Full text biomedical articles

Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPARγ-dependent pathway

Udo Walther, Kristin Emmrich, Robert Ramer, Nadine Mittag, Burkhard Hinz
Oncotarget. 2016 Mar 1; 7(9): 10345–10362. Published online 2016 Feb 5. doi: 10.18632/oncotarget.7213


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Inhibition of NF-κB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy

Pi Chu Liu, Gang Lu, Yi Deng, Cheng Dong Wang, Xian Wei Su, Jing Ye Zhou, Tat Ming Chan, Xiang Hu, Wai Sang Poon
PLoS One. 2017; 12(1): e0171157. Published online 2017 Jan 30. doi: 10.1371/journal.pone.0171157


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Lovastatin‐mediated MCF‐7 cancer cell death involves LKB1‐AMPK‐p38MAPK‐p53‐survivin signalling cascade

Shiu‐Wen Huang, I‐Tsu Chyuan, Ching Shiue, Meng‐Chieh Yu, Ya‐Fen Hsu, Ming‐Jen Hsu
J Cell Mol Med. 2020 Jan; 24(2): 1822–1836. Published online 2019 Dec 10. doi: 10.1111/jcmm.14879


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Lovastatin blocks Kv1.3 channel in human T cells: a new mechanism to explain its immunomodulatory properties

Ning Zhao, Qian Dong, Cheng Qian, Sen Li, Qiong-Feng Wu, Dan Ding, Jing Li, Bin-Bin Wang, Ke-fang Guo, Jiang-jiao Xie, Xiang Cheng, Yu-Hua Liao, Yi-Mei Du
Sci Rep. 2015; 5: 17381. Published online 2015 Nov 30. doi: 10.1038/srep17381


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On the Identification and Quantification of Ergothioneine and Lovastatin in Various Mushroom Species: Assets and Challenges of Different Analytical Approaches

Konstantinos Tsiantas, Thalia Tsiaka, Georgios Koutrotsios, Eleni Siapi, Georgios I. Zervakis, Nick Kalogeropoulos, Panagiotis Zoumpoulakis
Molecules. 2021 Apr; 26(7): 1832. Published online 2021 Mar 24. doi: 10.3390/molecules26071832


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Complex interactions of lovastatin with 10 chemotherapeutic drugs: a rigorous evaluation of synergism and antagonism

Kaitlyn A. Khandelwal Gilman, Seungmin Han, Young-Wook Won, Charles W. Putnam
BMC Cancer. 2021; 21: 356. Published online 2021 Apr 6. doi: 10.1186/s12885-021-07963-w


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Lovastatin enhances adenovirus-mediated TRAIL induced apoptosis by depleting cholesterol of lipid rafts and affecting CAR and death receptor expression of prostate cancer cells

Youhong Liu, Lin Chen, Zhicheng Gong, Liangfang Shen, Chinghai Kao, Janet M. Hock, Lunquan Sun, Xiong Li
Oncotarget. 2015 Feb; 6(5): 3055–3070. Published online 2014 Dec 26. doi: 10.18632/oncotarget.3073


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Additive Anti-Tumor Effects of Lovastatin and Everolimus In Vitro through Simultaneous Inhibition of Signaling Pathways

Svenja Nölting, Julian Maurer, Gerald Spöttl, Elke Tatjana Aristizabal Prada, Clemens Reuther, Karen Young, Márta Korbonits, Burkhard Göke, Ashley Grossman, Christoph J. Auernhammer
PLoS One. 2015; 10(12): e0143830. Published online 2015 Dec 4. doi: 10.1371/journal.pone.0143830


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Effects of naturally-produced lovastatin on feed digestibility, rumen fermentation, microbiota and methane emissions in goats over a 12-week treatment period

Su Chui Len Candyrine, Mazrul Fahmi Mahadzir, Sani Garba, Mohammad Faseleh Jahromi, Mahdi Ebrahimi, Yong Meng Goh, Anjas Asmara Samsudin, Awis Qurni Sazili, Wei Li Chen, Siva Ganesh, Ron Ronimus, Stefan Muetzel, Juan Boo Liang
PLoS One. 2018; 13(7): e0199840. Published online 2018 Jul 5. doi: 10.1371/journal.pone.0199840


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Lovastatin upregulates microRNA-29b to reduce oxidative stress in rats with multiple cardiovascular risk factors

Fu Wang, Hui Ma, Wen-Jing Liang, Jing-Jing Yang, Xue-Qing Wang, Mei-Rong Shan, Yuan Chen, Min Jia, Ya-Ling Yin, Xue-Ying Sun, Jia-Ning Zhang, Qi-Sheng Peng, Yu-Guo Chen, Li-Ying Liu, Peng Li, Tao Guo, Shuang-Xi Wang
Oncotarget. 2017 Feb 7; 8(6): 9021–9034. Published online 2017 Jan 3. doi: 10.18632/oncotarget.14462


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Lovastatin Inhibits HIV-1-Induced MHC-I Downregulation by Targeting Nef–AP-1 Complex Formation: A New Strategy to Boost Immune Eradication of HIV-1 Infected Cells

Bingfeng Liu, Xu Zhang, Wanying Zhang, Liyang Wu, Shuliang Jing, Weiwei Liu, Baijin Xia, Fan Zou, Lijuan Lu, Xiancai Ma, Dalian He, Qifei Hu, Yiwen Zhang, Kai Deng, Weiping Cai, Xiaoping Tang, Tao Peng, Hui Zhang, Linghua Li
Front Immunol. 2019; 10: 2151. Published online 2019 Sep 10. doi: 10.3389/fimmu.2019.02151


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Controlled trial of lovastatin combined with an open-label treatment of a parent-implemented language intervention in youth with fragile X syndrome

Angela John Thurman, Laura A. Potter, Kyoungmi Kim, Flora Tassone, Amy Banasik, Sarah Nelson Potter, Lauren Bullard, Vivian Nguyen, Andrea McDuffie, Randi Hagerman, Leonard Abbeduto
J Neurodev Disord. 2020; 12: 12. Published online 2020 Apr 22. doi: 10.1186/s11689-020-09315-4


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Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model

Melania Muscas, Susana R. Louros, Emily K. Osterweil
eNeuro. 2019 May-Jun; 6(3): ENEURO.0097-19.2019. Prepublished online 2019 May 30. Published online 2019 Jun 10. doi: 10.1523/ENEURO.0097-19.2019


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In Vivo and in Vitro Study on Drug-Drug Interaction of Lovastatin and Berberine from Pharmacokinetic and HepG2 Cell Metabolism Studies

Hanming Cui, Jialong Wang, Qiuyan Zhang, Mengmeng Dang, Hui Liu, Yu Dong, Lu Zhang, Fang Yang, Jianhua Wu, Xiaolin Tong
Molecules. 2016 Apr; 21(4): 464. Published online 2016 Apr 8. doi: 10.3390/molecules21040464


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Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade

Chia-Sheng Yen, Jung-Chien Chen, Yi-Fang Chang, Ya-Fen Hsu, Pei-Ting Chiu, Ching Shiue, Yu-Fan Chuang, George Ou, Ming-Jen Hsu
Sci Rep. 2016; 6: 25082. Published online 2016 Apr 28. doi: 10.1038/srep25082


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Controlled release of lovastatin from poly(lactic-co-glycolic acid) nanoparticles for direct pulp capping in rat teeth

Hung-Pin Lin, Han-Ping Tu, Yu-Ping Hsieh, Bor-Shiunn Lee
Int J Nanomedicine. 2017; 12: 5473–5485. Published online 2017 Jul 31. doi: 10.2147/IJN.S138410


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Attenuation of Experimental Autoimmune Neuritis with Locally Administered Lovastatin-Encapsulating PLGA Nanoparticles

Kelly A. Langert, Bruktawit Goshu, Evan B. Stubbs, Jr.
J Neurochem. Author manuscript; available in PMC 2018 Jan 1.
Published in final edited form as: J Neurochem. 2017 Jan; 140(2): 334–346. Published online 2016 Dec 20. doi: 10.1111/jnc.13892


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Combination of 13-Cis Retinoic Acid and Lovastatin: Marked Antitumor Potential In Vivo in a Pheochromocytoma Allograft Model in Female Athymic Nude Mice

Svenja Nölting, Alessio Giubellino, Yasin Tayem, Karen Young, Michael Lauseker, Petra Bullova, Jan Schovanek, Miriam Anver, Stephanie Fliedner, Márta Korbonits, Burkhard Göke, George Vlotides, Ashley Grossman, Karel Pacak
Endocrinology. 2014 Jul; 155(7): 2377–2390. Published online 2014 Apr 24. doi: 10.1210/en.2014-1027


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Lovastatin Enhances Cytotoxicity of Temozolomide via Impairing Autophagic Flux in Glioblastoma Cells

Zhiyuan Zhu, Pingde Zhang, Ning Li, Karrie Mei Yee Kiang, Stephen Yin Cheng, Vincent Kam-Wai Wong, Gilberto Ka-Kit Leung
Biomed Res Int. 2019; 2019: 2710693. Published online 2019 Sep 23. doi: 10.1155/2019/2710693


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Combined Treatment with Troglitazone and Lovastatin Inhibited Epidermal Growth Factor-Induced Migration through the Downregulation of Cysteine-Rich Protein 61 in Human Anaplastic Thyroid Cancer Cells

Li-Han Chin, Sung-Po Hsu, Wen-Bin Zhong, Yu-Chih Liang
PLoS One. 2015; 10(3): e0118674. Published online 2015 Mar 5. doi: 10.1371/journal.pone.0118674


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