Silvadene cream review


If you have suffered a serious injury or burn to the body , your doctor may prescribe Silvaden cream to treat infections and prevent new ones from developing. This is because silvaden, also known as silver sulfadiazine, is a micronized topical form of silver with antimicrobial properties.

How does it work

When it comes to wound care and healing, silver is not new; it is used in methods other than Silvaden. For example, it is added to wound dressings and other products due to its powerful broad-spectrum infection-fighting properties.

Silvaden belongs to a class of drugs called sulfonamides, but the exact mechanism of action is unknown. Unlike other drugs in the sulfamine category, silvaden does not show its anti-infective properties, inhibiting the synthesis of folic acid.

Instead, it protects against infectious agents by damaging both the cell membrane and the cell wall. This makes it suitable for inhibiting the growth of bacteria and yeasts such as Candida albicans .

When there is a wound or burn, Silvaden helps prevent infections from spreading to the surrounding skin or invading the bloodstream, where, if used correctly, it can cause a life-threatening condition known as sepsis .

Get Medication Information / Brianna Gilmartin

How to use

Silvaden is a topical antimicrobial agent that is applied directly to the skin over wounds, most commonly second and third degree burns. There may be other skin infections for which your healthcare provider will also recommend a cream.

The National Institutes of Health (NIH) list the following guidelines for using Silvadene cream:

  • Burn wounds should be cleaned and treated before applying the cream.
  • Silvaden must be used under sterile conditions.
  • Burns should be covered with cream at all times to avoid and reduce the risk of infection.
  • The cream is usually applied twice a day, 1/16 inch thick.
  • If your daily activities make it quicker to remove the cream, you should reapply it as soon as possible.
  • The cream can be used with or without a wound dressing.
  • The patient should continue to use the cream until the burn area has healed to the desired level or until the wound is ready for skin grafting.

Silvadene cream is for topical use only and should not be taken orally. Do not share your medicine with other people.

You should continue to apply the cream to wounds and burns as directed, unless you experience unwanted side effects or your healthcare provider stops treatment for another reason. Check with your doctor if you notice that your skin is not improving or is getting worse.

Side effects

There are some side effects associated with the use of Silvaden and they can range from mild to severe. If you persist with unpleasant symptoms, talk to your doctor so he can assess whether drug treatment is right for you.


Side effects can include the following:

  • Pain
  • Skin itch
  • Burning skin at the treatment site.
  • Skin discoloration

Severe form

Although many people can use this drug without serious problems, some people may experience serious side effects. If you experience any of the following symptoms, tell your doctor as soon as possible:

  • Unexplained bruising or bleeding
  • Fatigue
  • Joint aches and pains
  • Hot
  • Throat pain
  • Soft spot
  • Blood in the urine
  • Acne
  • Yellowing of the eyes or skin

Also, some people may develop leukopenia, a decrease in white blood cells (white blood cells) when Silvaden cream is used to treat wounds and burns.

Studies show that the onset of leukopenia generally occurs two to four days after starting treatment, and that recovery of leukocytes occurs two to three days after the initial decline or after stopping the drug. Leukopenia caused by the use of Silvaden does not increase the risk of infections and does not affect the results of treatment.

Precautions and contraindications.

If you are sensitive to silver sulfadiazine or the ingredients in this product, this medicine may not be suitable for you.

If you are allergic to antibiotics in the sulfamine family (such as septra, bactrim, or erythromycin), discuss treatment options with your doctor or pharmacist, as silvaden may cause an allergic reaction.

Silvaden may be contraindicated in people with certain liver, kidney or blood disorders. These conditions can affect the metabolism and excretion of the drug from the body. In some cases, the drug can build up in the body and you and your healthcare provider will need to weigh the benefits of continuing or stopping treatment.

Silvadene cream is not recommended for premature babies, newborns, or children 2 months and younger.

Make sure to inform your doctor if you are pregnant, as Silvaden is not recommended for use in or around women who are pregnant. There are not enough well-controlled studies on the use of the cream during pregnancy.

In theory, drugs in the sulfonamide family can cause kernicterus (brain damage that results from excessive levels of bilirubin) in newborns and therefore should only be used with extreme caution in pregnant women.

Also tell your doctor if you are breastfeeding. It is not known whether Silvaden is excreted in human milk, but since sulfonamides and their derivatives can contribute to the development of kernicterus, it is recommended to discontinue breastfeeding or consider discontinuing the use of the drug.


Tell your doctor if you are taking additional medications, vitamins, herbs, or other dietary supplements. Certain products can interfere with the proper working of Silvadene or cause side effects.

Get the word of drug information

When a patient begins taking medications, the unfamiliar drug regimen sometimes seems overwhelming. It is imperative that you use Silvadene Cream as directed and keep follow-up appointments to stay in contact with your healthcare provider.

In this way, the healthcare provider can assess whether the medicine is helping you heal and evaluate any additional symptoms and side effects that may result from the treatment.

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