Full text biomedical articles

Renal cyst growth is attenuated by a combination treatment of tolvaptan and pioglitazone, while pioglitazone treatment alone is not effective

Anish A. Kanhai, Hester Bange, Lotte Verburg, Kyra L. Dijkstra, Leo S. Price, Dorien J. M. Peters, Wouter N. Leonhard
Sci Rep. 2020; 10: 1672. Published online 2020 Feb 3. doi: 10.1038/s41598-020-58382-z


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Pioglitazone and PPAR-γ modulating treatment in hypertensive and type 2 diabetic patients after ischemic stroke: a national cohort study

Chi-Hung Liu, Tsong-Hai Lee, Yu-Sheng Lin, Pi-Shan Sung, Yi-Chia Wei, Yan-Rong Li
Cardiovasc Diabetol. 2020; 19: 2. Published online 2020 Jan 7. doi: 10.1186/s12933-019-0979-x


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Pioglitazone improves phagocytic activity of liver recruited macrophages in elderly mice possibly by promoting glucose catabolism

Masahiro Nakashima, Manabu Kinoshita, Hiroyuki Nakashima, Aya Kotani, Takuya Ishikiriyama, Shoichiro Kato, Sadayuki Hiroi, Shuhji Seki
Innate Immun. 2019 Aug; 25(6): 356–368. Published online 2019 May 16. doi: 10.1177/1753425919849620


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Pioglitazone improves hepatic mitochondrial function in a mouse model of nonalcoholic steatohepatitis

Srilaxmi Kalavalapalli, Fernando Bril, Jeremy P. Koelmel, Kaitlyn Abdo, Joy Guingab, Paige Andrews, Wen-Yi Li, Dhanya Jose, Richard A. Yost, Reginald F. Frye, Timothy J. Garrett, Kenneth Cusi, Nishanth E. Sunny
Am J Physiol Endocrinol Metab. 2018 Aug 1; 315(2): E163–E173. Published online 2018 Apr 10. doi: 10.1152/ajpendo.00023.2018


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Influence of drug transporters and stereoselectivity on the brain penetration of pioglitazone as a potential medicine against Alzheimer's disease

Kai Lun Chang, Hai Ning Pee, Shili Yang, Paul C. Ho
Sci Rep. 2015; 5: 9000. Published online 2015 Mar 11. doi: 10.1038/srep09000


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Effect of pioglitazone in acute ischemic stroke patients with diabetes mellitus: a nested case–control study

Min-Hee Woo, Hye Sun Lee, Jinkwon Kim
Cardiovasc Diabetol. 2019; 18: 67. Published online 2019 May 31. doi: 10.1186/s12933-019-0874-5


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Efficacy and Safety of Pioglitazone Monotherapy in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Fahmida Alam, Md. Asiful Islam, Mafauzy Mohamed, Imran Ahmad, Mohammad Amjad Kamal, Richard Donnelly, Iskandar Idris, Siew Hua Gan
Sci Rep. 2019; 9: 5389. Published online 2019 Mar 29. doi: 10.1038/s41598-019-41854-2


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Pioglitazone for primary stroke prevention in Asian patients with type 2 diabetes and cardiovascular risk factors: a retrospective study

Yi-Chih Hung, Lu-Ting Chiu, Hung-Yu Huang, Da-Tian Bau
Cardiovasc Diabetol. 2020; 19: 94. Published online 2020 Jun 20. doi: 10.1186/s12933-020-01056-x


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Pioglitazone suppresses excessive follicular development in murine preantral follicles

Sachiko Nagao, Tsuyoshi Baba, Yuya Fujibe, Sayaka Adachi, Keiko Ikeda, Miyuki Morishita, Yoshika Kuno, Hiroyuki Honnma, Toshiaki Endo, Tamotsu Kiya, Tsuyoshi Saito
J Ovarian Res. 2019; 12: 82. Published online 2019 Aug 31. doi: 10.1186/s13048-019-0556-7


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Pioglitazone Normalizes Insulin Signaling in the Diabetic Rat Retina through Reduction in Tumor Necrosis Factor α and Suppressor of Cytokine Signaling 3

Youde Jiang, Shalini Thakran, Rajini Bheemreddy, Eun-Ah Ye, Hui He, Robert J. Walker, Jena J. Steinle
J Biol Chem. 2014 Sep 19; 289(38): 26395–26405. Published online 2014 Aug 1. doi: 10.1074/jbc.M114.583880


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Heart Failure after Ischemic Stroke or TIA in Insulin-Resistant Patients without Diabetes Treated with Pioglitazone

Lawrence H. Young, Catherine M. Viscoli, Gregory G. Schwartz, Silvio E. Inzucchi, Jeptha P. Curtis, Mark J. Gorman, Karen L. Furie, Robin Conwit, Erica Spatz, Anne Lovejoy, J. Dawn Abbott, Daniel L. Jacoby, Daniel M. Kolansky, Frederick S. Ling, Steven E. Pfau, Walter N. Kernan
Circulation. Author manuscript; available in PMC 2019 Sep 18.
Published in final edited form as: Circulation. 2018 Sep 18; 138(12): 1210–1220. doi: 10.1161/CIRCULATIONAHA.118.034763


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Pioglitazone Enhances Cytosolic Lipolysis, β-oxidation and Autophagy to Ameliorate Hepatic Steatosis

Pi-Jung Hsiao, Hsin-Ying Clair Chiou, He-Jiun Jiang, Mei-Yueh Lee, Tusty-Jiuan Hsieh, Kung-Kai Kuo
Sci Rep. 2017; 7: 9030. Published online 2017 Aug 22. doi: 10.1038/s41598-017-09702-3


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Pioglitazone Protects Compression-Mediated Apoptosis in Nucleus Pulposus Mesenchymal Stem Cells by Suppressing Oxidative Stress

Yiqiang Hu, Liang Huang, Min Shen, Yunlu Liu, Guohui Liu, Yongchao Wu, Fan Ding, Kaige Ma, Wentian Wang, Yanbin Zhang, Zengwu Shao, Xianyi Cai, Liming Xiong
Oxid Med Cell Longev. 2019; 2019: 4764071. Published online 2019 Nov 22. doi: 10.1155/2019/4764071


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Pioglitazone increases VEGFR3 expression and promotes activation of M2 macrophages via the peroxisome proliferator-activated receptor γ

Conghui Zhang, Ying Zhang, Chunxiu Zhang, Yang Liu, Yanyan Liu, Gang Xu
Mol Med Rep. 2019 Apr; 19(4): 2740–2748. Published online 2019 Feb 7. doi: 10.3892/mmr.2019.9945


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Assessment of pioglitazone and proinflammatory cytokines during buprenorphine taper in patients with opioid use disorder

Jennifer R. Schroeder, Karran A. Phillips, David H. Epstein, Michelle L. Jobes, Melody A. Furnari, Ashley P. Kennedy, Markus Heilig, Kenzie L. Preston
Psychopharmacology (Berl) Author manuscript; available in PMC 2020 Jun 10.
Published in final edited form as: Psychopharmacology (Berl). 2018 Oct; 235(10): 2957–2966. Published online 2018 Aug 6. doi: 10.1007/s00213-018-4986-5


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Metabolomic and lipidomic analysis of the effect of pioglitazone on hepatic steatosis in a rat model of obese Type 2 diabetes

Hyekyung Yang, Dong Ho Suh, Dae Hee Kim, Eun Sung Jung, Kwang‐Hyeon Liu, Choong Hwan Lee, Cheol‐Young Park
Br J Pharmacol. 2018 Sep; 175(17): 3610–3625. Published online 2018 Jul 26. doi: 10.1111/bph.14434


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Bioenergetic restoration and neuroprotection after therapeutic targeting of mitoNEET: new mechanism of Pioglitazone following traumatic brain injury

Heather M. Yonutas, W. Brad Hubbard, Jignesh D. Pandya, Hemendra J. Vekaria, Werner J. Geldenhuys, Patrick G. Sullivan
Exp Neurol. Author manuscript; available in PMC 2021 May 1.
Published in final edited form as: Exp Neurol. 2020 May; 327: 113243. Published online 2020 Feb 10. doi: 10.1016/j.expneurol.2020.113243


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Pioglitazone Induces Cardiomyocyte Apoptosis and Inhibits Cardiomyocyte Hypertrophy Via VEGFR-2 Signaling Pathway

Wenliang Zhong, Wen Jin, Shanghua Xu, Yanqing Wu, Shunxiang Luo, Minlie Liang, Lianglong Chen
Arq Bras Cardiol. 2018 Aug; 111(2): 162–169. doi: 10.5935/abc.20180108


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Pioglitazone Inhibits Periprostatic White Adipose Tissue Inflammation in Obese Mice

Miki Miyazawa, Kotha Subbaramaiah, Priya Bhardwaj, Xi K. Zhou, Hanhan Wang, Domenick J Falcone, Dilip D. Giri, Andrew J. Dannenberg
Cancer Prev Res (Phila) Author manuscript; available in PMC 2019 Apr 1.
Published in final edited form as: Cancer Prev Res (Phila). 2018 Apr; 11(4): 215–226. Published online 2017 Dec 8. doi: 10.1158/1940-6207.CAPR-17-0296


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Pioglitazone Ameliorates Smooth Muscle Cell Proliferation in Cuff-Induced Neointimal Formation by Both Adiponectin-Dependent and -Independent Pathways

Tetsuya Kubota, Naoto Kubota, Hiroyuki Sato, Mariko Inoue, Hiroki Kumagai, Tomokatsu Iwamura, Iseki Takamoto, Tsuneo Kobayashi, Masao Moroi, Yasuo Terauchi, Kazuyuki Tobe, Kohjiro Ueki, Takashi Kadowaki
Sci Rep. 2016; 6: 34707. Published online 2016 Oct 5. doi: 10.1038/srep34707


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