Clinical Trials

A Relative Bioavailability Study of 60 mg Nifedipine ER Tablets Under Non-fasting Conditions

Condition:   Healthy
Interventions:   Drug: Nifedipine Extended Release tablets 60 mg, single dose;   Drug: ADALAT® CC Extended Release Tablets 60 mg
Sponsor:   Actavis Inc.
Completed
Thu, 19 Mar 2009 12:00:00 EDT

A Relative Bioavailability Study of 60 mg Nifedipine Extended Release Tablets Under Fasting Conditions

Condition:   Healthy
Interventions:   Drug: Nifedipine Extended Release tablets 60 mg, single dose;   Drug: ADALAT® CC Extended Release Tablets 60 mg
Sponsor:   Actavis Inc.
Completed
Thu, 19 Mar 2009 12:00:00 EDT

Individualized Dosing of Nifedipine For Tocolysis in Preterm Labor

Condition:   Preterm Labor
Intervention:   Drug: Nifedipine
Sponsor:   Indiana University
Completed
Tue, 18 Mar 2014 12:00:00 EDT

The Pharmacokinetics of Nifedipine Controlled Release Tablets in Hypertensive Patients on Hemodialysis

Condition:   Hypertension on Chronic Maintenance Hemodialysis
Intervention:   Drug: nifedipine controlled release tablets
Sponsor:   Guangzhou First People's Hospital
Unknown status
Mon, 30 Nov 2009 12:00:00 EST

Bioequivalence of Extended Release Nifedipine Tablets in Healthy Chinese Subjects

Condition:   Therapeutic Equivalency
Interventions:   Drug: Extended Release Nifedipine Tablets 30 mg;   Drug: Extended Release Nifedipine Tablets 30 mg (Adalat® GITS)
Sponsor:   Cao Yu
Recruiting
Fri, 19 Jun 2020 12:00:00 EDT

Nifedipine Pharmacokinetics and Pharmacodynamics When Used as a Tocolytic in Acute Threatened Preterm Labour

Condition:   Preterm Labor
Intervention:   Drug: Nifedipine
Sponsor:   Chantal Csajka
Unknown status
Fri, 21 Feb 2014 12:00:00 EST

Bioavailability Of A Single Dose Of Nifedipine Oral Solution Compared To Adalat Capsules In Healthy Female Volunteers

Condition:   Bioequivalence
Interventions:   Drug: Nifedipine soft gelatine capsules;   Drug: Nifedipine oral solution
Sponsor:   Reig Jofre Group
Completed
Wed, 26 Feb 2014 12:00:00 EST

Is Procardia XL 60 mg Q Daily Equivalent to 30 mg XL Given Twice Daily?

Conditions:   Hypertension in Pregnancy;   Hypertension in Postpartum
Interventions:   Drug: Procardia XL 30Mg;   Drug: Procardia XL 60Mg
Sponsor:   Icahn School of Medicine at Mount Sinai
Terminated
Mon, 23 Jul 2018 12:00:00 EDT

Nifedipine GITS and Amlodipine Besylate on Recovery of Blood Pressure Rhythm and Arterial Stiffness

Condition:   Hypertension
Interventions:   Drug: Nifedipine GITS;   Drug: Amlodipine besylate
Sponsors:   Jing Liu;   Bayer
Unknown status
Fri, 21 Oct 2016 12:00:00 EDT

Nifedipine XL Versus Placebo for the Treatment of Preeclampsia With Severe Features During Induction of Labor

Condition:   Preeclampsia Severe
Interventions:   Drug: Nifedipine 30 MG;   Drug: Placebos
Sponsor:   Ohio State University
Recruiting
Mon, 18 May 2020 12:00:00 EDT

Nifedipine Bioavailability Study With Oral Single Doses Under Fasting and Fed Conditions

Condition:   Bioavailability, Therapeutical Indication Not Studied
Interventions:   Drug: Nifedipine (Gen-nifedipine extended release, previously referred to as Gen-Nifedipine XL);   Drug: Nifedipine (Bayer Healthcare AG manufactured as Adalat® XL®, Adalat® LA, Adalat® Crono, Adalat® OROS)
Sponsors:   SocraTec R&D GmbH;   SocraMetrics GmbH
Completed
Mon, 20 Apr 2009 12:00:00 EDT

Nifedipine or Nifedipine Plus Indomethacin for Treatment of Acute Preterm Labor

Condition:   Preterm Labor
Interventions:   Drug: Nifedipine;   Drug: Indomethacin
Sponsor:   The University of Texas Health Science Center, Houston
Terminated
Fri, 08 May 2015 12:00:00 EDT

Nifedipine Treatment on Uterine Contractility in IVF

Condition:   Embryo Implantation
Intervention:   Drug: Nifedipine
Sponsor:   Hadassah Medical Organization
Unknown status
Wed, 26 Feb 2014 12:00:00 EST

Two Dose Regimens of Nifedipine for the Management of Preterm Labor

Condition:   Labor, Premature
Intervention:   Drug: Nifedipine
Sponsor:   American University of Beirut Medical Center
Terminated
Tue, 30 Aug 2005 12:00:00 EDT

Comparison of Nifedipine Versus Indomethacin for Acute Preterm Labor

Condition:   Obstetric Labor, Premature
Interventions:   Drug: Nifedipine;   Drug: Indomethacin
Sponsors:   University of California, Irvine;   University of California, San Francisco;   University of California, Davis;   University of California, San Diego;   University of California, Los Angeles
Unknown status
Wed, 26 Apr 2017 12:00:00 EDT

Extended Release Nifedipine Treatment as Maintenance Tocolysis to Prevent Preterm Delivery

Condition:   Preterm Labor
Intervention:   Drug: Nifedipine extended release
Sponsor:   The Baruch Padeh Medical Center, Poriya
Terminated
Wed, 05 Sep 2007 12:00:00 EDT

Effectiveness of Valsartan/Amlodipine (EXforge®) and Nifedipine treAtment coMparison in Treating Chinese Hypertensive Patients

Condition:   Hypertension
Interventions:   Drug: Valsartan/Amlodipine;   Drug: Nifedipine
Sponsor:   Novartis
Completed
Thu, 22 Jul 2010 12:00:00 EDT

Genetic Polymorphisms of ABCG2/BCRP on the Transport of Nifedipine to Breast Milk.

Condition:   Drug Transporter
Interventions:   Procedure: Blood and breast milk sampling;   Drug: Nifedipine
Sponsors:   Natalia Valadares de Moraes;   Hospital das Clínicas de Ribeirão Preto
Unknown status
Thu, 18 Oct 2018 12:00:00 EDT

Efficacy of Nifedipine Versus Hydralazine in Management of Severe Hypertension in Pregnancy

Condition:   Hypertension
Interventions:   Drug: Hydralazine;   Drug: Nifedipine
Sponsor:   Adebayo Joshua Adeniyi
Completed
Wed, 17 Jun 2020 12:00:00 EDT

Nifedipine vs Placebo for Maintenance Tocolysis of Preterm Labor.

Conditions:   Obstetric Labor, Premature;   Venous Thrombosis
Intervention:   Drug: Nifedipine
Sponsors:   Stanford University;   Santa Clara Valley Health & Hospital System
Completed
Fri, 16 Sep 2005 12:00:00 EDT

Trial of Magnesium Sulfate Tocolysis Versus Nifedipine Tocolysis in Women With Preterm Labor

Conditions:   Premature Birth;   Premature Labor
Interventions:   Drug: Magnesium sulfate;   Drug: Oral Nifedipine or placebo
Sponsors:   University of Cincinnati;   University Hospital
Terminated
Thu, 23 Mar 2006 12:00:00 EST

Drug Interaction With Proton Pump Inhibitors for Nifedipine ER Tablets

Condition:   Healthy Volunteers
Interventions:   Drug: Nifedipine 60 MG Extended Release Oral Tablet;   Drug: omeprazole/sodium bicarbonate;   Device: SmartPill (TM)
Sponsors:   Food and Drug Administration (FDA);   BioPharma Services, Inc
Completed
Tue, 04 Apr 2017 12:00:00 EDT

Changes in Central Arterial Pressure of Normotensive Women Taking Nifedipine for Tocolysis

Condition:   Tocolysis With Nifedipine
Intervention:   Other: Nifedipine for tocolysis
Sponsor:   St. Louis University
Withdrawn
Thu, 15 Sep 2016 12:00:00 EDT

An Open Label Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing in Human Subjects

Condition:   Chronic Anal Fissure
Intervention:   Drug: Nifedipine coated suppositories
Sponsor:   RDD Pharma Ltd
Completed
Wed, 09 Sep 2009 12:00:00 EDT

Pivotal Bioequivalence FDC Nifedipine / Candesartan vs. Loose Combination of Single Components, Fed

Condition:   Hypertension, Essential
Interventions:   Drug: Nifedipine/Candesartan (BAY 98-7106);   Drug: Nifedipine (Adalat, BAY A1040) and Candesartan (Atacand, BAY 12-9333)
Sponsor:   Bayer
Completed
Tue, 10 May 2011 12:00:00 EDT

Nifedipine Versus Indomethacin in the Treatment of Preterm Labour

Condition:   Obstetric Labor, Premature
Interventions:   Drug: Nifedipine;   Drug: Indomethacin
Sponsor:   Saint Thomas Hospital, Panama
Unknown status
Wed, 25 May 2011 12:00:00 EDT

The Effect of Intra-anal Nifedipine, Used As Add-on to Conservative Therapy, on Pain in Patients With Anal Fissure

Condition:   Chronic Anal Fissure
Intervention:   Drug: Nifedipine
Sponsor:   RDD Pharma Ltd
Completed
Tue, 18 Aug 2015 12:00:00 EDT

Effectiveness and Tolerability of Long-Acting Nifedipine Gastrointestinal Therapeutic System in Chronic Kidney Disease With Uncontrolled Hypertension Patients, a Prospective, Multicenter, Observational Study

Condition:   Hypertension
Intervention:   Drug: Nifedipine controlled-release tablets(Nifedipine GITS, ADALAT, BAYA1040)
Sponsor:   Bayer
Completed
Wed, 21 Jun 2017 12:00:00 EDT

Efficacy Study of Nifedipine Controlled-Release Tablets (Xin Ran) to Treat Mild to Moderate Essential Hypertension

Condition:   Essential Hypertension
Interventions:   Drug: nifedipine CR tablets (Xin Ran);   Drug: nifedipine CR tablets (Adalat)
Sponsor:   Shanghai Shyndec Pharmaceutical Co., Ltd.
Completed
Thu, 09 Jan 2014 12:00:00 EST

Comparing Nifedipine and Enalapril in Medical Resources Used in the Postpartum Period

Conditions:   Hypertension in Pregnancy;   Preeclampsia Severe;   Gestational Hypertension;   Postpartum Preeclampsia;   Postpartum
Interventions:   Drug: NIFEdipine ER;   Drug: Enalapril
Sponsor:   Brigham and Women's Hospital
Recruiting
Wed, 22 Jan 2020 12:00:00 EST

An Open Label Multi-Dose Study to Examine the Effect of Coated Nifedipine Suppository on Anal Fissure Pain and Healing

Condition:   Anal Fissure
Intervention:   Drug: Nifedipine 12 mg coated suppositories
Sponsor:   RDD Pharma Ltd
Terminated
Mon, 30 Dec 2013 12:00:00 EST

Oral Nifedipine Versus Oral Labetalol

Condition:   Severe Postpartum Hypertension
Interventions:   Drug: Labetalol;   Drug: Nifedipine
Sponsor:   Cedars-Sinai Medical Center
Completed
Fri, 20 Jun 2014 12:00:00 EDT

Oral Nifedipine Versus IV Labetalol in Severe Pre Eclampsia

Condition:   Severe Pre-Eclampsia, Antepartum
Interventions:   Drug: Nifedipine 10 mg;   Drug: Labetalol
Sponsor:   Services Institute of Medical Sciences, Pakistan
Unknown status
Mon, 30 Oct 2017 12:00:00 EDT

A Study Examining the Use of Vaginal Nifedipine With Pelvic Floor Physical Therapy for Levator Myalgia and Pelvic Pain

Condition:   Levator Ani Syndrome
Interventions:   Drug: Nifedipine;   Drug: Placebo Ointment Base
Sponsor:   Vanderbilt University
Withdrawn
Thu, 26 Apr 2012 12:00:00 EDT

Comparative Study Between Nifedipine and Ritodrine as Maintenance Tocolytic Therapy in Preterm Labor

Condition:   Preterm Birth
Interventions:   Drug: Nifedipine 20 Mg;   Drug: Ritodrine Oral Tablet
Sponsor:   Cairo University
Completed
Thu, 02 Feb 2017 12:00:00 EST

Effect of Nifedipine GITS in Patients With Mild-to-moderate Primary Hypertension

Condition:   Hypertension
Intervention:   Drug: Nifedipine GITS
Sponsors:   Peking University First Hospital;   Bayer
Unknown status
Tue, 29 Dec 2015 12:00:00 EST

The Effects of Doxazosin and Nifedipine on Blood Pressure Variability and Uric Acid in Plasma in Hypertensive Patients

Condition:   Hypertension
Interventions:   Drug: Doxazosin;   Drug: Nifedipine
Sponsor:   First Affiliated Hospital of Harbin Medical University
Unknown status
Wed, 30 Sep 2015 12:00:00 EDT

Blood Pressure Control of Nifedipine GITS 60mg Treatment in Chinese Hypertensive Subjects Uncontrolled on Starting-dose Mono-therapyo-therapy.

Condition:   Hypertension
Intervention:   Drug: Nifedipine (Adalat GITS, BAY1040)
Sponsor:   Bayer
Completed
Fri, 10 Apr 2015 12:00:00 EDT

Oral Combined Hydrochlorothiazide/Lisinopril Versus Oral Nifedipine for Postpartum Hypertension

Conditions:   Hypertension in Pregnancy;   Postpartum Preeclampsia
Interventions:   Drug: ACE Inhibitors and Diuretics;   Drug: NIFEdipine ER
Sponsor:   The University of Texas Health Science Center, Houston
Not yet recruiting
Mon, 20 Sep 2021 12:00:00 EDT

The Efficacy of Nifedipine in the Management of Preterm Labor

Conditions:   Preterm Labor;   Preterm Birth;   Preterm Labor Without Delivery;   Preterm Labor With Preterm Delivery in Third Trimester;   Calcium-Channel Blockers Toxicity;   Side Effect of Drug
Intervention:   Drug: Nifedipine 10 mg
Sponsor:   Ethem Unal, M.D., PhD, Associate Prof of Surgery & Surgic
Not yet recruiting
Wed, 25 Nov 2020 12:00:00 EST

Nifedipine (Adalat CR, BAY A1040) High Dose PK/PD Study

Condition:   Hypertension
Interventions:   Drug: Nifedipine (Adalat CR, BAYA1040) 80mg OD;   Drug: Nifedipine (Adalat CR, BAYA1040) 40mg BID;   Drug: Nifedipine (Adalat CR, BAYA1040) 40mg OD
Sponsor:   Bayer
Completed
Wed, 08 Oct 2008 12:00:00 EDT

Diastolic Heart Failure Management by Nifedipine

Condition:   Diastolic Heart Failure
Interventions:   Drug: Conventional therapy plus nifedipine;   Drug: Conventional therapy
Sponsor:   Demand Investigators
Unknown status
Wed, 07 Jul 2010 12:00:00 EDT

Nifedipine for Acute Tocolysis of Preterm Labor

Condition:   Preterm Labor
Interventions:   Drug: Nifedipine;   Drug: Placebo;   Other: Usual care
Sponsor:   University of Texas Southwestern Medical Center
Completed
Wed, 07 May 2014 12:00:00 EDT

Indomethacin Versus Nifedipine for Preterm Labor Tocolysis

Condition:   Obstetric Labor, Premature
Interventions:   Drug: Indomethacin;   Drug: Nifedipine
Sponsor:   Stanford University
Completed
Fri, 15 Jun 2007 12:00:00 EDT

Topical 10 % Nifedipine Versus 5% Sildenafil in Secondary Raynaud

Conditions:   Raynaud Phenomenon Due to Trauma;   Raynaud Disease;   System; Sclerosis;   Lupus Erythematosus, Systemic;   Dermatomyositis;   Ultrasound Therapy; Complications
Interventions:   Drug: 10% nifedipine cream;   Drug: 5% sildenafil cream
Sponsor:   Pontificia Universidad Catolica de Chile
Completed
Mon, 23 Jan 2017 12:00:00 EST

Nifedipine vs Telmisartan on Prevention of Atrial Fibrillation (AF) Recurrence in Hypertensive Patients With AF

Condition:   Atrial Fibrillation
Interventions:   Drug: Nifedipine,;   Drug: Telmisartan
Sponsor:   The Second Affiliated Hospital of Chongqing Medical University
Completed
Fri, 16 Sep 2011 12:00:00 EDT

Amlodipine Versus Nifedipine ER for the Management of Postpartum Hypertension

Condition:   Hypertension in Pregnancy
Interventions:   Drug: Amlodipine;   Drug: NIFEdipine ER
Sponsor:   Prisma Health-Upstate
Recruiting
Wed, 10 Mar 2021 12:00:00 EST

Magnesium Sulfate Versus Nifedipine for the Acute Tocolysis of Preterm Labor: A Prospective, Randomized Trial

Condition:   Obstetric Labor, Premature
Interventions:   Drug: Magnesium Sulfate;   Drug: Nifedipine
Sponsor:   Stanford University
Completed
Fri, 16 Sep 2005 12:00:00 EDT

High Dose BAYA1040 CR: a Long Term Extension Study

Condition:   Hypertension
Intervention:   Drug: Nifedipine (Adalat, BAYA1040)
Sponsor:   Bayer
Completed
Wed, 18 May 2011 12:00:00 EDT

Nifedipine Treatment in Preterm Labor

Condition:   Threatened Preterm Labor
Interventions:   Drug: Nifedipine;   Drug: Atosiban
Sponsors:   Hospital Clinico Universitario de Santiago;   Fundación Ramón Domínguez
Withdrawn
Tue, 15 Mar 2011 12:00:00 EDT

REducing Blood Pressure Variability in Essential Hypertension With RAmipril vErsus Nifedipine GITS Trial

Conditions:   Hypertension;   High Blood Pressure Variability
Interventions:   Drug: Nifedipine GITS;   Drug: Ramipril
Sponsors:   Istituto Auxologico Italiano;   Bayer
Completed
Thu, 16 Jul 2015 12:00:00 EDT

High Dose BAYA1040_Nifedipine: a Dose-comparative Study

Condition:   Hypertension
Intervention:   Drug: Nifedipine (Adalat, BAYA1040)
Sponsor:   Bayer
Completed
Tue, 01 Feb 2011 12:00:00 EST

High Dose BAYA1040_Nifedipine: a Long Term Combination Study

Condition:   Hypertension
Intervention:   Drug: Nifedipine (Adalat, BAYA1040)
Sponsor:   Bayer
Completed
Fri, 11 Feb 2011 12:00:00 EST

Treating Postictal Symptoms Using Ibuprofen and Nifedipine

Conditions:   Epilepsy;   Epilepsies, Partial
Interventions:   Drug: Ibuprofen;   Drug: Nifedipine;   Drug: Placebo
Sponsor:   University of Calgary
Recruiting
Tue, 14 May 2019 12:00:00 EDT

Efficacy Study of Nifedipine Controlled-Release Tablets (Xin Ran) to Treat Early Morning Blood Pressure and Central Arterial Pressure

Condition:   Essential Hypertension
Interventions:   Drug: nifedipine CR tablets (Xin Ran);   Drug: Adalat
Sponsor:   Shanghai Shyndec Pharmaceutical Co., Ltd.
Unknown status
Fri, 06 Feb 2015 12:00:00 EST

Open-Label Long-Term Safety and Efficacy Study of Fixed Dose Combination of Nifedipine Gastrointestinal Therapeutic System and Candesartan Cilexetil in Subjects With Moderate to Severe Essential Hypertension

Condition:   Hypertension
Intervention:   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106)
Sponsor:   Bayer
Completed
Mon, 11 Feb 2013 12:00:00 EST

Effect of Labetalol, Atenolol, and Nifedipine on Maternal Hemodynamics Measured by ICG in Early Pregnancy

Conditions:   Systolic Hypertension;   Pregnancy Related;   Diastolic Hypertension;   Cardiac Output, Low;   Cardiac Output, High
Interventions:   Drug: Labetalol;   Drug: Atenolol;   Drug: Nifedipine
Sponsor:   Marshall University
Recruiting
Tue, 16 Feb 2021 12:00:00 EST

Transdermal Nitroglycerin and Nifedipine in Preterm Labor

Condition:   Managing Preterm Labor
Interventions:   Drug: Transdermal nitroglycerin;   Drug: nifedipine
Sponsor:   Shiraz University of Medical Sciences
Completed
Thu, 22 Oct 2015 12:00:00 EDT

Nifedipine Versus Magnesium Sulfate for Prevention of Preterm Labor in Symptomatic Placenta Previa

Condition:   Placenta Previa
Interventions:   Drug: Magnesium Sulfate;   Drug: Nifedipine
Sponsor:   Assiut University
Completed
Thu, 31 May 2018 12:00:00 EDT

The Effects of Nifedipine and Metoprolol on Blood Pressure Variability in Northern Chinese

Condition:   Hypertension
Interventions:   Drug: metoprolol;   Drug: Nifedipine
Sponsor:   First Affiliated Hospital of Harbin Medical University
Unknown status
Mon, 03 Aug 2015 12:00:00 EDT

Single Dose Bioequivalence Study Comparing Nifedipine/Candesartan FDC (Fixed Dose Combination) With Loose Combination of Nifedipine GITS (Gastro-intestinal Therapeutic System) Plus Candesartan and Single Components Under Fasting Conditions

Condition:   Hypertension, Essential
Interventions:   Drug: Nifedipine-candesartan FDC (BAY 98-7106);   Drug: Nifedipine GITS (Adalat LA, BAYA1040);   Drug: Candesartan (Atacand)
Sponsor:   Bayer
Completed
Mon, 25 Oct 2010 12:00:00 EDT

Nifedipine Compared to Atosiban for Treating Preterm Labor

Condition:   Labor, Premature
Interventions:   Drug: Atosiban;   Drug: Nifedipine
Sponsor:   Raed Salim
Completed
Thu, 24 Jan 2008 12:00:00 EST

An Open Label Study to Examine the Effect of Coated Nifedipine Suppositories on Anal Pressure in Healthy Subjects

Condition:   Anal Resting Pressure
Intervention:   Drug: Coated Nifedipine Suppositories
Sponsor:   RDD Pharma Ltd
Completed
Thu, 01 Jan 2009 12:00:00 EST

Comparison of Tab.Labetalol and Tab.Nifedipine for Management of Postpartum Hypertension

Condition:   Postnatal Hypertension
Interventions:   Drug: Labetalol;   Drug: Nifedipine
Sponsor:   Dow University of Health Sciences
Unknown status
Fri, 24 Apr 2015 12:00:00 EDT

Adalat XL vs Diltiazem on Proteinuria and Blood Pressure in Hypertensive Diabetic Patients

Conditions:   Diabetic Nephropathies;   Hypertension
Interventions:   Drug: Adalat XL;   Drug: Tiazac XC
Sponsor:   Bayer
Withdrawn
Fri, 11 Jul 2008 12:00:00 EDT

Treatment of Hypertension With Adalat® in Combination With Other Drugs

Condition:   Hypertension
Intervention:   Drug: Nifedipine (Adalat, BAYA1040)
Sponsor:   Bayer
Completed
Thu, 06 May 2010 12:00:00 EDT

Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis

Conditions:   Vulvar Diseases;   Vulvar Pain;   Vestibulitis;   Vestibulodynia;   Vulvodynia
Intervention:   Drug: Nifedipine cream topical application
Sponsor:   Western Galilee Hospital-Nahariya
Completed
Wed, 04 Jul 2007 12:00:00 EDT

Changes in Central Arterial Pressure When Comparing Nifedipine/Labetalol for Routine Hypertension Control in Pregnancy

Condition:   Hypertension
Interventions:   Other: Nifedipine;   Other: Labetalol
Sponsor:   St. Louis University
Withdrawn
Fri, 23 Sep 2016 12:00:00 EDT

Utrogestan Versus Nifedipine as Tocolysis for Preterm Labor: a Randomised Controlled Trial

Condition:   Preterm Labor
Interventions:   Drug: utrogestan;   Drug: Nifedipine
Sponsor:   nor zila hassan malek
Unknown status
Fri, 15 Nov 2013 12:00:00 EST

FOCUS (Nifedipine GITS's Effect on Central Pressure Assessed by Applanation Tonometry)

Condition:   Hypertension
Interventions:   Drug: Nifedipine (Adalat, BAYA1040) and Valsartan;   Drug: Nifedipine (Adalat, BAYA1040);   Drug: Valsartan
Sponsor:   Bayer
Completed
Fri, 19 Feb 2010 12:00:00 EST

Low-dose Nifedipine-Valsartan Combination Compared to Up-titrated Valsartan Monotherapy in Essential Hypertension

Condition:   Hypertension
Interventions:   Drug: Adalat (Nifedipine, BAYA1040);   Drug: Diovan (Valsartan)
Sponsor:   Bayer
Completed
Mon, 12 Oct 2009 12:00:00 EDT

Effects of Adalat LA and Coracten on Drug Levels, Blood Pressure, and Heart Rate in Fed Patients With Hypertension

Condition:   Hypertension
Interventions:   Drug: Adalat (Nifedipine, BAYA1040);   Drug: Coracten
Sponsor:   Bayer
Completed
Tue, 06 May 2008 12:00:00 EDT

Tocolysis in the Management of Preterm Premature Rupture of Membranes Before 34 Weeks of Gestation

Condition:   Preterm Premature Rupture of Membrane
Interventions:   Drug: Nifedipine;   Drug: Placebo of Nifedipine
Sponsors:   Assistance Publique - Hôpitaux de Paris;   INSERM U1153;   Ministry of Health, France;   Groupe de Recherche en Obstétrique et Gynécologie
Recruiting
Wed, 05 Jun 2019 12:00:00 EDT

HIGH Altitude CArdiovascular REsearch in the ANDES

Conditions:   Hypertension;   High Altitude
Interventions:   Drug: Telmisartan;   Drug: Nifedipine;   Drug: placebo
Sponsors:   Istituto Auxologico Italiano;   Bayer
Completed
Fri, 12 Apr 2013 12:00:00 EDT

Vaginal Indomethacin for Preterm Labor

Condition:   Obstetric Labor, Premature
Interventions:   Drug: Indomethacin;   Drug: Nifedipine
Sponsors:   Hadassah Medical Organization;   Sheba Medical Center;   Soroka University Medical Center
Not yet recruiting
Wed, 27 May 2020 12:00:00 EDT

Goal-Directed Therapy in Pregnant Women at High Risk of Developing Preeclampsia

Conditions:   Pre-Eclampsia;   Pregnancy;   Hypertension
Intervention:   Drug: Nifedipine
Sponsor:   Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Completed
Tue, 10 May 2011 12:00:00 EDT

Monotherapy-Controlled Study of Nifedipine Gastrointestinal Therapeutic System and Candesartan Cilexetil in Combination in Subjects With Essential Hypertension Inadequately Controlled on Candesartan Cilexetil

Condition:   Hypertension
Interventions:   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106);   Drug: Candesartan Cilexetil;   Drug: Candesartan matching placebo;   Drug: Nifedipine GITS/Candesartan Cilexetil FDC(BAY98-7106) 30/16mg matching placebo
Sponsor:   Bayer
Withdrawn
Tue, 28 Jan 2014 12:00:00 EST

Preeclamptic Postpartum Antihypertensive Treatment

Conditions:   Preeclampsia;   Hypertension in Pregnancy
Intervention:   Drug: Labetalol, Nifedipine
Sponsor:   Medical College of Wisconsin
Recruiting
Fri, 06 Mar 2020 12:00:00 EST

Amlodipine Prevents Morning Blood Pressure Surge Study

Condition:   Hypertension
Interventions:   Drug: Amlodipine (Norvasc®);   Drug: Nifedipine GITS (Adalat® XL 30
Sponsor:   Shanghai Jiao Tong University School of Medicine
Completed
Fri, 11 Dec 2009 12:00:00 EST

Role of Calcium Channels in Vascular Function

Condition:   Endothelium, Vascular
Interventions:   Drug: Efonidipine;   Drug: Nifedipine
Sponsor:   University of Southern Denmark
Completed
Wed, 31 Aug 2016 12:00:00 EDT

Single Dose Escalation Study to Investigate the Pharmacokinetics as Well as Safety and Tolerability of a Concomitant Administration of Nifedipne GITS and Candesartan Tablets Under Fasting Conditions in Healthy Male Subjects in an Open Label, Non-randomized, Sequential Design.

Condition:   Clinical Pharmacology
Intervention:   Drug: Nifedipine gastrointestinal therapeutic system (GITS) (Adalat LA, BAY a1040) + Candesartan cilexetil
Sponsor:   Bayer
Completed
Tue, 02 May 2017 12:00:00 EDT

Tocolytic Therapy in Conservative Management of Symptomatic Placenta Previa

Condition:   Placenta Previa
Interventions:   Drug: Placebo;   Drug: Nifedipine
Sponsor:   University Hospital, Rouen
Completed
Thu, 21 Feb 2008 12:00:00 EST

Single Versus Combination Therapy in Acute Tocolysis

Condition:   Preterm Labour
Interventions:   Drug: Atosiban;   Drug: Atosiban and nifedipine
Sponsor:   Tawam Hospital
Completed
Wed, 07 Sep 2011 12:00:00 EDT

Diltiazem Ointment With Lidocaine vs. Nifedipine Ointment With Lidocaine Ointment for Treatment of Chronic Anal Fissure

Conditions:   Fissure in Ano;   Rectal Diseases;   Rectal Bleed
Interventions:   Drug: 2% Diltiazem ointment with 1.5% lidocaine;   Drug: 0.3% Nifedipine ointment with 1.5% lidocaine
Sponsor:   University of Calgary
Not yet recruiting
Fri, 14 May 2021 12:00:00 EDT

Sitaxsentan in Proteinuric Chronic Kidney Disease

Conditions:   Chronic Kidney Disease;   Proteinuria;   Blood Pressure
Interventions:   Drug: Sitaxsentan;   Drug: Nifedipine;   Drug: Placebo tablet
Sponsors:   University of Edinburgh;   Encysive Pharmaceuticals
Unknown status
Tue, 06 Jan 2009 12:00:00 EST

Endothelin Receptor Antagonism in Proteinuric Nephropathy

Conditions:   Chronic Kidney Disease;   Proteinuria
Interventions:   Drug: BQ-123 (selective endothelin A receptor antagonist);   Drug: 0.9 % saline;   Drug: Nifedipine
Sponsors:   University of Edinburgh;   British Heart Foundation
Completed
Fri, 25 Jul 2008 12:00:00 EDT

Tocolytic Therapy for Preterm Labor in Multiple Gestation

Condition:   Labor Preterm Multiple
Interventions:   Drug: Atosiban;   Drug: Nifedipine
Sponsor:   Tel-Aviv Sourasky Medical Center
Unknown status
Fri, 01 Apr 2016 12:00:00 EDT

Study Evaluating the Efficacy of Nifedipine GITS - Telmisartan Combination in Blood Pressure Control.

Condition:   Hypertension
Interventions:   Drug: Nifidipine;   Drug: Telmisartan;   Drug: Nifedipine/Telmisartan
Sponsor:   Bayer
Completed
Wed, 10 Sep 2008 12:00:00 EDT

Oral Nifedipine Versus Labetalol in Treatment of Postpartum Hypertension

Condition:   Postpartum Preeclampsia
Intervention:   Drug: Oral Tablet
Sponsors:   Hossam Ahmed Abd Ellah;   Assiut University
Unknown status
Wed, 28 Feb 2018 12:00:00 EST

A Study To Test The Effect Of Apatinib On P450 Enzymes

Condition:   Cytochrome P450 Interaction
Interventions:   Drug: Apatinib;   Drug: Nifedipine GTIS;   Drug: Warfarin Potassium
Sponsor:   Jiangsu HengRui Medicine Co., Ltd.
Unknown status
Thu, 10 Aug 2017 12:00:00 EDT

Study of Nifedipine GITS and Candesartan Combination Compared to Monotherapy in Patients With Essential Hypertension

Condition:   Hypertension, Essential
Interventions:   Drug: Candesartan cilexetil (Atacand), 4 mg;   Drug: Candesartan cilexetil (Atacand), 8 mg;   Drug: Nifedipine GITS (Adalat, BAYA1040), 20 mg;   Drug: Nifedipine GITS (Adalat, BAYA1040), 30 mg;   Drug: Nifedipine GITS (Adalat, BAYA1040), 60 mg;   Drug: Placebo;   Drug: Candesartan cilexetil (Atacand), 16 mg;   Drug: Candesartan cilexetil (Atacand), 32 mg
Sponsor:   Bayer
Completed
Fri, 25 Feb 2011 12:00:00 EST

Oral Nifedipine to Treat Iron Overload

Conditions:   Thalassemia;   Iron Overload;   Hemochromatosis
Interventions:   Drug: Nifedipine;   Procedure: Phlebotomy;   Procedure: Urinalysis;   Procedure: Echocardiogram;   Procedure: Electrocardiogram
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed
Thu, 10 Jul 2008 12:00:00 EDT

Post-marketing Surveillance for Hypertensive Patients With Diabetes and/or Chronic Kidney Disease

Condition:   Hypertension
Intervention:   Drug: Nifedipine (Adalat CR, BAYA1040)
Sponsor:   Bayer
Completed
Wed, 01 Jun 2011 12:00:00 EDT

Response to Anti-hypertensives in Pregnant and Postpartum Patients

Conditions:   Hypertension in Pregnancy;   Preeclampsia
Interventions:   Drug: Nifedipine;   Drug: Labetalol
Sponsors:   Icahn School of Medicine at Mount Sinai;   Mount Sinai Hospital, New York;   Maimonides Medical Center
Completed
Tue, 24 Apr 2018 12:00:00 EDT

Calcium Channel Blockers Compared to Magnesium Sulfate in Fetal Cerebral Blood Flow

Conditions:   Preterm Labor;   Cerebral Palsy
Interventions:   Drug: Magesium sulphate;   Drug: Nifedipine;   Radiation: Doppler on fetal middle cerebral artery
Sponsor:   Kasr El Aini Hospital
Completed
Thu, 29 Oct 2015 12:00:00 EDT

Changes in Central Arterial Pressure When Comparing ACOG Hypertensive Urgency Protocols

Condition:   Hypertension
Interventions:   Drug: Labetalol;   Drug: Hydralazine;   Drug: nifedipine
Sponsor:   St. Louis University
Withdrawn
Fri, 14 Oct 2016 12:00:00 EDT

Utility of Tocolytic Therapy for Maintenance Tocolysis in the Management of Threatened Preterm Delivery

Condition:   Preterm Delivery.
Interventions:   Drug: progesterone 200 mg / day vaginally;   Drug: nifedipine (60 mg / day orally)
Sponsor:   Instituto de Investigacion Sanitaria La Fe
Withdrawn
Thu, 21 Feb 2013 12:00:00 EST

Comparative Study Between Nicorandil and Nifedipine for the Treatment of Preterm Labour

Condition:   Preterm Labor With Preterm Delivery
Interventions:   Drug: Potassium Channel Opener;   Drug: Calcium channel blocker
Sponsor:   Ain Shams University
Recruiting
Thu, 15 Apr 2021 12:00:00 EDT

Controlled Release Nifedipine and Valsartan Combination Therapy in Patients With Essential Hypertension

Condition:   Hypertension
Interventions:   Drug: Nifedipine (Adalat, BAYA1040);   Drug: Amlodipine (Norvasc);   Drug: Diovan
Sponsor:   Bayer
Completed
Thu, 26 Jan 2012 12:00:00 EST

Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema

Conditions:   High Altitude Pulmonary Edema;   Non-Invasive Positive Pressure Ventilation;   Hypoxia
Interventions:   Device: Non-Invasive Positive Pressure Ventilation;   Drug: Nifedipine;   Other: supplemental oxygen
Sponsors:   Massachusetts General Hospital;   Himalayan Rescue Association
Recruiting
Fri, 28 Feb 2020 12:00:00 EST

The Effect of LipoCol Forte® Capsules on the Pharmacokinetics of Nifedipine After Administering Single-dose Combination to Healthy Subjects

Condition:   Healthy Volunteers
Intervention:   Drug: Nifidipine & LipoCol
Sponsor:   Taipei Medical University WanFang Hospital
Completed
Tue, 03 May 2011 12:00:00 EDT

Choroidal Blood Flow Regulation During Isometric Exercise: Effects of Ca2+-Channel Blockade

Conditions:   Ocular Physiology;   Regional Blood Flow
Interventions:   Drug: Nifedipine (drug);   Drug: L-Arginin (drug);   Drug: Placebo
Sponsor:   Medical University of Vienna
Completed
Mon, 23 Jan 2006 12:00:00 EST

Effects Of Sitaxsentan On Proteinuria, 24-Hour Blood Pressure, And Arterial Stiffness In Chronic Kidney Disease Subjects

Conditions:   Chronic Kidney Disease;   CRD
Interventions:   Drug: Sitaxsentan;   Drug: Nifedipine;   Drug: Placebo
Sponsor:   Pfizer
Completed
Thu, 18 Dec 2008 12:00:00 EST

Tocolysis for Preterm Labor

Condition:   Preterm Labor
Interventions:   Drug: 1 Magnesium Sulfate;   Drug: Nifedipine;   Drug: Indomethacin
Sponsor:   University of Mississippi Medical Center
Completed
Thu, 18 Dec 2008 12:00:00 EST

Use of Impedance Cardiography to Decrease the Risk of Pre-eclampsia in Obese Patients

Conditions:   Obesity, Morbid;   Preeclampsia
Interventions:   Drug: Labetalol Hydrochloride 200 mg;   Drug: NIFEdipine 60 mg;   Drug: Atenolol 25 mg
Sponsor:   University of Tennessee Graduate School of Medicine
Unknown status
Mon, 10 Apr 2017 12:00:00 EDT

Clinical Study on the Effect of PTH on CYP3A4 Activity

Condition:   Chronic Kidney Diseases
Intervention:   Drug: Nifedipine controlled released tablets
Sponsor:   The Third Xiangya Hospital of Central South University
Unknown status
Wed, 03 Oct 2018 12:00:00 EDT

Impedance Cardiography to Decrease the Risk of Preeclampsia

Conditions:   Chronic Hypertension Complicating Pregnancy (Diagnosis);   Preeclampsia
Interventions:   Drug: Labetalol Hydrocholoride 200 mg orally every 12 hours;   Drug: Nifedipine 60 mg orally daily;   Drug: Atenolol 25 mg daily
Sponsor:   University of Tennessee Medical Center
Withdrawn
Thu, 10 Aug 2017 12:00:00 EDT

Early Vascular Adjustments During Hypertensive Pregnancy

Conditions:   Hypertension, Pregnancy-Induced;   Pre-Eclampsia
Interventions:   Drug: Labetalol;   Drug: Nifedipine;   Drug: Methyldopa
Sponsor:   Maastricht University Medical Center
Recruiting
Mon, 24 Aug 2015 12:00:00 EDT

Oral Antihypertensive Regimens for Management of Hypertension in Pregnancy

Conditions:   Hypertension in Pregnancy;   Preeclampsia
Interventions:   Drug: Nifedipine;   Drug: Labetalol;   Drug: Methyldopa
Sponsors:   Gynuity Health Projects;   Government Medical College, Nagpur;   Daga Memorial Women's Hospital, Nagpur, India;   University of British Columbia;   Bill and Melinda Gates Foundation
Completed
Wed, 31 Jul 2013 12:00:00 EDT

Chronic Hypertension and Pregnancy (CHAP) Project

Condition:   Hypertension
Interventions:   Drug: Anti-hypertensive therapy;   Other: No anti-hypertensive therapy (unless BP is severe)
Sponsors:   University of Alabama at Birmingham;   Columbia University;   Drexel University College of Medicine;   Rutgers, The State University of New Jersey;   Lehigh Valley Hospital;   Saint Peters University Hospital;   Christiana Care Health Services;   Washington University School of Medicine;   Duke University;   University of Texas Southwestern Medical Center;   The University of Texas Health Science Center, Houston;   Stanford University;   University of Pennsylvania;   The University of Texas Medical Branch, Galveston;   University of Utah;   Intermountain Health Care, Inc.;   University of California, San Francisco;   Johns Hopkins University;   University of Pittsburgh;   Ochsner Health System;   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI);   WakeMed Health and Hospitals;   San Francisco General Hospital;   McKay-Dee Hospital;   Winthrop University Hospital;   New York Hospital Queens;   Latter Day Saints Hospital;   Lyndon B Johnson General Hospital;   Virtua Medical Group;   Bayview Medical Center;   Duke Regional Hospital;   Utah Valley Regional Medical Center;   Northwestern;   Brown (WIHRI);   Baylor College of Medicine;   Case Western/Metro Health;   Ohio State University;   University of Iowa;   University of California, San Diego;   Indiana University;   Unity Point Health-Meriter Hospital WI;   Weill Medical College of Cornell University;   University of Oklahoma;   Medical University of South Carolina;   Beaumont Hospital;   University of Colorado, Denver;   University of Kansas Medical Center;   Denver Health and Hospital Authority;   Gundersen Health System;   Aurora Health Care;   Oregon Health and Science University;   Medical College of Wisconsin;   Temple University;   New Jersey Medical School;   University of South Alabama;   Vanderbilt University;   University of Arkansas;   Miami Valley Hospital;   Emory University;   St. Luke's Hospital and Health Network, Pennsylvania;   Cleveland Clinic Fairview Hospital;   University of Tennessee Health Science Center;   TriHealth Inc.;   Cleveland Clinic Hillcrest Hospital;   Tulane University;   Yale University;   Arrowhead Regional Medical Center;   Geisinger Clinic
Active, not recruiting
Mon, 24 Nov 2014 12:00:00 EST

Compare the Therapeutic Effect Treated With Tamsulosin and Progesterone After ESWL( Extra Corporeal Shock Wave Lithotripsy) in Urinary Calculus

Condition:   Urinary Calculus
Intervention:   Drug: progesterone,tamsulosin,propantheline Bromide and nifedipine
Sponsor:   Chongqing Medical University
Unknown status
Mon, 09 Nov 2009 12:00:00 EST

Evaluating the Utility of Continuous Positive Airway Pressure in the Treatment of High Altitude Pulmonary Edema

Conditions:   Continuous Positive Airway Pressure;   High Altitude Pulmonary Edema
Interventions:   Device: CPAP mask system;   Drug: Nifedipine 30 MG;   Device: CPAP mask system without PEEP
Sponsors:   Centura Health;   Pulmodyne, Inc.
Recruiting
Thu, 05 Dec 2019 12:00:00 EST

Persistent Postpartum Hypertension Pilot Trial

Condition:   Hypertension in Pregnancy
Interventions:   Drug: Nifedipine Extended-Release Tablets;   Other: No Antihypertensive Medication
Sponsor:   Duke University
Recruiting
Thu, 16 Apr 2020 12:00:00 EDT

Drugs for High Blood Pressure and High Cholesterol in American Indians With Type 2 Diabetes

Condition:   Diabetic Nephropathy
Interventions:   Drug: Lisinopril;   Drug: Nifedipine;   Drug: Simvastatin
Sponsors:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   Hennepin County Medical Center, Minneapolis
Completed
Tue, 19 Oct 1999 12:00:00 EDT

The Efficacy, Safety and Genetic Polymorphism of Hypoca and Adalat OROS in Hypertensive Patients

Condition:   Hypertension
Intervention:  
Sponsor:   National Taiwan University Hospital
Completed
Wed, 06 Aug 2008 12:00:00 EDT

Autologous Adipose Tissue in the Treatment of Systemic Sclerosis Digital Ulcers

Conditions:   Systemic Sclerosis;   Digital Ulcer
Interventions:   Procedure: Autologous fat grafting;   Procedure: Sham procedure
Sponsors:   ASST Gaetano Pini-CTO;   Società Italiana di Reumatologia
Unknown status
Tue, 23 Jan 2018 12:00:00 EST

Raynaud's Treatment Study (RTS)

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Raynaud's Disease;   Vascular Diseases
Interventions:   Drug: nifedipine;   Behavioral: biofeedback (psychology);   Procedure: electromyography
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed
Thu, 28 Oct 1999 12:00:00 EDT

Effect of Renin-angiotensin System Blockers on Glomerular Filtration Rate in Patients With Hypertension, Type 2 Diabetes With Normoalbuminuria

Conditions:   Diabetes;   Hypertensive Disease
Interventions:   Drug: Renin-angiotensin system blockers;   Drug: non-renin angiotensin system blockers
Sponsor:   Hospital Authority, Hong Kong
Unknown status
Wed, 28 Dec 2011 12:00:00 EST

Vardenafil ODT (Orally Disintegrating Tablet) - Nifedipine Interaction Study

Condition:   Erectile Dysfunction
Interventions:   Drug: Vardenafil ODT, (Staxyn, BAY38-9456);   Drug: Placebo
Sponsors:   Bayer;   GlaxoSmithKline;   Merck Sharp & Dohme Corp.
Completed
Fri, 06 May 2011 12:00:00 EDT

Effects of the Use of Adjuvant Drugs After Extracorporeal Shockwave Lithotripsy (ESWL) in Renal Calculus

Condition:   Renal Calculi
Intervention:   Drug: Tamsulosin
Sponsors:   University of Sao Paulo General Hospital;   Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.
Unknown status
Wed, 06 Oct 2010 12:00:00 EDT

Alfuzosin for Medical Expulsion Therapy of Ureteral Stones

Condition:   Kidney Stones
Interventions:   Drug: Alfuzosin;   Drug: nifedipine;   Drug: doxazosin;   Drug: prazosin
Sponsor:   United States Naval Medical Center, San Diego
Unknown status
Fri, 11 Jul 2008 12:00:00 EDT

The Effects of Cilnidipine on Metabolic Syndrome Improvement

Conditions:   Hypertension;   Metabolic Syndrome X
Intervention:   Drug: Cilnidipine
Sponsor:   Boryung Pharmaceutical Co., Ltd
Completed
Mon, 15 May 2006 12:00:00 EDT

Management of Acute Preterm Labor: Nifedipen Alone or Combined With Cildenafil Citrate

Condition:   Labor Preterm Requiring Hospitalization
Interventions:   Drug: nifedipen;   Drug: Sildenafil
Sponsors:   Al Hayat National Hospital;   Menoufia University
Unknown status
Wed, 14 Jan 2015 12:00:00 EST

Treatment of Supine Hypertension in Autonomic Failure

Condition:   Hypertension
Interventions:   Drug: Clonidine;   Drug: Nitroglycerin transdermal;   Drug: Dipyridamole/ Aspirin (Aggrenox);   Drug: Desmopressin (DDAVP);   Drug: Sildenafil;   Drug: Nifedipine;   Drug: Hydralazine;   Drug: Hydrochlorothiazide;   Drug: Placebo;   Drug: Bosentan;   Drug: Diltiazem;   Drug: Eplerenone;   Drug: guanfacine;   Dietary Supplement: L-arginine;   Drug: captopril;   Drug: carbidopa;   Drug: losartan;   Drug: metoprolol tartrate;   Drug: nebivolol hydrochloride;   Drug: prazosin hydrochloride;   Drug: tamsulosin hydrochloride;   Other: Head-up tilt.;   Drug: aliskiren;   Other: Local heat stress
Sponsor:   Vanderbilt University
Completed
Thu, 22 Sep 2005 12:00:00 EDT

Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients With Severe Preeclampsia

Condition:   Postpartum Preeclampsia
Intervention:   Drug: Diltiazem
Sponsors:   Hospital de la Mujer;   Ocharan-Hernández, Esther, MD, PhD;   Vargas-De-León, Cruz, MSc;   Calzada-Mendoza, Claudia, PhD
Completed
Fri, 10 Jan 2020 12:00:00 EST

Three New Ideas to Protect Special Forces From the Stress of High Altitude

Condition:   Mountain Sickness
Interventions:   Dietary Supplement: Quercetin;   Drug: Nifedipine extended release;   Drug: Methazolamide;   Drug: Metformin;   Drug: Placebo;   Drug: Nitrite
Sponsors:   University of Colorado, Denver;   Alma College
Completed
Thu, 04 Jun 2015 12:00:00 EDT

The Antihypertensives and Vascular, Endothelial and Cognitive Function Trial

Conditions:   Cognitive Impairment;   Hypertension;   Aging
Interventions:   Drug: candesartan;   Drug: lisinopril;   Drug: hydrochlorothiazide;   Drug: nifedipine, long acting;   Drug: metoprolol, long-acting
Sponsors:   University of Southern California;   National Institute on Aging (NIA);   Hebrew SeniorLife
Completed
Wed, 30 Jan 2008 12:00:00 EST

The Effect of Zinc, β-carotene, and Vitamin D3 in Preterm Delivery Through Placental MyD88, TRIF, NFkB, and IL-1β

Condition:   PreTerm Birth
Interventions:   Drug: Zinc;   Drug: Nifedipine;   Drug: Beta Carotene;   Drug: Vitamin D3;   Drug: Dexamethasone
Sponsor:   Indonesia University
Completed
Thu, 29 Dec 2016 12:00:00 EST

Treatment Targets for Chronic Hypertension in Pregnancy

Conditions:   Pregnancy Toxemia;   Hypertension;   Proteinuria
Interventions:   Drug: methyldopa;   Drug: labetalol;   Drug: nifedipine;   Drug: clonidine
Sponsor:   Weill Medical College of Cornell University
Withdrawn
Mon, 19 Sep 2005 12:00:00 EDT

Drug Discrimination in Methadone-Maintained Humans Study 3

Condition:   Drug Dependence
Intervention:   Drug: 2-4 of the drugs listed below
Sponsors:   University of Arkansas;   National Institute on Drug Abuse (NIDA)
Completed
Mon, 15 Feb 2010 12:00:00 EST

Drug Discrimination in Methadone-Maintained Humans Study 2

Condition:   Opioid Dependence
Intervention:   Drug: 2-4 of the drugs listed below
Sponsors:   University of Arkansas;   National Institute on Drug Abuse (NIDA)
Completed
Wed, 13 Aug 2008 12:00:00 EDT

Tocolytics Trial: Intravenous (IV) Magnesium Versus Oral Nifedpine in Fetal Fibronectin (FFN) Postive Population

Condition:   Labor, Premature
Interventions:   Drug: Magnesium;   Drug: Nifedlipine
Sponsor:   MemorialCare
Terminated
Mon, 24 Mar 2008 12:00:00 EDT

Drug Discrimination in Methadone-Maintained Humans Study 1

Condition:   Drug Dependence
Interventions:   Drug: Cycloserine;   Drug: Diltiazem;   Drug: Gabapentin;   Drug: Isradipine;   Drug: Naloxone;   Drug: Nifedipine;   Drug: Placebo;   Device: Saline;   Drug: Verapamil
Sponsor:   University of Arkansas
Completed
Tue, 15 Jan 2008 12:00:00 EST

Evaluation of Vaginal PAMG-1 Detection by PartoSure Test in Preterm Delivery Threat in Actual Clinical Situation: Randomized Controlled Trial

Condition:   Pregnancy Preterm
Interventions:   Other: Current care;   Device: PartoSure Test negative;   Device: PartoSure Test positive
Sponsor:   University Hospital, Brest
Completed
Tue, 18 Sep 2018 12:00:00 EDT

Coronavirus (COVID-19) ACEi/ARB Investigation

Conditions:   Hypertension;   COVID-19
Interventions:   Drug: Thiazide or Thiazide-like diuretics;   Drug: Calcium Channel Blockers;   Drug: ACE inhibitor;   Drug: Angiotensin receptor blocker
Sponsor:   National University of Ireland, Galway, Ireland
Suspended
Wed, 01 Apr 2020 12:00:00 EDT

Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

Conditions:   Lactating Women on Select DOI;   Breastfed Infants of Mothers on Select DOI
Interventions:   Other: Tranexamic acid (TXA);   Other: labetalol;   Other: metformin;   Other: nifedipine;   Other: clindamycin;   Other: oxycodone;   Other: azithromycin;   Other: escitalopram;   Other: sertraline;   Other: ondansetron;   Other: Ciprofloxacin;   Other: Doxycycline;   Other: Levofloxacin;   Other: Methylphenidate;   Other: Sumatriptan;   Other: Citalopram;   Other: Cyclobenzaprine;   Other: Furosemide;   Other: Gabapentin;   Other: Hydrochlorothiazide;   Other: Hydroxyurea;   Other: Rosuvastatin;   Other: Topiramate;   Other: Trazodone;   Other: Valganciclovir;   Other: Venlafaxine;   Other: Verapamil;   Other: Remdesivir;   Other: Anakinra;   Other: Tocilizumab;   Other: Fluvoxamine
Sponsors:   Duke University;   The Emmes Company, LLC;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting
Fri, 27 Apr 2018 12:00:00 EDT

Maternal Serum Level of ACTH as a Predictive Marker of Preterm Labor in Patients With Threatened Preterm Labor

Condition:   Threatened Preterm Labor
Intervention:   Other: collection of blood sample and tocolysis adminstration
Sponsor:   Ain Shams Maternity Hospital
Completed
Wed, 23 Jan 2013 12:00:00 EST

Asymptomatic Cardiac Ischemia Pilot (ACIP) Study

Conditions:   Cardiovascular Diseases;   Coronary Disease;   Heart Diseases;   Myocardial Ischemia
Interventions:   Drug: atenolol;   Drug: nifedipine;   Drug: diltiazem;   Drug: isosorbide dinitrate;   Procedure: coronary artery bypass coronary artery bypass;   Procedure: angioplasty, transluminal, percutaneous coronary
Sponsor:   National Heart, Lung, and Blood Institute (NHLBI)
Completed
Thu, 28 Oct 1999 12:00:00 EDT

Standard Medical Management in Secondary Prevention of Ischemic Stroke in China

Condition:   Stroke
Interventions:   Drug: Aspirin / Clopidogrel, Atorvastatin / Simvastatin;   Drug: Asprin / Clopidogrel, Atorvastatin / Simvastatin
Sponsor:   Peking Union Medical College Hospital
Completed
Wed, 23 Apr 2008 12:00:00 EDT

Efficacy and Safety of Stent Implantation in Symptomatic Extra- and Intracranial Artery Stenosis

Conditions:   Stroke;   Transient Ischemic Attack;   Atherosclerosis;   Stenosis;   Stents
Interventions:   Device: Stent implantation (Wingspan, Coroflex, and TiTAN2);   Drug: Standard medical treatment
Sponsor:   Peking Union Medical College Hospital
Completed
Thu, 05 Jun 2008 12:00:00 EDT

Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension

Condition:   Hypertension
Interventions:   Drug: clinical hypertension specialist-no specific med. Any anti-hypertension meds.;   Drug: renin guided therapeutics-no specific med. Any anti-hypertensive med.
Sponsors:   Medical University of South Carolina;   New York Presbyterian Hospital
Completed
Mon, 26 May 2008 12:00:00 EDT

Early Vascular Adjustments to Prevent Preeclampsia

Conditions:   Preeclampsia;   Small for Gestational Age at Delivery;   HELLP Syndrome
Intervention:   Drug: tailored pharmaceutical treatment
Sponsor:   Maastricht University Medical Center
Completed
Fri, 03 Jan 2020 12:00:00 EST

The Standardized Management of Hypertension in Rural Shaanxi

Condition:   Hypertension
Intervention:   Drug: Hydrochlorothiazide, Captopril, Nitrendipine, Aspirin
Sponsor:   First Affiliated Hospital Xi'an Jiaotong University
Completed
Fri, 01 May 2020 12:00:00 EDT

Black Education and Treatment of Hypertension (BEAT HTN)

Condition:   Hypertension
Interventions:   Drug: Hydrochlorothiazide;   Drug: Lisinopril;   Drug: Lisinopril and Hydrochlorothiazide;   Drug: Nifedipine XL;   Drug: Metoprolol tartrate;   Drug: Atenolol;   Drug: Valsartan;   Drug: Doxazosin;   Drug: Clonidine;   Drug: Hydralazine;   Drug: Metoprolol succinate;   Drug: Amlodipine
Sponsor:   Creighton University
Completed
Mon, 21 Apr 2008 12:00:00 EDT

Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure

Conditions:   Mitral Valve Insufficiency;   Heart Failure
Interventions:   Procedure: Surgical mitral valvuloplasty with placement of annular ring (SMVR);   Drug: Optimal medical therapy (OMT)
Sponsors:   Duke University;   National Heart, Lung, and Blood Institute (NHLBI);   Heart Failure Clinical Research Network
Terminated
Wed, 06 Feb 2008 12:00:00 EST

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

Conditions:   Coronavirus Infection (COVID-19);   Pulmonary Arterial Hypertension;   Urinary Tract Infections in Children;   Hypertension;   Pain;   Hyperphosphatemia;   Primary Hyperaldosteronism;   Edema;   Hypokalemia;   Heart Failure;   Hemophilia;   Menorrhagia;   Insomnia;   Pneumonia;   Skin Infection;   Arrythmia;   Asthma in Children;   Bronchopulmonary Dysplasia;   Adrenal Insufficiency;   Fibrinolysis; Hemorrhage;   Attention Deficit Hyperactivity Disorder;   Multisystem Inflammatory Syndrome in Children (MIS-C);   Kawasaki Disease;   Coagulation Disorder;   Down Syndrome
Intervention:   Drug: The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
Sponsors:   Duke University;   The Emmes Company, LLC;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting
Thu, 20 Feb 2020 12:00:00 EST

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care

Conditions:   Adenovirus;   Anesthesia;   Anxiety;   Anxiolysis;   Autism;   Autistic Disorder;   Bacterial Meningitis;   Bacterial Septicemia;   Benzodiazepine;   Bipolar Disorder;   Bone and Joint Infections;   Central Nervous System Infections;   Convulsions;   Cytomegalovirus Retinitis;   Early-onset Schizophrenia Spectrum Disorders;   Epilepsy;   General Anesthesia;   Gynecologic Infections;   Herpes Simplex Virus;   Infantile Hemangioma;   Infection;   Inflammation;   Inflammatory Conditions;   Intra-abdominal Infections;   Lower Respiratory Tract Infections;   Migraines;   Pain;   Pneumonia;   Schizophrenia;   Sedation;   Seizures;   Skeletal Muscle Spasms;   Skin and Skin-structure Infections;   Treatment-resistant Schizophrenia;   Urinary Tract Infections;   Withdrawal;   Sepsis;   Gram-negative Infection;   Bradycardia;   Cardiac Arrest;   Cardiac Arrhythmia;   Staphylococcal Infections;   Nosocomial Pneumonia;   Neuromuscular Blockade;   Methicillin Resistant Staphylococcus Aureus;   Endocarditis;   Neutropenia;   Headache;   Fibrinolytic Bleeding;   Pulmonary Arterial Hypertension;   CMV Retinitis;   Hypertension;   Chronic Kidney Diseases;   Hyperaldosteronism;   Hypokalemia;   Heart Failure;   Hemophilia;   Heavy Menstrual Bleeding;   Insomnia
Intervention:   Drug: The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
Sponsors:   Daniel Benjamin;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   The Emmes Company, LLC
Completed
Fri, 09 Sep 2011 12:00:00 EDT

Sevoflurane Versus Intravenous Anaesthetic Agents in Morbid Obese Patients

Condition:   Morbid Obesity
Interventions:   Drug: Sevoflurane;   Drug: Propofol- Remifentanyl;   Drug: Propofol, Remifentanyl
Sponsor:   University of Patras
Unknown status
Wed, 19 Jan 2011 12:00:00 EST

ACEI or ARB and COVID-19 Severity and Mortality in US Veterans

Conditions:   Hypertension;   COVID
Interventions:   Drug: ACEI/ARB;   Drug: Non-ACEI/ARB;   Drug: ACEI;   Drug: ARB
Sponsors:   University of Utah;   VA Salt Lake City Health Care System;   University of Pennsylvania;   Wake Forest University Health Sciences;   University of Florida;   Johns Hopkins Bloomberg School of Public Health;   Boston University;   Northwestern University;   Edith Nourse Rogers Memorial Veterans Hospital;   Columbia University;   MedStar Georgetown University Hospital
Completed
Mon, 13 Jul 2020 12:00:00 EDT

Pragmatic Clinical Trials in Scleroderma

Conditions:   Scleroderma, Systemic;   Sclerosis, Systemic
Interventions:   Other: Interstitial lung disease induction algorithm;   Other: Pulmonary arterial hypertension algorithm;   Other: Raynaud's phenomenon algorithm;   Other: Digital ulcer algorithm;   Other: Inflammatory arthritis algorithm;   Other: Gastroesophageal reflux algorithm;   Other: Bacterial overgrowth algorithm;   Other: Constipation algorithm;   Other: Skin involvement algorithm;   Other: Pain algorithm
Sponsors:   University of West London;   University of Western Ontario, Canada
Unknown status
Wed, 01 Aug 2018 12:00:00 EDT