Full text biomedical articles

Haem oxygenase‐1 up‐regulation by rosiglitazone via ROS‐dependent Nrf2‐antioxidant response elements axis or PPARγ attenuates LPS‐mediated lung inflammation

Rou‐Ling Cho, Chien‐Chung Yang, Hui‐Ching Tseng, Li‐Der Hsiao, Chih‐Chung Lin, Chuen‐Mao Yang
Br J Pharmacol. 2018 Oct; 175(20): 3928–3946. Published online 2018 Sep 6. doi: 10.1111/bph.14465


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Rosiglitazone augments antioxidant response in the human trophoblast and prevents apoptosis

Hamid-Reza Kohan-Ghadr, Brian A Kilburn, Leena Kadam, Eugenia Johnson, Bradley L Kolb, Javier Rodriguez-Kovacs, Michael Hertz, D Randall Armant, Sascha Drewlo
Biol Reprod. 2019 Feb; 100(2): 479–494. Published online 2018 Aug 18. doi: 10.1093/biolre/ioy186


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Repurposing rosiglitazone, a PPAR-? agonist and oral antidiabetic, as an inhaled formulation, for the treatment of PAH

Jahidur Rashid, Ahmad Alobaida, Taslim A. Al-Hilal, Samia Hammouda, Ivan F. McMurtry, Eva Nozik-Grayck, Kurt R Stenmark, Fakhrul Ahsan
J Control Release. Author manuscript; available in PMC 2019 Jun 28.
Published in final edited form as: J Control Release. 2018 Jun 28; 280: 113–123. Published online 2018 Apr 30. doi: 10.1016/j.jconrel.2018.04.049


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Updating insights into rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses

Joshua D Wallach, Kun Wang, Audrey D Zhang, Deanna Cheng, Holly K Grossetta Nardini, Haiqun Lin, Michael B Bracken, Mayur Desai, Harlan M Krumholz, Joseph S Ross
BMJ. 2020; 368: l7078. Published online 2020 Feb 5. doi: 10.1136/bmj.l7078
Correction in:
BMJ. 2021; 373: n1302.


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The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism

Raymond L. Konger, Ethel Derr-Yellin, Nurmukambed Ermatov, Lu Ren, Ravi P. Sahu
Molecules. 2019 Jun; 24(11): 2192. Published online 2019 Jun 11. doi: 10.3390/molecules24112192


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Effect of hyperglycemia and rosiglitazone on renal and urinary neprilysin in db/db diabetic mice

Laale F. Alawi, Sana E. Emberesh, Brenda A. Owuor, Harshita Chodavarapu, Rucha Fadnavis, Salim S. El‐Amouri, Khalid M. Elased
Physiol Rep. 2020 Feb; 8(3): e14364. Published online 2020 Feb 5. doi: 10.14814/phy2.14364


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Rosiglitazone increases endothelial cell migration and vascular permeability through Akt phosphorylation

Yun Hyi Ku, Bong-Jun Cho, Min Joo Kim, Soo Lim, Young Joo Park, Hak C. Jang, Sung Hee Choi
BMC Pharmacol Toxicol. 2017; 18: 62. Published online 2017 Aug 30. doi: 10.1186/s40360-017-0169-y


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Involvement of Prolyl Hydroxylase Domain Protein in the Rosiglitazone-Induced Suppression of Osteoblast Differentiation

Ju-Hee Kang, Hyun Jeong Kwak, Hye-Eun Choi, Juyoung Kim, Sangmee Hong, Ok-Hee Kim, Byung Chul Oh, Hyae Gyeong Cheon
PLoS One. 2015; 10(9): e0139093. Published online 2015 Sep 29. doi: 10.1371/journal.pone.0139093


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Rosiglitazone has a neutral effect on the risk of dementia in type 2 diabetes patients

Chin-Hsiao Tseng
Aging (Albany NY) 2019 May 15; 11(9): 2724–2734. Published online 2019 May 14. doi: 10.18632/aging.101944


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Rosiglitazone Metabolism in Human Liver Microsomes Using a Substrate Depletion Method

Maryam Bazargan, David J. R. Foster, Andrew K. Davey, Beverly S. Muhlhausler
Drugs R D. 2017 Mar; 17(1): 189–198. Published online 2017 Jan 10. doi: 10.1007/s40268-016-0166-4


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Rosiglitazone Enhances Browning Adipocytes in Association with MAPK and PI3-K Pathways During the Differentiation of Telomerase-Transformed Mesenchymal Stromal Cells into Adipocytes

Abeer Maher Fayyad, Amir Ali Khan, Sallam Hasan Abdallah, Sara Sultan Alomran, Khalid Bajou, Muhammad Nasir Khan Khattak
Int J Mol Sci. 2019 Apr; 20(7): 1618. Published online 2019 Apr 1. doi: 10.3390/ijms20071618


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Lack of Impact by SCY‐078, a First‐in‐Class Oral Fungicidal Glucan Synthase Inhibitor, on the Pharmacokinetics of Rosiglitazone, a Substrate for CYP450 2C8, Supports the Low Risk for Clinically Relevant Metabolic Drug‐Drug Interactions

Stephen Wring, Gail Murphy, George Atiee, Christy Corr, Michele Hyman, Michael Willett, David Angulo
J Clin Pharmacol. 2018 Oct; 58(10): 1305–1313. Published online 2018 May 10. doi: 10.1002/jcph.1146


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Rosiglitazone Promotes Bone Marrow Adipogenesis to Impair Myelopoiesis under Stress

Wenyi Lu, Weimin Wang, Shujuan Wang, Yonghuai Feng, Kaiyan Liu
PLoS One. 2016; 11(2): e0149543. Published online 2016 Feb 19. doi: 10.1371/journal.pone.0149543


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Rosiglitazone in the thawing medium improves mitochondrial function in stallion spermatozoa through regulating Akt phosphorylation and reduction of caspase 3

José M. Ortiz-Rodriguez, Carolina Balao da Silva, Javier Masot, Eloy Redondo, Antonio Gazquez, José A. Tapia, Cruz Gil, Cristina Ortega-Ferrusola, Fernando J. Peña
PLoS One. 2019; 14(7): e0211994. Published online 2019 Jul 5. doi: 10.1371/journal.pone.0211994


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Rosiglitazone promotes ENaC-mediated alveolar fluid clearance in acute lung injury through the PPARγ/SGK1 signaling pathway

Jing He, Di Qi, Xu-mao Tang, Wang Deng, Xin-yu Deng, Yan Zhao, Dao-xin Wang
Cell Mol Biol Lett. 2019; 24: 35. Published online 2019 May 28. doi: 10.1186/s11658-019-0154-0


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Rosiglitazone polarizes microglia and protects against pilocarpine‐induced status epilepticus

Jing Peng, Kan Wang, Weiwei Xiang, Yan Li, Yong Hao, Yangtai Guan
CNS Neurosci Ther. 2019 Dec; 25(12): 1363–1372. Published online 2019 Nov 14. doi: 10.1111/cns.13265


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Rosiglitazone Suppresses In Vitro Seizures in Hippocampal Slice by Inhibiting Presynaptic Glutamate Release in a Model of Temporal Lobe Epilepsy

Shi-Bing Wong, Sin-Jhong Cheng, Wei-Chen Hung, Wang-Tso Lee, Ming-Yuan Min
PLoS One. 2015; 10(12): e0144806. Published online 2015 Dec 14. doi: 10.1371/journal.pone.0144806


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iNKT-CELL ACTIVATION INDUCES LATE PRETERM BIRTH THAT IS ATTENUATED BY ROSIGLITAZONE

Derek St Louis, Roberto Romero, Olesya Plazyo, Marcia Arenas-Hernandez, Bogdan Panaitescu, Yi Xu, Tatjana Milovic, Zhonghui Xu, Gaurav Bhatti, Mi Qing-Sheng, Sascha Drewlo, Adi L. Tarca, Sonia S. Hassan, Nardhy Gomez-Lopez
J Immunol. Author manuscript; available in PMC 2017 Feb 1.
Published in final edited form as: J Immunol. 2016 Feb 1; 196(3): 1044–1059. Published online 2016 Jan 6. doi: 10.4049/jimmunol.1501962


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The effects of rosiglitazone on the neonatal rat cardiomyocyte transcriptome: a temporal analysis

Willian Abraham da Silveira, Esteban Vazquez-Hidalgo, Elesha Bartolotta, Ludivine Renaud, Paul Paolini, Gary Hardiman
Pharmacogenomics. 2019 Nov; 20(16): 1125–1141. Published online 2019 Nov 22. doi: 10.2217/pgs-2019-0077


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Inhaled combination of sildenafil and rosiglitazone improves pulmonary hemodynamics, cardiac function, and arterial remodeling

Jahidur Rashid, Eva Nozik-Grayck, Ivan F. McMurtry, Kurt R. Stenmark, Fakhrul Ahsan
Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316(1): L119–L130. Published online 2018 Oct 11. doi: 10.1152/ajplung.00381.2018


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