Full text biomedical articles

Morphine-Induced Modulation of Endolysosomal Iron Mediates Upregulation of Ferritin Heavy Chain in Cortical Neurons

Bradley Nash, Kevin Tarn, Elena Irollo, Jared Luchetta, Lindsay Festa, Peter Halcrow, Gaurav Datta, Jonathan D. Geiger, Olimpia Meucci
eNeuro. 2019 Jul-Aug; 6(4): ENEURO.0237-19.2019. Prepublished online 2019 Jul 12. Published online 2019 Jul 29. doi: 10.1523/ENEURO.0237-19.2019


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Entanglement between thermoregulation and nociception in the rat: the case of morphine

Nabil El Bitar, Bernard Pollin, Elias Karroum, Ivanne Pincedé, Daniel Le Bars
J Neurophysiol. 2016 Dec 1; 116(6): 2473–2496. Published online 2016 Sep 7. doi: 10.1152/jn.00482.2016


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Chronic morphine-mediated upregulation of high mobility group box 1 in the spinal cord contributes to analgesic tolerance and hyperalgesia in rats

Junliang Qian, Yanan Zhu, Liying Bai, Yan Gao, Mingjun Jiang, Fei Xing, Jian Zhang, Wenchao Zhao, Hanwen Gu, Yang Mi, Yuan-Xiang Tao, Ji-Tian Xu
Neurotherapeutics. 2020 Apr; 17(2): 722–742. Published online 2019 Dec 26. doi: 10.1007/s13311-019-00800-w


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Timing of Morphine Administration Differentially Alters Paraventricular Thalamic Neuron Activity

Dillon S. McDevitt, Nicholas M. Graziane
eNeuro. 2019 Nov-Dec; 6(6): ENEURO.0377-19.2019. Prepublished online 2019 Dec 4. Published online 2019 Dec 17. doi: 10.1523/ENEURO.0377-19.2019


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Blocking ATP-sensitive potassium channel alleviates morphine tolerance by inhibiting HSP70-TLR4-NLRP3-mediated neuroinflammation

Jie Qu, Xue-You Tao, Peng Teng, Yan Zhang, Ci-Liang Guo, Liang Hu, Yan-Ning Qian, Chun-Yi Jiang, Wen-Tao Liu
J Neuroinflammation. 2017; 14: 228. Published online 2017 Nov 25. doi: 10.1186/s12974-017-0997-0


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Morphine-mediated brain region-specific astrocytosis involves the ER stress-autophagy axis

Susmita Sil, Palsamy Periyasamy, Ming-Lei Guo, Shannon Callen, Shilpa Buch
Mol Neurobiol. Author manuscript; available in PMC 2019 May 23.
Published in final edited form as: Mol Neurobiol. 2018 Aug; 55(8): 6713–6733. Published online 2018 Jan 17. doi: 10.1007/s12035-018-0878-2


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Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation

Ming Chen, Yanfang Zhao, Hualan Yang, Wenjie Luan, Jiaojiao Song, Dongyang Cui, Yi Dong, Bin Lai, Lan Ma, Ping Zheng
eLife. 2015; 4: e09275. Published online 2015 Jul 24. doi: 10.7554/eLife.09275


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Stable isotope‐labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice

Ivan Weinsanto, Alexis Laux‐Biehlmann, Jinane Mouheiche, Tando Maduna, François Delalande, Virginie Chavant, Florian Gabel, Pascal Darbon, Alexandre Charlet, Pierrick Poisbeau, Marc Lamshöft, Alain Van Dorsselaer, Sarah Cianferani, Marie‐Odile Parat, Yannick Goumon
Br J Pharmacol. 2018 Oct; 175(19): 3844–3856. Published online 2018 Aug 31. doi: 10.1111/bph.14454


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Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model

Fuyuan Wang, Jingjing Meng, Li Zhang, Timothy Johnson, Chi Chen, Sabita Roy
Sci Rep. 2018; 8: 3596. Published online 2018 Feb 26. doi: 10.1038/s41598-018-21915-8


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CCR5 mediates HIV-1 Tat-induced neuroinflammation and influences morphine tolerance, dependence, and reward

Maciej Gonek, Virginia D. McLane, David L. Stevens, Kumiko Lippold, Hamid I. Akbarali, Pamela E. Knapp, William L. Dewey, Kurt F. Hauser, Jason J. Paris
Brain Behav Immun. Author manuscript; available in PMC 2019 Mar 1.
Published in final edited form as: Brain Behav Immun. 2018 Mar; 69: 124–138. Published online 2017 Nov 13. doi: 10.1016/j.bbi.2017.11.006


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Inhibition of alpha7 nicotinic receptors in the ventral hippocampus selectively attenuates reinstatement of morphine‐conditioned place preference and associated changes in AMPA receptor binding

Victoria L. Wright, Polymnia Georgiou, Alexis Bailey, David J. Heal, Christopher P. Bailey, Susan Wonnacott
Addict Biol. 2019 Jul; 24(4): 590–603. Published online 2018 Apr 17. doi: 10.1111/adb.12624


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A Prospective Population Pharmacokinetic Study on Morphine Metabolism in Cancer Patients

Astrid W. Oosten, João A. Abrantes, Siv Jönsson, Maja Matic, Ron H. N. van Schaik, Peter de Bruijn, Carin C. D. van der Rijt, Ron H. J. Mathijssen
Clin Pharmacokinet. 2017; 56(7): 733–746. Published online 2016 Nov 5. doi: 10.1007/s40262-016-0471-7


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A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal

Travis W. Grim, Cullen L. Schmid, Edward L. Stahl, Fani Pantouli, Jo-Hao Ho, Agnes Acevedo-Canabal, Nicole M. Kennedy, Michael D. Cameron, Thomas D. Bannister, Laura M. Bohn
Neuropsychopharmacology. 2020 Jan; 45(2): 416–425. Published online 2019 Aug 23. doi: 10.1038/s41386-019-0491-8


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Targeting Cytokines for Morphine Tolerance: A Narrative Review

Dai-Qiang Liu, Ya-Qun Zhou, Feng Gao
Curr Neuropharmacol. 2019 Apr; 17(4): 366–376. Published online 2019 Apr. doi: 10.2174/1570159X15666171128144441


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Morphine tolerance is attenuated in germfree mice and reversed by probiotics, implicating the role of gut microbiome

Li Zhang, Jingjing Meng, Yuguang Ban, Richa Jalodia, Irina Chupikova, Irina Fernandez, Nivis Brito, Umakant Sharma, Maria T. Abreu, Sundaram Ramakrishnan, Sabita Roy
Proc Natl Acad Sci U S A. 2019 Jul 2; 116(27): 13523–13532. Published online 2019 Jun 17. doi: 10.1073/pnas.1901182116


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Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice

Po-Kuan Chao, Hsiao-Fu Chang, Li-Chin Ou, Jian-Ying Chuang, Pin-Tse Lee, Wan-Ting Chang, Shu-Chun Chen, Shau-Hua Ueng, John Tsu-An Hsu, Pao-Luh Tao, Ping-Yee Law, Horace H. Loh, Shiu-Hwa Yeh
Sci Rep. 2019; 9: 2405. Published online 2019 Feb 20. doi: 10.1038/s41598-019-39555-x


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Site-Specific Regulation of P2X7 Receptor Function in Microglia Gates Morphine Analgesic Tolerance

Heather Leduc-Pessah, Nicholas L. Weilinger, Churmy Y. Fan, Nicole E. Burma, Roger J. Thompson, Tuan Trang
J Neurosci. 2017 Oct 18; 37(42): 10154–10172. doi: 10.1523/JNEUROSCI.0852-17.2017


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Chronic morphine regulates TRPM8 channels via MOR-PKCβ signaling

Mircea Iftinca, Lilian Basso, Robyn Flynn, Charlie Kwok, Corinne Roland, Ahmed Hassan, Manon Defaye, Rithwik Ramachandran, Tuan Trang, Christophe Altier
Mol Brain. 2020; 13: 61. Published online 2020 Apr 14. doi: 10.1186/s13041-020-00599-0


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Phosphorylation of unique C-terminal sites of the mu-opioid receptor variants 1B2 and 1C1 influences their Gs association following chronic morphine

Sumita Chakrabarti, Nai-Jiang Liu, Alan R Gintzler
J Neurochem. Author manuscript; available in PMC 2021 Feb 1.
Published in final edited form as: J Neurochem. 2020 Feb; 152(4): 449–467. Published online 2019 Oct 20. doi: 10.1111/jnc.14863


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Sex-Dependent Influences of Morphine and its Metabolites on Pain Sensitivity in the Rat

H.H. Doyle, A.Z. Murphy
Physiol Behav. Author manuscript; available in PMC 2019 Apr 1.
Published in final edited form as: Physiol Behav. 2018 Apr 1; 187: 32–41. Published online 2017 Dec 1. doi: 10.1016/j.physbeh.2017.11.030


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