Tocopheryl Acetate: Benefits, Side Effects, Dosage and


Tocopheryl acetate is a special type of vitamin E that belongs to a class of organic chemicals known as tocopherols. These compounds are considered fat-soluble antioxidants, but they are also said to perform many other functions in the body. Tocopheryl acetate is "natural tocopherol and one of the most potent antioxidant tocopherols," according to PubChem of the US National Library of Medicine . The antioxidants in vitamin E are known to protect cells from damage naturally caused by free radicals . These free radicals are produced in the body during normal processes (such as energy production). Other free radicals come from a variety of sources, including X-rays, air pollution, smoking, and industrial chemicals. So, vitamin E (tocopheryl acetate) acts as an antioxidant, protects cells and DNA, and promotes your health. Because vitamin E is fat soluble, this means it can stop the production of free radicals, which are created when the body breaks down fat for energy.

Please note: there are eight different types of natural vitamin E; Alpha-tocopherol is the most abundant type in human tissues. It is the only variant of vitamin E used to treat vitamin E deficiency.

Tocopheryl Acetate is commonly used to make nutritional supplements and skin care products.

Tocopheryl Acetate (Alpha Tocopheryl Acetate) is also known as:

  • Alpha Tocopheryl Acetate (ATA)
  • Vitamin E Acetate
  • Tocopherol Acetate
  • A-tocopherol
  • Alpha-tocopherol
  • D-alpha tocopherol

What is tocopheryl acetate used for?

Tocopheryl Acetate is claimed to have many potential benefits, including:

  • Treatment of vitamin E deficiency
  • Provide healthy skin (how to hydrate and prevent wrinkles)
  • Helps in the healing of wounds.
  • Reduce inflammation
  • Slowing the progression of age-related macular degeneration (AMD )
  • Cancer prevention and treatment symptoms (such as radiation therapy side effects)
  • Treatment of heart disease
  • Improve cognitive abilities like Alzheimer's.

But what does the research say?

Many studies on tocopheryl acetate and skin health involve so-called in vitro studies. This means that the research was carried out in cell cultures outside the body. But, according to the Oregon State University Micronutrient Information Center , 'These models do not recreate the complex structure of skin tissues. Therefore, in vivo research [carried out within a living organism] is needed. "

While there are some promising research results regarding the benefits of tocopheryl acetate, much of the research on the success of tocopheryl acetate supplements is mixed. For example, data on the efficacy of vitamin E in treating heart disease, cancer, and cognitive problems (such as Alzheimer's) are conflicting .

Wound healing

Human studies on the effects of tocopheryl acetate on wound healing have shown no beneficial effects. Research has not shown that topical vitamin E contributes to scar formation, and one study found that it actually worsened the appearance of scars in some people and caused contact dermatitis by 30 percent.

Reduce wrinkles

A study that examined the diet of Japanese women found that there was no link between vitamin E intake and the appearance of wrinkles on the skin. Research data confirming that vitamin E and tocopherol oils and their hydrating properties are limited. Cross-sectional studies (studies involving a specific population to assess data such as age, ethnicity, geographic location, and social origin) found that there was no association between skin hydration and vitamin E intake in men or women

However, there have been two small studies that show a possible link between the skin's ability to retain moisture and topical vitamin E (applied directly to the skin). 'Long-term studies of topical vitamin E are needed to establish whether this hydrating effect can persist. – explains the University of Oregon .

Skin cancer

There have been many human studies that have concluded that the use of tocopheryl acetate is useless in treating skin cancer .

Clinical research results are conflicting when it comes to the use of tocopheryl acetate in treating the side effects of chemotherapy and radiation therapy .
These therapies are believed to work by creating free radicals that kill cancer cells, so it stands to reason that a very powerful antioxidant like tocopheryl acetate could reverse the harmful side effects of these cancer treatments.

According to Memorial Slone Kettering Cancer Center , 'What protects healthy cells may also protect cancer cells. This problem is not entirely clear yet, and patients who are interested in taking any antioxidant in excess of the recommended daily allowance should consult their physician. "


Many studies have examined the ability of vitamin E to prevent cancer. But several very large human studies of tocopheryl acetate have found no preventive effect on cancer .

Reduce inflammation

A randomized controlled trial in humans has confirmed the successful treatment of an inflammatory skin condition called atopic dermatitis (eczema) with vitamin D and vitamin E.

Slowdown in AMD development

The 2017 scoping study looked at the initial results of a very large study (involving approximately 4,000 participants) called the Age-Related Eye Diseases Study (ARED). The ARED study found that participants with age-related late macular degeneration who took supplements in combination with very high doses of vitamin E, vitamin C, and beta-carotene and zinc delayed the progression of AMD.

Antioxidant effects

According to the Oregon State University Micronutrient Information Clearinghouse , "Although topical application of vitamin E is not well understood, it can reduce free radical damage associated with environmental pollution." However, vitamin E can cause contact dermatitis in some people.

Possible side effects.

Although tocopheryl acetate is considered relatively safe, there are some potential risks, especially if the recommended dose is exceeded: the recommended dose is 15 milligrams (mg) or 22.4 internal units (IU). In fact, taking too much vitamin E can lead to poisoning .

Because vitamin E is fat soluble, the body cannot eliminate the excess in the urine. Some studies have shown an increase in death rates among people who take high doses of vitamin E, especially in people with multiple medical problems. Other possible side effects include breast tenderness, gonadal dysfunction, abdominal pain, high blood pressure, or diarrhea.

According to the Memorial Slone Kettering Cancer Center, symptoms of vitamin E toxicity from long-term intake of more than 400 to 800 IU per day can include:

  • Dizziness
  • Soft spot
  • Headache
  • Blurry vision
  • Rash
  • Thrombophlebitis (inflammation of a vein due to a blood clot)

Vitamin E supplements can also increase your risk of stroke. The reason that tocopheryl acetate can increase the risk of stroke is due to its side effects that prevent the blood from clotting.

A 2011 study found that men who took very high doses of vitamin E supplements had an increased risk of prostate cancer .

If a person is taking a high dose of vitamin E, it can increase the risk of bleeding. It is important to check with your doctor before taking vitamin E supplements, especially for those taking blood thinners like Coumadin (warfarin).

Tocopheryl acetate skin care products can cause local skin reactions. Symptoms of an allergic skin reaction include redness or a rash in the area where the cream or ointment was applied.


A contraindication is a situation where a particular drug, treatment, or procedure should not be used because it could be harmful. Often times, the two drugs or supplements should not be taken together and / or the drug / supplement should not be used when a person has a certain condition as it could make it worse.

Contraindications to taking tocopheryl acetate include:

  • Coumadin (warfarin) or other blood thinners such as aspirin or heparin: Do not take high doses of vitamin E (more than 400 IU per day) with these medications, as this can increase the risk of bleeding .
  • Heart disease: A study that looked at the effects of vitamin E in combination with other supplements (such as selenium, beta-carotene, and vitamin C) showed that this combined supplement reduced the beneficial effects of other inhuman cardiovascular drugs (such as statins and niacin). Reduce blood cholesterol levels.
  • Chemotherapy or radiation therapy: Taking antioxidants during chemotherapy or radiation therapy can affect the benefits of these cancer treatments .

If you are taking any prescription or over-the-counter medications, natural or dietary supplements, or have a medical condition, it is very important to discuss the use of tocopheryl acetate with your healthcare professional.

Dosage and preparation


Tocopheryl acetate is available as an oral supplement or topical solution. It can be found in a variety of commercial formulations including capsules, lotions, skin moisturizers and oils, anti-aging products, and more. Most commercial vitamin E preparations are available in doses that are sold in international units (IU), but you can also view milligram (mg) lists .


The daily amount of vitamin E depends on the person's age and other factors, such as the condition being treated. The National Institutes of Health lists the average recommended daily values.

Recommended daily allowance

From birth to 6 months: 4 mg (6 IU)
Infants 7 to 12 months: 5 mg (7.5 IU)
Children 1 to 3 years: 6 mg (9 IU)
Children 4-8 years: 7 mg (10.4 IU)
Children 9 to 13 years: 11 mg (16.4 IU)
Adolescents 14-18: 15 mg (22.4 IU)
Adults: 15 mg (22.4 IU)
Adolescents and pregnant women: 15 mg (22.4 IU)
Adolescents and women who breastfeed: 19 mg (28.4 IU)

Note: Toxicity can occur with long-term vitamin E supplementation in doses greater than 800 IU and a daily intake of more than 400 IU .

Long-term daily intake of vitamin E greater than 400 IU can increase the risk of death from all causes ( the death rate from all causes in a population over a period of time).

What to look for

Although vitamin E supplements are regulated by the Food and Drug Administration (FDA), vitamins are considered dietary supplements. Consequently, they are not as strictly regulated as prescription or over-the-counter drugs. Supplements like vitamin E can be mislabeled or even contaminated; vitamin supplements cannot be tested for safety or effectiveness.

A recent survey of several commercial brands of vitamin E found that the actual content varied significantly from the dose on the label, from 41% less to 57% more, ”said Memorial Slone Kettering Cancer Center.

It is strongly recommended that you purchase a product that is organic and has been evaluated / certified by an outside agency such as USP, NSF International, or They are institutions that specialize in informing about the safety, purity and efficacy of a product.

Other questions

What Foods Contain Vitamin E?
Food sources high in vitamin E include vegetable oils such as wheat germ oils, sunflower oils, safflower oil, and, to a lesser extent, corn and soybean oils. Other foods rich in vitamin E include:

  • Wheat germ
  • Eggs
  • Broccoli and green leafy vegetables like spinach (contain some vitamin E)
  • Whole grain
  • Walnuts
  • Fortified breakfast cereals (and other foods fortified with vitamin E, check labels to be sure)

Is it possible to overdose on vitamin E from food sources?

An overdose of vitamin E from food sources is highly unlikely, but it can occur, especially in those taking tocopheryl acetate supplements. Very high doses of supplements (especially with long-term use), including tocopheryl acetate, are not recommended.

How do I know if I have a vitamin E deficiency?

It is rare for people in good health to be deficient in vitamin E.
This is usually due to certain conditions in which fats are not digested properly (for example, cystic fibrosis or Crohn 's disease). This is due to the fact that vitamin E needs fat for its proper absorption.

What are the symptoms of vitamin E deficiency?

Symptoms of vitamin E deficiency can include:

  • Loss of sensation in the extremities (arms and legs).
  • Muscular weakness
  • Loss of body control
  • Eye sight problems
  • Nerve damage
  • Muscle damage
  • Weakened immune system

Get Meds Info Word

While clinical research data is insufficient to support the many health (and safety) claims for tocopheryl acetate, this does not mean that vitamin E supplements, topical creams, and lotions are not beneficial. It simply indicates that more research is needed to conclusively demonstrate the safety and efficacy of these products. That is why it is vital to consult a professional physician before taking vitamin E (or any other natural or herbal supplement).

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