References from scientific journals

Rosiglitazone polarizes microglia and protects against pilocarpine-induced status epilepticus.

Peng J, Wang K, Xiang W, Li Y, Hao Y, Guan Y. Peng J, et al. CNS Neurosci Ther. 2019 Dec;25(12):1363-1372. doi: 10.1111/cns.13265. Epub 2019 Nov 14. CNS Neurosci Ther. 2019. PMID: 31729170 Free PMC article.

The peroxisome proliferator-activated receptor gamma (PPAR gamma) agonist rosiglitazone has been shown to prevent microglial activation. However, its role in pilocarpine-induced status epilepticus remains unknown. ...CONCLUSION: Rosiglitazone reverses microglial pol …
The peroxisome proliferator-activated receptor gamma (PPAR gamma) agonist rosiglitazone has been shown to prevent microglial activati …

Rosiglitazone ameliorates tissue plasminogen activator-induced brain hemorrhage after stroke.

Li Y, Zhu ZY, Lu BW, Huang TT, Zhang YM, Zhou NY, Xuan W, Chen ZA, Wen DX, Yu WF, Li PY. Li Y, et al. CNS Neurosci Ther. 2019 Dec;25(12):1343-1352. doi: 10.1111/cns.13260. Epub 2019 Nov 22. CNS Neurosci Ther. 2019. PMID: 31756041 Free PMC article.

OBJECTIVE: Delayed thrombolytic therapy with recombinant tissue plasminogen activator (tPA) may exacerbate blood-brain barrier (BBB) breakdown after ischemic stroke and lead to catastrophic hemorrhagic transformation (HT). Rosiglitazone(RSG), a widely used antidiabetic dru …
OBJECTIVE: Delayed thrombolytic therapy with recombinant tissue plasminogen activator (tPA) may exacerbate blood-brain barrier (BBB) breakdo …

Effects of metformin, rosiglitazone and insulin on bone metabolism in patients with type 2 diabetes.

Stage TB, Christensen MH, Jørgensen NR, Beck-Nielsen H, Brøsen K, Gram J, Frost M. Stage TB, et al. Bone. 2018 Jul;112:35-41. doi: 10.1016/j.bone.2018.04.004. Epub 2018 Apr 12. Bone. 2018. PMID: 29654849 Free article. Clinical Trial.

Participants were randomized to short or long-acting human insulin (non-blinded) and then further randomized to metformin + placebo, rosiglitazone + placebo, metformin + rosiglitazone or placebo + placebo (blinded). ...Allocation of insulin regimens was not associat …
Participants were randomized to short or long-acting human insulin (non-blinded) and then further randomized to metformin + placebo, rosi …

Rosiglitazone.

Goldstein BJ. Goldstein BJ. Int J Clin Pract. 2000 Jun;54(5):333-7. Int J Clin Pract. 2000. PMID: 10954962

Unlike troglitazone, which has been associated with idiosyncratic hepatotoxicity and rare cases of liver failure and death, rosiglitazone has shown a low incidence of liver abnormalities in more than 3500 patient-years of exposure. No significant food or drug interactions …
Unlike troglitazone, which has been associated with idiosyncratic hepatotoxicity and rare cases of liver failure and death, rosiglitazone …

Rosiglitazone binds to RXRalpha to induce RXRalpha tetramerization and NB4 cell differentiation.

Huang F, Li Y, Chen J, Zhang XK, Zhou H. Huang F, et al. Biochem Biophys Res Commun. 2020 Sep 10;530(1):160-166. doi: 10.1016/j.bbrc.2020.06.134. Epub 2020 Jul 30. Biochem Biophys Res Commun. 2020. PMID: 32828280

Rosiglitazone is a ligand of peroxisome proliferation-activated receptor gamma (PPARgamma). ...Together, our study identified RXRalpha as a novel target of rosiglitazone and RXRalpha mediating the anti-APL activity of rosiglitazone....
Rosiglitazone is a ligand of peroxisome proliferation-activated receptor gamma (PPARgamma). ...Together, our study identified RXRalph …

Metformin, rosiglitazone, or both for obese women with polycystic ovary syndrome?

Arya S, Hansen KR, Wild RA. Arya S, et al. Fertil Steril. 2020 Jan;113(1):87-88. doi: 10.1016/j.fertnstert.2019.10.006. Fertil Steril. 2020. PMID: 32033735 No abstract available.


Rosiglitazone and pioglitazone for the treatment of Alzheimer's disease.

Miller BW, Willett KC, Desilets AR. Miller BW, et al. Ann Pharmacother. 2011 Nov;45(11):1416-24. doi: 10.1345/aph.1Q238. Epub 2011 Oct 25. Ann Pharmacother. 2011. PMID: 22028424 Review.

OBJECTIVE: To review the literature on the efficacy and safety of rosiglitazone and pioglitazone for the treatment of Alzheimer's disease (AD). ...Five clinical trials were evaluated (3 assessing rosiglitazone, 2 assessing pioglitazone); 1 trial evaluating …
OBJECTIVE: To review the literature on the efficacy and safety of rosiglitazone and pioglitazone for the treatment of Alzheimer's …

Thiazolidinediones: the Forgotten Diabetes Medications.

Lebovitz HE. Lebovitz HE. Curr Diab Rep. 2019 Nov 27;19(12):151. doi: 10.1007/s11892-019-1270-y. Curr Diab Rep. 2019. PMID: 31776781 Free PMC article. Review.

RECENT FINDINGS: Recent studies indicate that cardiovascular toxicity with rosiglitazone and increase in bladder cancer with pioglitazone are no longer significant issues. ...New data concerning TZD-mediated edema, congestive heart failure, and bone fractures improves the …
RECENT FINDINGS: Recent studies indicate that cardiovascular toxicity with rosiglitazone and increase in bladder cancer with pioglita …

Rosiglitazone, myocardial ischemic risk, and recent regulatory actions.

Bourg CA, Phillips BB. Bourg CA, et al. Ann Pharmacother. 2012 Feb;46(2):282-9. doi: 10.1345/aph.1Q400. Epub 2012 Jan 31. Ann Pharmacother. 2012. PMID: 22298606 Review.

CONCLUSIONS: Data involving rosiglitazone and an association with ischemic cardiovascular risk have yielded variable results. ...Drug labeling was revised in February 2011, and the rosiglitazone REMS program took full effect in November 2011....
CONCLUSIONS: Data involving rosiglitazone and an association with ischemic cardiovascular risk have yielded variable results. ...Drug …

Effect of rosiglitazone on myocardial injury in septic rats through NF-kappaB pathway.

Zhang SM, Cai XF, Ma YL, Lu Q. Zhang SM, et al. Eur Rev Med Pharmacol Sci. 2020 Jan;24(1):452-460. doi: 10.26355/eurrev_202001_19945. Eur Rev Med Pharmacol Sci. 2020. PMID: 31957860 Free article.

MATERIALS AND METHODS: A total of 60 healthy adult female Sprague-Dawley (SD) rats were randomly divided into 4 groups, namely, group A (sepsis model group, n=15), group B (sham operation group, n=15), group C (sepsis model + 3 mg/kg rosiglitazone, n=15), and group D (sham …
MATERIALS AND METHODS: A total of 60 healthy adult female Sprague-Dawley (SD) rats were randomly divided into 4 groups, namely, group A (sep …