Full text biomedical articles

Prodrug Strategies for Paclitaxel

Ziyuan Meng, Quanxia Lv, Jun Lu, Houzong Yao, Xiaoqing Lv, Feng Jiang, Aiping Lu, Ge Zhang
Int J Mol Sci. 2016 May; 17(5): 796. Published online 2016 May 23. doi: 10.3390/ijms17050796


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Paclitaxel and Its Evolving Role in the Management of Ovarian Cancer

Nirmala Chandralega Kampan, Mutsa Tatenda Madondo, Orla M. McNally, Michael Quinn, Magdalena Plebanski
Biomed Res Int. 2015; 2015: 413076. Published online 2015 Jun 7. doi: 10.1155/2015/413076


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Paclitaxel-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish

Thomas S. Lisse, Leah J. Middleton, Adriana D. Pellegrini, Paige B. Martin, Emily L. Spaulding, Olivia Lopes, Elizabeth A. Brochu, Erin V. Carter, Ashley Waldron, Sandra Rieger
Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15): E2189–E2198. Published online 2016 Mar 28. doi: 10.1073/pnas.1525096113


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A New 2α,5α,10β,14β-tetraacetoxy-4(20),11-taxadiene (SIA) Derivative Overcomes Paclitaxel Resistance by Inhibiting MAPK Signaling and Increasing Paclitaxel Accumulation in Breast Cancer Cells

Mei Mei, Dan Xie, Yi Zhang, Jing Jin, Feng You, Yan Li, Jungui Dai, Xiaoguang Chen
PLoS One. 2014; 9(8): e104317. Published online 2014 Aug 5. doi: 10.1371/journal.pone.0104317


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Pathogenesis of paclitaxel-induced peripheral neuropathy: A current review of in vitro and in vivo findings using rodent and human model systems

Nathan P. Staff, Jill C. Fehrenbacher, Martial Caillaud, M. Imad Damaj, Rosalind A. Segal, Sandra Rieger
Exp Neurol. Author manuscript; available in PMC 2021 Feb 1.
Published in final edited form as: Exp Neurol. 2020 Feb; 324: 113121. Published online 2019 Nov 21. doi: 10.1016/j.expneurol.2019.113121


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Effects of paclitaxel on the development of neuropathy and affective behaviors in the mouse

Wisam Toma, S. Lauren Kyte, Deniz Bagdas, Yasmin Alkhlaif, Shakir D. Alsharari, Aron H. Lichtman, Zhi-Jian Chen, Egidio Del Fabbro, John W. Bigbee, David A. Gewirtz, M Imad Damaj
Neuropharmacology. Author manuscript; available in PMC 2018 May 1.
Published in final edited form as: Neuropharmacology. 2017 May 1; 117: 305–315. Published online 2017 Feb 22. doi: 10.1016/j.neuropharm.2017.02.020


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Albumin-bound nanoparticle (nab) paclitaxel exhibits enhanced paclitaxel tissue distribution and tumor penetration

Nianhang Chen, Carrie Brachmann, Xiping Liu, Daniel W. Pierce, Joyoti Dey, William S. Kerwin, Yan Li, Simon Zhou, Shihe Hou, Michael Carleton, Richard A. Klinghoffer, Maria Palmisano, Rajesh Chopra
Cancer Chemother Pharmacol. 2015; 76: 699–712. Published online 2015 Aug 1. doi: 10.1007/s00280-015-2833-5


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Monoacylglycerol Lipase Inhibitors Reverse Paclitaxel-Induced Nociceptive Behavior and Proinflammatory Markers in a Mouse Model of Chemotherapy-Induced Neuropathy

Zachary A. Curry, Jenny L. Wilkerson, Deniz Bagdas, S. Lauren Kyte, Nipa Patel, Giulia Donvito, Mohammed A. Mustafa, Justin L. Poklis, Micah J. Niphakis, Ku-Lung Hsu, Benjamin F. Cravatt, David A. Gewirtz, M. Imad Damaj, Aron H. Lichtman
J Pharmacol Exp Ther. 2018 Jul; 366(1): 169–183. Published online 2018 Jul. doi: 10.1124/jpet.117.245704


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Nano albumin bound-paclitaxel in pancreatic cancer: Current evidences and future directions

Guido Giordano, Massimo Pancione, Nunzio Olivieri, Pietro Parcesepe, Marianna Velocci, Tania Di Raimo, Luigi Coppola, Giuseppe Toffoli, Mario Rosario D’Andrea
World J Gastroenterol. 2017 Aug 28; 23(32): 5875–5886. Published online 2017 Aug 28. doi: 10.3748/wjg.v23.i32.5875


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Paclitaxel Enhances the Innate Immunity by Promoting NLRP3 Inflammasome Activation in Macrophages

Qiong-zhen Zeng, Fan Yang, Chen-guang Li, Li-hui Xu, Xian-hui He, Feng-yi Mai, Chen-ying Zeng, Cheng-cheng Zhang, Qing-bing Zha, Dong-yun Ouyang
Front Immunol. 2019; 10: 72. Published online 2019 Jan 29. doi: 10.3389/fimmu.2019.00072


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Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects

Erica L. Gornstein, Thomas L. Schwarz
Exp Neurol. Author manuscript; available in PMC 2018 Feb 1.
Published in final edited form as: Exp Neurol. 2017 Feb; 288: 153–166. Published online 2016 Nov 26. doi: 10.1016/j.expneurol.2016.11.015


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Truncated HDAC9 identified by integrated genome-wide screen as the key modulator for paclitaxel resistance in triple-negative breast cancer

Bi Lian, Yu-Chen Pei, Yi-Zhou Jiang, Meng-Zhu Xue, Da-Qiang Li, Xiao-Guang Li, Yi-Zi Zheng, Xi-Yu Liu, Feng Qiao, Wei-Li Sun, Hong Ling, Min He, Ling Yao, Xin Hu, Zhi-Ming Shao
Theranostics. 2020; 10(24): 11092–11109. Published online 2020 Sep 2. doi: 10.7150/thno.44997


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Paclitaxel induces acute pain via directly activating toll like receptor 4

Xisheng Yan, Dylan W Maixner, Ruchi Yadav, Mei Gao, Pei Li, Michael G Bartlett, Han-Rong Weng
Mol Pain. 2015; 11: 10. Published online 2015 Mar 11. doi: 10.1186/s12990-015-0005-6


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Paclitaxel Treatment and Proprotein Convertase 1/3 (PC1/3) Knockdown in Macrophages is a Promising Antiglioma Strategy as Revealed by Proteomics and Cytotoxicity Studies

Marie Duhamel, Mélanie Rose, Franck Rodet, Adriana Natalia Murgoci, Lea Zografidou, Anne Régnier-Vigouroux, Fabien Vanden Abeele, Firas Kobeissy, Serge Nataf, Laurent Pays, Maxence Wisztorski, Dasa Cizkova, Isabelle Fournier, Michel Salzet
Mol Cell Proteomics. 2018 Jun; 17(6): 1126–1143. Published online 2018 Mar 12. doi: 10.1074/mcp.RA117.000443


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Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms

Mark Borris D. Aldonza, Jayoung Ku, Ji-Young Hong, Donghwa Kim, Seung Jung Yu, Min-Seok Lee, Monica Celine Prayogo, Stephanie Tan, Dayeon Kim, Jinju Han, Sang Kook Lee, Sung Gap Im, Han Suk Ryu, Yoosik Kim
Sci Adv. 2020 Feb; 6(6): eaav7416. Published online 2020 Feb 7. doi: 10.1126/sciadv.aav7416


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Dietary bakers yeast sensitizes Ehrlich mammary adenocarcinoma to paclitaxel in mice bearing tumor

Mamdooh Ghoneum, Nariman K. Badr El-Din, Ashraf Z. Mahmoud, Lucilene Tolentino, Deyu Pan, Tahia Ali Hassan
Oncol Rep. 2019 Jun; 41(6): 3155–3166. Published online 2019 Apr 10. doi: 10.3892/or.2019.7107


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Chemotherapeutic Agent Paclitaxel Mediates Priming of NLRP3 Inflammasome Activation

Seunghwan Son, Do-Wan Shim, Inhwa Hwang, Jong-Hwan Park, Je-Wook Yu
Front Immunol. 2019; 10: 1108. Published online 2019 May 16. doi: 10.3389/fimmu.2019.01108


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Paclitaxel-activated astrocytes produce mechanical allodynia in mice by releasing tumor necrosis factor-α and stromal-derived cell factor 1

Xiaojuan Liu, Raquel Tonello, Yuejuan Ling, Yong-Jing Gao, Temugin Berta
J Neuroinflammation. 2019; 16: 209. Published online 2019 Nov 10. doi: 10.1186/s12974-019-1619-9


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Wnt Signaling Protects against Paclitaxel-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea In Vitro

Xue Wang, Yuechen Han, Man Wang, Chuan Bo, Zhenbiao Zhang, Lei Xu, Wenwen Liu, Haibo Wang
Biomed Res Int. 2019; 2019: 7878906. Published online 2019 Oct 7. doi: 10.1155/2019/7878906


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The Cancer Chemotherapeutic Paclitaxel Increases Human and Rodent Sensory Neuron Responses to TRPV1 by Activation of TLR4

Yan Li, Pavel Adamek, Haijun Zhang, Claudio Esteves Tatsui, Laurence D. Rhines, Petra Mrozkova, Qin Li, Alyssa K. Kosturakis, Ryan M. Cassidy, Daniel S. Harrison, Juan P. Cata, Kenneth Sapire, Hongmei Zhang, Ross M. Kennamer-Chapman, Abdul Basit Jawad, Andre Ghetti, Jiusheng Yan, Jiri Palecek, Patrick M. Dougherty
J Neurosci. 2015 Sep 30; 35(39): 13487–13500. doi: 10.1523/JNEUROSCI.1956-15.2015


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