   Major Depressive Disorder
Interventions:   Drug: LY2216684;   Drug: Placebo;   Drug: Lorazepam
Sponsor:   Eli Lilly and Company

Wed, 12 Jan 2011 12:00:00 EST

Promethazine vs. Lorazepam for Treatment of Vertigo

Condition:   Peripheral Vertigo.
Interventions:   Drug: Promethazine;   Drug: Lorazepam
Sponsor:   Shahid Beheshti University of Medical Sciences

Tue, 09 Apr 2013 12:00:00 EDT

ADASUVE-Lorazepam Drug-Drug Interaction

Condition:   Healthy Volunteers
Interventions:   Drug: Lorazepam 1 mg IM;   Drug: Inhaled loxapine 10 mg;   Drug: Inhaled Placebo;   Drug: Placebo IM
Sponsor:   Alexza Pharmaceuticals, Inc.

Fri, 14 Jun 2013 12:00:00 EDT

Clinical Study Assessing a New Scale to Measure Onset of Action in Generalized Anxiety Disorder

Condition:   Anxiety Disorders
Interventions:   Drug: lorazepam;   Drug: placebo;   Drug: paroxetine
Sponsor:   Pfizer

Tue, 15 Jul 2008 12:00:00 EDT

Lorazepam for the Treatment of Status Epilepticus in Children

Condition:   Status Epilepticus
Intervention:   Drug: lorazepam
Sponsors:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   The Emmes Company, LLC

Thu, 16 Jun 2005 12:00:00 EDT

Randomized Trial Comparing 3 Routes of Delivering Lorazepam to Children.

Conditions:   Status Epilepticus;   Convulsions
Intervention:   Drug: Lorazepam
Sponsor:   University of Malawi College of Medicine

Thu, 22 Jun 2006 12:00:00 EDT

Oral Sedation During Cervical Dilator Placement

Condition:   Oral Sedation and Cervical Dilator Pain
Interventions:   Drug: Oxycodone and Lorazepam (Active Comparator);   Drug: Placebo Comparator
Sponsors:   Johns Hopkins University;   Society of Family Planning

Wed, 28 Jun 2017 12:00:00 EDT

Treatment of Adolescent Antimuscarinic (Anticholinergic) Toxidrome

Condition:   Anticholinergics Toxicity
Interventions:   Drug: Physostigmine;   Drug: Lorazepam
Sponsors:   University of Colorado, Denver;   American Academy of Clinical Toxicology

Mon, 27 Mar 2017 12:00:00 EDT

Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol Gel in Healthy Volunteers

Condition:   Healthy
Interventions:   Drug: lorazepam;   Drug: diphenhydramine hydrochloride;   Drug: haloperidol;   Other: questionnaire administration;   Other: laboratory biomarker analysis
Sponsors:   Virginia Commonwealth University;   National Cancer Institute (NCI);   American Cancer Society, Inc.

Fri, 17 Sep 2010 12:00:00 EDT

Lorazepam-Induced Toxicity in the Aged

Conditions:   Anxiety Disorders;   Generalized Anxiety Disorder
Intervention:   Drug: Lorazepam
Sponsors:   Nathan Kline Institute for Psychiatric Research;   National Institute of Mental Health (NIMH)

Thu, 05 Sep 2002 12:00:00 EDT

A Sedation/Cognition/EEG Study Using AZD6280 and Comparator

Condition:   Healthy Volunteer
Interventions:   Drug: AZD6280;   Drug: Lorazepam;   Drug: Placebo
Sponsor:   AstraZeneca

Thu, 11 Sep 2008 12:00:00 EDT

Exploring the Effects of Diazepam and Lorazepam

Condition:   Healthy Subjects
Interventions:   Drug: Diazepam;   Drug: Lorazepam;   Drug: placebo
Sponsor:   University Hospital, Strasbourg, France

Thu, 12 Jun 2008 12:00:00 EDT

Evaluation of the Effects of Etifoxine 100 mg and Lorazepam 2 mg on Vigilance and Cognitive Functions in the Elderly

Condition:   Healthy Volunteers
Interventions:   Drug: etifoxine;   Drug: lorazepam;   Drug: Placebo
Sponsor:   Biocodex

Mon, 26 May 2014 12:00:00 EDT

Multi-modal Assessment of Gamma-aminobutyric Acid (GABA) Function in Psychosis

Conditions:   Schizophrenia;   Bipolar Disorder;   Healthy;   Psychosis;   Schizophreniform Disorders;   Schizo Affective Disorder
Interventions:   Other: Placebo and fMRI;   Drug: Lorazepam and fMRI
Sponsors:   University of Michigan;   National Institute of Mental Health (NIMH)

Tue, 02 Jul 2019 12:00:00 EDT

Haloperidol and Lorazepam for Delirium in Patients With Advanced Cancer

Condition:   Advanced Cancers
Interventions:   Drug: Lorazepam;   Drug: Placebo;   Drug: Haloperidol decanoate;   Behavioral: Questionnaires
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting

Tue, 24 Sep 2013 12:00:00 EDT

Acute Effect of Lorazepam on Brain Activity Measured by Magnetoencephalograpy (MEG) and Electroencephalography (EEG)

Condition:   Healthy Subjects
Interventions:   Drug: Lorazepam;   Drug: Placebo
Sponsor:   Orasi Medical, Inc.
Unknown status

Mon, 10 Jan 2011 12:00:00 EST

Comparison Between Lorazepam, Clonazepam and Clonazepam + Fosphenytoin for the Treatment of Out-of-hospital Generalized Status Epilepticus

Conditions:   Status Epilepticus;   Epilepsy
Interventions:   Drug: Clonazepam;   Drug: Fosphenytoin;   Drug: Placebo;   Drug: Lorazepam
Sponsor:   Assistance Publique - Hôpitaux de Paris

Wed, 05 Jun 2013 12:00:00 EDT

EDG004 Treatment of Adult Patients With Generalized Anxiety Disorder (GAD)

Condition:   Generalized Anxiety Disorder (GAD)
Interventions:   Drug: Extended-release lorazepam;   Drug: Placebo
Sponsor:   Edgemont Pharmaceuticals, LLC

Wed, 03 Dec 2014 12:00:00 EST

Clobazam Use in Epilepsia Partialis Continua - Pilot Study

Conditions:   Epilepsia Partialis Continua;   Kojewnikov's Epilepsy;   Epilepsy
Interventions:   Drug: Clobazam;   Drug: Clonazepam;   Drug: Lorazepam
Sponsors:   The Cooper Health System;   Lundbeck LLC

Fri, 09 May 2014 12:00:00 EDT

Therapeutic Hypothermia With Propofol in Survival and Neurological Prognoses After Cardiac Arrest

Conditions:   Hypothermia;   Cardiac Arrest
Interventions:   Drug: Propofol;   Drug: Lorazepam
Sponsor:   Far Eastern Memorial Hospital
Unknown status

Fri, 20 Feb 2015 12:00:00 EST

A Multi-level Life-span Characterization of Adult-depression and Effects of Medication and Exercise

Conditions:   Depression;   Depressive Disorder, Major;   Depressive Disorder;   Unipolar Depression;   Major Depressive Disorder
Interventions:   Drug: Venlafaxine XR;   Other: Aerobic Exercise;   Drug: Lorazepam
Sponsor:   Kirk Erickson, PhD

Fri, 03 Apr 2015 12:00:00 EDT

Diphenhydramine, Lorazepam, and Dexamethasone in Treating Nausea and Vomiting Caused By Chemotherapy

Conditions:   Nausea;   Vomiting;   Unspecified Childhood Solid Tumor, Protocol Specific
Interventions:   Drug: Decadron®;   Drug: Benadryl®;   Drug: Ativan®;   Drug: ondansetron hydrochloride
Sponsors:   University of South Florida;   National Cancer Institute (NCI)

Thu, 01 Feb 2007 12:00:00 EST

EEG (Electroencephalogram) Platform Standardization in Healthy Male Subjects (3134-010)

Condition:   Dementia
Interventions:   Drug: MK3134;   Drug: Comparator: Lorazepam;   Drug: Comparator: Placebo
Sponsor:   Merck Sharp & Dohme Corp.

Mon, 26 Apr 2010 12:00:00 EDT

A Study to Investigate the Effects of GW876008 on Brain Activation During Emotional Processing in Healthy Subjects.

Condition:   Healthy Subjects
Interventions:   Drug: placebo;   Drug: lorazepam;   Drug: GW876008
Sponsor:   GlaxoSmithKline

Fri, 19 Jan 2007 12:00:00 EST

Resistance Under the Microscope

Condition:   Anxiety
Interventions:   Drug: Lorazepam;   Drug: NaCl 0.9% (Sodium Chloride)
Sponsor:   Erasmus Medical Center

Wed, 28 Sep 2011 12:00:00 EDT

MENDS Study: Trial in Ventilated ICU Patients Comparing an Alpha2 Agonist Versus a Gamma Aminobutyric Acid (GABA)-Agonist to Determine Delirium Rates, Efficacy of Sedation, Analgesia and Discharge Cognitive Status

Condition:   Delirium
Interventions:   Drug: Dexmedetomidine;   Drug: Lorazepam
Sponsor:   Vanderbilt University

Tue, 02 Nov 2004 12:00:00 EST

Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care

Conditions:   Delirium;   Locally Advanced Malignant Neoplasm;   Metastatic Malignant Neoplasm;   Recurrent Malignant Neoplasm
Interventions:   Drug: Haloperidol;   Drug: Lorazepam;   Other: Placebo;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)

Fri, 16 Nov 2018 12:00:00 EST

Assessment of Valproate on Ethanol Withdrawal

Conditions:   Alcohol Dependence;   Alcohol Withdrawal Syndrome;   Trauma;   Heavy Drinking;   Alcohol Use Disorder
Interventions:   Drug: Valproate;   Drug: Lorazepam
Sponsor:   CAMC Health System
Unknown status

Tue, 01 Aug 2017 12:00:00 EDT

Psilocybin for Treatment of Obsessive Compulsive Disorder

Condition:   Obsessive-compulsive Disorder (OCD)
Interventions:   Drug: Psilocybin 100 mcg/kg;   Drug: Psilocybin 300 mcg/kg;   Drug: Lorazepam 1 mg
Sponsor:   University of Arizona
Active, not recruiting

Wed, 04 Oct 2017 12:00:00 EDT

PF-06372865 in Subjects With Photosensitive Epilepsy

Condition:   Reflex Epilepsy, Photosensitive
Interventions:   Drug: PF-06372865;   Drug: Placebo;   Drug: Lorazepam
Sponsor:   Pfizer

Wed, 30 Sep 2015 12:00:00 EDT

Alcohol Withdrawal Syndrome Treated With Adjunctive Phenobarbital or Ketamine

Condition:   Alcohol Withdrawal Syndrome
Interventions:   Drug: Ketamine;   Drug: Phenobarbital;   Drug: Lorazepam;   Drug: Placebo A;   Drug: Placebo B
Sponsor:   Santa Barbara Cottage Hospital

Fri, 28 Dec 2018 12:00:00 EST

The Comparison of Stress Response to Rapid Opioid Detoxification Applying Different Methods of Opioid Antagonism

Condition:   Opiate Addiction
Interventions:   Drug: Naltrexone;   Drug: Clonidine;   Drug: Lorazepam
Sponsor:   Vilnius University

Thu, 12 Feb 2015 12:00:00 EST

A Study to Assess the Efficacy and Safety of Brivaracetam as Treatment for Increased Seizure Activity in an Epilepsy Monitoring Unit Setting

Condition:   Epilepsy
Interventions:   Drug: Brivaracetam;   Drug: Lorazepam
Sponsor:   UCB Biopharma S.P.R.L.

Fri, 13 Jan 2017 12:00:00 EST

A Sedation/Cognition/Electroencephalogram (EEG) Study Using AZD7325 and Comparator.

Condition:   Healthy Volunteer
Interventions:   Drug: AZD7325;   Drug: Lorazepam
Sponsor:   AstraZeneca

Tue, 22 Jul 2008 12:00:00 EDT

Paramedic Treatment of Prolonged Seizures by Intramuscular Versus Intravenous Anticonvulsant Medications

Condition:   Status Epilepticus
Interventions:   Drug: Intramuscular route of active treatment;   Drug: Intravenous route of active treatment
Sponsors:   Robert Silbergleit;   Medical University of South Carolina;   University of California, San Francisco;   National Institute of Neurological Disorders and Stroke (NINDS)

Wed, 17 Dec 2008 12:00:00 EST

Sedative Premedication: Efficacy On Patient Experience

Condition:   Perioperative Anxiety
Interventions:   Drug: Lorazepam;   Other: no premedication;   Drug: Placebo (microcrystalline celluloses)
Sponsor:   Assistance Publique Hopitaux De Marseille

Wed, 17 Jul 2013 12:00:00 EDT

Explanation About Sleep in Post Trauma Patients

Conditions:   Post Traumatic Stress Disorder;   Sleep Deprivation
Interventions:   Behavioral: Explanation encouraging sleep;   Behavioral: Explanation discouraging sleep;   Drug: Lorazepam
Sponsor:   Sheba Medical Center
Unknown status

Wed, 12 Sep 2012 12:00:00 EDT

Prodrome-Based Early Intervention With Antipsychotics vs. Benzodiazepines in First-Episode Schizophrenia

Conditions:   Schizophrenia;   Psychoses
Intervention:   Drug: antipsychotics vs. Lorazepam (Drugs)
Sponsors:   Heinrich-Heine University, Duesseldorf;   German Federal Ministry of Education and Research;   German Research Network On Schizophrenia;   Janssen-Cilag Ltd.;   University of Bonn;   Humboldt-Universität zu Berlin;   Ludwig-Maximilians - University of Munich;   University of Göttingen;   University of Cologne;   Mainz University;   University Hospital Tuebingen;   Universität Duisburg-Essen;   University of Mannheim;   University of Jena;   Martin-Luther-Universität Halle-Wittenberg;   RWTH Aachen University;   University of Wuerzburg

Mon, 12 Sep 2005 12:00:00 EDT

SPECT Investigation Of The NMDA Receptor System In Healthy Volunteers And Patients With Schizophrenia

Condition:   Schizophrenia
Interventions:   Drug: [123]I-CNS 1261;   Drug: Lorazepam;   Drug: Risperidone
Sponsor:   GlaxoSmithKline

Tue, 15 Aug 2006 12:00:00 EDT

Proof of Concept in Patients With Generalized Anxiety Disorder (GAD)AZD7325

Condition:   Anxiety Disorders
Interventions:   Drug: AZD7325;   Drug: Lorazepam;   Drug: Placebo
Sponsor:   AstraZeneca

Mon, 15 Dec 2008 12:00:00 EST

Characterizing and Predicting Drug Effects on Cognition

Condition:   Cognitive Deficits
Interventions:   Drug: Lorazepam;   Other: Placebo;   Drug: Topiramate 100mg;   Drug: Topiramate 150mg;   Drug: Topiramate 200mg
Sponsor:   University of Minnesota

Fri, 28 Jun 2013 12:00:00 EDT

Acute Effect of Three Neuroactive Drugs Measured by Magnetoencephalography (MEG), Electroencephalography (EEG) and the Synchronous Neural Interaction Test

Condition:   Healthy
Interventions:   Drug: modafinil;   Drug: methylphenidate;   Drug: lorazepam;   Drug: placebo
Sponsor:   Orasi Medical, Inc.

Wed, 09 Sep 2009 12:00:00 EDT

Analgesia for Endometrial Scratching

Conditions:   Subfertility;   Infertility
Interventions:   Drug: Ibuprofen 600 mg;   Drug: Lorazepam 1 mg;   Drug: Placebo
Sponsor:   University of Sao Paulo

Thu, 11 Aug 2016 12:00:00 EDT

A Study To Investigate Effects Of GSK561679 On Brain Activation During Emotional Processing In Healthy Volunteers

Condition:   Depressive Disorder and Anxiety Disorders
Intervention:   Drug: single dose
Sponsor:   GlaxoSmithKline

Wed, 08 Aug 2007 12:00:00 EDT

Effects of H1-Antagonist on Cognition

Condition:   Cognition
Intervention:   Drug: dexchlorpheniramine, lorazepam
Sponsor:   Maastricht University Medical Center

Thu, 19 Feb 2009 12:00:00 EST

Developing Individualized Strategies to Prevent Nausea and Vomiting

Conditions:   Postoperative Nausea and Vomiting;   Genetic Polymorphisms
Interventions:   Drug: Ondansetron;   Drug: Lorazepam;   Drug: Aprepitant
Sponsors:   University of California, San Francisco;   National Cancer Institute (NCI)

Wed, 13 Jul 2011 12:00:00 EDT

Meth-OD: A Study of IXT-m200 in Patients With Toxicity From Methamphetamine Overdose

Condition:   Methamphetamine Intoxication (Disorder)
Interventions:   Biological: IXT-m200;   Drug: Lorazepam;   Drug: Haloperidol
Sponsors:   InterveXion Therapeutics, LLC;   National Institute on Drug Abuse (NIDA)

Wed, 20 Jan 2021 12:00:00 EST

Benzodiazepine-free Anesthetic for Reduction of Delirium (B-Free)

Condition:   Post-operative Delirium
Interventions:   Drug: Benzodiazepine - limited use strategy;   Drug: Benzodiazepine - Ad libitum strategy
Sponsors:   McMaster University;   Hamilton Health Sciences Corporation

Wed, 15 Feb 2017 12:00:00 EST

Glutamatergic Modulation of Cocaine-related Deficits

Condition:   Cocaine Dependence
Interventions:   Drug: Ketamine 0.41 mg/kg;   Drug: Ketamine 0.71 mg/kg;   Drug: Lorazepam 2 mg
Sponsor:   New York State Psychiatric Institute

Wed, 13 Feb 2013 12:00:00 EST

Effect of Daily Interruption of Continuous Sedation on Delirium, Sleep Perception in Intensive Care Unit (ICU) Patients

Conditions:   Delirium;   Sleep Perception
Interventions:   Procedure: Normal continuous sedation;   Other: Daily interruption of continuous sedation
Sponsor:   University of California, San Francisco

Mon, 14 Jul 2008 12:00:00 EDT

Dextromethorphan to Treat Patients With Voice Spasms

Condition:   Voice Disorders
Interventions:   Drug: Dextromethorphan;   Drug: Lorazepam
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)

Wed, 05 Mar 2003 12:00:00 EST

Optimization of Procedural Sedation Protocol Used for Dental Care Delivery in People With Mental Disability

Condition:   Dental Care for Disabled
Interventions:   Drug: Midazolam Mylan;   Drug: Lorazepam Mylan;   Drug: Valium + Akineton + Dehydrobenzperidol + Atropine sulfate
Sponsor:   Universitaire Ziekenhuizen Leuven
Unknown status

Wed, 05 Mar 2014 12:00:00 EST

Study to Evaluate the Abuse Potential of AZD7325 in Healthy Recreational Central Nervous System (CNS) Depressant Users

Condition:   Recreational CNS Depressant Use
Interventions:   Drug: Lorazepam;   Drug: AZD7325;   Drug: Placebo
Sponsor:   AstraZeneca

Fri, 15 May 2009 12:00:00 EDT

Treating Alcohol Withdrawal With Oral Baclofen

Condition:   Alcohol Withdrawal Delirium
Interventions:   Drug: Baclofen;   Drug: Placebo;   Drug: Lorazepam
Sponsor:   Essentia Health

Fri, 18 Jan 2008 12:00:00 EST

A Study of Risperidone in Combination With Lorazepam Compared With Standard Therapy for Emergency Treatment of Schizophrenic Patients

Conditions:   Schizophrenia;   Psychotic Disorders;   Emergency Treatment
Intervention:   Drug: risperidone
Sponsor:   Janssen Pharmaceutica N.V., Belgium

Mon, 07 Nov 2005 12:00:00 EST

Blood Concentration in Lorazepam and Treatment in Adult Catatonia

Condition:   Catatonia
Sponsor:   University Hospital, Lille

Fri, 28 Aug 2020 12:00:00 EDT

Treatment Resistant Depression (Pilot)

Condition:   Depressive Disorder, Treatment-Resistant
Interventions:   Drug: Ketamine;   Drug: Clonidine;   Drug: placebo;   Drug: Scopolamine Transdermal Product;   Drug: lorazepam Injection
Sponsors:   Washington University School of Medicine;   Florida Atlantic University
Active, not recruiting

Tue, 10 Aug 2010 12:00:00 EDT

Comparing the Effectiveness of Oral Versus Intravenous Pain Medicine for Suction Curettage (D&C)

Condition:   Undesired Pregnancy
Intervention:   Drug: oxycodone + lorazepam versus fentanyl + midazolam
Sponsor:   Planned Parenthood League of Massachusetts

Fri, 16 Jun 2006 12:00:00 EDT

A Comparison Study of the Efficacy of Quetiapine and Haloperidol in Agitated Adults in Emergency Room

Condition:   Agitation
Interventions:   Drug: Quetiapine;   Drug: Haloperidol;   Drug: Lorazepam;   Drug: Cogentin
Sponsors:   University of Southern California;   AstraZeneca

Fri, 06 Apr 2007 12:00:00 EDT

Stanford Accelerated Recovery Trial (START)

Conditions:   Pain;   Breast Cancer;   Lung Cancer
Interventions:   Drug: Gabapentin;   Drug: Lorazepam (active control);   Drug: Placebo (inactive)
Sponsor:   Stanford University

Thu, 11 Feb 2010 12:00:00 EST

Randomized Trial of the Effectiveness of Topical "ABH Gel" vs. Placebo in Cancer Patients With Nausea

Conditions:   Nausea;   Vomiting
Interventions:   Drug: ABH gel;   Other: placebo
Sponsors:   Virginia Commonwealth University;   National Cancer Institute (NCI)

Mon, 19 Mar 2012 12:00:00 EDT

Clinical Study in Healthy Volunteers to Investigate the Neurocognitive Effects of a New Antiepileptic Drug: Brivaracetam

Condition:   Epilepsy
Interventions:   Drug: Brivaracetam;   Drug: levetiracetam;   Drug: lorazepam;   Other: placebo
Sponsor:   UCB Pharma

Mon, 18 Aug 2008 12:00:00 EDT

A First In Human Study In Healthy People To Evaluate Safety, Toleration, Pharmacokinetics and Pharmacodynamics of Single Oral Doses Of PF-06372865

Condition:   Healthy
Interventions:   Drug: PF-06372865 or Placebo;   Drug: PF-06372865 or Placebo or Lorazepam
Sponsor:   Pfizer

Thu, 26 Sep 2013 12:00:00 EDT

Nitrous Oxide for Pain Management During In-office Transcervical Sterilization

Conditions:   Contraception;   Inhalation of Nitrous Oxide
Interventions:   Procedure: In-office Transcervical Sterilization (Essure®);   Drug: Standard Oral pain medications;   Drug: Intramuscular Ketorolac;   Drug: Placebo pills;   Other: Oxygen;   Other: Nitrous Oxide
Sponsors:   University of New Mexico;   Society of Family Planning;   Bayer

Tue, 09 Dec 2014 12:00:00 EST

Safety and Efficacy Evaluation Of Pregabalin (Lyrica) With Patients With Generalized Anxiety Disorder

Condition:   Generalized Anxiety Disorder
Interventions:   Drug: Pregabalin;   Drug: Lorazepam;   Drug: Placebo
Sponsor:   Pfizer's Upjohn has merged with Mylan to form Viatris Inc.

Wed, 27 Feb 2008 12:00:00 EST

Allogeneic Stem Cell Transplantation (ALLOSCT) in Recessive Dystrophic Epidermolysis Bullosa (RDEB)

Condition:   Epidermolysis Bullosa
Interventions:   Drug: Palifermin;   Drug: Fludarabine;   Drug: Busulfan;   Drug: Lorazepam;   Drug: Alemtuzumab;   Drug: Tacrolimus
Sponsor:   Columbia University

Wed, 15 Apr 2009 12:00:00 EDT

Pharmacological Mechanisms of Low-intensity Focused Ultrasound for Motor Cortex Neuroplasticity

Condition:   Low Intensity Focussed Ultrasound
Interventions:   Drug: Carbamazepine;   Drug: Lorazepam;   Drug: Dextromethorphan;   Drug: Nimodipine;   Drug: Placebo
Sponsor:   University Health Network, Toronto

Fri, 11 Jun 2021 12:00:00 EDT

Hydrocodone For Pain Control in First Trimester Surgical Abortion

Condition:   Pain
Interventions:   Drug: Hydrocodone/acetaminophen;   Drug: Placebo;   Drug: Ibuprofen;   Drug: Lorazepam;   Drug: Lidocaine
Sponsors:   Elizabeth Micks;   Planned Parenthood Federation of America

Thu, 07 Apr 2011 12:00:00 EDT

Treating Benign Paroxysmal Positional Vertigo (BPPV) in ED Patients

Condition:   Benign Paroxysmal Positional Vertigo
Interventions:   Drug: Meclizine;   Other: Epley Maneuver;   Drug: Lorazepam;   Drug: Diphenhydramine;   Drug: Ondansetron
Sponsor:   Lehigh Valley Hospital

Mon, 24 Mar 2008 12:00:00 EDT

Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD)

Conditions:   Liver Fibrosis;   Alpha-1 Antitrypsin Deficiency;   AAT Deficiency;   AATD
Interventions:   Device: Abdominal ultrasound;   Procedure: History and physical;   Procedure: Intravenous catheter;   Procedure: Blood draw;   Other: Liver questionnaire;   Procedure: Liver Biopsy;   Drug: Midazolam;   Drug: Fentanyl;   Drug: Lidocaine;   Drug: Acetaminophen;   Drug: Lorazepam;   Drug: Oxycodone/Acetaminophen;   Drug: Ondansetron
Sponsor:   University of Florida

Wed, 13 Mar 2013 12:00:00 EDT

Assessment of Peripheral GABA Receptors for Local Pain Relief

Condition:   Pain
Interventions:   Drug: GABA oral solution;   Drug: Intramuscular GABA;   Drug: Pain modulation
Sponsor:   Aalborg University
Unknown status

Mon, 10 Oct 2016 12:00:00 EDT

Post Operative Pain Control After Pediatric Hip Surgery

Conditions:   Hip Surgery;   Post Operative Pain Control
Interventions:   Procedure: Lumbar Plexus Catheter;   Procedure: Lumbar Epidural Catheter;   Procedure: Patient Controlled Analgesia;   Drug: Fentanyl;   Drug: Morphine;   Drug: Lorazepam;   Drug: Ondansetron;   Drug: Diphenhydramine;   Drug: Acetaminophen;   Drug: Oxycodone;   Drug: Ropivacaine
Sponsors:   Seattle Children's Hospital;   Seattle Children's Research Institute Center for Clinical and Translational Research

Mon, 19 Feb 2018 12:00:00 EST

Biological Basis of Individual Variation in Social Cooperation

Condition:   Healthy
Interventions:   Drug: Intranasal Oxytocin (OT) 24 IU;   Drug: Intranasal Vasopressin (AVP);   Drug: Intranasal Placebo;   Drug: Intranasal Vasopressin (AVP) 40 IU;   Drug: Lorazepam
Sponsors:   Emory University;   National Institute of Mental Health (NIMH);   John Templeton Foundation

Thu, 29 Mar 2012 12:00:00 EDT

SM-1 vs. an Active Comparator in A Model of Transient Insomnia

Condition:   Transient Insomnia
Interventions:   Drug: SM-1;   Drug: Active Comparator
Sponsor:   Sequential Medicine Ltd
Not yet recruiting

Wed, 20 May 2020 12:00:00 EDT

Dexmedetomidine (Precedex®) for Severe Alcohol Withdrawal Syndrome (AWS) and Alcohol Withdrawal Delirium (AWD)

Conditions:   Alcohol Withdrawal Delirium;   Alcohol Withdrawal Associated Autonomic Hyperactivity;   Alcohol Withdrawal Hallucinosis;   Alcohol Withdrawal-Induced Delirium Tremens
Interventions:   Drug: Dexmedetomidine;   Drug: Placebos
Sponsor:   Denver Health and Hospital Authority

Mon, 30 May 2011 12:00:00 EDT

SM-1 vs 2 Comparators and Placebo in Participants With a History of Transient Insomnia.

Condition:   Transient Insomnia
Interventions:   Drug: SM-1;   Drug: D+Z;   Drug: D+L;   Drug: Placebo
Sponsor:   Sequential Medicine Ltd

Mon, 06 Nov 2017 12:00:00 EST

Naturalistic Adasuve Clinical Trial Study

Condition:   Agitation
Sponsors:   Mt Sinai Hospital, Chicago;   Teva Pharmaceuticals USA
Unknown status

Wed, 24 Aug 2016 12:00:00 EDT

Enteral Versus Intravenous Sedation in Critically Ill High-risk ICU Patients

Conditions:   Critical Illness;   Mechanical Ventilation Complication
Interventions:   Procedure: Enteral Sedation (EN);   Procedure: Control group: Intravenous Sedation (IV)
Sponsors:   University of Milan;   Ospedale San Paolo;   Ospedale Maggiore Policlinico Mangiagalli e Regina Elena;   Azienda Ospedaliera San Gerardo di Monza;   Azienda Ospedaliera Niguarda Cà Granda;   Azienda Ospedaliera Fatebenefratelli e Oftalmico;   IRCCS Policlinico S. Matteo;   San Luigi Gonzaga Hospital;   Ospedale S. Giovanni Bosco;   Ospedale Cardinal Massaia;   Azienda Ospedaliera, Ospedale Civile di Legnano;   Nuovo Ospedale Civile S.Agostino Estense
Unknown status

Wed, 25 May 2011 12:00:00 EDT

Nitrous Oxide for Pain Management of First Trimester Surgical Abortion

Condition:   Abortion in First Trimester
Intervention:   Other: Nitrous oxide administration
Sponsor:   University of New Mexico

Wed, 26 Mar 2014 12:00:00 EDT

Gabapentin for Alcohol Withdrawal Syndrome

Condition:   Alcohol Withdrawal Syndrome
Interventions:   Drug: Gabapentin;   Drug: Benzodiazepines;   Drug: Divalproex Sodium
Sponsor:   Mayo Clinic

Fri, 06 Jan 2017 12:00:00 EST

Pharmaco-Economic Study Of Ultiva In Intensive Care Unit(ICU)Subjects

Condition:   Sedation
Interventions:   Drug: midazolam;   Drug: lorazepam;   Drug: fentanyl;   Drug: morphine;   Drug: remifentanil;   Drug: propofol
Sponsor:   GlaxoSmithKline

Mon, 12 Sep 2005 12:00:00 EDT

GEM 1.5 mg b.i.d. to 4.5 mg b.i.d. Versus Lorazepam in GAD (0777-026)

Condition:   Anxiety Disorder
Intervention:   Drug: MK0777
Sponsor:   Merck Sharp & Dohme Corp.

Fri, 19 Oct 2007 12:00:00 EDT

How Your Patients' Non-REM Sleep Changes On Sedatives in the Intensive Care Units

Conditions:   Delirium;   Respiratory Failure
Interventions:   Drug: Dexmedetomidine;   Drug: GABA agonist
Sponsor:   Vanderbilt University Medical Center

Thu, 22 Jan 2009 12:00:00 EST

An Investigational Study to Assess Efficacy and Pattern of Use of SM-1 in Subjects With a History of Transient Insomnia

Condition:   Transient Insomnia
Interventions:   Drug: SM-1;   Drug: Placebo
Sponsor:   Sequential Medicine Ltd
Not yet recruiting

Thu, 09 Nov 2017 12:00:00 EST

Emesis Control Study in Non-Hodgkin Lymphoma Patients Receiving R-CHOP

Condition:   Lymphoma, Non-Hodgkin
Intervention:   Drug: Standard anti-emetics in conjunction with R-CHOP
Sponsors:   Australasian Leukaemia and Lymphoma Group;   Merck Sharp & Dohme Corp.
Unknown status

Wed, 01 May 2013 12:00:00 EDT

TELSTAR: Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation

Conditions:   Cardiac Arrest;   Anoxic Encephalopathy;   Status Epilepticus
Interventions:   Drug: Anti-epileptic drugs;   Other: No anti-epileptic drugs
Sponsors:   University of Twente;   Rijnstate Hospital;   Medisch Spectrum Twente;   Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA);   Radboud University;   University Medical Center Groningen;   St. Antonius Hospital;   VieCuri Medical Centre;   Université Libre de Bruxelles;   Maasstad Hospital
Active, not recruiting

Wed, 05 Feb 2014 12:00:00 EST

ERP N1 as a Treatment Predictor of Generalized Anxiety Disorder

Condition:   Generalized Anxiety Disorder
Intervention:   Drug: escitalopram
Sponsor:   Inje University

Tue, 12 Feb 2008 12:00:00 EST

Ziprasidone vs Standard Therapy for Agitated Patients in the ED

Conditions:   Psychosis;   Agitation;   Delirium
Interventions:   Drug: ziprasidone;   Drug: Standard therapy
Sponsors:   George Washington University;   Pfizer

Thu, 06 Nov 2008 12:00:00 EST

Efficacy and Safety of Umbilical Cord Blood Injection for Critical Limb Ischemia

Condition:   Critical Limb Ischemia
Intervention:   Biological: Cord blood stem cell injection
Sponsor:   Richard Burt, MD

Wed, 25 Nov 2009 12:00:00 EST

Phase II Trial of Stereotactic Radiosurgery Boost Following Surgical Resection for Brain Metastases

Conditions:   Brain Metastasis;   Bladder Cancer;   Breast Cancer;   Cervical Cancer;   Colon Cancer;   HEENT Cancer;   Lung Cancer;   Melanoma;   Pancreatic Cancer;   Prostate Cancer;   Rectal Cancer;   Sarcoma;   Testicular Cancer
Intervention:   Radiation: Stereotactic Radiosurgery
Sponsor:   Memorial Sloan Kettering Cancer Center

Tue, 08 Jan 2008 12:00:00 EST

The Use of Clonidine in Pain and Anxiety Associated With Acute Burn Injury in Children

Conditions:   Pain;   Anxiety
Interventions:   Drug: clonidine;   Drug: placebo
Sponsor:   The University of Texas Medical Branch, Galveston

Mon, 24 Dec 2007 12:00:00 EST

Intravenous Levetiracetam as First-line Anticonvulsive Treatment in Patients With Non-convulsive Status Epilepticus

Condition:   Status Epilepticus, Non-Convulsive
Intervention:   Drug: first-line i/v-levetiracetam
Sponsors:   University Hospital, Basel, Switzerland;   University Hospital, Basel, Switzerland, Dr. med. Stephan Rüegg, Neurology;   Clinical Trial Unit, University Hospital Basel, Switzerland

Mon, 28 Jan 2008 12:00:00 EST

Multi-day Doses in Prevention of Nausea and Emesis

Conditions:   Myeloma, Plasma-Cell;   Lymphoma, Malignant
Interventions:   Drug: Palonosetron;   Drug: Aprepitant;   Drug: Dexamethasone
Sponsors:   University of Kansas Medical Center;   Eisai Inc.

Fri, 25 Jan 2008 12:00:00 EST

Multimodal Analgesia Effect on Post Surgical Patient

Conditions:   Obesity, Morbid;   Surgery;   Bariatric Surgery Candidate
Interventions:   Drug: Neurontin;   Drug: Dilaudid Injectable Product;   Drug: Marcaine Injectable Product;   Drug: Oxycodone Hydrochloride;   Drug: Hycet 7.5Mg-325Mg/15Ml Solution;   Drug: Zofran Injection;   Drug: Scopolamine patch;   Drug: Ativan;   Drug: Flexeril Oral Product;   Drug: Tylenol Suspension
Sponsor:   University of California, Davis

Mon, 27 Jan 2020 12:00:00 EST

Evaluation of D3 Receptor Occupancy Using FLUORTRIOPRIDE ([18F]FTP) PET/CT

Conditions:   D3 Dopamine Receptor;   Cocaine-dependent;   Healthy Volunteer
Intervention:   Drug: [18F]FTP PET/CT
Sponsor:   University of Pennsylvania
Active, not recruiting

Tue, 28 Jun 2016 12:00:00 EDT

Trial Comparing Intravenous and Oral Moderate Sedation for First Trimester Surgical Abortions

Conditions:   Undesired Intrauterine Pregnancy;   First Trimester Pregnancy
Intervention:   Drug: Intravenous moderate sedation versus oral medication
Sponsor:   University of California, San Francisco

Wed, 11 Nov 2009 12:00:00 EST

A Pilot Study of Induction Chemotherapy Followed by Surgery for Locally Advanced Resectable Head and Neck Cancer

Condition:   Head and Neck Cancer
Interventions:   Other: radiation combined with weekly carboplatin;   Procedure: conservation surgery
Sponsor:   Southern Illinois University

Wed, 28 Apr 2010 12:00:00 EDT

Blood Brain Barrier Differences in Patients With Brain Tumors Undergoing Surgery

Conditions:   Central Nervous System Neoplasm;   Metastatic Malignant Neoplasm in the Brain;   Primary Brain Neoplasm;   Recurrent Brain Neoplasm
Interventions:   Procedure: Biospecimen Collection;   Other: Laboratory Biomarker Analysis
Sponsors:   Mayo Clinic;   National Cancer Institute (NCI)

Tue, 07 Mar 2017 12:00:00 EST

Pharmacovigilance in Gerontopsychiatric Patients

Conditions:   Dementia;   Depression;   Schizophrenia;   Psychosomatic Disorders;   Anxiety Disorders
Interventions:   Drug: Phenobarbital;   Drug: Phenytoin;   Drug: Carbamazepine;   Drug: Oxcarbazepine;   Drug: Valproic Acid;   Drug: Lamotrigine;   Drug: Topiramate;   Drug: Gabapentin;   Drug: Levetiracetam;   Drug: Pregabalin;   Drug: Lacosamide;   Drug: Clonazepam;   Drug: Biperiden;   Drug: Levomepromazine;   Drug: Fluphenazine;   Drug: Perphenazine;   Drug: Perazine;   Drug: Thioridazine;   Drug: Haloperidol;   Drug: Melperone;   Drug: Pipamperone;   Drug: Bromperidol;   Drug: Benperidol;   Drug: Sertindole;   Drug: Ziprasidone;   Drug: Flupentixol;   Drug: Chlorprothixene;   Drug: Zuclopenthixol;   Drug: Fluspirilene;   Drug: Pimozide;   Drug: Clozapine;   Drug: Olanzapine;   Drug: Quetiapine;   Drug: Sulpiride;   Drug: Tiapride;   Drug: Amisulpride;   Drug: Prothipendyl;   Drug: Risperidone;   Drug: Aripiprazole;   Drug: Paliperidone;   Drug: Diazepam;   Drug: Oxazepam;   Drug: Lorazepam;   Drug: Bromazepam;   Drug: Clobazam;   Drug: Alprazolam;   Drug: Hydroxyzine;   Drug: Buspirone;   Drug: Chloral Hydrate;   Drug: Flurazepam;   Drug: Nitrazepam;   Drug: Triazolam;   Drug: Lormetazepam;   Drug: Temazepam;   Drug: Midazolam;   Drug: Brotizolam;   Drug: Zopiclone;   Drug: Zolpidem;   Drug: Zaleplon;   Drug: Melatonin;   Drug: Clomethiazole;   Drug: Diphenhydramine;   Drug: Promethazine;   Drug: Imipramine;   Drug: Clomipramine;   Drug: Opipramol;   Drug: Trimipramine;   Drug: Amitriptyline;   Drug: Nortriptyline;   Drug: Doxepin;   Drug: Maprotiline;   Drug: Amitriptyline oxide;   Drug: Fluoxetine;   Drug: Citalopram;   Drug: Paroxetine;   Drug: Sertraline;   Drug: Fluvoxamine;   Drug: Escitalopram;   Drug: Tranylcypromine;   Drug: Moclobemide;   Drug: Mianserin;   Drug: Trazodone;   Drug: Mirtazapine;   Drug: Bupropion;   Drug: Venlafaxine;   Drug: Reboxetine;   Drug: Duloxetine;   Drug: Agomelatine;   Drug: Pyritinol;   Drug: Piracetam;   Drug: Donepezil;   Drug: Rivastigmine;   Drug: Galantamine;   Drug: Memantine;   Drug: Nicergoline;   Drug: Acamprosate;   Drug: Lithium
Sponsor:   Hannover Medical School

Mon, 02 Mar 2015 12:00:00 EST

Effects of Hallucinogens and Other Drugs on Mood and Performance

Condition:   Healthy
Intervention:   Drug: Hallucinogens and psychoactive substances
Sponsor:   Johns Hopkins University

Mon, 13 Jan 2014 12:00:00 EST

Effectiveness of Ziprasidone for Patients With Schizophrenia

Conditions:   Schizophrenia;   Schizoaffective Disorder
Intervention:   Drug: Ziprasidone
Sponsors:   Soonchunhyang University Hospital;   Pfizer

Fri, 10 Sep 2010 12:00:00 EDT

Pilot Study of a Combination Drug Product for Treatment of Short-term Insomnia

Condition:   Short-term Insomnia
Interventions:   Drug: SM-1;   Drug: Comparator;   Drug: Placebo
Sponsors:   Sequential Medicine Ltd;   Clinilabs, Inc.

Tue, 02 Feb 2016 12:00:00 EST

Phase II Trial of Pentostatin and Targeted Busulfan

Condition:   Hematologic Malignancies
Interventions:   Drug: Pentostatin;   Drug: Busulfan;   Drug: Rituximab;   Procedure: Allogeneic Hematopoietic Cell Transplant
Sponsor:   H. Lee Moffitt Cancer Center and Research Institute

Wed, 04 Jul 2007 12:00:00 EDT

IMPACT: A Study to Explore the Efficacy and Safety of Paliperidone ER in Patients With Acute Agitation

Conditions:   Psychomotor Agitation;   Acute Disease
Interventions:   Drug: Paliperidone ER;   Drug: Benzodiazepine
Sponsor:   Janssen Cilag N.V./S.A.

Fri, 15 Jan 2010 12:00:00 EST

Continuation Electroconvulsive Therapy (C-ECT) for Relapse Prevention in Major Depression

Condition:   Depression
Interventions:   Device: C-ECT;   Drug: PHARMACOTHERAPY
Sponsor:   Hospital Universitari de Bellvitge

Tue, 01 Mar 2011 12:00:00 EST

Influence of Cardiopulmonary Bypass, and Sevoflurane or Propofol Anesthesia, on Tissue Oxygen Saturation.

Condition:   NIR Spectroscopy
Interventions:   Procedure: NIRS during VOT;   Procedure: General anaesthesia with propofol use;   Procedure: General anaesthesia with sevoflurane use
Sponsor:   Medical University of Gdansk

Sun, 01 Nov 2015 12:00:00 EDT

Extension Study of Asenapine [P06107 (NCT01244815)] for Pediatric Bipolar Disorder (P05898)

Condition:   Bipolar Disorder
Interventions:   Drug: Asenapine;   Drug: Rescue medication
Sponsor:   Merck Sharp & Dohme Corp.

Mon, 09 May 2011 12:00:00 EDT

Clonidine to Prevent Delirium After Electroconvulsive Therapy.

Conditions:   Major Depressive Disorder;   Catatonia;   Bipolar Disorder;   Delirium Postseizure
Interventions:   Drug: Clonidine;   Drug: Placebo
Sponsors:   University Hospital Inselspital, Berne;   University of Bern

Thu, 01 Apr 2021 12:00:00 EDT

Ketamine for Pain Control After Severe Traumatic Injury

Conditions:   Hospital Inpatient Trauma Injury;   Pain Management
Interventions:   Drug: Ketamine;   Drug: Placebo
Sponsor:   Medical College of Wisconsin

Tue, 18 Feb 2020 12:00:00 EST

Levetiracetam, Lacosamide and Ketamine as Adjunctive Treatment of Refractory Status Epilepticus

Conditions:   Epilepsy;   Status Epilepticus
Interventions:   Drug: levetiracetam;   Drug: lacosamide;   Drug: Ketamine;   Drug: Phenobarbital
Sponsor:   Mid-Atlantic Epilepsy and Sleep Center, LLC

Mon, 04 Apr 2016 12:00:00 EDT

Gabapentin Treatment of Benzodiazepine Dependence

Condition:   Benzodiazepine Dependence
Interventions:   Drug: gabapentin;   Drug: Placebo
Sponsor:   New York State Psychiatric Institute

Tue, 09 Jul 2013 12:00:00 EDT

Safety and Efficacy Study on the Implantation of the Tension-Free Vaginal Tape (TVT-Secur) Under Local Anesthesia

Condition:   Urinary Stress Incontinence
Interventions:   Procedure: TVT-SECUR - 'Hammock' technique;   Procedure: TVT-SECUR - 'U-Method';   Drug: Local anesthesia (30 to 40 ml of a mixture of 35 ml of lidocaine 2% and 5 ml of bicarbonate 3%).
Sponsors:   Université de Sherbrooke;   Ethicon, Inc.

Tue, 19 May 2009 12:00:00 EDT

Risk and Benefit Assessment of Hypnotic Agents for Sleep Disorders Among Elderly

Condition:   Sleep Disorders
Intervention:   Drug: Exposure to sedative-hypnotic drugs
Sponsors:   China Medical University Hospital;   National Health Research Institutes, Taiwan
Unknown status

Thu, 07 Jan 2016 12:00:00 EST

Auto Transplant for High Risk or Relapsed Solid or CNS Tumors

Conditions:   Ewing's Family Tumors;   Renal Tumors;   Hepatoblastoma;   Rhabdomyosarcoma;   Soft Tissue Sarcoma;   Primary Malignant Brain Neoplasms;   Retinoblastoma;   Medulloblastoma;   Supra-tentorial Primative Neuro-Ectodermal Tumor (PNET);   Atypical Teratoid/Rhabdoid Tumor (AT/RT);   CNS Tumors;   Germ Cell Tumors
Interventions:   Drug: Ifosfamide;   Drug: Etoposide;   Drug: Mesna;   Biological: G-CSF;   Drug: Busulfan;   Drug: Melphalan;   Drug: Thiotepa;   Biological: Autologous stem cell infusion;   Radiation: Radiation;   Drug: Carboplatin;   Drug: Paclitaxel;   Procedure: Leukapheresis;   Drug: Anti-seizure prophylaxis;   Drug: Ursodiol
Sponsor:   Masonic Cancer Center, University of Minnesota

Fri, 06 Jan 2012 12:00:00 EST

Oxytocin Treatment of Alcohol Withdrawal

Condition:   Alcohol Withdrawal
Interventions:   Drug: intranasal oxytocin spray;   Other: intranasal spray without oxytocin
Sponsor:   University of North Carolina, Chapel Hill

Thu, 30 Sep 2010 12:00:00 EDT

Myeloablative Hematopoietic Progenitor Cell Transplantation (HPCT) for Pediatric Malignancies

Conditions:   Leukemia, Myelogenous, Chronic;   Leukemia, Lymphoblastic, Acute;   Leukemia, Myelogenous, Acute;   Myeloproliferative-Myelodysplastic Diseases;   Lymphoma, Malignant
Interventions:   Drug: Myeloablative Chemotherapy Regimen for Lymphoid Malignancies or Cord Blood Unit Recipients;   Drug: Myeloablative Chemotherapy Regimen for Non-Cord Blood Unit Recipients with Myeloid Malignancies;   Other: Hematopoietic Progenitor Cell Transplantation (HPCT);   Radiation: CNS radiation treatment for ALL with prior CNS disease patients
Sponsor:   Ann & Robert H Lurie Children's Hospital of Chicago
Unknown status

Thu, 21 Feb 2008 12:00:00 EST

Orthostatic Hypotension Treatment on Rehab Unit

Conditions:   Orthostatic Hypotension;   Falls
Interventions:   Other: Medication review;   Other: Nutrition/Salt intake;   Other: Education;   Other: Exercise;   Other: Drug Recommendations
Sponsor:   VA Office of Research and Development

Mon, 14 Dec 2009 12:00:00 EST