Colchicine is a prescription drug available under the brand name Colcrys or in generic form. Colchicine is the preferred treatment for gouty arthritis and is obtained from the dried seeds of Colchicum autumnale (also known as fall saffron or meadow saffron) .
Indications for the use of colchicine.
The use of C. autumnale alkaloids for the treatment of gout dates back to 1810. The medicinal value of colchicum was reported as early as the 1st century AD Colchicine can be used to treat other conditions besides gout , including:
- Behcet 's disease
- Dermatitis herpetiformis
- Familial Mediterranean fever
- Paget 's disease
Mechanism of action
Although colchicine has powerful anti-inflammatory properties, its efficacy in treating pain other than gout is limited. Colchicine is not considered a pain reliever (pain reliever) and does not affect the high uric acid levels associated with gout .
Colchicine also has a suppressive effect that helps reduce acute attacks of gout, thereby relieving pain and discomfort associated with gout .
Colchicine is only prescribed for people with gout when they have two or more attacks a year. The starting dose is two 0.6 mg colchicine tablets per day; this continues with titration of uric acid lowering therapy with ulorin or allopurinol. Colchicine therapy to lower uric acid is continued until uric acid levels are below 6.0. In acute exacerbations, the intake of koklhin can be increased to three tablets a day for several days; if there is discomfort in the gastrointestinal tract, the daily dose can be reduced to one tablet per day.
The drug should be discontinued if gastrointestinal upset or diarrhea occurs.
Regular consumption of colchicine between attacks is also recommended as prophylactic (prophylactic) therapy.
For people who have less than one gout attack per year, the usual dose is 0.5 or 0.6 mg a day, three or four days a week. For those with more than one seizure per year, the usual dose is 0.5 or 0.6 mg per day. Severe cases may require two or three 0.5 or 0.6 mg tablets per day .
Although colchicine is indicated for adults with acute gout attacks, it can be used prophylactically in adolescents 16 years of age and older. Its only approved use in children is in the treatment of familial Mediterranean fever (FMF).
Side reactions can occur with colchicine and it is important that you are aware of this potential. People receiving long-term therapy may experience bone marrow suppression , aplastic anemia, agranulocytosis, or thrombocytopenia .
Other possible side reactions include:
- Peripheral neuritis
- Hair loss
- Reversible azoospermia (total absence of sperm )
Vomiting, diarrhea, and nausea are side effects that can occur with colchicine therapy, especially when the maximum dose is given. To reduce side effects, colchicine can be taken with food .
Considerations and contraindications for taking colchicine.
Pregnant women should weigh the risks and benefits of using colchicine. Colchicine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Colchicine can stop cell division, so taking the drug during pregnancy can pose significant risk. Care should also be taken when administering colchicine to a nursing woman .
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Colchicine should also not be used by people known to be hypersensitive to this drug or those with severe gastrointestinal, kidney, liver, or heart conditions. Also, colchicine should not be used by people with blood disorders .