Clinical Trials

Does Treatment of Androgen Excess Using Spironolactone Improve Ovulatory Rates in Girls With Androgen Excess?

Conditions:   Polycystic Ovary Syndrome;   Puberty Disorders;   Ovulation Disorder
Intervention:   Drug: Spironolactone
Sponsors:   University of Virginia;   Waterloo Foundation
Recruiting

Fri, 30 Aug 2019 12:00:00 EDT

Diuretic and Natriuretic Effect of High-dose Spironolactone in Patients With Acute Heart Failure

Conditions:   Heart Failure Acute;   Heart Failure; With Decompensation
Intervention:   Drug: Spironolactone
Sponsor:   Laikο General Hospital, Athens
Active, not recruiting

Fri, 06 Nov 2020 12:00:00 EST

Short Term Spironolactone for Prevention of Acute Kidney Injury After Cardiac Surgery

Conditions:   Acute Kidney Injuries;   Kidney Injuries, Acute;   Kidney Injury, Acute;   Acute Renal Injury;   Acute Renal Injuries
Intervention:   Drug: Spironolactone
Sponsors:   Instituto Nacional de Cardiologia Ignacio Chavez;   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Unknown status

Thu, 16 Apr 2015 12:00:00 EDT

High-Dose Aldactone for Treatment of Diuretic Resistant Heart Failure

Condition:   Heart Failure
Intervention:   Drug: Spironolactone
Sponsor:   The University of Texas Health Science Center at San Antonio
Withdrawn

Wed, 29 Apr 2015 12:00:00 EDT

Spironolactone for the Treatment of Melasma

Condition:   Melasma
Interventions:   Drug: Spironolactone 50Mg Tablet;   Drug: Spironolactone 100Mg Tablet;   Drug: Spironolactone 200Mg
Sponsor:   Medical University of South Carolina
Withdrawn

Thu, 16 May 2019 12:00:00 EDT

Spironolactone Safety in African Americans With Mild Cognitive Impairment and Early Alzheimer's Disease

Conditions:   Mild Cognitive Impairment;   Alzheimer Disease
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   Emory University;   Alzheimer's Association
Not yet recruiting

Fri, 21 Aug 2020 12:00:00 EDT

Antiarrhythmic Effects of Spironolactone in Patients With ICDs

Condition:   Ventricular Arrhythmias
Interventions:   Drug: spironolactone;   Drug: placebo
Sponsor:   VA Office of Research and Development
Completed

Mon, 03 Aug 2020 12:00:00 EDT

The Effect of Spironolactone on Pain in Older People With Osteoarthritis

Condition:   Osteoarthritis, Knee
Intervention:   Drug: spironolactone
Sponsors:   University of Dundee;   Arthritis Research UK
Completed

Tue, 28 Jan 2014 12:00:00 EST

Spironolactone in Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsor:   University of Birmingham
Unknown status

Thu, 04 Feb 2016 12:00:00 EST

Spironolactone Administration to Prevent Ischemic Kidney Injury in Critically Ill Cancer Patients

Conditions:   Critically Ill;   Cancer
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsor:   Instituto Nacional de Cancerologia de Mexico
Unknown status

Mon, 24 Aug 2015 12:00:00 EDT

Effect of Spironolactone on Adrenal or Ovarian Androgen Production in Overweight Pubertal Girls With Androgen Excess

Conditions:   Obesity;   Hyperandrogenemia;   Polycystic Ovary Syndrome
Intervention:   Drug: Spironolactone
Sponsor:   University of Virginia
Recruiting

Wed, 24 Aug 2011 12:00:00 EDT

Spironolactone Against Anthracycline-induced Cardiomyopathy

Condition:   Anthracycline Induced Cardiotoxicity
Interventions:   Drug: Spironolactone;   Other: Placebo
Sponsor:   TC Erciyes University
Completed

Tue, 04 Feb 2014 12:00:00 EST

Study of High-dose Spironolactone vs. Placebo Therapy in Acute Heart Failure

Condition:   Heart Failure
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   Duke University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Tue, 09 Sep 2014 12:00:00 EDT

Effects of Spironolactone on Collagen Metabolism in Patients With Pulmonary Arterial Hypertension

Condition:   Pulmonary Hypertension
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   Baylor College of Medicine;   National Heart, Lung, and Blood Institute (NHLBI)
Unknown status

Wed, 09 Nov 2011 12:00:00 EST

Determining the Effect of Spironolactone on Electrolyte Supplementation in Preterm Infants With Chronic Lung Disease

Conditions:   Chronic Lung Disease;   Bronchopulmonary Dysplasia
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsor:   West Virginia University Healthcare
Unknown status

Tue, 06 Nov 2012 12:00:00 EST

Spironolactone on Acute Kidney Injury in Critically Ill Patients

Condition:   Acute Kidney Injury
Interventions:   Drug: Spironolactone 25 mg;   Drug: Placebo oral capsule
Sponsors:   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran;   National Council of Science and Technology, Mexico;   Universidad Nacional Autonoma de Mexico
Unknown status

Sun, 02 Jul 2017 12:00:00 EDT

Effect of Spironolactone in Treating Chronic Non-resolutive Central Serous Chorioretinitis

Condition:   Central Serous Chorioretinitis
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsor:   Institut National de la Santé Et de la Recherche Médicale, France
Completed

Tue, 13 Mar 2012 12:00:00 EDT

Spironolactone in Adult Congenital Heart Disease

Conditions:   Congenital Heart Disease;   Heart Failure;   Endomyocardial Fibrosis
Interventions:   Drug: Spironolactone 25mg;   Other: Placebo
Sponsors:   Oregon Health and Science University;   National Heart, Lung, and Blood Institute (NHLBI);   Oregon Clinical and Translational Research Institute
Completed

Wed, 17 Feb 2010 12:00:00 EST

Spironolactone for Paroxysmal Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsor:   Taichung Veterans General Hospital
Unknown status

Tue, 03 Jun 2008 12:00:00 EDT

Efficacy of Spironolactone in Cameroonian Diabetic Patients With Resistant Hypertension

Conditions:   Hypertension, Resistant to Conventional Therapy;   Diabetes Mellitus
Interventions:   Drug: Low dose spironolactone;   Other: Routine intensification of antihypertensive treatment
Sponsors:   Sobngwi Eugene;   University of Yaounde 1
Completed

Fri, 24 Apr 2015 12:00:00 EDT

Drug-drug Interaction (DDI) Study of Spironolactone (Perpetrator) and Digoxin (Substrate Drug)

Condition:   Drug Drug Interaction
Interventions:   Drug: Digoxin 250 MCG Oral Tablet;   Drug: Spironolactone 25 mg/ 5 mL S/F Suspension
Sponsor:   CMP Development, LLC
Completed

Wed, 10 Apr 2019 12:00:00 EDT

Prevention of the Progression of Coronary Calcification With Use of Spironolactone in Peritoneal Dialysis Patients

Conditions:   Coronary Artery Calcification;   Vascular Calcification
Intervention:   Drug: Spironolactone 25Mg Tablet
Sponsors:   Professor Fernando Figueira Integral Medicine Institute;   Federal University of São Paulo
Completed

Thu, 19 Oct 2017 12:00:00 EDT

L-Arginine and Spironolactone Trial in Dialysis-Dependent ESRD

Conditions:   End Stage Renal Disease;   Hemodialysis
Interventions:   Drug: Spironolactone;   Dietary Supplement: L-arginine;   Drug: Placebo
Sponsors:   Brigham and Women's Hospital;   Massachusetts General Hospital;   Beth Israel Deaconess Medical Center;   Joslin Diabetes Center
Withdrawn

Thu, 16 May 2013 12:00:00 EDT

Effects of Spironolactone in Dialysis

Condition:   Renal Failure
Intervention:   Drug: Spironolactone
Sponsor:   UPECLIN HC FM Botucatu Unesp
Unknown status

Fri, 21 May 2010 12:00:00 EDT

Spironolactone After Liver Transplant

Condition:   Transplant, Liver
Intervention:   Drug: Spironolactone
Sponsor:   Atrium Health
Completed

Tue, 30 Aug 2016 12:00:00 EDT

Impacts of Aldosterone Blockade on Myocardial Remodeling in Hypertensive Patients With Diastolic Failing Heart

Condition:   Diastolic Heart Failure
Intervention:   Drug: aldactone
Sponsor:   National Taiwan University Hospital
Completed

Tue, 17 Sep 2013 12:00:00 EDT

Mineralocorticoid Receptor Antagonist and Kidney Allograft Histology

Condition:   Kidney Failure, Chronic
Intervention:   Drug: spironolactone
Sponsor:   Clinical Hospital Merkur
Unknown status

Wed, 18 Jan 2012 12:00:00 EST

The Comparison Between Spironolactone and Indapamide Monotherapy or in Combination With Amlodipine to Reduce the Risk of Heart Failure

Condition:   Hypertension
Interventions:   Drug: Spironolactone;   Drug: Indapamide
Sponsor:   Shanghai Jiao Tong University School of Medicine
Recruiting

Thu, 02 Jul 2020 12:00:00 EDT

Evaluating the Effect of Spironolactone on Hypertrophic Cardiomyopathy

Conditions:   Hypertrophic Cardiomyopathy;   Fibrosis
Intervention:   Drug: Spironolactone
Sponsors:   Xinhua Hospital, Shanghai Jiao Tong University School of Medicine;   Ruijin Hospital;   RenJi Hospital;   Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Unknown status

Mon, 31 Oct 2016 12:00:00 EDT

Effect of Aldosterone on Energy Starvation in Heart Failure

Conditions:   Heart Failure;   Nonischemic Dilated Cardiomyopathy
Intervention:   Drug: spironolactone
Sponsor:   Vanderbilt University
Completed

Mon, 17 Dec 2007 12:00:00 EST

Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne

Condition:   Acne
Interventions:   Drug: Spironolactone;   Drug: Doxycycline Hyclate
Sponsor:   University of Pennsylvania
Not yet recruiting

Fri, 09 Oct 2020 12:00:00 EDT

The Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension Study

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Ambrisentan plus Spironolactone;   Drug: Ambrisentan plus Placebo
Sponsors:   Brigham and Women's Hospital;   Gilead Sciences
Terminated

Wed, 01 Oct 2014 12:00:00 EDT

The Effect of Spironolactone on Acute Kidney Injury in Patients Undergoing Coronary Angiography

Conditions:   Acute Kidney Injury;   IHD;   Contrast-induced Nephropathy
Interventions:   Drug: Spironolactone;   Drug: Placebo Oral Tablet
Sponsors:   Alhasan Mujtaba Abdul-Wahid;   Ministry of Health-Basra Health Directorate-Al-Sader Teaching Hospital
Completed

Mon, 06 Nov 2017 12:00:00 EST

Effect of Spironolactone and Vitamin E in Patients With Nonalcoholic Fatty Liver Disease

Conditions:   Fatty Liver;   Steatohepatitis
Intervention:   Drug: Spironolactone/Vitamin E
Sponsor:   Aristotle University Of Thessaloniki
Completed

Tue, 22 Jun 2010 12:00:00 EDT

Novel Treatment for Diastolic Heart Failure in Women

Condition:   Heart Failure
Intervention:   Drug: Spironolactone
Sponsor:   Baylor College of Medicine
Completed

Wed, 21 Sep 2005 12:00:00 EDT

Non-Responsive Diabetic Macular Edema and Spironolactone

Condition:   Diabetic Maculopathy
Intervention:   Drug: Spironolactone 50 mg
Sponsor:   Wake Forest University Health Sciences
Not yet recruiting

Wed, 21 Apr 2021 12:00:00 EDT

Comparison of Spironolactone and Amiloride on Home Blood Pressure in Resistant Hypertension

Condition:   Resistant Hypertension
Interventions:   Drug: Spironolactone;   Drug: Amiloride
Sponsor:   Yonsei University
Not yet recruiting

Thu, 02 Apr 2020 12:00:00 EDT

Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Trial

Condition:   Atherosclerosis
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   University Hospitals Cleveland Medical Center;   University of Maryland, College Park;   University of Toronto;   Winthrop University
Recruiting

Fri, 20 Jun 2014 12:00:00 EDT

Comparison of Eplerenone Versus Spironolactone in Heart Failure Patients With Glucose Intolerance or Type 2 Diabetes

Conditions:   Heart Failure;   Type 2 Diabetes;   Glucose Intolerance
Interventions:   Drug: Eplerenone;   Drug: Spironolactone
Sponsors:   Montreal Heart Institute;   Pfizer
Unknown status

Thu, 26 Apr 2012 12:00:00 EDT

Spironolactone Versus Amiloride as an Add on Agent in Resistant Hypertension

Condition:   Hypertension
Interventions:   Drug: spironolactone;   Drug: amiloride
Sponsor:   VA Salt Lake City Health Care System
Withdrawn

Thu, 03 Jul 2008 12:00:00 EDT

A Registry-based Cluster Randomized Trial to Compare the Effect of Spironolactone vs. Eplerenone on Clinical Outcomes in Patients With Symptomatic Systolic Heart Failure

Condition:   Systolic Heart Failure
Interventions:   Drug: Eplerenone;   Drug: Spironolactone
Sponsors:   Bispebjerg Hospital;   Rigshospitalet, Denmark
Enrolling by invitation

Thu, 13 Jun 2019 12:00:00 EDT

Clinical and Therapeutic Implications of Fibrosis in Hypertrophic Cardiomyopathy

Conditions:   Myocardial Fibrosis;   Hypertrophic Cardiomyopathy
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsor:   Tufts Medical Center
Completed

Thu, 09 Apr 2009 12:00:00 EDT

Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?

Conditions:   Hyperandrogenism;   Polycystic Ovary Syndrome;   Puberty
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   University of Virginia;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Tue, 26 Jan 2021 12:00:00 EST

Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure With Preserved Ejection Fraction

Condition:   Heart Failure With Preserved Ejection Fraction
Interventions:   Drug: Spironolactone;   Other: Standard care
Sponsors:   Uppsala University;   Karolinska University;   Duke Clinical Research Institute;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Thu, 15 Sep 2016 12:00:00 EDT

Spironolactone and Prevention of Calcineurin Inhibitor Toxicity in Kidney Transplant Recipients

Condition:   Kidney Transplant
Interventions:   Drug: spironolactone;   Drug: Placebo
Sponsor:   Instituto Nacional de Cardiologia Ignacio Chavez
Suspended

Tue, 01 Dec 2009 12:00:00 EST

Spironolactone Therapy In Young Women With NASH

Condition:   NASH - Nonalcoholic Steatohepatitis
Interventions:   Drug: Spironolactone 100mg;   Drug: Placebo oral capsule
Sponsor:   University of California, San Francisco
Recruiting

Tue, 03 Jul 2018 12:00:00 EDT

Spironolactone in Covid-19 Induced ARDS

Condition:   Respiratory Distress Syndrome, Adult
Interventions:   Drug: Spironolactone 100mg;   Drug: Placebo oral tablet
Sponsor:   Istanbul University-Cerrahpasa
Not yet recruiting

Wed, 15 Apr 2020 12:00:00 EDT

Losartan and Spironolactone Treatment for ICU Patients With COVID-19 Suffering From ARDS

Conditions:   COVID-19;   ARDS
Intervention:   Drug: Losartan 50 mg and Spironolactone 25 mg pillules oral use
Sponsor:   Assistance Publique Hopitaux De Marseille
Recruiting

Wed, 25 Nov 2020 12:00:00 EST

High-dose Aldosterone Antagonist for Acute Decompensated Heart Failure

Condition:   Acute Decompensated Heart Failure
Intervention:   Drug: Spironolactone and patiromer
Sponsors:   The University of Texas Health Science Center at San Antonio;   Relypsa, Inc.
Completed

Wed, 06 Jul 2016 12:00:00 EDT

Study in HFpEF Patients to Compare the Effect of AZD9977 and Spironolactone on Serum Potassium

Condition:   Heart Failure
Interventions:   Drug: AZD9977;   Drug: Spironolactone
Sponsor:   AstraZeneca
Terminated

Mon, 24 Sep 2018 12:00:00 EDT

Spironolactone Versus Prednisolone in DMD

Condition:   Muscular Dystrophy, Duchenne
Interventions:   Drug: Spironolactone;   Drug: Prednisolone
Sponsors:   Kevin Flanigan;   Muscular Dystrophy Association
Recruiting

Mon, 17 Dec 2018 12:00:00 EST

Spironolactone to Improve Apnea and Cardiovascular Markers in Obstructive Sleep Apnea Patients

Condition:   Obstructive Sleep Apnea
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsor:   University of Michigan
Not yet recruiting

Thu, 19 Dec 2019 12:00:00 EST

Pilot Study on Withdrawal of Spironolactone Among Heart Failure With Improved Ejection Fraction

Condition:   Heart Failure
Interventions:   Drug: Withdrawal of Spironolactone;   Drug: Continuation of spironolactone
Sponsor:   Asan Medical Center
Active, not recruiting

Wed, 29 Apr 2020 12:00:00 EDT

Hemodynamic Effects of Spironolactone in Patients With Heart Failure

Condition:   Congestive Heart Failure
Intervention:   Drug: Spironolactone
Sponsor:   University of Toledo Health Science Campus
Completed

Thu, 12 Mar 2009 12:00:00 EDT

Is Spironolactone Safe and Effective in the Treatment of Cardiovascular Disease in Mild Chronic Renal Failure?

Conditions:   Chronic Kidney Disease;   Cardiovascular Disease
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   University Hospital Birmingham;   British Heart Foundation
Completed

Tue, 14 Feb 2006 12:00:00 EST

Mineralocorticoid Receptor Antagonists (MRA) in Heart Failure (HF) and Loop Diuretic Resistance

Condition:   Heart Failure
Interventions:   Drug: Spironolactone 100mg;   Drug: Spironolactone 25mg
Sponsor:   Columbia University
Completed

Fri, 23 Oct 2015 12:00:00 EDT

Addition of Spironolactone in Patients With Resistant Arterial Hypertension

Condition:   Hypertension
Intervention:   Drug: spironolactone
Sponsors:   Jan Vaclavík;   Czech Society of Hypertension;   Prostejov Hospital;   Brno University Hospital;   Olomouc Military Hospital;   Gedeon Richter Ltd.
Unknown status

Mon, 03 Sep 2007 12:00:00 EDT

Comparing the Effects of Spironolactone With Chlortalidone on LV Mass in Patients With CKD

Conditions:   Renal Insufficiency, Chronic;   Cardio-Renal Syndrome
Interventions:   Drug: Spironolactone;   Drug: Chlortalidone
Sponsors:   University Hospital Birmingham;   Royal Free Hospital NHS Foundation Trust;   University of Edinburgh;   University of Cambridge
Unknown status

Mon, 20 Jul 2015 12:00:00 EDT

Randomized Double-blind Study on the Benefit of Spironolactone for Treating Acne of Adult Woman.

Condition:   Acne Vulgaris
Interventions:   Drug: spironolactone;   Drug: Doxycycline
Sponsor:   Nantes University Hospital
Recruiting

Tue, 07 Nov 2017 12:00:00 EST

Acetazolamide and Spironolactone to Increase Natriuresis in Congestive Heart Failure

Condition:   Heart Failure
Interventions:   Drug: Combination therapy with acetazolamide and low-dose loop diuretics;   Drug: High-dose loop diuretics;   Drug: Upfront therapy with oral spironolactone
Sponsors:   Hasselt University;   Ziekenhuis Oost-Limburg;   Universitaire Ziekenhuizen Leuven
Completed

Thu, 31 Oct 2013 12:00:00 EDT

BromhexIne And Spironolactone For CoronаVirUs Infection Requiring HospiTalization

Condition:   COVID 19
Interventions:   Drug: Bromhexine and Spironolactone;   Drug: Base therapy
Sponsor:   Lomonosov Moscow State University Medical Research and Educational Center
Recruiting

Tue, 09 Jun 2020 12:00:00 EDT

Spironolactone In The Treatment of Heart Failure

Conditions:   Heart Failure With Mid-range Ejection Fraction;   Heart Failure With Preserved Ejection Fraction
Interventions:   Drug: Experimental: Spironolactone;   Drug: Placebo Comparator
Sponsors:   Charite University, Berlin, Germany;   Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK);   Echo Core Lab Berlin;   University of Göttingen;   University Medicine Greifswald;   Ludwig-Maximilians - University of Munich;   Institute for Cardiovascular Computer-assisted Medicine, Charité;   Coordinating Centre for Clinical Trials, Charité
Recruiting

Wed, 27 Jan 2021 12:00:00 EST

Safety and Cardiovascular Efficacy of Spironolactone in Dialysis-Dependent ESRD Trial

Condition:   End-Stage Renal Disease
Intervention:   Drug: Spironolactone
Sponsors:   University of Pennsylvania;   Brigham and Women's Hospital;   George Washington University;   Vanderbilt University;   University of Washington
Completed

Fri, 07 Nov 2014 12:00:00 EST

Spironolactone Plus Metformin in Polycystic Ovary Syndrome

Condition:   Polycystic Ovary Syndrome
Interventions:   Drug: Metformin;   Drug: Metformin plus Spironolactone
Sponsor:   University Magna Graecia
Completed

Mon, 06 Feb 2012 12:00:00 EST

The Effects of Spironolactone on Calcineurin Inhibitor Induced Nephrotoxicity

Condition:   Disorder Related to Renal Transplantation
Interventions:   Drug: Spironolactone;   Drug: placebo
Sponsors:   Odense University Hospital;   Fredericia Hosptial
Completed

Mon, 21 May 2012 12:00:00 EDT

Spironolactone on Fibrosis Progrssion-Portal Hypertension(FP-PH)in Cirrhosis

Conditions:   Cirrhosis;   Portal Hypertension
Interventions:   Drug: Spironolactone and carvedilol;   Drug: Carvedilol
Sponsor:   Changqing Yang
Completed

Tue, 20 Sep 2016 12:00:00 EDT

Therapeutic Potential for Aldosterone Inhibition in Duchenne Muscular Dystrophy

Condition:   Duchenne Muscular Dystrophy
Interventions:   Drug: Eplerenone;   Drug: Spironolactone
Sponsors:   Ohio State University;   University of California, Los Angeles;   University of Utah;   University of Colorado, Denver;   University of Kansas Medical Center;   Vanderbilt University Medical Center
Completed

Tue, 03 Feb 2015 12:00:00 EST

Spironolactone Versus Indapamide in Obese and Hypertensive Patients

Condition:   Hypertension
Interventions:   Drug: Spironolactone;   Drug: Indapamide;   Drug: Amlodipine
Sponsors:   Peking University Third Hospital;   University of Michigan;   Peking University
Unknown status

Mon, 13 Aug 2018 12:00:00 EDT

Effect of Add-on Spironolactone to Losartan Versus Losartan Alone on Peritoneal Membrane Among Peritoneal Dialysis Patients

Conditions:   End Stage Renal Disease;   Peritoneal Dialysis
Interventions:   Drug: Spironolactone;   Drug: Losartan
Sponsor:   Chiang Mai University
Unknown status

Fri, 17 May 2019 12:00:00 EDT

Spironolactone and Perioperative Atrial Fibrillation Occurrence in Cardiac Surgery Patients.

Conditions:   Cardiac Surgery;   Atrial Fibrillation;   Aldosterone Blockade
Interventions:   Drug: Spironolactone 25mg;   Drug: Placebo oral capsule
Sponsors:   University Hospital, Caen;   Ministry of Health, France
Unknown status

Mon, 11 Jun 2018 12:00:00 EDT

Evaluation of the Efficacy of Diuretics for Symptomatic Malignant Ascites Episodes in Advanced Stage of Cancer (DIASC)

Condition:   Cancer
Intervention:   Drug: Spironolactone (+/- Furosemide)
Sponsors:   Centre Oscar Lambret;   National Cancer Institute, France
Terminated

Fri, 17 Jul 2015 12:00:00 EDT

Effects of Spironolactone on Cardio- and Cerebrovascular Morbidity and Mortality in Hemodialysis Patients

Condition:   End-stage Renal Failure
Intervention:   Drug: Spironolactone
Sponsor:   Dialysis Outcomes Heart Failure Aldactone Study Group
Completed

Wed, 19 Sep 2012 12:00:00 EDT

Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin B

Condition:   Patients With Fungic Infections
Interventions:   Drug: Spironolactone 100mg;   Drug: Spironolactone 200mg;   Drug: Placebo
Sponsor:   Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Terminated

Tue, 30 Apr 2013 12:00:00 EDT

Spironolactone Safety in Dialysis Patients

Conditions:   End Stage Renal Disease;   Congestive Heart Failure
Intervention:   Drug: spironolactone
Sponsor:   State University of New York - Upstate Medical University
Withdrawn

Mon, 22 May 2006 12:00:00 EDT

Search of Biomarkers of Mineralocorticoid Receiver Activity : the Value of Neutrophil Gelatinase Associated Lipocalin (NGAL)in Serum or Urine in Human

Condition:   Cardiovascular Diseases
Interventions:   Procedure: Urinary and blood lipococalin levels determination;   Drug: Spironolactone
Sponsor:   Central Hospital, Nancy, France
Completed

Fri, 02 May 2014 12:00:00 EDT

Spironolactone and Insulin Resistance in Chronic Heart Failure (CHF)

Condition:   Chronic Stable Heart Failure
Intervention:   Drug: spironolactone + furosemide
Sponsor:   Tottori University Hospital
Completed

Tue, 22 Apr 2008 12:00:00 EDT

Spironolactone in Patients With Single Ventricle Heart

Condition:   Congenital Disorders
Intervention:   Drug: Spironolactone (drug)
Sponsor:   Emory University
Completed

Wed, 21 Sep 2005 12:00:00 EDT

Spironolactone Therapy in Chronic Stable Right HF Trial

Conditions:   Chronic Right-Sided Heart Failure;   Pulmonary Arterial Hypertension;   Pulmonary Hypertension, Primary, 2;   Pulmonary Hypertension, Primary, 3;   Pulmonary Hypertension, Primary, 4;   Cardiomyopathy Right Ventricular
Interventions:   Drug: Spironolactone;   Drug: Placebo;   Radiation: PET/CT Scan: Two PET scans using 1. C-11 HED and 2. N-13 Ammonia or rubidium-82;   Diagnostic Test: Cardiac MRI (Gadolinium enhanced)
Sponsor:   Ottawa Heart Institute Research Corporation
Recruiting

Fri, 17 Nov 2017 12:00:00 EST

Effects of Spironolactone on Matrix Metalloproteinases (MMPs) in Heart Failure

Condition:   Chronic Stable Heart Failure
Intervention:   Drug: spironolactone + furosemide
Sponsor:   Tottori University Hospital
Completed

Tue, 22 Apr 2008 12:00:00 EDT

Early Sequential Nephron Blockade in Acute Heart Failure Patients: A Randomised, Controlled Study

Conditions:   Acute Heart Failure;   Acute Kidney Injury
Interventions:   Drug: Spironolactone or hydrochlorothiazide;   Drug: Placebo
Sponsor:   Chiang Mai University
Recruiting

Thu, 09 Jul 2020 12:00:00 EDT

Spironolactone and Dexamethasone in Patients Hospitalized With COVID-19

Conditions:   Coronavirus Infection;   Pneumonia, Viral
Interventions:   Drug: Spironolactone + Dexamethasone;   Drug: Standard-of-care SARS-CoV-2 treatment
Sponsor:   Chita State Regional Clinical Hospital Number 1
Recruiting

Thu, 01 Apr 2021 12:00:00 EDT

Spironolactone for Hidradenitis Suppurativa

Condition:   Hidradenitis Suppurativa
Interventions:   Drug: Spironolactone 50 MG;   Drug: Spironolactone 100mg;   Drug: Spironolactone 200 mg
Sponsor:   Medical University of South Carolina
Withdrawn

Tue, 24 Sep 2019 12:00:00 EDT

Larger Dose of Spironolactone for the Treatment of Patients With Nonischemic Cardiomyopathy

Condition:   Heart Failure, Congestive
Intervention:   Drug: spironolactone
Sponsor:   Hebei Medical University
Terminated

Mon, 01 Aug 2005 12:00:00 EDT

Evaluation of CLP With and Without Spironolactone in Heart Failure Patients With Chronic Kidney Disease

Condition:   Heart Failure
Interventions:   Drug: CLP;   Drug: Spironolactone
Sponsor:   Sorbent Therapeutics
Completed

Tue, 15 May 2012 12:00:00 EDT

PIE II: Pharmacological Intervention in the Elderly II

Conditions:   Diastolic Heart Failure;   Heart Failure, Congestive
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   Wake Forest University;   National Institute on Aging (NIA)
Completed

Tue, 26 Jul 2005 12:00:00 EDT

Spironolactone and Prevention of Peritoneal Fibrosis in Peritoneal Dialysis

Condition:   End Stage Renal Disease
Interventions:   Drug: spironolactone;   Drug: Placebo
Sponsor:   Instituto Nacional de Cardiologia Ignacio Chavez
Completed

Thu, 19 Mar 2009 12:00:00 EDT

Spironolactone for Reducing Proteinuria in Diabetic Nephropathy

Condition:   Diabetic Nephropathy
Intervention:   Drug: spironolactone
Sponsor:   US Department of Veterans Affairs
Completed

Tue, 10 Jul 2007 12:00:00 EDT

Spironolactone for Pulmonary Arterial Hypertension

Condition:   Pulmonary Arterial Hypertension
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   National Institutes of Health Clinical Center (CC);   National Heart, Lung, and Blood Institute (NHLBI);   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK);   University of Pennsylvania;   University of Maryland, College Park;   Medstar Health Research Institute;   New England Medical Center, Tufts University School of Medicine
Recruiting

Tue, 23 Oct 2012 12:00:00 EDT

The Efficacy of Spironolactone in Patients With Resistant Hypertension

Condition:   Hypertension
Intervention:   Drug: Spironolactone
Sponsors:   Sheffield Teaching Hospitals NHS Foundation Trust;   University of Sheffield
Terminated

Fri, 02 Feb 2007 12:00:00 EST

Hemodynamic Effects of Chronic Administration of Spironolactone and/or Propranolol in Alcoholic Cirrhotic Patients

Condition:   Alcoholic Cirrhosis
Intervention:   Drug: Propranolol - Spironolactone
Sponsor:   University Hospital, Angers
Terminated

Fri, 16 Sep 2005 12:00:00 EDT

Pharmacokinetic Study of Spironolactone 25 mg, 50 mg and 100 mg Tablets

Condition:   Healthy
Intervention:   Drug: Spironolactone
Sponsor:   Orion Corporation, Orion Pharma
Completed

Tue, 09 Mar 2010 12:00:00 EST

The Effect of Spironolactone on Blood Pressure in Type-2 Diabetics With Resistant Hypertension

Conditions:   Arterial Hypertension;   Hypertension, Resistant to Conventional Therapy;   Diabetes Mellitus
Interventions:   Drug: spironolactone;   Drug: placebo
Sponsor:   Ib Abildgaard Jacobsen
Completed

Thu, 04 Feb 2010 12:00:00 EST

Spironolactone Combined With Captopril and Carvedilol for the Treatment of Pulmonary Arterial Hypertension

Condition:   Hypertension, Pulmonary
Intervention:   Drug: spironolactone captopril carvedilol
Sponsor:   Hebei Medical University
Completed

Tue, 18 Oct 2005 12:00:00 EDT

Clinical Trial Studying the Effects of Spironolactone on Heart and Skeletal Muscle Function in Chronic Alcoholics

Conditions:   Cardiomyopathy, Alcoholic;   Alcoholism
Intervention:   Drug: spironolactone
Sponsor:   University of Aarhus
Suspended

Mon, 26 Sep 2005 12:00:00 EDT

Spironolactone With Patiromer in the Treatment of Resistant Hypertension in Chronic Kidney Disease

Conditions:   Hyperkalemia;   Resistant Hypertension
Interventions:   Drug: Patiromer;   Drug: Placebo;   Drug: Spironolactone
Sponsor:   Relypsa, Inc.
Completed

Mon, 06 Mar 2017 12:00:00 EST

Regulating Blood Pressure During Recovery From Intracerebral Hemorrhage (REDUCE)

Conditions:   Intracerebral Hemorrhage;   Spironolactone
Intervention:   Drug: Spironolactone Pill
Sponsors:   Yale University;   American Heart Association
Recruiting

Thu, 18 Feb 2021 12:00:00 EST

Spironolactone to Decrease Potassium Wasting in Hypercalciurics on Thiazides Diuretics

Conditions:   Idiopathic Hypercalciuria;   Hypokalemia Caused by Thiazide Diuretics
Intervention:   Drug: Spironolactone
Sponsor:   Indiana University School of Medicine
Completed

Fri, 13 Jan 2006 12:00:00 EST

The Use of 5mg Finasteride Versus 200mg Spironolactone and Topical 5% Minoxidil in Treating Postmenopausal Female Androgenetic Alopecia

Condition:   Female Androgenetic Alopecia
Interventions:   Drug: 5% Minoxidil;   Drug: 200mg Spironolactone;   Drug: 5mg Finasteride;   Other: Placebo
Sponsor:   University of Florida
Withdrawn

Fri, 26 Jun 2015 12:00:00 EDT

Fibrosis and the Fontan

Condition:   Single-ventricle
Intervention:   Drug: Spironolactone
Sponsors:   Children's Hospital of Philadelphia;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Wed, 26 May 2021 12:00:00 EDT

Study to Assess Efficacy and Safety of SZC for the Management of High Potassium in Patients With Symptomatic HFrEF Receiving Spironolactone

Conditions:   Hyperkalaemia;   Heart Failure With Reduced Ejection Fraction
Interventions:   Drug: Sodium zirconium cyclosilicate;   Drug: Placebo;   Other: Spironolactone
Sponsor:   AstraZeneca
Recruiting

Mon, 21 Dec 2020 12:00:00 EST

Autoregulation of Glomerular Filtration Rate in Patients With Type 1 Diabetes During Spironolactone Therapy

Condition:   Hypertension
Intervention:   Drug: Spironolactone
Sponsor:   Steno Diabetes Center Copenhagen
Completed

Fri, 09 Jun 2006 12:00:00 EDT

Etiology of Sleep Apnea-related Hyperaldosteronism - BP Treatment

Conditions:   Obstructive Sleep Apnea;   Resistant Hypertension;   Hyperaldosteronism
Interventions:   Drug: Spironolactone;   Drug: BP medication uptitration
Sponsors:   University of Alabama at Birmingham;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Fri, 12 Jul 2013 12:00:00 EDT

Efficacy of Therapy With the Spironolactone Pills Compared to Minoxidil Lotion in Female Pattern Hair Loss

Condition:   Female Pattern Hair Loss
Interventions:   Drug: Spironolactone;   Drug: Minoxidil
Sponsor:   University of British Columbia
Completed

Thu, 15 Sep 2005 12:00:00 EDT

Interest of Topical Spironolactone's Administration to Prevent Corticoid-induced Epidermal Atrophy

Condition:   Cutaneous Atrophy Due to Corticosteroids
Interventions:   Drug: Clobetasol + Spironolactone;   Drug: Clobetasol + Placebo;   Drug: Placebo + Spironolactone;   Drug: Placebo + Placebo
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Société de Dermatologie Française
Completed

Tue, 02 Aug 2011 12:00:00 EDT

Aldosterone Blockade Early After Acute Myocardial Infarction

Condition:   Myocardial Infarction
Intervention:   Drug: Spironolactone
Sponsor:   Assistance Publique - Hôpitaux de Paris
Completed

Fri, 29 Jan 2010 12:00:00 EST

Colchicine and Spironolactone in Patients With MI / SYNERGY Stent Registry

Conditions:   ST Elevation Myocardial Infarction;   Non ST Elevation Myocardial Infarction
Interventions:   Drug: Colchicine;   Drug: Spironolactone;   Device: SYNERGY Bioabsorbable Polymer Drug-Eluting Stent;   Drug: Colchicine-Placebo;   Drug: Spironolactone-Placebo
Sponsors:   Population Health Research Institute;   Canadian Institutes of Health Research (CIHR);   BSC
Recruiting

Thu, 09 Feb 2017 12:00:00 EST

Mineralocorticoid Receptor Antagonists in End Stage Renal Disease

Condition:   End Stage Renal Disease / Hemodialysis
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   Wuerzburg University Hospital;   German Federal Ministry of Education and Research;   Clinical Trial Center Wuerzburg (CTCW)
Completed

Mon, 24 Sep 2012 12:00:00 EDT

ALdosterone Antagonist Chronic HEModialysis Interventional Survival Trial

Condition:   End Stage Renal Failure on Dialysis
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   University Hospital, Brest;   Central Hospital, Nancy, France;   Institut National de la Santé Et de la Recherche Médicale, France
Active, not recruiting

Tue, 07 May 2013 12:00:00 EDT

Evaluating Drug Interactions Between Doravirine With Estradiol and Spironolactone in Healthy Transgender Women

Conditions:   Transgender Health;   Gender Dysphoria;   Transgender Women;   Human Immunodeficiency Virus
Interventions:   Drug: Doravirine/Lamivudine/Tenofovir;   Drug: Spironolactone 100mg;   Drug: Estradiol 2mg;   Other: Placebo
Sponsor:   Thomas Jefferson University
Not yet recruiting

Tue, 25 Feb 2020 12:00:00 EST

Aliskiren and Renin Inhibition in Diastolic Heart Failure

Condition:   Diastolic Heart Failure
Intervention:   Drug: Aliskiren plus spironolactone vs. Lisinopril plus spironolactone
Sponsor:   Texas Tech University Health Sciences Center
Withdrawn

Thu, 16 Oct 2008 12:00:00 EDT

Effects of Cyproterone Compound-spironolactone, Metformin and Pioglitazone on Inflammatory Markers in PCOS

Condition:   Polycystic Ovary Syndrome
Interventions:   Drug: Cyproterone compound + Spironolactone;   Drug: Metformin;   Drug: Pioglitazone
Sponsor:   Shiraz University of Medical Sciences
Completed

Wed, 24 Feb 2016 12:00:00 EST

Hyperandrogenemia and Altered Day-night LH Pulse Patterns

Conditions:   Hyperandrogenism;   Polycystic Ovary Syndrome;   Puberty
Interventions:   Drug: Micronized progesterone;   Drug: Spironolactone;   Drug: Placebo
Sponsors:   University of Virginia;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Fri, 03 Mar 2017 12:00:00 EST

The Effect of Amiloride and Spironolactone in Patients With Hypertension

Condition:   Hypertension
Interventions:   Drug: Spironolactone;   Drug: Amiloride;   Drug: Placebo
Sponsor:   Erling Bjerregaard Pedersen
Completed

Wed, 06 Jul 2011 12:00:00 EDT

The Effects of Amiloride and Spironolactone on Renophysiological and Cardiovascular Variables

Condition:   Essential Hypertension
Interventions:   Drug: Spironolactone;   Other: Placebo;   Drug: Amiloride
Sponsor:   Regional Hospital Holstebro
Completed

Mon, 06 Sep 2010 12:00:00 EDT

The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes

Condition:   Type 1 Diabetes
Interventions:   Other: Exercise;   Drug: Spironolactone
Sponsors:   University of Virginia;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Fri, 02 Jun 2017 12:00:00 EDT

Inhibition of Aldosterone to Reduce Myocardial Diffuse Fibrosis in Patients With Paroxysmal and Persistent Atrial Fibrillation in Preventing Recurrent Episodes of Atrial Fibrillation

Condition:   Atrial Fibrillation
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   Svendborg Hospital;   Region of Southern Denmark;   Takeda
Unknown status

Fri, 06 May 2016 12:00:00 EDT

Aldosterone bloCkade for Health Improvement EValuation in End-stage Renal Disease

Condition:   Endstage Renal Disease
Interventions:   Drug: Spironolactone 25Mg Tablet;   Drug: Placebo Oral Tablet
Sponsors:   Population Health Research Institute;   Canadian Institutes of Health Research (CIHR)
Recruiting

Fri, 13 Jan 2017 12:00:00 EST

Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Heart Failure, Congestive
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   HealthCore-NERI;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Fri, 15 Oct 2004 12:00:00 EDT

Exploring Mechanisms and Morphology of QT Interval Prolongation

Conditions:   Long Qt Syndrome 1-2;   Sudden Cardiac Death
Interventions:   Drug: Beta Blockers;   Drug: Spironolactone
Sponsor:   Herlev and Gentofte Hospital
Completed

Mon, 25 Sep 2017 12:00:00 EDT

The Effect of Amiloride and Spironolactone in Healthy Persons

Condition:   High Blood Pressure
Interventions:   Drug: Amiloride;   Drug: Spironolactone;   Drug: Placebo;   Drug: Placebo and spironolactone
Sponsor:   Regional Hospital Holstebro
Completed

Mon, 09 Mar 2009 12:00:00 EDT

Metabolic and Neuro-Endocrine Effect of Treating PCOS in Adolescents

Condition:   PCOS
Intervention:   Drug: Metformin and Spironolactone
Sponsor:   Children's Mercy Hospital Kansas City
Completed

Tue, 11 Jun 2019 12:00:00 EDT

Biomarker Guided Therapies in Stage A/B Heart Failure

Conditions:   Hypertension;   Diabetes;   Cardiovascular Disease
Interventions:   Drug: Carvedilol;   Drug: Spironolactone
Sponsors:   VA Office of Research and Development;   Baylor College of Medicine
Completed

Wed, 03 Sep 2014 12:00:00 EDT

Efficacy of Aldosterone Antagonist Therapy for Prevention of New Atrial Fibrillation

Condition:   AFib
Interventions:   Drug: Spironolactone;   Drug: No Spironolactone
Sponsor:   Piedmont Healthcare
Recruiting

Mon, 29 Apr 2019 12:00:00 EDT

Mineralocorticoid Receptor and Obesity Induced Cardiovascular Complications

Conditions:   Obesity;   Insulin Resistance
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsor:   Brigham and Women's Hospital
Completed

Fri, 29 Jul 2011 12:00:00 EDT

Spironolactone Versus Spironolactone Plus Furosemide (SVSSF)

Conditions:   Cirrhosis;   Ascites
Intervention:   Drug: Spironolactone and furosemide
Sponsor:   University of Padova
Completed

Tue, 26 Aug 2008 12:00:00 EDT

Sympathetic Renal Denervation Versus Increment of Pharmacological Treatment in Resistant Arterial Hypertension.

Condition:   Resistant Arterial Hypertension
Interventions:   Procedure: Sympathetic Renal Denervation;   Drug: Treatment with aldactone
Sponsor:   Parc de Salut Mar
Completed

Fri, 17 Jan 2014 12:00:00 EST

Residual Renal Function Preservation in Peritoneal Dialysis Patients

Condition:   Chronic Renal Disease
Interventions:   Drug: Losartan;   Drug: spirolactone;   Other: blank control
Sponsors:   Second Xiangya Hospital of Central South University;   Baxter Healthcare Corporation
Unknown status

Tue, 15 Jul 2014 12:00:00 EDT

Mineralocorticoid Receptor Antagonism Clinical Evaluation in Atherosclerosis Add-On

Conditions:   Type2 Diabetes;   Hyperkalemia
Intervention:   Drug: Spironolactone
Sponsors:   University Hospitals Cleveland Medical Center;   Relypsa, Inc.
Unknown status

Tue, 24 Jul 2018 12:00:00 EDT

Effect of Aldosterone Blockade on Arterial Compliance

Conditions:   Arterial Stiffness;   Arterial Elasticity
Intervention:   Drug: Spironolactone
Sponsor:   Wolfson Medical Center
Completed

Thu, 18 Mar 2010 12:00:00 EDT

Adjuvant Anti-Mineralocorticoid-Receptor Treatment in Anti-VEGF Refractory Neovascular Age-Related Macular Degeneration

Condition:   Neovascular Age-related Macular Degeneration
Intervention:   Drug: Spironolactone 50 MG
Sponsor:   Dr Irmela MANTEL
Completed

Fri, 16 Nov 2018 12:00:00 EST

Vascular Effects of Mineralocorticoid Receptor Antagonism in Kidney Disease

Conditions:   Chronic Kidney Disease;   Albuminuria
Interventions:   Drug: Spironolactone;   Drug: Amiloride
Sponsors:   University of Alabama at Birmingham;   National Institutes of Health (NIH)
Completed

Tue, 14 Jul 2015 12:00:00 EDT

Resistant Hypertension Optimal Treatment

Condition:   Hypertension
Interventions:   Drug: Spironolactone;   Drug: Clonidine
Sponsors:   Instituto do Coracao;   Conselho Nacional de Desenvolvimento Científico e Tecnológico
Unknown status

Wed, 18 Jul 2012 12:00:00 EDT

Effects of Spironolactone Combination Therapy on Proteinuria, Kidney Function, and Blood Pressure

Conditions:   Type 2 Diabetes Mellitus;   Diabetic Nephropathy;   Essential Hypertension
Intervention:   Drug: spironolacone 25 mg tablets added to losartan
Sponsor:   Tehran University of Medical Sciences
Completed

Fri, 17 Aug 2012 12:00:00 EDT

Blockade of the Renin-angiotensin-aldosterone System in Patients With ARVD

Condition:   Arrhythmogenic Right Ventricular Dysplasia
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsor:   Hospices Civils de Lyon
Not yet recruiting

Fri, 20 Jul 2018 12:00:00 EDT

Body Volume Regulation in Pulmonary Arterial Hypertension With Right Ventricular Failure

Conditions:   Right Heart Failure;   Pulmonary Hypertension
Intervention:   Drug: Spironolactone and conivaptan
Sponsor:   University of Colorado, Denver
Withdrawn

Fri, 19 Dec 2008 12:00:00 EST

Safety and Efficacy of Two Year Spnol and Maximal R Blockad Therapy

Conditions:   Renal Insufficiency, Chronic;   Diabetic Nephropathy Type 2
Interventions:   Drug: Renin-Angiotensin (RAAS) bers (ACE/ARB) alone;   Drug: Renin-Angiotensin (RAAS) blockers in combination with Spironolactone
Sponsor:   James A. Tumlin, MD
Withdrawn

Wed, 18 Apr 2018 12:00:00 EDT

Mineralocorticoid Antagonism and Endothelial Dysfunction in Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Condition:   ADPKD
Interventions:   Drug: Spironolactone;   Drug: Sugar pill
Sponsors:   University of Colorado, Denver;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Wed, 15 May 2013 12:00:00 EDT

Effects of Adrenal Artery Ablation and Spironolactone in Patients With Primary Aldosteronism

Conditions:   Primary Aldosteronism;   Hypertension
Intervention:   Procedure: Endovascular chemical Ablation of Adrenal Gland
Sponsor:   Third Military Medical University
Recruiting

Mon, 01 Jun 2020 12:00:00 EDT

Aldosterone Blockade in Heart Failure

Condition:   Heart Failure
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsor:   Justin Ezekowitz
Completed

Fri, 31 Aug 2007 12:00:00 EDT

Spironolactone in Preventing Rash in Patients With Advanced Cancer Receiving Panitumumab and Cetuximab

Conditions:   Advanced Malignant Neoplasm;   Dermatologic Complication
Interventions:   Drug: Doxycycline;   Procedure: Management of Therapy Complications;   Other: Placebo;   Other: Questionnaire Administration;   Drug: Spironolactone;   Drug: Sunscreen;   Drug: Therapeutic Hydrocortisone
Sponsors:   Academic and Community Cancer Research United;   National Cancer Institute (NCI)
Completed

Tue, 04 Jun 2013 12:00:00 EDT

Evaluation of Patiromer Titration in Heart Failure Patients With Chronic Kidney Disease

Condition:   Heart Failure
Interventions:   Drug: patiromer;   Drug: spironolactone
Sponsor:   Relypsa, Inc.
Completed

Wed, 26 May 2010 12:00:00 EDT

Proteomic Prediction and Renin Angiotensin Aldosterone System Inhibition Prevention Of Early Diabetic nephRopathy In TYpe 2 Diabetic Patients With Normoalbuminuria

Conditions:   Diabetic Nephropathy;   Diabetic Retinopathy
Interventions:   Drug: Spironolactone;   Drug: Placebo;   Drug: Standard care
Sponsors:   Peter Rossing;   Mosaiques Diagnostics GmbH;   University Medical Center Groningen;   University of Glasgow;   Istituto Di Ricerche Farmacologiche Mario Negri;   Univerzita Karlova v Praze;   Geniko Nosokomeio Athinas Ippokrateio;   Institut Klinické a Experimentální Mediciny Praze;   Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz;   Klinikum St. Georg Leipzig;   Cyril and Methodius University in Skopje;   Hannover Clinical Trial Center;   European Commission;   Diabetes Vascular Research Foundation Hoogeveen;   Universitair Ziekenhuis Gent;   Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden;   Stichting VUMC;   Diabetologen Hessen
Completed

Mon, 20 Jan 2014 12:00:00 EST

Early Aldosterone Blockade in Acute Heart Failure: An Exploratory Safety Study

Condition:   Acute Heart Failure
Interventions:   Drug: Spironolactone;   Other: Placebo
Sponsors:   Indiana University;   National Heart, Lung, and Blood Institute (NHLBI);   Vanderbilt University;   Wayne State University
Withdrawn

Mon, 24 Nov 2014 12:00:00 EST

A Study To Evaluate The Safety And Tolerability Of PF-03882845 In Patients With Type 2 Diabetic Nephropathy

Condition:   Type 2 Diabetic Nephropathy
Interventions:   Drug: PF-03882845;   Drug: Spironolactone;   Other: placebo
Sponsor:   Pfizer
Terminated

Thu, 08 Dec 2011 12:00:00 EST

Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease

Condition:   Primary Hypertension
Interventions:   Drug: spironolactone;   Drug: placebo
Sponsor:   University of Erlangen-Nürnberg Medical School
Completed

Thu, 19 Mar 2009 12:00:00 EDT

Mineralocorticoid Antagonism to Stop Progression of Atrial Fibrillation (MONITOR-AF) Study

Condition:   Atrial Fibrillation
Interventions:   Drug: Spironolactone 25mg;   Drug: Placebo oral tablet
Sponsors:   National University Hospital, Singapore;   University of Otago
Recruiting

Tue, 31 Mar 2020 12:00:00 EDT

Venetoclax and Lintuzumab-Ac225 in AML Patients

Conditions:   Acute Myeloid Leukemia;   Relapsed Adult AML
Interventions:   Biological: Lintuzumab-Ac225;   Drug: Venetoclax;   Drug: Spironolactone
Sponsor:   Actinium Pharmaceuticals
Recruiting

Fri, 08 Mar 2019 12:00:00 EST

Aldosterone and the Metabolic Syndrome

Conditions:   Metabolic Diseases;   Diabetes Mellitus;   Endocrine System Diseases;   Glucose Metabolism Disorders
Interventions:   Drug: Hydrochlorothiazide (HCTZ);   Drug: Aliskiren 150 mg (ALI 150);   Drug: Spironolactone (SPL 25);   Drug: Aliskiren 300 mg (ALI 300);   Drug: Spironolactone 50 mg (SPL 50)
Sponsor:   Vanderbilt University Medical Center
Completed

Wed, 14 Apr 2010 12:00:00 EDT

Eplerenone Versus Spironolactone as Treatment of Ascites Due to Liver Cirrhosis; a Study of Efficacy and Side Effects

Conditions:   Ascites;   Cirrhosis
Intervention:   Drug: Eplerenone
Sponsors:   Emma Nilsson;   Göteborg University;   Uppsala University Hospital;   Karolinska University Hospital;   University Hospital, Linkoeping;   University Hospital, Umeå;   Region Örebro County
Withdrawn

Thu, 28 Feb 2013 12:00:00 EST

Fracture Risk With Thiazolidinediones

Conditions:   Fractures, Bone;   Type II Diabetes
Interventions:   Drug: TZD only (RSG or PIO or troglitazone);   Drug: TZD + spironolactone;   Drug: TZD + amiloride
Sponsor:   GlaxoSmithKline
Completed

Mon, 25 Jan 2010 12:00:00 EST

Safety of Hormonal Contraceptives Therapies in Polycystic Ovary Syndrome (PCOS) Women

Condition:   Polycystic Ovary Syndrome
Interventions:   Drug: oral contraceptive;   Drug: Oral contraceptive plus spironolactone;   Drug: Oral contraceptive plus metformin
Sponsor:   University of Sao Paulo
Completed

Thu, 12 Feb 2009 12:00:00 EST

A Study of LY3045697 After Multiple Oral Dosing in Healthy Participants

Condition:   Healthy Volunteers
Interventions:   Drug: LY3045697;   Drug: Placebo;   Drug: Spironolactone
Sponsor:   Eli Lilly and Company
Completed

Mon, 01 Apr 2013 12:00:00 EDT

Hypoglycemia and Autonomic Nervous System Function-B

Conditions:   Hypoglycemia;   Healthy
Interventions:   Drug: Spironolactone;   Drug: Placebo;   Other: Hypoglycemic Hyperinsulinemic Clamp;   Other: Euglycemic Hyperinsulinemic Clamp
Sponsors:   Brigham and Women's Hospital;   Beth Israel Deaconess Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Active, not recruiting

Mon, 12 Feb 2018 12:00:00 EST

Postoperative Cardiovascular Index Change of Primary Aldosteronism

Condition:   Aldosteronism
Intervention:   Other: with the clinical treatment ( ex adrenalectomy or spironolactone
Sponsor:   National Taiwan University Hospital
Unknown status

Wed, 03 Sep 2008 12:00:00 EDT

Lintuzumab-Ac225 in Older Acute Myeloid Leukemia (AML) Patients

Condition:   AML
Interventions:   Drug: Cytarabine (Phase 1 only);   Biological: Lintuzumab-Ac225;   Drug: Furosemide (Phase 1 only);   Drug: Spironolactone
Sponsor:   Actinium Pharmaceuticals
Active, not recruiting

Thu, 15 Oct 2015 12:00:00 EDT

Treatment of Boys With Precocious Puberty

Condition:   Precocious Puberty
Interventions:   Drug: Spironolactone;   Drug: Testolactone;   Drug: Deslorelin
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed

Thu, 04 Nov 1999 12:00:00 EST

Aldosterone in Diabetic Nephropathy

Condition:   Diabetic Nephropathy
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsor:   Universidad de los Andes, Chile
Unknown status

Fri, 27 Mar 2009 12:00:00 EDT

Transgender Estradiol Affirming Therapy

Condition:   Transgenderism
Interventions:   Drug: Transdermal patch;   Diagnostic Test: Pro-thrombotic markers;   Diagnostic Test: Metabolic markers;   Diagnostic Test: Hormone Profile;   Drug: Sublingual Tablet;   Drug: Spironolactone
Sponsor:   Washington University School of Medicine
Recruiting

Wed, 18 Aug 2021 12:00:00 EDT

SCREEN-HFI (SCReening Evaluation of the Evolution of New Heart Failure Intervention Study)

Condition:   Heart Failure
Interventions:   Drug: Spironolactone;   Drug: Placebo
Sponsors:   Monash University;   National Heart Foundation, Australia
Completed

Tue, 29 Jan 2008 12:00:00 EST

A Prospective, Single-center, Open-label, Pilot Study to Compare the Effectiveness and Safety of Diuretics Add-On Strategy in Chronic Heart Failure Patients (DIOS 1)

Condition:   Congestive Heart Failure
Interventions:   Drug: furosemide/no spironolactone;   Drug: metolazone/no spironolactone;   Drug: furosemid/spironolactone;   Drug: metolazone/spironolactone
Sponsor:   Yonsei University
Withdrawn

Mon, 25 Mar 2013 12:00:00 EDT

Recurrent Stroke Prevention Clinical Outcome Study

Conditions:   Hypertension;   Stroke;   Blood Pressure
Intervention:   Drug: Losartan, Losartan and HCTZ, Amlodipine , Spironolactone
Sponsor:   Biomedis International Ltd.
Unknown status

Fri, 10 Sep 2010 12:00:00 EDT

AuTophagy Activation for Cardiomyopathy Due to Anthracycline tReatment (ATACAR)Trial

Condition:   Lymphoma
Interventions:   Drug: Carvedilol;   Drug: Lisinopril;   Drug: Pravastatin;   Drug: Spironolactone
Sponsor:   Mayo Clinic
Recruiting

Mon, 09 Dec 2019 12:00:00 EST

A Prospective, Single-center, Randomized, Controlled, Open-label, Pilot Study to Compare the Effectiveness and Safety of DIuretics Add-On Strategy in Acute Decompensated Heart Failure Patients (DIOS II)

Condition:   Congestive Heart Failure
Interventions:   Drug: Furosemide;   Drug: metolazone;   Drug: furosemid/spironolactone;   Drug: metolazone/spironolactone
Sponsor:   Yonsei University
Withdrawn

Tue, 28 Jan 2014 12:00:00 EST

BAY94-8862 Dose Finding Trial in Subjects With Chronic Heart Failure and Mild (Part A) or Moderate (Part B) Chronic Kidney Disease

Condition:   Heart Failure
Interventions:   Drug: BAY94-8862;   Drug: Placebo;   Drug: Spironolactone
Sponsor:   Bayer
Completed

Mon, 02 May 2011 12:00:00 EDT

Optimum Treatment for Drug-Resistant Hypertension

Condition:   Hypertension, Resistant to Conventional Therapy
Interventions:   Drug: Spironolactone;   Drug: Bisoprolol;   Drug: Doxazosin;   Drug: Placebo
Sponsors:   University of Cambridge;   British Heart Foundation
Unknown status

Mon, 23 Feb 2015 12:00:00 EST

STITCH2 (Simplified Therapeutic Intervention to Control Hypertension and Hypercholesterolemia)

Conditions:   Hypertension;   Hypercholesterolemia
Intervention:   Other: Treatment algorithm:caduet, Amlodipine, ACEI-ARB combo dose, a-blocker, b-blocker or spironolactone, dyslipidemic therapy with ezetamide
Sponsors:   University of Western Ontario, Canada;   Pfizer
Completed

Mon, 17 Mar 2008 12:00:00 EDT

Role of Mineralocorticoid Receptor in Diabetic Cardiovascular Disease

Conditions:   Type 2 Diabetes Mellitus;   Vascular Disease
Interventions:   Drug: Spironolactone;   Drug: Hydrochlorothiazide + potassium;   Other: Placebo
Sponsors:   Brigham and Women's Hospital;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Thu, 19 Mar 2009 12:00:00 EDT

Effect of Betablocker or Aldosterone Antagonist Therapy on Patients With Liver Cirrhosis

Conditions:   Liver Cirrhosis;   Portal Hypertension
Interventions:   Drug: propranolol;   Drug: spironolactone
Sponsor:   Hvidovre University Hospital
Unknown status

Fri, 02 Jun 2006 12:00:00 EDT

Sodium-Restricted Diet and Diuretic in the Treatment of Severe Sleep Apnea

Condition:   Obstructive Sleep Apnea
Interventions:   Drug: Lasilactone;   Other: Sodium-Restricted Diet;   Drug: Placebo
Sponsor:   Hospital de Clinicas de Porto Alegre
Completed

Thu, 19 Sep 2013 12:00:00 EDT

The Effect in Renal Function on Patients With Type 1 Cardiorenal Syndrome Treated With Two Strategies of Furosemide.

Condition:   Cardiorenal Syndrome
Interventions:   Drug: Furosemide intravenous solution;   Drug: Chlortalidone;   Drug: Spironolactone
Sponsor:   Hospital Civil de Guadalajara
Completed

Tue, 19 May 2020 12:00:00 EDT

Tissue Sodium in Pre-hypertensive Patients

Condition:   Hypertension
Interventions:   Drug: Spironolactone;   Drug: Chlorthalidone;   Dietary Supplement: Diet;   Drug: Placebo
Sponsors:   Vanderbilt University;   American Heart Association
Completed

Wed, 10 Sep 2014 12:00:00 EDT

Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension

Condition:   Hypertension Resistant to Conventional Therapy
Interventions:   Drug: Spironolactone;   Drug: Furosemide,;   Drug: Amiloride;   Drug: Ramipril;   Drug: Bisoprolol
Sponsor:   Sao Jose do Rio Preto Medical School
Completed

Thu, 14 Jul 2016 12:00:00 EDT

Renin-angiotensin-aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (AF)

Condition:   Atrial Fibrillation
Interventions:   Drug: Placebo;   Drug: Ramipril;   Drug: Spironolactone
Sponsors:   Vanderbilt University;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Thu, 01 Sep 2005 12:00:00 EDT

Patiromer in the Treatment of Hyperkalemia in Patients With Hypertension and Diabetic Nephropathy (AMETHYST-DN)

Conditions:   Chronic Kidney Disease;   Hypertension;   Hyperkalemia
Interventions:   Drug: patiromer;   Drug: losartan;   Drug: spironolactone
Sponsor:   Relypsa, Inc.
Completed

Mon, 13 Jun 2011 12:00:00 EDT

Effects of Adding Hypertonic Saline Solutions and/or Etilefrine to Standard Diuretics Therapy in Hepatic Ascites

Condition:   Hepatic Ascites
Interventions:   Drug: Oral standard diuretics therapy;   Drug: Hypertonic saline solution;   Drug: Etilefrine
Sponsor:   Hala Abd EL-Tawab Ibrahim Radwan
Completed

Mon, 08 Mar 2021 12:00:00 EST

Examining the Effect of Different Diuretics on Fluid Retention in Diabetics Treated With Rosiglitazone.

Condition:   Diabetes Mellitus
Interventions:   Drug: Rosiglitazone;   Drug: spironolactone;   Drug: hydrochlorothiazide;   Drug: frusemide
Sponsor:   GlaxoSmithKline
Completed

Fri, 24 Mar 2006 12:00:00 EST

Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men

Conditions:   Cortisol Resistance;   Negative Feedback;   ACTH;   Mineralcorticoid;   Glucocorticoid
Interventions:   Drug: Mifepristone;   Drug: Placebo;   Drug: Spironolactone;   Drug: Combined;   Drug: Dexamethasone
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed

Fri, 11 Feb 2011 12:00:00 EST

Changes in Endothelial Function and Biomarkers in African Americans (AA) With Metabolic Syndrome

Condition:   Hypertension
Interventions:   Drug: amlodipine and olmesartan;   Drug: losartan and HCTZ
Sponsor:   InVasc Therapeutics, Inc.
Unknown status

Thu, 06 Jan 2011 12:00:00 EST

Effects of Thiazide Diuretics on Sympathetic Nervous System in Hypertension

Condition:   Hypertension
Interventions:   Drug: Study#1: chlorthalidone (CTD), titrated dose;   Drug: Study #1: spironolactone (SP), titrated dose;   Drug: Study# 2 chlorthalidone (CTD), fixed dose;   Drug: Study# 2 spironolactone (SP), fixed dose;   Drug: Study# 2 irbsesartan (IR), fixed dose
Sponsors:   University of Texas Southwestern Medical Center;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Wed, 19 Jul 2006 12:00:00 EDT

Improving Outcomes in Patients With Kidney Disease Due to Diabetes

Conditions:   Diabetes;   Kidney Disease;   Hypertension
Interventions:   Drug: losartan 100 mg orally once daily;   Drug: spironolactone 25 mg orally once daily;   Drug: placebo once orally once daily
Sponsor:   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Wed, 27 Sep 2006 12:00:00 EDT

A Single Dose Study Of Antimineralocorticoid Activity Of PF-03882845 In Healthy Volunteers

Condition:   Healthy Volunteers
Interventions:   Drug: 3 mg PF-03882845;   Drug: 10 mg PF-03882845;   Drug: 30 mg PF-03882845;   Drug: 100 mg PF-03882845;   Drug: Spironolactone
Sponsor:   Pfizer
Completed

Tue, 15 Mar 2011 12:00:00 EDT

Glucose Metabolism in Subjects With Aldosterone-Producing Adenomas

Condition:   Primary Aldosteronism
Interventions:   Other: Adrenalectomy;   Drug: mineralocorticoid receptor antagonist
Sponsors:   Vanderbilt University;   Brigham and Women's Hospital;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Completed

Thu, 12 Feb 2015 12:00:00 EST

Mineralocorticoid Receptor in the Treatment of Severe Depression

Condition:   Major Depression
Interventions:   Drug: Spironolactone;   Drug: fludrocortisone;   Drug: escitalopram
Sponsor:   Universitätsklinikum Hamburg-Eppendorf
Completed

Thu, 23 Feb 2006 12:00:00 EST

A Study of LY2623091 in Participants With High Blood Pressure

Condition:   Primary Hypertension
Interventions:   Drug: LY2623091;   Drug: Tadalafil;   Drug: Spironolactone;   Drug: Placebo
Sponsor:   Eli Lilly and Company
Completed

Fri, 18 Jul 2014 12:00:00 EDT

Management of Decompensated HCV Cirrhotic Patients

Condition:   Decompensated Cirrhosis
Interventions:   Drug: Sofosbuvir 400mg (Sovaldi) + Daclatasvir 60 mg (Daklinza) + Ribavirin 200 mg (Rebetol);   Drug: vitamin K (Phytomenadione) 10 mg+ furosemide and spironolactone (Lasilactone) 50 mg + milk thistle (Silymarin) 140 mg + Albumin infusion
Sponsor:   Zagazig University
Completed

Wed, 06 Jun 2018 12:00:00 EDT

Role of Midodrine and Tolvaptan in Patients With Cirrhosis With Refractory or Recurrent Ascites

Conditions:   Cirrhosis;   Refractory/Recurrent Ascites
Interventions:   Drug: Standard medical therapy;   Drug: Tolvaptan;   Drug: Midodrine
Sponsor:   Postgraduate Institute of Medical Education and Research
Completed

Tue, 24 Jun 2014 12:00:00 EDT

Curing Atrial Fibrillation in Heart Failure

Conditions:   Chronic Heart Failure;   Atrial Fibrillation
Interventions:   Procedure: radiofrequency ablation;   Drug: ACE inhibitor - ramipril, enalapril, captopril, perindopril, lisinopril;   Drug: Beta Blocker (BB) - metoprolol, bisoprolol, carvedilol;   Drug: Aldosterone Antagonists - spironolactone
Sponsor:   NHS Greater Glasgow and Clyde
Completed

Wed, 15 Feb 2006 12:00:00 EST

Safety and Efficacy of Early, seQUential Oral dIuretic Nephron blockAde In Acute Heart Failure

Condition:   Acute Heart Failure
Interventions:   Drug: Standard diuretic therapy;   Drug: Early sequential nephron blockade
Sponsors:   University of Parma;   Azienda Ospedaliero-Universitaria di Parma;   Azienda USL di Parma;   Azienda Unità Sanitaria Locale Reggio Emilia
Not yet recruiting

Tue, 20 Aug 2019 12:00:00 EDT

Mineralocorticoid Receptor Antagonist and Pulmonary Fibrosis in COVID-19.

Condition:   COVID-19 Pneumonia
Interventions:   Drug: Canrenoate Potassium;   Drug: Normal Saline
Sponsor:   Pomeranian Medical University Szczecin
Recruiting

Thu, 03 Jun 2021 12:00:00 EDT

Prospective Study Assessing Blood Pressure and Other Outcomes Post-treatment in Patients With Primary Aldosteronism

Conditions:   Primary Aldosteronism;   Primary Aldosteronism Due to Aldosterone Producing Adenoma;   Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
Interventions:   Procedure: Adrenalectomy;   Drug: Mineralocorticoid Receptor Antagonists
Sponsor:   Changi General Hospital
Recruiting

Mon, 05 Jun 2017 12:00:00 EDT

Acne and Mood: Impact of Treatment on Depression, Anxiety, and Sexual Function

Condition:   Acne Vulgaris
Intervention:   Other: Online survey
Sponsor:   Northwestern University
Withdrawn

Fri, 19 Apr 2019 12:00:00 EDT

Treatment of Resistant Hypertension by Prevention of T-Cell Co-Stimulation

Condition:   Hypertension
Interventions:   Drug: Abatacept;   Drug: Placebo
Sponsors:   Vanderbilt University Medical Center;   Bristol-Myers Squibb
Terminated

Fri, 05 Sep 2014 12:00:00 EDT

Risk Stratification of Heart Failure in Cardiomyopathies.

Condition:   Cardiomyopathy With Unknown Etiology
Interventions:   Drug: etiologic treatment,anti-myocardial remodeling;   Drug: anti-myocardial remodeling;   Drug: anti-myocardial remodeling,anti-acute heart failure;   Drug: Etiological, anti-remodeling and symptom treatment
Sponsor:   RenJi Hospital
Recruiting

Fri, 21 Oct 2016 12:00:00 EDT

European Alport Therapy Registry - European Initiative Towards Delaying Renal Failure in Alport Syndrome

Conditions:   Alport Syndrome;   Hereditary Kidney Disease;   Pediatric Kidney Disease;   Thin Basement Membrane Disease;   Familial Benign Hematuria
Interventions:   Drug: ACE-inhibitor;   Drug: AT1-inhibitor;   Drug: HMG-Coenzyme inhibitor (statin);   Drug: Spironolactone;   Drug: Paricalcitol
Sponsors:   University Hospital Goettingen;   Society for Pediatric Nephrology (Germany);   Deutsche Gesellschaft für Nephrologie;   Alport Selbsthilfe e.V.;   Association pour l'Information et la Recherche sur les Maladies Rénales Génétiques (AIRG);   KfH Foundation Preventive Medicine
Recruiting

Wed, 04 Mar 2015 12:00:00 EST

Remission From Stage D Heart Failure

Conditions:   Heart Failure NYHA Class III;   Heart Failure NYHA Class IV
Intervention:   Drug: Pharmacological Treatment
Sponsors:   University of Louisville;   Thoratec Corporation
Unknown status

Thu, 24 Jan 2013 12:00:00 EST

Tissue K+ in Primary Hyperaldosteronism

Conditions:   Primary Hyperaldosteronism;   Electrolyte Disturbance
Interventions:   Procedure: Surgical Treatment of Hyperaldosteronism;   Drug: Drug treatment of Hyperaldosteronism
Sponsor:   University of Erlangen-Nürnberg Medical School
Recruiting

Wed, 05 Feb 2020 12:00:00 EST

RELieving Increasing oEdema Due to Heart Failure

Condition:   Heart Failure,Congestive
Intervention:   Drug: Patiromer
Sponsors:   NHS Greater Glasgow and Clyde;   University of Glasgow
Not yet recruiting

Tue, 29 Oct 2019 12:00:00 EDT

The Effect of Enalapril and Losartan on Peritoneal Membrane in Continuous Ambulatory Peritoneal Dialysis Patients

Condition:   Continuous Ambulatory Peritoneal Dialysis
Interventions:   Drug: Enalapril;   Drug: Enalapril plus Losartan;   Drug: Placebo
Sponsor:   Chulalongkorn University
Unknown status

Tue, 05 Jan 2010 12:00:00 EST

Renal Denervation in Refractory Hypertension

Conditions:   Hypertension;   Resistant to Conventional Therapy
Intervention:   Device: Renal denervation (Symplicity® Catheter System™)
Sponsors:   Charles University, Czech Republic;   General University Hospital, Prague;   University Hospital Olomouc;   Cardiocenter Podlesí, Trinec, Czech Republic
Terminated

Thu, 22 Mar 2012 12:00:00 EDT

Safety And Efficacy Of Spirinolactone Plus Hydroflumethiazide In The Treatment Of Filipino Patients With Hypertension

Condition:   Hypertension
Intervention:   Drug: Aldazide
Sponsor:   Pfizer
Withdrawn

Wed, 15 Dec 2010 12:00:00 EST

Polypill Strategy for Heart Failure With Reduced Ejection Fraction

Condition:   Heart Failure
Interventions:   Drug: Polypill;   Drug: Control Rx
Sponsor:   University of Texas Southwestern Medical Center
Not yet recruiting

Tue, 17 Nov 2020 12:00:00 EST

Efficacy of Targeted And Response-Guided Albumin Therapy Versus Standard Medical Treatment In Outcomes Of Recurrent Ascites In Patients With Decompensated Cirrhosis.

Condition:   Decompensated Cirrhosis
Interventions:   Biological: Albumin;   Drug: Standard Medical Treatment
Sponsor:   Institute of Liver and Biliary Sciences, India
Not yet recruiting

Tue, 22 Dec 2020 12:00:00 EST

Early Mineralocorticoid Receptor Antagonist Treatment to Reduce Myocardial Infarct Size

Condition:   ST-elevation Myocardial Infarction
Interventions:   Drug: Mineralocorticoid receptor antagonist potassium-canrenoate;   Drug: placebo
Sponsors:   University College, London;   British Heart Foundation
Completed

Thu, 20 Jun 2013 12:00:00 EDT

Randomized Control Trial (RCT) of Early Palliative Care for HCC

Condition:   Carcinoma, Hepatocellular
Intervention:   Behavioral: Early Palliative Care/Symptom Control
Sponsors:   The University of Texas Health Science Center, Houston;   American Cancer Society, Inc.
Recruiting

Tue, 22 Sep 2015 12:00:00 EDT

Controlling Blood Pressure in Treatment Resistant Hypertension: A Pilot Study

Condition:   Hypertension
Interventions:   Drug: Renin treatment-guided Therapeutics;   Other: Referral Hypertension specialist;   Drug: Aldosterone Antagonist
Sponsors:   Medical University of South Carolina;   University of South Carolina
Completed

Thu, 19 Jun 2014 12:00:00 EDT

Effects of Aging and Gender-Affirming Hormone Therapy on Vascular Endothelial Function and Metabolic Profiles in Transgender Women

Conditions:   Transgenderism;   Gender Identity;   Vascular Stiffness;   Vascular Inflammation;   Insulin Sensitivity;   Blood Pressure;   Lipid Disorder;   Appetitive Behavior
Intervention:  
Sponsors:   University of Colorado, Denver;   National Institutes of Health (NIH)
Recruiting

Mon, 26 Aug 2019 12:00:00 EDT

CLEAR SYNERGY Neutrophil Substudy

Conditions:   Neutrophils.Hypersegmented | Bld-Ser-Plas;   STEMI - ST Elevation Myocardial Infarction
Intervention:   Drug: Colchicine Pill
Sponsors:   NYU Langone Health;   Population Health Research Institute;   National Heart, Lung, and Blood Institute (NHLBI)
Recruiting

Thu, 14 Mar 2019 12:00:00 EDT

Acetazolamide in Patients With Acute Heart Failure

Conditions:   Heart Failure;   Acute Heart Failure
Interventions:   Drug: Acetazolamide;   Drug: Placebo
Sponsor:   University of Sao Paulo General Hospital
Unknown status

Thu, 25 Oct 2018 12:00:00 EDT

Role of Active Deresuscitation After Resuscitation-2

Conditions:   Critical Illness;   Sepsis;   Trauma
Interventions:   Other: Conservative fluid and deresuscitation strategy;   Other: Usual care strategy
Sponsors:   Belfast Health and Social Care Trust;   Queen's University, Belfast;   University of Toronto
Active, not recruiting

Mon, 30 Apr 2018 12:00:00 EDT

Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension

Condition:   Hypertension
Interventions:   Drug: clinical hypertension specialist-no specific med. Any anti-hypertension meds.;   Drug: renin guided therapeutics-no specific med. Any anti-hypertensive med.
Sponsors:   Medical University of South Carolina;   New York Presbyterian Hospital
Completed

Mon, 26 May 2008 12:00:00 EDT

Systematic Withdrawal of Neurohumoral Blocker Therapy in Optimally Responding CRT Patients

Condition:   Heart Failure (HF)
Interventions:   Drug: beta blockers;   Drug: RAAS blockers
Sponsors:   Hasselt University;   Ziekenhuis Oost-Limburg
Completed

Fri, 25 Jul 2014 12:00:00 EDT

Transgender Youth and PrEP: PK, Safety, Uptake & Adherence - PK Study

Conditions:   HIV/AIDS;   Gender;   Behavior and Behavior Mechanisms
Intervention:   Drug: TDF/FTC
Sponsors:   Hektoen Institute for Medical Research;   National Institute of Mental Health (NIMH)
Unknown status

Wed, 29 Aug 2018 12:00:00 EDT

Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation

Conditions:   Cardiovascular Diseases;   Heart Diseases;   Coronary Disease
Interventions:   Drug: Angiotensin-Converting Enzyme Inhibitors;   Procedure: Coronary Artery Bypass Graft;   Drug: Angiotensin Receptor Blockers;   Drug: Spironolactone;   Drug: Aspirin;   Drug: Clopidogrel;   Procedure: Surgical Ventricular Restoration
Sponsors:   Baylor Research Institute;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Fri, 23 Sep 2005 12:00:00 EDT

Digoxin In Treatment of Alcohol Associated Hepatitis

Conditions:   Acute Alcoholic Hepatitis;   Chemical and Drug Induced Liver Injury;   Alcohol-Induced Disorders;   Steatohepatitis Caused by Ingestible Alcohol
Intervention:   Drug: Intravenous digoxin
Sponsor:   Yale University
Not yet recruiting

Fri, 20 Aug 2021 12:00:00 EDT

Surgery of Subclinical Cortisol Secreting Adrenal Incidentalomas

Condition:   Adrenal Incidentalomas
Interventions:   Procedure: Laparoscopic surgical removal of the adrenal tumor;   Drug: Standardized medical treatment of hypertension by SAHR
Sponsor:   University Hospital, Bordeaux
Active, not recruiting

Mon, 16 Feb 2015 12:00:00 EST

Matão Controlling Hypertension (MatCH Study): Rationale and Design

Conditions:   Hypertension;   Blood Pressure
Interventions:   Drug: Captopril 25Mg, Hydrochlorothiazide 25Mg Oral Tablet,;   Drug: Atenolol;   Drug: Losartan potassium 50mg;   Drug: Clonidine
Sponsor:   Centro Neurológico de Pesquisa e Reabiitação, Brazil
Unknown status

Wed, 10 May 2017 12:00:00 EDT

Effect of Genetic Polymorphism on the Clinical Outcome of Patients With Heart Failure

Condition:   Heart Failure
Intervention:  
Sponsors:   Ain Shams University;   Misr International University
Completed

Fri, 21 Apr 2017 12:00:00 EDT

To Study the Safety and Efficacy of Midodrine With Albumin Versus Albumin Alone in Hepatic Hydrothorax

Condition:   Hepatic Hydrothorax
Interventions:   Drug: Midodrine;   Biological: Albumin;   Drug: Diuretics
Sponsor:   Institute of Liver and Biliary Sciences, India
Completed

Fri, 24 Aug 2018 12:00:00 EDT

Evaluation of Heart Failure Treatment Guided by N-terminal Pro B-type Natriuretic Peptide (NTproBNP) vs Clinical Symptoms and Signs Alone

Conditions:   Heart Failure;   Ventricular Dysfunction, Left
Interventions:   Drug: Captopril;   Drug: Enalapril;   Drug: Lisinopril;   Drug: Ramipril;   Drug: Trandolapril;   Drug: Bisoprolol;   Drug: Carvedilol;   Drug: Metoprolol succinate;   Drug: Candesartan;   Drug: Valsartan;   Drug: Eplerenone;   Drug: Spironolactone;   Drug: Diuretics;   Drug: HF treatment according to Swedish guidelines;   Procedure: Blood samples;   Procedure: The Kansas City Cardiomyopathy Questionnaire (KCCQ)
Sponsor:   AstraZeneca
Completed

Wed, 25 Oct 2006 12:00:00 EDT

Cardiovascular Improvements With MV ASV Therapy in Heart Failure

Conditions:   Acute Decompensated Heart Failure;   Sleep Disordered Breathing
Interventions:   Device: MV ASV;   Drug: Optimized Medical Treatment
Sponsors:   ResMed;   ResMed Foundation
Terminated

Tue, 01 Oct 2013 12:00:00 EDT

Standard Drug Therapy vs. Implanted Defibrillator for Primary Prevention of Sudden Cardiac Death

Conditions:   Coronary Heart Disease;   Congestive Heart Failure;   Ventricular Dysfunction;   Low Cardiac Output;   Sudden Cardiac Death
Interventions:   Drug: Optimized medical therapy;   Device: Implantable Cardioverter Defibrillator
Sponsors:   Unity Health Toronto;   Institute for Clinical Evaluative Sciences;   Ontario Ministry of Health and Long Term Care
Terminated

Wed, 05 Sep 2007 12:00:00 EDT

Adrenal Artery Ablation for Primary Aldosteronism

Conditions:   Primary Aldosteronism;   Hypertension
Interventions:   Procedure: Endovascular chemical Ablation of Adrenal Gland;   Drug: Sequenced antihypertensvie drugs with titrated dosage
Sponsor:   Third Military Medical University
Unknown status

Fri, 31 Aug 2018 12:00:00 EDT

Gender-Affirmative Transgender Care to Improve the HIV Treatment Cascade

Condition:   HIV-1-infection
Interventions:   Drug: Feminizing hormone therapy;   Behavioral: Peer navigation
Sponsors:   Asociación Civil Impacta Salud y Educación, Peru;   The Fenway Institute;   Epicentro;   amfAR, The Foundation for AIDS Research
Completed

Wed, 28 Nov 2018 12:00:00 EST

Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

Conditions:   Coronavirus Infection (COVID-19);   Pulmonary Arterial Hypertension;   Urinary Tract Infections in Children;   Hypertension;   Pain;   Hyperphosphatemia;   Primary Hyperaldosteronism;   Edema;   Hypokalemia;   Heart Failure;   Hemophilia;   Menorrhagia;   Insomnia;   Pneumonia;   Skin Infection;   Arrythmia;   Asthma in Children;   Bronchopulmonary Dysplasia;   Adrenal Insufficiency;   Fibrinolysis; Hemorrhage;   Attention Deficit Hyperactivity Disorder;   Multisystem Inflammatory Syndrome in Children (MIS-C);   Kawasaki Disease;   Coagulation Disorder;   Down Syndrome
Intervention:   Drug: The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
Sponsors:   Duke University;   The Emmes Company, LLC;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting

Thu, 20 Feb 2020 12:00:00 EST

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care

Conditions:   Adenovirus;   Anesthesia;   Anxiety;   Anxiolysis;   Autism;   Autistic Disorder;   Bacterial Meningitis;   Bacterial Septicemia;   Benzodiazepine;   Bipolar Disorder;   Bone and Joint Infections;   Central Nervous System Infections;   Convulsions;   Cytomegalovirus Retinitis;   Early-onset Schizophrenia Spectrum Disorders;   Epilepsy;   General Anesthesia;   Gynecologic Infections;   Herpes Simplex Virus;   Infantile Hemangioma;   Infection;   Inflammation;   Inflammatory Conditions;   Intra-abdominal Infections;   Lower Respiratory Tract Infections;   Migraines;   Pain;   Pneumonia;   Schizophrenia;   Sedation;   Seizures;   Skeletal Muscle Spasms;   Skin and Skin-structure Infections;   Treatment-resistant Schizophrenia;   Urinary Tract Infections;   Withdrawal;   Sepsis;   Gram-negative Infection;   Bradycardia;   Cardiac Arrest;   Cardiac Arrhythmia;   Staphylococcal Infections;   Nosocomial Pneumonia;   Neuromuscular Blockade;   Methicillin Resistant Staphylococcus Aureus;   Endocarditis;   Neutropenia;   Headache;   Fibrinolytic Bleeding;   Pulmonary Arterial Hypertension;   CMV Retinitis;   Hypertension;   Chronic Kidney Diseases;   Hyperaldosteronism;   Hypokalemia;   Heart Failure;   Hemophilia;   Heavy Menstrual Bleeding;   Insomnia
Intervention:   Drug: The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
Sponsors:   Daniel Benjamin;   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD);   The Emmes Company, LLC
Completed

Fri, 09 Sep 2011 12:00:00 EDT

Renal Artery Stenting in Patients With Documented Resistant Hypertension and Atherosclerotic Renal Artery Stenosis (ANDORRA)

Conditions:   Hypertension;   Hypertension Resistant to Conventional Therapy;   Angiographically Proven Grade III Unilateral or Bilateral Atherosclerotic Renal Artery Stenosis (ARAS) Greater Than or Equal to 60 Percent
Interventions:   Device: Renal artery Angioplasty plus stenting.;   Drug: Anti hypertensive, statin and antiplatelet medication.
Sponsors:   Assistance Publique - Hôpitaux de Paris;   Ministry of Health, France
Terminated

Thu, 03 Sep 2015 12:00:00 EDT

Liver Transplantation Versus Alternative Therapies for Patients With Pugh B Alcoholic Cirrhosis

Condition:   Cirrhosis
Interventions:   Procedure: liver transplantation;   Other: standard care for liver disease
Sponsor:   Centre Hospitalier Universitaire de Besancon
Completed

Thu, 19 Jun 2008 12:00:00 EDT

Early Specialized Cardiovascular Intervention Based on Impedance Cardiography in Locally Advanced Non-small Cell Lung Cancer Patients

Conditions:   Non-small Cell Lung Cancer;   Cardiovascular Complication
Intervention:   Drug: Multiple cardiovascular drugs related to "Golden Triangle"
Sponsor:   Sun Yat-sen University
Recruiting

Wed, 28 Jul 2021 12:00:00 EDT

Left Cardiac Sympathetic Denervation for Cardiomyopathy Feasibility Pilot Study

Conditions:   Dilated Cardiomyopathy;   Ischemic Cardiomyopathy;   Non-ischemic Cardiomyopathy
Interventions:   Procedure: Left Cardiac Sympathetic Denervation (LCSD);   Other: Optimal Medical Therapy
Sponsors:   University of Cape Town;   Medtronic
Suspended

Tue, 07 Mar 2017 12:00:00 EST

The Effect of Aliskiren and Losartan on Peritoneal Membrane in Continuous Ambulatory Peritoneal Dialysis Patients

Condition:   Peritoneal Membrane Failure
Interventions:   Drug: placebo;   Drug: Aliskiren;   Drug: Aliskiren plus Losartan;   Drug: Enalapril plus Losartan
Sponsor:   Chulalongkorn University
Unknown status

Tue, 01 Mar 2011 12:00:00 EST

Resistant Arterial Hypertension Cohort Study

Conditions:   Hypertension;   Essential Hypertension;   Resistant Hypertension
Interventions:   Drug: chlorthalidone;   Behavioral: motivational intervention for non-compliant individuals;   Drug: standardized anti-hypertensive treatment
Sponsor:   University Hospital, Geneva
Completed

Tue, 09 Mar 2010 12:00:00 EST

Treatment of Advanced Hepatocellular Carcinoma

Condition:   HCC
Interventions:   Other: Basic drugs therapy of HCC;   Drug: Arginine hydrochloride;   Drug: Trimetazidine hydrochloride
Sponsors:   The First Affiliated Hospital of Zhengzhou University;   First Affiliated Hospital of Xinjiang Medical University;   Jiaozuo third people's hospital;   Luoyang Central Hospital;   Nanyang Central Hospital;   Anyang Tumor Hospital;   Pingmei Shenma Medical Group General Hospital;   First People's Hospital of Shangqiu
Unknown status

Mon, 11 Sep 2017 12:00:00 EDT

Treatment of Intermediate-stage Hepatocellular Carcinoma

Condition:   HCC
Interventions:   Device: Basic drugs therapy of HCC by TACE;   Drug: Arginine hydrochloride;   Drug: Trimetazidine hydrochloride
Sponsors:   The First Affiliated Hospital of Zhengzhou University;   First Affiliated Hospital of Xinjiang Medical University;   Luoyang Central Hospital;   Nanyang Central Hospital;   Anyang Tumor Hospital;   Shenma Medical Group General Hospital;   First People's Hospital of Shangqiu;   Jiaozuo third people's hospital
Unknown status

Thu, 07 Sep 2017 12:00:00 EDT

ACEI or ARB and COVID-19 Severity and Mortality in US Veterans

Conditions:   Hypertension;   COVID
Interventions:   Drug: ACEI/ARB;   Drug: Non-ACEI/ARB;   Drug: ACEI;   Drug: ARB
Sponsors:   University of Utah;   VA Salt Lake City Health Care System;   University of Pennsylvania;   Wake Forest University Health Sciences;   University of Florida;   Johns Hopkins Bloomberg School of Public Health;   Boston University;   Northwestern University;   Edith Nourse Rogers Memorial Veterans Hospital;   Columbia University;   MedStar Georgetown University Hospital
Completed

Mon, 13 Jul 2020 12:00:00 EDT

4beta-hydroxycholesterol in Cirrhosis

Condition:   Cirrhosis, Liver
Intervention:   Other: There is no intervention, only research blood samples are collected
Sponsor:   University of Oulu
Recruiting

Mon, 16 Dec 2019 12:00:00 EST

Dapagliflozin on Hypotensive Heart Failure Patients After Sacubitril/Valsartan Therapy

Conditions:   Hypotension;   Heart Failure
Interventions:   Drug: Dapagliflozin;   Drug: Sacubitril-Valsartan;   Drug: Beta blocker;   Drug: Mineralocorticoid Receptor Antagonist;   Device: Cardiac resynchronization therapy and/or implantable cardioverter defibrillator
Sponsor:   Cheng-Hsin General Hospital
Completed

Mon, 05 Oct 2020 12:00:00 EDT

Patiromer for the Management of Hyperkalemia in Subjects Receiving RAASi Medications for the Treatment of Heart Failure (DIAMOND)

Condition:   Hyperkalemia
Interventions:   Drug: Patiromer;   Drug: Placebos
Sponsor:   Vifor Pharma, Inc.
Active, not recruiting

Mon, 25 Mar 2019 12:00:00 EDT