Clinical Trials

Atralin Gel for the Treatment of Rosacea

Condition:   Rosacea
Interventions:   Drug: vehicle gel;   Drug: Atralin gel
Sponsors:   Lisa E. Maier;   Bausch Health Americas, Inc.
Terminated

Wed, 19 May 2010 12:00:00 EDT

Pembrolizumab and All-Trans Retinoic Acid Combination Treatment of Advanced Melanoma

Conditions:   Stage IV Melanoma;   Stage III Melanoma;   Advanced Melanoma
Intervention:   Drug: Pembrolizumab with All-Trans Retinoic Acid
Sponsors:   University of Colorado, Denver;   Merck Sharp & Dohme Corp.
Active, not recruiting

Tue, 27 Jun 2017 12:00:00 EDT

Safety and Tolerability of Acanya Gel in Combination With Atralin Gel for Acne Vulgaris

Condition:   Acne Vulgaris
Intervention:   Drug: Benzoyl peroxide 2.5%/clindamycin phosphate 1.2% in the morning with with tretinoin 0.05% gel in the evening
Sponsor:   Zeichner, Joshua, M.D.
Unknown status

Fri, 07 Oct 2011 12:00:00 EDT

A Trial of All-trans Retinoic Acid (ATRA) in Advanced Adenoid Cystic Carcinoma

Condition:   Adenoid Cystic Carcinoma
Intervention:   Drug: Tretinoin
Sponsors:   Dana-Farber Cancer Institute;   The V Foundation;   ACCRF
Completed

Thu, 27 Jun 2019 12:00:00 EDT

Effectivity of 1 Finger Tip Unit Compared to 2 Finger Tip Units 0.05% Tretinoin Cream

Condition:   Photoaging
Intervention:   Drug: 0.05% Tretinoin
Sponsor:   Dr.dr.Irma Bernadette, SpKK (K)
Not yet recruiting

Fri, 13 Aug 2021 12:00:00 EDT

A Study Comparing Tretinoin Cream 0.025% and RETIN-A® Cream 0.025% in the Treatment of Acne Vulgaris

Condition:   Acne Vulgaris
Intervention:   Drug: Tretinoin Cream 0.025%
Sponsor:   Taro Pharmaceuticals USA
Completed

Tue, 26 Jan 2021 12:00:00 EST

Clinical Evaluation of the Photoallergy Potential of Atralin Gel

Condition:   Healthy
Intervention:   Drug: Atralin (tretinoin) gel, 0.05%
Sponsor:   Coria Laboratories, Ltd.
Completed

Tue, 29 Jan 2008 12:00:00 EST

Ipilimumab and All-Trans Retinoic Acid Combination Treatment of Advanced Melanoma

Condition:   Melanoma
Interventions:   Drug: VESANOID;   Drug: Ipilimumab
Sponsor:   University of Colorado, Denver
Active, not recruiting

Tue, 31 Mar 2015 12:00:00 EDT

90Y DOTA/Retinoic Acid for Neuroblastoma and Neuroendocrine Tumor (NET)

Conditions:   Neuroblastoma;   Neuroendocrine Tumor
Interventions:   Drug: Retinoic Acid;   Drug: Placebo
Sponsors:   University of Iowa;   Molecular Insight Pharmaceuticals, Inc.
Withdrawn

Wed, 13 Jan 2010 12:00:00 EST

A Study That Evaluates the Decrease in Irritation When Using Additional Acne Treatment Products

Condition:   Acne Vulgaris
Interventions:   Drug: Dapsone plus Tretinoin Gel;   Drug: Tretinoin Gel
Sponsor:   Bausch Health Americas, Inc.
Completed

Mon, 14 Mar 2011 12:00:00 EDT

Altreno for Chest Rejuvenation

Conditions:   Photodamaged Skin;   Photoaging
Interventions:   Drug: tretinoin 0.05% lotion (Altreno);   Other: Vehicle
Sponsors:   Goldman, Butterwick, Fitzpatrick and Groff;   Bausch Health Americas, Inc.
Active, not recruiting

Fri, 20 Sep 2019 12:00:00 EDT

To Evaluate the Therapeutic Equivalence and Safety of TRETINOIN CREAM, 0.1% and RLD in the Treatment of Acne Vulgaris

Condition:   Acne Vulgaris
Interventions:   Drug: Tretinoin cream 0.1%;   Drug: RETIN-A® Cream;   Drug: Vehicle of the test product
Sponsor:   Taro Pharmaceuticals USA
Completed

Fri, 09 Feb 2018 12:00:00 EST

Prevention of Drug Rash From Certain Cancer Therapies Using Tretinoin Cream

Condition:   Medication Reaction
Intervention:   Drug: Tretinoin
Sponsor:   Johns Hopkins University
Withdrawn

Fri, 06 May 2011 12:00:00 EDT

Study to Determine the Phototoxity of Atralin (Tretinoin) Gel, 0.05%

Condition:   Healthy
Intervention:   Drug: Atralin (tretinoin) Gel, 0.05%
Sponsor:   Coria Laboratories, Ltd.
Completed

Tue, 29 Jan 2008 12:00:00 EST

To Evaluate the Therapeutic Equivalence and Safety of TRETINOIN CREAM, 0.05% and RLD in the Treatment of Acne Vulgaris

Condition:   Acne Vulgaris
Interventions:   Drug: Tretinoin cream, 0.05%;   Drug: RETIN-A® (tretinoin) cream, 0.05%;   Drug: Vehicle of the test product
Sponsor:   Taro Pharmaceuticals USA
Completed

Wed, 14 Feb 2018 12:00:00 EST

A Comparative Study of Adapalene Gel,0.3% Versus Tretinoin Emollient Cream, 0.05% for the Treatment of Photoaging

Conditions:   Photoaging;   Photodamage
Interventions:   Drug: Adapalene;   Drug: Tretinoin
Sponsor:   Galderma Brasil Ltda.
Completed

Fri, 29 Jul 2011 12:00:00 EDT

Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and Wrinkles

Conditions:   Photodamaged Skin;   Wrinkles
Interventions:   Drug: Retinol;   Drug: Tretinoin
Sponsor:   Johns Hopkins University
Completed

Wed, 26 Jan 2011 12:00:00 EST

Randomized,International Multi-center Clinical Trial of RIF Plus RA for Non-high-risk APL

Condition:   Acute Promyelocytic Leukaemia
Intervention:   Drug: Compound Realgar-Indigo Naturalis Formula Plus Retinoic Acid
Sponsors:   Peking University People's Hospital;   Ministry of Science and Technology of the People´s Republic of China
Not yet recruiting

Mon, 25 Nov 2019 12:00:00 EST

Cabozantinib in Combination With 13-cis-Retinoic Acid in Children With Relapsed or Refractory Solid Tumors

Condition:   Solid Tumor
Interventions:   Drug: Cabozantinib;   Drug: 13-cis-retinoic acid
Sponsors:   Peter Zage;   Exelixis
Recruiting

Thu, 02 Aug 2018 12:00:00 EDT

PHNA, Efficacy of Tretinoin Cream on Post-phototherapy Hyperpigmentation

Condition:   Vitiligo
Interventions:   Drug: Tretinoin 0.05% cream;   Drug: Placebo cream
Sponsor:   The Catholic University of Korea
Completed

Wed, 01 May 2019 12:00:00 EDT

Combination Therapy With Ursodeoxycholic Acid (UDCA) and All-Trans Retinoic Acid (ATRA) for Treatment of Primary Sclerosing Cholangitis

Condition:   Cholangitis, Sclerosing
Intervention:   Drug: Oral all-trans retinoic acid (ATRA)
Sponsors:   Yale University;   Mayo Clinic
Completed

Thu, 20 Oct 2011 12:00:00 EDT

Trial Comparing Treatment of Tretinoin or Superficial Dermabrasion for Stretch Marks

Conditions:   Stretch Marks;   Striae;   Treatment
Interventions:   Drug: Tretinoin cream 0.005%;   Device: Superficial Dermabrasion
Sponsor:   Brazilan Center for Studies in Dermatology
Completed

Wed, 09 Dec 2009 12:00:00 EST

Dapsone Gel 5% and Tretinoin Gel 0.025% Versus Tretinoin Gel 0.025% Monotherapy for Facial Acne Vulgaris

Condition:   Acne Vulgaris
Interventions:   Drug: Dapsone; Tretinoin;   Drug: Tretinoin
Sponsor:   Allergan
Completed

Tue, 03 Feb 2009 12:00:00 EST

Investigating the Potential Role of Aerosolized All-trans Retinoic Acid for Treating COVID-19 Anosmia and Regaining Sense of Smell.

Condition:   Post COVID-19 Anosmia (Loss of Smell)
Interventions:   Drug: Aerosolized All trans retinoic acid;   Drug: Placebo/Control
Sponsors:   Amr kamel khalil Ahmed;   Faculty of Medicine, Kafrelshiekh Univversity,Egypt.
Not yet recruiting

Thu, 12 Aug 2021 12:00:00 EDT

RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia

Condition:   Male Infertility, Azoospermia
Intervention:   Drug: 13-cis retinoic acid
Sponsor:   University of Washington
Completed

Fri, 27 Oct 2017 12:00:00 EDT

Combined Tretinoin and Arsenic Trioxide for Patients With Newly Diagnosed Acute Promyelocytic Leukemia Followed by Risk-Adapted Postremission Therapy

Condition:   Acute Promyelocytic Leukemia
Intervention:   Drug: Tretinoin and Arsenic Trioxide
Sponsors:   Memorial Sloan Kettering Cancer Center;   Northwestern University;   New York Presbyterian Hospital;   University of Southern California;   Princess Margaret Hospital, Canada;   National Heart, Lung, and Blood Institute (NHLBI)
Completed

Thu, 28 Jul 2011 12:00:00 EDT

Study Comparing Acne in Patients Taking Oral Minocycline to Patients Taking Minocycline Plus Topical Tretinoin

Condition:   Acne Vulgaris
Interventions:   Drug: Minocycline;   Drug: Minocycline plus tretinoin
Sponsors:   Derm Research @ 888 Inc.;   Stiefel, a GSK Company
Terminated

Tue, 18 Oct 2005 12:00:00 EDT

A Study to Determine the Safety and Efficacy of Atralin (Tretinoin 0.05%) Gel for the Treatment of Rosacea

Condition:   Rosacea
Interventions:   Drug: tretinoin gel 0.05%;   Drug: vehicle
Sponsor:   Coria Laboratories, Ltd.
Completed

Fri, 22 Feb 2008 12:00:00 EST

ZD6474 Alone and in Combination With Retinoic Acid in Pediatric Neuroblastoma

Condition:   Neuroblastoma
Interventions:   Drug: ZD6474;   Drug: Retinoic Acid
Sponsors:   M.D. Anderson Cancer Center;   AstraZeneca
Terminated

Fri, 21 Sep 2007 12:00:00 EDT

Adapalene Gel 0.3% Versus Tretinoin 0.05% Emollient Cream for Treatment of Photodamage

Condition:   Photoaging
Interventions:   Drug: adapalene gel, 0.3%;   Drug: tretinoin 0.05% emollient cream
Sponsor:   Galderma Laboratories, L.P.
Completed

Mon, 31 Mar 2008 12:00:00 EDT

Opsin Receptors in Melasma

Condition:   Melasma
Intervention:   Drug: Retinoic acid
Sponsors:   Universidad Autonoma de San Luis Potosí;   Hospital Central "Dr. Ignacio Morones Prieto"
Completed

Thu, 04 Jun 2020 12:00:00 EDT

3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of First Remission After Non-Myeloablative Therapy in Patients With High-Risk Neuroblastoma

Condition:   Neuroblastoma
Intervention:   Drug: 3F8 and 13-cis-retinoic acid
Sponsor:   Memorial Sloan Kettering Cancer Center
Completed

Tue, 17 Aug 2010 12:00:00 EDT

Phase I/II Trial of ATRA and TCP in Patients With Relapsed or Refractory AML and no Intensive Treatment is Possible

Condition:   AML
Interventions:   Drug: Tranylcypromine;   Drug: Tretinoin
Sponsor:   Martin-Luther-Universität Halle-Wittenberg
Unknown status

Fri, 10 Oct 2014 12:00:00 EDT

3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of Second or Greater Remission of High-Risk Neuroblastoma

Condition:   Neuroblastoma
Intervention:   Biological: 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid
Sponsor:   Memorial Sloan Kettering Cancer Center
Terminated

Wed, 18 Aug 2010 12:00:00 EDT

Bioequivalence Study of Tretinoin Gel 0.05% to Brand Tretinoin Gel

Condition:   Acne
Intervention:   Drug: Tretinoin
Sponsor:   Spear Pharmaceuticals
Completed

Fri, 26 Sep 2014 12:00:00 EDT

Split-face Tolerability Comparison Between Adapalene-Benzoyl Peroxide Gel Versus Tretinoin Gel

Condition:   Acne Vulgaris
Interventions:   Drug: Epiduo Gel;   Drug: Retin-A Micro Microsphere 0.1%
Sponsor:   Galderma Laboratories, L.P.
Completed

Tue, 31 Jan 2012 12:00:00 EST

Lithium Carbonate and Tretinoin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Conditions:   Adult Acute Megakaryoblastic Leukemia (M7);   Adult Acute Monoblastic Leukemia (M5a);   Adult Acute Monocytic Leukemia (M5b);   Adult Acute Myeloblastic Leukemia With Maturation (M2);   Adult Acute Myeloblastic Leukemia Without Maturation (M1);   Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities;   Adult Acute Myeloid Leukemia With Del(5q);   Adult Acute Myeloid Leukemia With Inv(16)(p13;q22);   Adult Acute Myeloid Leukemia With t(16;16)(p13;q22);   Adult Acute Myeloid Leukemia With t(8;21)(q22;q22);   Adult Acute Myelomonocytic Leukemia (M4);   Adult Erythroleukemia (M6a);   Adult Pure Erythroid Leukemia (M6b);   Recurrent Adult Acute Myeloid Leukemia
Interventions:   Drug: tretinoin;   Drug: lithium carbonate;   Other: laboratory biomarker analysis
Sponsors:   Paolo Caimi, MD;   National Cancer Institute (NCI)
Completed

Fri, 29 Mar 2013 12:00:00 EDT

An Efficacy Trial of Low Dose All-trans Retinoic Acid in Patients With Primary Sclerosing Cholangitis

Condition:   Cholangitis, Sclerosing
Intervention:   Drug: All-trans retinoic acid
Sponsor:   Yale University
Terminated

Sat, 02 Dec 2017 12:00:00 EST

Assessing the Effects of Tretinoin Cream on Human Skin With Optical Imaging Technologies

Condition:   Collagen Fibril Alteration
Intervention:   Drug: Tretinoin cream 0.1%
Sponsors:   University of California, Irvine;   Unilever R&D;   Beckman Laser Institute University of California Irvine
Completed

Wed, 08 Apr 2015 12:00:00 EDT

Combination of Chemopreventive Agents (All- Trans Retinoic Acid and Tamoxifen) as Potential Treatment for the Lung Complication of COVID-19

Condition:   the Lung Complication of COVID-19
Interventions:   Combination Product: Aerosolized All-Trans Retinoic acid plus oral Tamoxifen;   Other: Standard treatment
Sponsor:   Kafrelsheikh University
Not yet recruiting

Tue, 29 Sep 2020 12:00:00 EDT

Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative Treatment

Condition:   COVID-19
Interventions:   Drug: Aerosolized 13 cis retinoic acid;   Drug: Aerosolized All trans retinoic acid;   Other: Placebo
Sponsors:   Kafrelsheikh University;   Damietta University
Not yet recruiting

Wed, 20 May 2020 12:00:00 EDT

Revlimid / All-Trans Retinoic Acid (ATRA) / Dexamethasone in Relapsed/Refractory Multiple Myeloma

Condition:   Myeloma
Interventions:   Drug: Lenalidomide;   Drug: Dexamethasone;   Drug: All-Trans Retinoic Acid (ATRA)
Sponsors:   M.D. Anderson Cancer Center;   Celgene Corporation
Terminated

Fri, 15 Nov 2013 12:00:00 EST

All-Trans Retinoic Acid (ATRA) and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung Cancer

Conditions:   Metastatic Lung Non-Small Cell Carcinoma;   Recurrent Lung Non-Small Cell Carcinoma;   Stage IV Lung Cancer AJCC v8;   Stage IVA Lung Cancer AJCC v8;   Stage IVB Lung Cancer AJCC v8
Interventions:   Biological: Atezolizumab;   Drug: Tretinoin
Sponsor:   Dwight Owen
Not yet recruiting

Wed, 09 Jun 2021 12:00:00 EDT

Bioequivalence Study of Generic Tretinoin 0.1% Microsphere Gel, 0.1% Retin-A Micro® and Placebo

Condition:   Acne
Interventions:   Drug: Tretinoin microsphere 0.1%;   Drug: Brand Retin-A Micro tretinoin microsphere gel 0.1%;   Drug: placebo microsphere gel
Sponsor:   Spear Pharmaceuticals
Completed

Wed, 02 Jun 2010 12:00:00 EDT

Evaluation of Irritation That Potentially Could be Caused by Two Facial Gels Applied to Opposite Sides of the Face

Condition:   Acne Vulgaris
Interventions:   Drug: Tretinoin Facial Gel;   Drug: Adapalene/Benzoyl Peroxide Facial Gel
Sponsor:   Bausch Health Americas, Inc.
Completed

Thu, 06 Aug 2009 12:00:00 EDT

Retinoic Acid Supplementation and Subjects With Hypercholesterolemia

Condition:   Hypercholesterolemia
Interventions:   Dietary Supplement: retinoic acid;   Other: placebo
Sponsor:   Sun Yat-sen University
Completed

Wed, 15 Jul 2015 12:00:00 EDT

High-Dose 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of First Remission After Myeloablative Therapy and Autologous Stem-Cell Transplantation

Condition:   Neuroblastoma
Intervention:   Drug: 3F8 monoclonal antibody and 13-cis-Retinoic Acid
Sponsor:   Memorial Sloan Kettering Cancer Center
Completed

Tue, 17 Aug 2010 12:00:00 EDT

Single Dose of 9-cis-retinoic Acid in Hepatic Patients

Condition:   Hepatic Insufficiency
Intervention:   Drug: 9-cis-retinoic acid
Sponsor:   University Hospital, Gentofte, Copenhagen
Completed

Wed, 03 Jul 2013 12:00:00 EDT

Proof of Concept Study to Investigate the Recurrence of Acne Post Isotretinoin

Condition:   Acne
Interventions:   Drug: tretinoin microsphere 0.04% gel;   Drug: vehicle gel
Sponsors:   Dermatrials Research;   Johnson & Johnson
Completed

Tue, 14 Jul 2009 12:00:00 EDT

Efficacy of Aerosol Combination Therapy of 13 Cis Retinoic Acid and Captopril for Treating Covid-19 Patients Via Indirect Inhibition of Transmembrane Protease, Serine 2 (TMPRSS2)

Condition:   Covid19
Interventions:   Combination Product: Aerosolized 13 cis retinoic acid plus Inhalation administration by nebulization captopril 25mg;   Drug: Drug: Standard treatment Standard treatment
Sponsor:   Kafrelsheikh University
Not yet recruiting

Thu, 08 Oct 2020 12:00:00 EDT

A Study Comparing Combination Clindamycin Phosphate/Tretinoin Gel Alone Versus With Benzoyl Peroxide Foaming Cloths for Facial Acne

Condition:   Acne Vulgaris
Interventions:   Drug: clindamycin phosphate 1.2%/tretinoin 0.025% gel alone;   Drug: clindamycin phosphate 1.2%/tretinoin 0.025% gel plus benzoyl peroxide 6% foaming cloths
Sponsor:   Zeichner, Joshua, M.D.
Unknown status

Wed, 24 Aug 2011 12:00:00 EDT

Retinoids in ANCA Small Vessel Vasculitis: Silencing Autoantigens

Condition:   Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Interventions:   Drug: Retinoic acid;   Drug: Standard of care
Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Withdrawn

Wed, 12 Jan 2011 12:00:00 EST

Oral Isotretinoin Versus Topical Tretinoin for Actinic Keratosis

Condition:   Actinic Keratosis
Interventions:   Drug: Oral isotretinoin;   Drug: Tretinoin 0,05% cream;   Drug: Sunscreen FPS 60
Sponsors:   Universidade Federal de Goias;   Conselho Nacional de Desenvolvimento Científico e Tecnológico;   Theraskin;   Germed Pharma
Completed

Thu, 30 Oct 2014 12:00:00 EDT

A Study of Different Use Regimens Using Two Acne Treatments

Condition:   Acne Vulgaris
Interventions:   Drug: benzoyl peroxide wash;   Drug: Tretinoin gel
Sponsor:   Bausch Health Americas, Inc.
Completed

Fri, 22 May 2009 12:00:00 EDT

Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized)

Condition:   COVID19
Interventions:   Drug: Drug Isotretinoin (13 cis retinoic acid ) capsules+standard treatment;   Drug: Isotretinoin(Aerosolized 13 cis retinoic acid) +standard treatment;   Drug: Isotretinoin (13 cis retinoic acid ) capsules;   Drug: Aerosolized 13 cis retinoic acid;   Drug: Standard treatment
Sponsors:   Kafrelsheikh University;   1-Foshan University Laboratory of Emerging Infectious Disease Institute of Translational Medicine The First Hospital of Jilin University China;   2-Montefiore Health System and Albert Einstein College of Medicine, Newyork, United States of America (U.S.A).;   2-Faculty of Science, Kafrelsheikh University, Egypt.
Not yet recruiting

Mon, 20 Apr 2020 12:00:00 EDT

W0265-104: A Single-Center, Evaluator-Blinded, Randomized, Placebo-Controlled, Phase 1 Clinical Trial Evaluating the Photoallergic Potential of Topically Applied Clindamycin Phosphate 1.0% and Tretinoin 0.025% (CT Gel) in Healthy Volunteers

Condition:   Acne Vulgaris
Interventions:   Drug: clindamycin1%/tretinoin 0.025% gel;   Drug: vehicle gel
Sponsor:   GlaxoSmithKline
Completed

Mon, 05 Aug 2013 12:00:00 EDT

Evaluation of Irritation That Could be Caused by Two Facial Gels Applied to Opposite Sides of the Face.

Condition:   Acne Vulgaris
Interventions:   Drug: Adapalene Gel;   Drug: Tretinoin Gel
Sponsor:   Bausch Health Americas, Inc.
Completed

Mon, 14 Jul 2008 12:00:00 EDT

Liposomal Tretinoin in Treating Patients With Recurrent or Refractory Hodgkin's Disease

Condition:   Lymphoma
Interventions:   Drug: Chemotherapy;   Drug: Tretinoin Liposome
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Withdrawn

Wed, 28 Apr 2004 12:00:00 EDT

Efficiency And Safety Of Association Arbutin, Triamcinolone And Tretinoin In Treatment Of Melasma

Condition:   Melasma
Interventions:   Drug: arbutin, tretinoin, triamcinolone;   Drug: Triluma
Sponsor:   Azidus Brasil
Suspended

Thu, 17 Jul 2008 12:00:00 EDT

A Study Comparing Tretinoin Gel Microsphere, 0.1% and RETIN-A MICRO ® Gel Microsphere, 0.1% in the Treatment of Acne Vulgaris

Condition:   Acne Vulgaris
Interventions:   Drug: Tretinoin Gel Microsphere, 0.1%;   Drug: RETIN-A MICRO® (Tretinoin) Gel Microsphere, 0.1%;   Drug: Placebo Control
Sponsor:   Taro Pharmaceuticals USA
Completed

Wed, 12 May 2021 12:00:00 EDT

Determine the Efficacy of Topical Tretinoin Cream for the Prevention of Nonmelanoma Skin Cancer

Conditions:   Carcinoma, Basal Cell;   Carcinoma, Squamous Cell;   Skin Neoplasms
Interventions:   Drug: Tretinoin 0.1% cream or placebo;   Other: Placebo
Sponsors:   US Department of Veterans Affairs;   Ortho Dermatologics
Completed

Mon, 01 Jan 2001 12:00:00 EST

RA-2 13-cis Retinoic Acid (Isotretinoin)

Conditions:   Male Infertility;   Klinefelter's Syndrome;   Y-chromosome Microdeletions
Interventions:   Drug: 13-cis retinoic acid;   Drug: Calcitriol
Sponsor:   University of Washington
Completed

Wed, 12 Feb 2014 12:00:00 EST

IMG-7289, With and Without ATRA, in Patients With Advanced Myeloid Malignancies

Conditions:   Acute Myeloid Leukemia;   Myelodysplastic Syndrome
Interventions:   Drug: IMG-7289;   Drug: All-trans retinoic acid
Sponsor:   Imago BioSciences,Inc.
Completed

Mon, 25 Jul 2016 12:00:00 EDT

Bioequivalence Study of Generic Tretinoin 0.04% Microsphere Gel, 0.04% Retin-A Micro® and Placebo

Condition:   Acne
Interventions:   Drug: Tretinoin;   Drug: placebo
Sponsor:   Spear Pharmaceuticals
Completed

Thu, 18 Nov 2010 12:00:00 EST

Safety and Efficacy Study of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel to Treat Rosacea

Condition:   Rosacea
Interventions:   Drug: Clindamycin Phosphate 1.2% And Tretinoin 0.025% Gel;   Drug: Placebo gel
Sponsors:   Massachusetts General Hospital;   Medicis Pharmaceutical Corporation
Completed

Fri, 16 Jan 2009 12:00:00 EST

Tretinoin in Treating Patients With Mycosis Fungoides or Sezary Syndrome

Condition:   Lymphoma
Intervention:   Drug: tretinoin
Sponsors:   Northwestern University;   National Cancer Institute (NCI)
Completed

Mon, 23 Aug 2004 12:00:00 EDT

Study of Dasatinib and All-Trans Retinoic Acid for Relapsed/Refractory and/or Elderly Patients With Acute Myelogenous Leukemia (AML) or Myelodysplastic Syndrome

Conditions:   Acute Myelogenous Leukemia;   Myelodysplastic Syndrome
Interventions:   Drug: dasatinib (SPRYCEL);   Drug: all trans retinoic acid (VESANOID)
Sponsor:   University of Pittsburgh
Completed

Mon, 04 May 2009 12:00:00 EDT

Profiling the Skin Microbiome in Response to Altreno in Acne Patients

Conditions:   Acne;   Healthy
Interventions:   Drug: Altreno;   Drug: Benzoyl peroxide
Sponsors:   Beth Israel Deaconess Medical Center;   Ortho Dermatologics
Recruiting

Mon, 14 Sep 2020 12:00:00 EDT

De Novo Lipogenesis of Sebaceous Glands in Acne

Condition:   Acne Vulgaris
Interventions:   Drug: Tretinoin;   Drug: Isotretinoin
Sponsor:   University of California, Davis
Completed

Thu, 03 Dec 2015 12:00:00 EST

Solar Lentigines Treatment With the Triple Combination Cream

Condition:   Lentigo
Interventions:   Drug: Triple combination cream;   Drug: Tretinoin 0.05%
Sponsors:   Pontificia Universidad Catolica de Chile;   Galderma Laboratories, L.P.
Completed

Fri, 11 Sep 2009 12:00:00 EDT

Efficacy and Safety of Oral Isotretinoin for Cutaneous Photodamage

Conditions:   Photodamage;   Photoaging
Interventions:   Drug: oral isotretinoin;   Drug: Tretinoin
Sponsor:   Federal University of São Paulo
Unknown status

Thu, 12 Feb 2009 12:00:00 EST

A Study of Acne Treatment in Children Ages 9 to 11

Condition:   Acne Vulgaris
Interventions:   Drug: Retin-A Micro 0.04% facial acne treatment;   Drug: Vehicle control
Sponsor:   Bausch Health Americas, Inc.
Completed

Fri, 22 May 2009 12:00:00 EDT

Efficacy & Safety of Clindamycin and Tretinoin in Acne

Condition:   Acne
Intervention:   Drug: Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel
Sponsors:   Callender Center for Clinical Research;   Society Hill Dermatology
Unknown status

Wed, 28 Apr 2010 12:00:00 EDT

13-Cis Retinoic Acid With or Without Vitamin E for Prevention of Lung Cancer

Conditions:   Drug Toxicity;   Lung Cancer
Interventions:   Drug: 13-cis retinoic acid;   Dietary Supplement: Tocopherol
Sponsor:   University of Colorado, Denver
Completed

Mon, 27 Jan 2003 12:00:00 EST

Bioequivalence Study Comparing Clindamycin Phosphate (1.2%) and Tretinoin (0.025%) Topical Gel to Ziana and Placebo

Condition:   MILD TO SEVERE ACNE VULGARIS
Interventions:   Drug: CLIND PHOSPHATE (1.2%) AND TRETINOIN (0.025%) TOPICAL GEL;   Drug: ZIANA®;   Drug: Vehicle Control
Sponsor:   Actavis Mid-Atlantic LLC
Completed

Fri, 10 Dec 2010 12:00:00 EST

Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne Vulgaris

Condition:   Acne Vulgaris
Interventions:   Drug: clindamycin phosphate 1.2% and tretinoin 0.025%;   Drug: clindamycin 1% gel;   Drug: tretinoin 0.025% cream
Sponsors:   Wake Forest University;   Medicis Pharmaceutical Corporation
Completed

Tue, 12 Jan 2010 12:00:00 EST

A Phase II Trial of All-Trans-Retinoic Acid in Combination With Interferon-Alpha 2a in Children With Recurrent Neuroblastoma or Wilms' Tumor

Conditions:   Nephroblastoma;   Neuroblastoma
Intervention:   Drug: IFN-alpha with retinoic acid
Sponsor:   National Cancer Institute (NCI)
Completed

Tue, 10 Dec 2002 12:00:00 EST

Investigating the Potential Role of a Novel Quadrate Combination Therapy Mifepristone(Antiprogestrone), Tamoxifen, Retinoic Acid and Cannabidiol ( Selective Cyp 26 Inhibitor) for Treating Early Breast Cancer.

Condition:   Breast Cancer Female
Interventions:   Drug: All trans-retinoic acid;   Drug: 13-Cis Retinoic Acid plus Tocopherol;   Drug: Mifepristone;   Drug: Cannabidiol;   Drug: 9 cis retinoic acid;   Drug: Tamoxifen;   Drug: Standard therapy
Sponsors:   Mahmoud Ramadan mohamed Elkazzaz;   Ministry of Health, Saudi Arabia
Not yet recruiting

Mon, 23 Aug 2021 12:00:00 EDT

Arsenic Trioxide With or Without Tretinoin in Treating Patients With Hematologic Cancer That Has Not Responded to Previous Therapy

Conditions:   Leukemia;   Lymphoma;   Multiple Myeloma and Plasma Cell Neoplasm;   Myelodysplastic Syndromes
Interventions:   Drug: arsenic trioxide;   Drug: tretinoin
Sponsors:   Washington University School of Medicine;   National Cancer Institute (NCI)
Terminated

Thu, 20 May 2004 12:00:00 EDT

To Immunize Patients With Extensive Stage SCLC Combined With Chemo With or Without All Trans Retinoic Acid

Condition:   Small Cell Lung Cancer
Interventions:   Drug: Paclitaxel;   Biological: Drug: Ad.p53-DC vaccines;   Drug: All -trans Retinoic Acid (ATRA)
Sponsor:   H. Lee Moffitt Cancer Center and Research Institute
Completed

Mon, 18 Feb 2008 12:00:00 EST

Decitabine and Tretinoin in Treating Patients With Myelodysplastic Syndromes

Condition:   Myelodysplastic Syndromes
Interventions:   Drug: decitabine;   Drug: tretinoin;   Genetic: DNA methylation analysis;   Genetic: cytogenetic analysis;   Genetic: microarray analysis;   Other: flow cytometry;   Other: immunohistochemistry staining method
Sponsors:   Memorial Sloan Kettering Cancer Center;   National Cancer Institute (NCI)
Active, not recruiting

Thu, 28 Sep 2006 12:00:00 EDT

Temozolomide,Thiotepa and Carboplatin With Autologous Stem Cell Rescue Followed by 13-cis-retinoic Acid in Patients With Recurrent/Refractory Malignant Brain Tumors

Condition:   Brain Tumors
Intervention:   Drug: temozolomide, thiotepa, carboplatin, 13-cis-retinoic acid
Sponsors:   NYU Langone Health;   Children's Hospitals and Clinics of Minnesota;   Schneider Children's Hospital
Completed

Wed, 12 Sep 2007 12:00:00 EDT

Tretinoin and Arsenic Trioxide With or Without Idarubicin in Treating Patients With Acute Promyelocytic Leukemia

Condition:   Leukemia
Interventions:   Drug: arsenic trioxide;   Drug: idarubicin;   Drug: tretinoin
Sponsors:   Memorial Sloan Kettering Cancer Center;   National Cancer Institute (NCI);   Cephalon
Terminated

Wed, 12 Sep 2007 12:00:00 EDT

All-Trans Retinoic Acid (ATRA) Combining Dexamethasone Versus High-dose Dexamethasone for Initial Treatment of Primary Immune Thrombocytopenia (ITP)

Conditions:   Purpura;   Idiopathic Thrombocytopenic Purpura
Interventions:   Drug: All-Trans Retinoid Acid(ATRA);   Drug: Dexamethasone
Sponsor:   Shandong University
Withdrawn

Thu, 20 Jun 2013 12:00:00 EDT

Oral Liquid 13-cis-retinoic Acid (13-CRA)

Condition:   Neuroblastoma
Interventions:   Drug: Liquid 13-Cis Retinoic Acid;   Drug: Extracted capsules 13-CRA
Sponsor:   Nova Laboratories Limited
Completed

Mon, 25 Sep 2017 12:00:00 EDT

ATRA Trial - ACTIVITY OF ATRA IN COMBINATION WITH ANASTROZOLE IN PRE-OPERATIVE PHASE OF OPERABLE HR-POSITIVE/HER2-NEGATIVE EARLY BREAST CANCER eBC ATRA TRIAL

Condition:   Breast Neoplasm Female
Interventions:   Drug: all-trans retinoic acid;   Drug: Anastrozole 1mg
Sponsor:   Mario Negri Institute for Pharmacological Research
Unknown status

Thu, 03 Oct 2019 12:00:00 EDT

Combined Retinoic Acid,Arsenic Trioxide and Chemo for Newly-diagnosed APL

Condition:   Acute Promyelocytic Leukemia
Interventions:   Drug: ATRA+Arsenic;   Drug: ATRA+Chemo
Sponsors:   Shanghai Jiao Tong University School of Medicine;   Tang-Du Hospital;   Peking University People's Hospital;   First Affiliated Hospital of Zhejiang University;   Tongji Hospital;   Wuhan Union Hospital, China;   First Hospital of China Medical University;   Southwest Hospital, China;   West China Hospital;   Ningbo No. 1 Hospital;   Qilu Hospital of Shandong University;   Shandong Provincial Hospital;   Union hospital of Fujian Medical University;   First Affiliated Hospital of Guangxi Medical University;   Guangdong Provincial People's Hospital;   First Affiliated Hospital, Sun Yat-Sen University;   The First Affiliated Hospital of Soochow University;   The First Affiliated Hospital with Nanjing Medical University;   The Second Affiliated Hospital of Dalian Medical University;   Nanfang Hospital of Southern Medical University;   The First Affiliated Hospital of Anhui Medical University;   Institute of Hematology & Blood Diseases Hospital
Unknown status

Tue, 19 Nov 2013 12:00:00 EST

A Phase I Trial of Tamoxifen and 9-Cis-Retinoic Acid in Breast Cancer Patients

Conditions:   Breast Cancer;   Breast Neoplasm
Intervention:   Drug: 9-cis-Retinoic Acid
Sponsor:   National Cancer Institute (NCI)
Completed

Thu, 04 Nov 1999 12:00:00 EST

A Pilot Study of the Combination of Retinoic Acid and Interferon-Alpha2a for the Treatment of Lymphoproliferative Disorders in Children With Immunodeficiency Syndromes

Conditions:   HIV Infections;   Immunologic Deficiency Syndromes;   Lymphoproliferative Disorders
Intervention:   Drug: all-trans-retinoic acid with IFN-alpha2a
Sponsor:   National Cancer Institute (NCI)
Completed

Tue, 10 Dec 2002 12:00:00 EST

Tretinoin With or Without Fenretinide in Treating Patients With Dysplastic Nevus Syndrome

Condition:   Melanoma (Skin)
Interventions:   Drug: fenretinide;   Drug: tretinoin
Sponsors:   Eastern Cooperative Oncology Group;   National Cancer Institute (NCI)
Completed

Thu, 26 Aug 2004 12:00:00 EDT

Combination Therapy in Amyotrophic Lateral Sclerosis (ALS)

Condition:   Amyotrophic Lateral Sclerosis
Interventions:   Drug: Pioglitazone and Tretinoin;   Drug: Tretinoin and Pioglitazone HCL;   Drug: Placebo
Sponsor:   Phoenix Neurological Associates, LTD
Completed

Fri, 12 Jun 2009 12:00:00 EDT

A Study of All-Trans Retinoic Acid (ATRA) and Bryostatin in Patients With Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)

Conditions:   Acute Myelogenous Leukemia;   Myelodysplastic Syndrome
Interventions:   Drug: All-trans retinoic acid;   Drug: Bryostatin 1
Sponsors:   Dana-Farber Cancer Institute;   Brigham and Women's Hospital
Completed

Mon, 29 Aug 2005 12:00:00 EDT

Phenylbutyrate and Tretinoin in Treating Patients With Hematologic Cancer

Conditions:   Leukemia;   Myelodysplastic Syndromes;   Myelodysplastic/Myeloproliferative Diseases
Interventions:   Drug: sodium phenylbutyrate;   Drug: tretinoin
Sponsors:   Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

Evaluation of Irritation by Two Facial Gels Applied to Opposite Sides of the Face

Condition:   Acne Vulgaris
Interventions:   Drug: Tretinoin gel;   Drug: Adapalene and Benzoyl peroxide
Sponsor:   Bausch Health Americas, Inc.
Completed

Fri, 12 Jun 2009 12:00:00 EDT

All-trans Retinoic Acid (ATRA) in the Treatment of Recurrent/Metastatic Adenoid Cystic Carcinoma of the Head and Neck

Condition:   Adenoid Cystic Carcinoma of the Head and Neck
Interventions:   Drug: All-trans Retinoic Acid;   Drug: VEGFR inhibitor;   Drug: Chemotherapy
Sponsor:   Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Recruiting

Tue, 16 Jun 2020 12:00:00 EDT

Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19

Condition:   Covid19
Interventions:   Drug: Drug: Isotretinoin(Aerosolized 13 cis retinoic acid) plus Aerosolized Itraconazole;   Drug: Drug: Isotretinoin(Aerosolized 13 cis retinoic acid)
Sponsor:   Kafrelsheikh University
Not yet recruiting

Tue, 06 Oct 2020 12:00:00 EDT

MUSE Study to Evaluate the Pharmacokinetics, Safety and Tolerability of S6G5T-3

Condition:   Acne Vulgaris
Interventions:   Drug: S6G5T-3;   Drug: Retin-A® 0.1% Cream
Sponsor:   Sol-Gel Technologies, Ltd.
Completed

Fri, 16 Aug 2019 12:00:00 EDT

Investigating the Role of 13cis Retinoic Acid in the Treatment of COVID-19 and Enhancement of Its Spike Protein Based Vaccine Efficacy and Safety.

Condition:   Covid19 Vaccine
Interventions:   Drug: Oral 13 cis retinoic acid;   Drug: Aerosolized 13 cis retinoic acid;   Combination Product: 13 cis retinoic acid doses orally in combination with spike protein based vaccine;   Combination Product: Aerosolized 13 cis retinoic acid in combination with spike protein based vaccine;   Biological: Biological: spike protein based vaccine such as ChAdOx1 nCoV-19 vaccine
Sponsor:   Kafrelsheikh University
Not yet recruiting

Fri, 29 Jan 2021 12:00:00 EST

The Combination of ATRA and Danazol as Second-line Treatment in Adult Immune Thrombocytopenia

Condition:   Autoimmune Thrombocytopenia
Interventions:   Drug: All-trans retinoic acid;   Drug: Danazol
Sponsors:   Peking University People's Hospital;   Beijing Municipal Science & Technology Commission;   Beijing Hospital;   Qilu Hospital of Shandong University;   Navy General Hospital, Beijing;   Beijing Tongren Hospital
Completed

Fri, 17 Aug 2012 12:00:00 EDT

UMCC 9609 Tretinoin in Preventing Cancer of the Cervix in Patients With Cervical Neoplasia

Conditions:   Cervical Cancer;   Precancerous/Nonmalignant Condition
Intervention:   Drug: tretinoin
Sponsors:   University of Michigan Rogel Cancer Center;   National Cancer Institute (NCI)
Completed

Fri, 05 Dec 2003 12:00:00 EST

Efficacy and Safety of Therapy With Tri-Luma® Cream in Sequence With Glycolic Acid Peels for Melasma

Condition:   Melasma
Intervention:   Drug: Fluocinolone acetonide 0.1%/hydroquinone 4%/tretinoin 0.05% Cream in sequence with glycolic acid peels
Sponsor:   Galderma Laboratories, L.P.
Completed

Mon, 14 May 2007 12:00:00 EDT

A Study of ATRA in the Treatment of ITP

Condition:   Immune Thrombocytopenia
Intervention:   Drug: all trans retinoic acid
Sponsors:   Peking University People's Hospital;   Qilu Hospital of Shandong University;   Beijing Hospital;   The Sixth Medical Center of PLA General Hospital
Not yet recruiting

Thu, 05 Nov 2020 12:00:00 EST

Phase II 5-Azacytidine Plus VPA Plus ATRA

Conditions:   Myelodysplastic Syndrome;   Acute Myelogenous Leukemia
Interventions:   Drug: 5-Azacytidine (5-aza);   Drug: Valproic Acid;   Drug: All-Trans Retinoic Acid (ATRA)
Sponsors:   M.D. Anderson Cancer Center;   Celgene Corporation
Completed

Tue, 16 May 2006 12:00:00 EDT

Study of TCP-ATRA for Adult Patients With AML and MDS

Conditions:   Acute Myelogenous Leukemia;   Myelodysplastic Syndromes;   Leukemia
Interventions:   Drug: Tranylcypromine;   Drug: Tretinoin
Sponsors:   University of Miami;   Women's Cancer Association;   Gabrielle's Angel Foundation
Completed

Thu, 23 Oct 2014 12:00:00 EDT

Pharmacokinetics of 9-cis-retinoic Acid (Alitretinoin, Toctino®) in Patients With Hepatic Disease

Condition:   Hepatic Insufficiency
Intervention:   Drug: Alitretinoin
Sponsor:   University Hospital, Gentofte, Copenhagen
Completed

Fri, 17 Dec 2010 12:00:00 EST

Study of Low-Dose Cytarabine and Etoposide With or Without All-Trans Retinoic Acid in Older Patients Not Eligible for Intensive Chemotherapy With Acute Myeloid Leukemia and NPM1 Mutation

Condition:   Acute Myeloid Leukemia (AML)
Interventions:   Drug: Cytarabine;   Drug: Etoposide;   Drug: All-trans retinoic acid (ATRA)
Sponsors:   University of Ulm;   German Federal Ministry of Education and Research
Completed

Wed, 10 Nov 2010 12:00:00 EST

Advanced Cervical Cancer Trial in India

Condition:   Cervical Cancer
Interventions:   Drug: Interferon, Retinoic Acid and radiation;   Drug: Cisplatin and radiation
Sponsors:   University of Louisville;   James Graham Brown Cancer Center
Completed

Thu, 13 Jan 2011 12:00:00 EST

Safety and Efficacy Study of Association Between Tretinoin and Clindamycin on the Treatment of Acne Mild and Moderate

Condition:   Acne Vulgaris
Intervention:   Drug: application of the topic gel
Sponsor:   Igefarma Laboratorios S.A.
Completed

Fri, 06 Feb 2009 12:00:00 EST

DNA Methylation in Malar Melasma and Its Change by Sunscreen, Retinoic Acid and Niacinamide.

Condition:   Melasma
Interventions:   Drug: Retinoic acid;   Device: colorimetry measurement;   Drug: sunscreen;   Drug: Niacinamide
Sponsor:   Universidad Autonoma de San Luis Potosí
Completed

Mon, 08 Jan 2018 12:00:00 EST

A Study of Daratumumab With Pomalidomide, Dexamethasone, and All-Transretinoic Acid in Patients With Multiple Myeloma

Condition:   Multiple Myeloma
Interventions:   Drug: Daratumumab;   Drug: Pomalidomide;   Drug: All-trans retinoic acid;   Drug: Dexamethasone
Sponsors:   Hackensack Meridian Health;   Janssen, LP
Not yet recruiting

Thu, 07 Jan 2021 12:00:00 EST

Comparison of Redermic, Rejuva-A and Combination of Both Redermic and Rejuva-A in Subjects With Signs of Aging

Condition:   Skin Aging
Interventions:   Other: Redermic;   Drug: Tretinoin (Rejuva-A)
Sponsors:   Cosmetique Active International;   Innovaderm Research Inc.
Completed

Thu, 10 Sep 2009 12:00:00 EDT

Daratumumab in Combination With ATRA

Condition:   Multiple Myeloma
Intervention:   Drug: all-trans retinoic acid (ATRA)
Sponsors:   VU University Medical Center;   Erasmus Medical Center;   UMC Utrecht;   University of Turin, Italy;   Vejle Hospital
Active, not recruiting

Tue, 26 Apr 2016 12:00:00 EDT

A Study of MAb-3F8 Plus Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Versus 13-cis-Retinoic Acid (RA) Plus GM-CSF in Primary Refractory Neuroblastoma Patients

Condition:   Primary Refractory Neuroblastoma
Interventions:   Biological: MAb-3F8;   Biological: Subcutaneous Granulocyte Macrophage Colony Stimulating Factor (GM-CSF);   Biological: 13-cis-Retinoic Acid
Sponsor:   United Therapeutics
Terminated

Tue, 01 Sep 2009 12:00:00 EDT

5-azacytidine Valproic Acid and ATRA in AML and High Risk MDS

Conditions:   Acute Myelogenous Leukaemia (AML);   Myelodysplastic Syndrome (MDS)
Intervention:   Drug: 5 azacytidine - VALPROIC acid- Retinoic acid
Sponsor:   Assistance Publique - Hôpitaux de Paris
Completed

Tue, 20 Jun 2006 12:00:00 EDT

Tretinoin and Arsenic Trioxide With or Without Gemtuzumab Ozogamicin in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia

Condition:   Acute Promyelocytic Leukemia With PML-RARA
Interventions:   Drug: Arsenic Trioxide;   Drug: Gemtuzumab Ozogamicin;   Other: Laboratory Biomarker Analysis;   Drug: Tretinoin
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Recruiting

Thu, 04 Aug 2011 12:00:00 EDT

All-trans Retinoic Acid, and Arsenic +/- Idarubicin

Condition:   Acute Promyelocytic Leukemia
Interventions:   Drug: All-Trans Retinoic Acid (ATRA);   Drug: Arsenic Trioxide (ATO);   Drug: Idarubicin;   Drug: Gemtuzumab Ozogamicin
Sponsor:   M.D. Anderson Cancer Center
Completed

Tue, 19 Dec 2006 12:00:00 EST

"AIDA" Protocol (LAP 0493)

Condition:   Leukemia
Intervention:   Drug: all-trans retinoic acid (ATRA)
Sponsor:   Gruppo Italiano Malattie EMatologiche dell'Adulto
Recruiting

Mon, 08 Feb 2010 12:00:00 EST

The Lipid Profile of the Skin Surface in Acne

Condition:   Acne
Interventions:   Drug: Tretinoin or Adapalene;   Drug: Isotretinoin
Sponsor:   University of California, Davis
Completed

Wed, 02 Jul 2014 12:00:00 EDT

Combination of Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP and Isotretinoin Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications

Condition:   COVID
Intervention:   Combination Product: Recombinant Bacterial ACE2 receptors -like enzyme of B38-CAP (rbACE2) plus Aerosolized 13 cis retinoic acid
Sponsor:   Kafrelsheikh University
Not yet recruiting

Mon, 11 May 2020 12:00:00 EDT

Retinyl Palmitate-loaded Ethosomes in Acne Vulgaris

Condition:   Facial Acne Vulgaris
Interventions:   Drug: retinyl palmitate;   Drug: Tretinoin
Sponsor:   Assiut University
Unknown status

Fri, 06 Sep 2019 12:00:00 EDT

W0265-103: A Single-Center, Evaluator-Blinded, Randomized, Placebo Controlled, Phase 1 Clinical Trial Evaluating The Phototoxic Potential Of Topically Applied Clindamycin 1.0% - Tretinoin 0.025% Gel (Ct Gel) In Healthy Volunteers

Condition:   Acne Vulgaris
Interventions:   Drug: CT Gel (clindamycin 1% and tretinoin 0.025%);   Other: Vehicle gel patch;   Other: Blank patch
Sponsors:   Stiefel, a GSK Company;   GlaxoSmithKline
Completed

Tue, 27 Aug 2013 12:00:00 EDT

A Study of TAS1440 With ATRA in Subjects With r/r AML

Condition:   Acute Myeloid Leukemia
Interventions:   Drug: TAS1440;   Drug: TAS1440 + ATRA
Sponsor:   Astex Pharmaceuticals, Inc.
Recruiting

Tue, 25 Feb 2020 12:00:00 EST

A Pilot Study of 5-AZA and ATRA for Prostate Cancer With PSA-only Recurrence After Local Treatment

Conditions:   Prostatic Neoplasms;   Prostate Neoplasms;   Prostate Cancer
Interventions:   Drug: 5-Azacitidine;   Drug: all trans retinoic acid;   Drug: Lupron
Sponsor:   Icahn School of Medicine at Mount Sinai
Recruiting

Thu, 28 Jun 2018 12:00:00 EDT

Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic Leukemia

Condition:   Acute Promyelocytic Leukemia With PML-RARA
Interventions:   Drug: Arsenic Trioxide;   Drug: Cytarabine;   Drug: Dexamethasone;   Drug: Idarubicin;   Other: Laboratory Biomarker Analysis;   Drug: Mitoxantrone Hydrochloride;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Drug: Tretinoin
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Active, not recruiting

Thu, 15 Jan 2015 12:00:00 EST

Clinical Role of Testosterone and Dihydrotestosterone and Which of Them Should be Inhibited in COVID-19 Patients - A Double-edged Sword?

Condition:   Covid19
Interventions:   Combination Product: Aerosolized 13 cis retinoic acid plus Inhalation Inhaled testosterone;   Drug: The standard therapy
Sponsor:   Kafrelsheikh University
Not yet recruiting

Tue, 10 Nov 2020 12:00:00 EST

Study of Decitabine Alone or in Combination With Valproic Acid and All-trans Retinoic Acid in Acute Myeloid Leukemia

Condition:   Acute Myeloid Leukemia
Interventions:   Drug: Decitabine;   Drug: VPA;   Drug: ATRA
Sponsor:   University Hospital Freiburg
Completed

Tue, 24 Mar 2009 12:00:00 EDT

Vaccine Therapy, Tretinoin, and Cyclophosphamide in Treating Patients With Metastatic Lung Cancer

Condition:   Lung Cancer
Interventions:   Biological: Vaccine Treatment;   Drug: Cyclophosphamide;   Drug: All-trans retinoic acid (ATRA)
Sponsors:   H. Lee Moffitt Cancer Center and Research Institute;   National Cancer Institute (NCI);   National Institutes of Health (NIH)
Completed

Mon, 28 Jan 2008 12:00:00 EST

Disease Stabilization in AML by Treatment With ATRA, Valproic Acid and Low-dose Cytarabine

Condition:   Acute Myelogenous Leukemia
Intervention:   Drug: Cytarabine, all-trans retinoic acid, valproic acid
Sponsor:   University of Bergen
Completed

Thu, 15 Oct 2009 12:00:00 EDT

Study of Sensitization of Non-M3 AML Blasts to ATRA by Epigenetic Treatment With Tranylcypromine (TCP)

Conditions:   Acute Myeloid Leukemia;   Myelodysplastic Syndrome
Interventions:   Drug: tranylcypromine;   Drug: all-trans retinoic acid;   Drug: cytarabine
Sponsors:   Michael Luebbert;   University Hospital Freiburg
Recruiting

Thu, 24 Mar 2016 12:00:00 EDT

Tretinoin, Cytarabine, and Daunorubicin Hydrochloride With or Without Arsenic Trioxide Followed by Tretinoin With or Without Mercaptopurine and Methotrexate in Treating Patients With Acute Promyelocytic Leukemia

Conditions:   Adult Acute Myeloid Leukemia With t(15;17)(q22;q12);   Adult Acute Promyelocytic Leukemia (M3);   Childhood Acute Promyelocytic Leukemia (M3);   Untreated Adult Acute Myeloid Leukemia;   Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Interventions:   Drug: tretinoin;   Drug: daunorubicin hydrochloride;   Drug: cytarabine;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: arsenic trioxide
Sponsor:   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

Study to Evaluate the Effect of a Nu Skin Product and Device for Brown Spots

Condition:   Hyperpigmentation
Interventions:   Other: Nu Skin Product;   Other: Cosmetic instrument;   Drug: Tretinoin cream 0.05;   Other: CeraVe moisturizer
Sponsor:   Massachusetts General Hospital
Completed

Thu, 24 Jun 2010 12:00:00 EDT

The Combination of Low-dose Rituximab and ATRA as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia

Condition:   Immune Thrombocytopenia
Interventions:   Drug: Rituximab;   Drug: All-trans retinoic acid
Sponsors:   Peking University People's Hospital;   Beijing Hospital;   Navy General Hospital, Beijing;   Beijing Tongren Hospital
Active, not recruiting

Mon, 09 Oct 2017 12:00:00 EDT

S0521, Combination Chemotherapy With or Without Gemtuzumab Followed By Tretinoin, Mercaptopurine, and Methotrexate or Observation in Treating Patients With Acute Promyelocytic Leukemia

Condition:   Leukemia
Interventions:   Drug: mercaptopurine;   Drug: methotrexate;   Drug: tretinoin
Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
Completed

Wed, 27 Jun 2007 12:00:00 EDT

Tretinoin Plus Interferon Alfa in Treating Patients With Metastatic Kidney Cancer

Condition:   Kidney Cancer
Interventions:   Biological: recombinant interferon alfa;   Drug: tretinoin liposome
Sponsor:   Weill Medical College of Cornell University
Completed

Mon, 27 Jan 2003 12:00:00 EST

Cladribine Based Induction Therapy With All-Trans Retinoic Acid and Midostaurin in Relapsed/Refractory AML

Condition:   Leukemia, Myeloid, Acute
Interventions:   Drug: Granulocyte colony-stimulating factor (G-CSF);   Drug: Cladribine;   Drug: Cytarabine;   Drug: All-Trans Retinoic Acid (ATRA);   Drug: Midostaurin
Sponsor:   Washington University School of Medicine
Completed

Tue, 13 Jul 2010 12:00:00 EDT

Efficacy of Immunomudulatory Therapy With All-trans Retinoid Acid for Adults With Chronic Immune Thrombocytopenia

Condition:   Immune Thrombocytopenic Purpura
Intervention:   Drug: all-trans-retinoid acid
Sponsor:   First Affiliated Hospital of Suzhou Medical College
Completed

Mon, 20 Aug 2012 12:00:00 EDT

Interferon Alfa, Isotretinoin, and Paclitaxel in Treating Patients With Recurrent Small Cell Lung Cancer

Condition:   Lung Cancer
Interventions:   Biological: interferon alpha;   Drug: 13-cis-retinoic acid;   Drug: paclitaxel
Sponsors:   Eastern Cooperative Oncology Group;   National Cancer Institute (NCI)
Completed

Fri, 06 Jun 2003 12:00:00 EDT

3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Primary Refractory Neuroblastoma in Bone Marrow

Condition:   Neuroblastoma
Intervention:   Biological: 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic
Sponsor:   Memorial Sloan Kettering Cancer Center
Completed

Wed, 18 Aug 2010 12:00:00 EDT

All-Trans Retinoic Acid in Combination With Standard Induction and Consolidation Therapy in Older Patients With Newly Diagnosed Acute Myeloid Leukemia

Condition:   Acute Myeloid Leukemia
Interventions:   Drug: Cytarabine;   Drug: Idarubicin;   Drug: All-trans retinoic acid;   Drug: Mitoxantrone;   Drug: Etoposid
Sponsor:   University of Ulm
Completed

Thu, 08 Sep 2005 12:00:00 EDT

AIDA 2000 Guidelines

Condition:   Acute Promyelocytic Leukemia
Intervention:   Drug: all-trans retinoic acid (ATRA)
Sponsor:   Gruppo Italiano Malattie EMatologiche dell'Adulto
Recruiting

Mon, 08 Feb 2010 12:00:00 EST

Study on All-Trans Retinoic Acid, Induction and Consolidation Therapy, and Pegfilgrastim After Consolidation Therapy in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia

Condition:   Acute Myeloid Leukemia
Interventions:   Drug: Cytarabine;   Drug: Idarubicin;   Drug: Etoposide;   Drug: All-trans retinoic acid;   Drug: Pegfilgrastim
Sponsor:   University of Ulm
Completed

Thu, 08 Sep 2005 12:00:00 EDT

Double Blind Phase III Trial of Effects of Low Dose 13-Cisretinoic Acid on Prevention of Second Primaries in Stages I-II Head and Neck Cancer

Condition:   Stage I-II Head and Neck Cancer
Interventions:   Drug: 13-cis retinoic acid;   Other: Placebo
Sponsor:   Eastern Cooperative Oncology Group
Completed

Tue, 12 Dec 2017 12:00:00 EST

Addition of a Topical Steroid to a Topical Retinoid in Acne Patients

Condition:   Acne
Interventions:   Drug: Triamcinolone;   Drug: Tretinoin;   Drug: Emollient
Sponsor:   Carilion Clinic
Unknown status

Thu, 10 Mar 2016 12:00:00 EST

ALFA-0703 Study in Older Patients With Acute Myeloblastic Leukemia (AML)

Condition:   Acute Myeloid Leukemia
Interventions:   Drug: Vesanoid (ATRA);   Drug: AZACITIDINE (VIDAZA);   Drug: CYTARABINE
Sponsors:   Acute Leukemia French Association;   Assistance Publique - Hôpitaux de Paris
Withdrawn

Thu, 11 Feb 2010 12:00:00 EST

Impact of a Novel Immune Modulating Dietary Supplement on House Dust Mite Induced Allergic Rhinoconjunctivitis

Conditions:   Dust Mite Allergy;   Allergic Rhinitis
Intervention:   Dietary Supplement: holo-BLG (beta-lactoglobulin) - a major component of the protein fraction of raw milk, is loaded with ligands such as retinoic acid, zinc and polyphenol-iron complexes.
Sponsors:   Ecarf Institute GmbH;   Bencard Allergie GmbH
Completed

Mon, 20 Jul 2020 12:00:00 EDT

Bexarotene, Tretinoin, and Combination Chemotherapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer

Condition:   Lung Cancer
Interventions:   Drug: bexarotene;   Drug: capecitabine;   Drug: carboplatin;   Drug: cisplatin;   Drug: docetaxel;   Drug: tretinoin
Sponsor:   Raghu Nandan, M.D., Inc
Unknown status

Thu, 09 Aug 2007 12:00:00 EDT

Isotretinoin, Interferon Alpha-2b, and Paclitaxel in Stage IV, Recurrent, or Persistent Cervical Cancer

Condition:   Cervical Cancer
Interventions:   Biological: recombinant interferon alpha-2b;   Drug: isotretinoin;   Drug: paclitaxel
Sponsors:   University of Medicine and Dentistry of New Jersey;   National Cancer Institute (NCI)
Terminated

Tue, 30 Aug 2005 12:00:00 EDT

Effect of All-trans Retinoic Acid With Chemotherapy Based on Paclitaxel and Cisplatin As First-line Treatment of Patients With Advanced Non-small Cell Lung Cancer and Expression of RAR-alfa and RAR-beta as Response Biomarker

Condition:   Non Small Cell Lung Cancer
Interventions:   Drug: atRA;   Drug: Placebo
Sponsor:   National Institute of Cancerología
Unknown status

Fri, 01 Jan 2010 12:00:00 EST

Temozolomide & RT Followed by Dose Dense vs Temozolomide & Retinoic Acid in Pts w/Glioblastoma

Conditions:   Glioblastoma;   Gliomas
Intervention:   Drug: Temozolomide
Sponsors:   Memorial Sloan Kettering Cancer Center;   Schering-Plough;   Columbia University;   Dana-Farber Cancer Institute
Completed

Tue, 20 Sep 2005 12:00:00 EDT

Effect of All-trans Retinoic Acid With Chemotherapy Based in Paclitaxel and Cisplatin as First Line Treatment of Patients With Advanced Non-small Cell Lung Cancer

Condition:   Non-Small-Cell Lung Carcinoma
Interventions:   Drug: ATRA;   Other: PLACEBO
Sponsors:   National Institute of Cancerología;   Instituto Nacional de Enfermedades Respiratorias
Completed

Wed, 13 Jan 2010 12:00:00 EST

Treatment of Non-high-risk Acute Promyelocytic Leukemia (APL) With Realgar-Indigo Naturalis Formula (RIF)

Condition:   Acute Promyelocytic Leukemia
Interventions:   Drug: Realgar-Indigo naturalis formula;   Drug: all-trans retinoic acid;   Drug: Arsenic trioxide;   Drug: Hydroxyurea
Sponsors:   First Affiliated Hospital Xi'an Jiaotong University;   Tang-Du Hospital
Recruiting

Wed, 14 Sep 2016 12:00:00 EDT

The Combination of ATRA and High-dose Dexamethasone as First-line Treatment in Adult Immune Thrombocytopenia

Condition:   Immune Thrombocytopenia
Interventions:   Drug: Dexamethasone;   Drug: ATRA
Sponsors:   Peking University People's Hospital;   Beijing Hospital;   The Sixth Medical Center of PLA General Hospital;   Beijing Aerospace General Hospital;   Qilu Hospital of Shandong University;   Beijing Tongren Hospital
Completed

Fri, 03 Jan 2020 12:00:00 EST

A Clinical Study to Evaluate the Tolerability of a Topical Antibiotic and Retinoid Used in a Combined Regimen With a BPO Wash

Condition:   Acne Vulgaris
Interventions:   Drug: CTGel/ BPO Wash;   Drug: Soap Free Cleanser and CTGel
Sponsors:   Stiefel, a GSK Company;   GlaxoSmithKline
Completed

Fri, 01 May 2009 12:00:00 EDT

Retinoic Acid Homeostasis in Neuropsychiatric Diseases

Conditions:   Major Depression;   Alzheimer's Disease;   Alcoholism;   Schizophrenia
Intervention:  
Sponsor:   Charite University, Berlin, Germany
Recruiting

Fri, 08 May 2015 12:00:00 EDT

Assessment of Atrophogenic Potential of Triple Combination Cream for Treatment of Melasma

Condition:   Melasma
Intervention:   Drug: Fluocinolone acetonide .1%, hydroquinone 4%, tretinoin .05%
Sponsor:   Galderma Laboratories, L.P.
Completed

Fri, 04 May 2007 12:00:00 EDT

Intranasal Retinoic Acid Treatment for Patients With OlfactoryLOSS: A RANDOMIZED CONTROLLED TRIAL

Condition:   Olfactory Disorder
Intervention:   Dietary Supplement: Vitamin A
Sponsor:   St. Paul's Hospital, Canada
Recruiting

Mon, 02 Jul 2018 12:00:00 EDT

Differentiation Induction in Acute Myelogenous Leukemia

Condition:   Acute Myelogenous Leukemia
Interventions:   Drug: all-trans retinoic acid (ATRA);   Drug: Valproic acid;   Drug: Theophyllin
Sponsor:   University of Bergen
Completed

Thu, 15 Sep 2005 12:00:00 EDT

Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung Cancer

Condition:   Lung Cancer
Interventions:   Drug: cisplatin;   Drug: mitomycin C;   Drug: tretinoin;   Drug: vinorelbine tartrate
Sponsor:   Raghu Nandan, M.D., Inc
Unknown status

Mon, 27 Jan 2003 12:00:00 EST

DLAAG in the Treatment of Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome With Blast Excess

Conditions:   Acute Myeloid Leukemia;   Myelodysplastic Syndrome
Interventions:   Drug: Decitabine;   Drug: Cytarabine;   Drug: All-transretinoic acid;   Drug: G-CSF
Sponsor:   Shanghai Tong Ren Hospital
Unknown status

Wed, 29 Nov 2017 12:00:00 EST

Pilot Study of Tolerability and Effectivity of Two Combination Topical Acne Products

Condition:   Acne Vulgaris
Interventions:   Drug: Acnatac® Gel left face;   Drug: Epiduo® Gel right face;   Drug: Acnatac® Gel right face;   Drug: Epiduo® Gel left face
Sponsor:   GWT-TUD GmbH
Completed

Thu, 07 Apr 2016 12:00:00 EDT

Study to Determine Effect of Gentle Wounding to Stimulate Hair Follicle Neogenesis

Condition:   Central Centrifugal Cicatricial Alopecia (CCCA)
Interventions:   Drug: Retinoic acid;   Device: Laser;   Drug: Sham treatment;   Device: Sham treatment
Sponsor:   Johns Hopkins University
Enrolling by invitation

Mon, 09 Apr 2018 12:00:00 EDT

Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With Neuroblastoma

Condition:   Neuroblastoma
Intervention:   Drug: Imetelstat
Sponsors:   NCIC Clinical Trials Group;   Geron Corporation
Withdrawn

Mon, 05 Aug 2013 12:00:00 EDT

The Effect of the Alga Dunaliella Bardawil as a Source of 9-cis Retinoic Acid on Lipid Profile in Fibrate Treated Patients.

Condition:   Low HDL Cholesterol
Intervention:   Drug: Dunaliella
Sponsor:   Sheba Medical Center
Completed

Mon, 12 Sep 2005 12:00:00 EDT

Treatment of the Anemia of Myelodysplastic Syndromes by the Association of Epoetin Beta and All Trans Retinoic Acid

Condition:   Anemia in Myelodysplastic Syndromes
Intervention:   Drug: Epoetin/Atra
Sponsor:   Groupe Francophone des Myelodysplasies
Unknown status

Wed, 21 Feb 2007 12:00:00 EST

Pharmacogenomics Study on Treatment of Psoriasis Vulgaris by Acitretin Capsules

Condition:   Psoriasis Vulgaris
Intervention:   Drug: Acitretin Capsules
Sponsor:   Central South University
Unknown status

Tue, 22 Mar 2016 12:00:00 EDT

Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas

Condition:   Brain and Central Nervous System Tumors
Interventions:   Drug: Isotretinoin;   Drug: Procarbazine Hydrochloride
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Withdrawn

Mon, 13 Sep 2004 12:00:00 EDT

Combination Treatment for Moderate to Severe Acne

Condition:   Acne
Intervention:   Drug: Minocycline, Clindamycin, Tretinoin, Benzoyl Peroxide
Sponsor:   Medicis Global Service Corporation
Completed

Tue, 21 Sep 2010 12:00:00 EDT

Frontline Oral Arsenic Trioxide for APL

Condition:   Acute Promyelocytic Leukemia
Intervention:   Drug: Oral Arsenic Trioxide Formulation
Sponsor:   The University of Hong Kong
Recruiting

Tue, 29 Dec 2020 12:00:00 EST

Treatment w/ Tri-Luma® Cream & Intense Pulsed Light (IPL) vs a Mild Inactive Control Cream & Intense Pulsed Light (IPL) in Melasma

Condition:   Melasma
Interventions:   Drug: Fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%;   Drug: Cetaphil® Moisturizing Cream as Inactive Control
Sponsor:   Galderma Laboratories, L.P.
Terminated

Tue, 29 Apr 2008 12:00:00 EDT

Phase IIb Randomised Trial of ATRA in a Novel Drug Combination for Pancreatic Cancer

Condition:   Pancreatic Cancer
Interventions:   Drug: ATRA;   Drug: Gemcitabine;   Drug: nab-paclitaxel
Sponsors:   Queen Mary University of London;   Medical Research Council;   Celgene
Not yet recruiting

Mon, 27 Jan 2020 12:00:00 EST

Stromal TARgeting for PAncreatic Cancer (STAR_PAC)

Condition:   Pancreatic Adenocarcinoma
Interventions:   Drug: ATRA;   Drug: Gemcitabine;   Drug: Nab-paclitaxel
Sponsors:   Barts & The London NHS Trust;   Medical Research Council;   Celgene Corporation;   Cancer Research UK Cambridge Institute;   King's College London;   Royal Free Hospital NHS Foundation Trust;   Imperial College Healthcare NHS Trust;   Institute of Cancer Research, United Kingdom;   Cambridge University Hospitals NHS Foundation Trust
Completed

Wed, 11 Oct 2017 12:00:00 EDT

An Open-Label, Dose-Escalation/Dose-Expansion Safety Study of INCB059872 in Subjects With Advanced Malignancies

Condition:   Solid Tumors and Hematologic Malignancy
Interventions:   Drug: INCB059872;   Drug: all-trans retinoic acid (ATRA);   Drug: azacitidine;   Drug: nivolumab
Sponsor:   Incyte Corporation
Active, not recruiting

Fri, 18 Mar 2016 12:00:00 EDT

A Clinical Study to Evaluate the Safety and Effectiveness of an Investigational Product Called CT Gel

Conditions:   Acne Vulgaris;   Acne
Interventions:   Drug: CT Gel;   Drug: Clindamycin Gel (clindamycin );   Drug: Tretinoin Gel (tretinoin);   Drug: Vehicle Gel
Sponsors:   Stiefel, a GSK Company;   GlaxoSmithKline
Completed

Tue, 03 Jun 2008 12:00:00 EDT

Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome Coronavirus

Condition:   COVID-19
Interventions:   Drug: Drug: Isotretinoin plus Tamoxifen;   Drug: Aerosolized Isotretinoin plus Tamoxifen
Sponsor:   Kafrelsheikh University
Not yet recruiting

Fri, 15 May 2020 12:00:00 EDT

Vitamin E in Preventing the Side Effects of Isotretinoin in Former and Current Smokers Who Are Receiving Isotretinoin to Prevent Lung Cancer

Condition:   Lung Cancer
Interventions:   Dietary Supplement: Vitamin E (AT);   Drug: Isotretinoin
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Withdrawn

Mon, 13 Sep 2004 12:00:00 EDT

Vorinostat and Isotretinoin in Treating Patients With High-Risk Refractory or Recurrent Neuroblastoma

Conditions:   Localized Unresectable Neuroblastoma;   Recurrent Neuroblastoma;   Regional Neuroblastoma;   Stage 4 Neuroblastoma;   Stage 4S Neuroblastoma
Interventions:   Drug: Isotretinoin;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study;   Drug: Vorinostat
Sponsor:   National Cancer Institute (NCI)
Completed

Fri, 24 Sep 2010 12:00:00 EDT

Belinostat and Isotretinoin in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by Surgery

Condition:   Adult Solid Neoplasm
Interventions:   Drug: Belinostat;   Drug: Isotretinoin;   Other: Pharmacological Study
Sponsor:   National Cancer Institute (NCI)
Completed

Thu, 08 Jun 2006 12:00:00 EDT

Combination Chemotherapy With or Without Filgrastim and/or Tretinoin in Treating Patients With Acute Myeloid Leukemia

Conditions:   Leukemia;   Myelodysplastic Syndromes;   Myelodysplastic/Myeloproliferative Neoplasms
Interventions:   Biological: filgrastim;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: etoposide;   Drug: fludarabine phosphate;   Drug: tretinoin
Sponsor:   Medical Research Council
Completed

Mon, 27 Jan 2003 12:00:00 EST

Treatment Study for Children and Adolescents With Acute Promyelocytic Leukemia

Condition:   Acute Promyelocytic Leukemia
Interventions:   Drug: Mylotarg;   Drug: Arsenic Trioxide;   Drug: All-trans retinoic acid
Sponsor:   Associazione Italiana Ematologia Oncologia Pediatrica
Recruiting

Thu, 11 Mar 2021 12:00:00 EST

Efficacy and Safety of ATO Plus ATRA in Nucleophosmin-1 Mutated Acute Myeloid Leukemia

Condition:   AML
Interventions:   Drug: Cytarabine;   Drug: all-trans retinoic acid;   Drug: Arsenic Trioxide
Sponsor:   Institute of Hematology & Blood Diseases Hospital
Recruiting

Wed, 25 Jan 2017 12:00:00 EST

ch14.18 Pharmacokinetic Study in High-risk Neuroblastoma

Condition:   Neuroblastoma
Interventions:   Biological: ch14.18 -NCI;   Biological: ch14.18-UTC;   Biological: Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF);   Biological: Aldesleukin (IL-2);   Drug: Isotretinoin
Sponsor:   United Therapeutics
Completed

Fri, 04 May 2012 12:00:00 EDT

Effects of Early Vitamin A Supplementation on the Risk for Retinopathy of Prematurity in Extremely Preterm Infants

Condition:   Retinopathy of Prematurity
Intervention:   Drug: Vitamin A
Sponsors:   Huiqing Sun;   Zhengzhou University
Completed

Tue, 16 May 2017 12:00:00 EDT

Sequential ATRA Then IL-2 for Modulation of Dendritic Cells and Treatment of Metastatic Renal Cell Cancer

Condition:   Kidney Cancer
Interventions:   Drug: IL-2;   Drug: ATRA
Sponsors:   H. Lee Moffitt Cancer Center and Research Institute;   National Cancer Institute (NCI);   National Institutes of Health (NIH);   Chiron Corporation
Completed

Fri, 07 Jan 2005 12:00:00 EST

Effect of Isotretinoin on Immune Activation Among HIV-1 Infected Subjects With Incomplete CD4+ T Cell Recovery

Condition:   HIV-1 Infection
Intervention:   Drug: Isotretinoin
Sponsors:   AIDS Clinical Trials Group;   National Institute of Allergy and Infectious Diseases (NIAID)
Completed

Fri, 25 Oct 2013 12:00:00 EDT

Therapy for Children With Neuroblastoma

Condition:   Neuroblastoma
Interventions:   Drug: Gefitinib, Irinotecan, Cycophosphamide, Doxorubicin, Etoposide, Cisplatin, Topotecan, Carboplatin, Melphalan, 13-cis retinoic acid;   Procedure: Radiation therapy, Surgery, Peripheral Stem cell transplant
Sponsors:   St. Jude Children's Research Hospital;   AstraZeneca;   National Institutes of Health (NIH)
Completed

Thu, 25 Aug 2005 12:00:00 EDT

Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Promyelocytic Leukemia

Condition:   Leukemia
Interventions:   Drug: busulfan;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: etoposide;   Drug: idarubicin;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: mitoxantrone hydrochloride;   Drug: thioguanine;   Drug: tretinoin;   Procedure: allogeneic bone marrow transplantation;   Procedure: autologous bone marrow transplantation;   Radiation: radiation therapy
Sponsors:   European Organisation for Research and Treatment of Cancer - EORTC;   Gruppo Italiano Malattie EMatologiche dell'Adulto
Unknown status

Fri, 11 Apr 2003 12:00:00 EDT

ATRA, Celecoxib, and Itraconazole as Maintenance

Condition:   Relapsed Multiple Myeloma
Interventions:   Drug: ATRA;   Drug: Celecoxib;   Drug: Itraconazole
Sponsor:   University of Iowa
Completed

Fri, 27 Mar 2015 12:00:00 EDT

NB2013-HR German (GPOH) / Dutch (DCOG) Trial

Condition:   Neuroblastoma
Interventions:   Drug: antibody ch14.18;   Drug: GM-CSF;   Drug: IL-2 i.v.;   Drug: IL-2 s.c.;   Drug: Retinoic acid
Sponsor:   University of Cologne
Terminated

Tue, 29 Dec 2015 12:00:00 EST

Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic Leukemia

Condition:   Acute Promyelocytic Leukemia
Interventions:   Drug: Arsenic trioxide;   Drug: Idarubicin;   Drug: Cytarabine;   Drug: Tretinoin;   Drug: Mitoxantrone;   Drug: Mercaptopurine;   Drug: Methotrexate
Sponsors:   Technische Universität Dresden;   Gruppo Italiano Malattie EMatologiche dell'Adulto;   Groupe Francophone des Myelodysplasies;   HOVON - Dutch Haemato-Oncology Association;   Programa para el Tratamiento de Hemopatías Malignas;   German Federal Ministry of Education and Research;   Teva Pharmaceuticals Europe
Recruiting

Tue, 23 Feb 2016 12:00:00 EST

Safety Study of Dinutuximab Combined With Immunotherapy to Treat Neuroblastoma

Conditions:   Neuroblastoma;   Neoplasm, Residual;   Effects of Immunotherapy
Intervention:   Drug: Dinutuximab. Immunotherapy
Sponsor:   Fundació Sant Joan de Déu
Unknown status

Mon, 23 Jun 2014 12:00:00 EDT

A Pilot Study of the Effects of Isotretinoin on Cognition, Learning and Memory

Condition:   Acne Vulgaris
Intervention:   Drug: Isotretinoin
Sponsor:   University of Aberdeen
Completed

Wed, 27 Jul 2011 12:00:00 EDT

Decreasing Severity of Acne Vulgaris After the Use of a Combination of Anti-Acne Cream

Condition:   Acne Vulgaris
Intervention:   Drug: Anti-Acne Preparations for Topical Use
Sponsor:   Sukma Skin Treatment
Completed

Tue, 08 Oct 2019 12:00:00 EDT

Treatment of Acute Leukemia Relapse After Allotransplantation

Condition:   Acute Myeloid Leukemia
Intervention:   Drug: Combined use of azacitidine, valproic acid, hydroxurea and eventually donor leukocyte infusions.
Sponsor:   University of Bergen
Unknown status

Wed, 08 Jun 2011 12:00:00 EDT

An Open-Label Extension Study of Palovarotene Treatment in Fibrodysplasia Ossificans Progressiva (FOP)

Condition:   Fibrodysplasia Ossificans Progressiva
Interventions:   Drug: Palovarotene dose level 1;   Drug: Palovarotene dose level 2;   Drug: Palovarotene dose level 3;   Drug: Palovarotene dose level 4
Sponsor:   Clementia Pharmaceuticals Inc.
Active, not recruiting

Thu, 30 Oct 2014 12:00:00 EDT

The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic Patients

Condition:   Dry Eye Syndromes
Interventions:   Drug: Hydroxypropylmethylcellulose;   Drug: Carboxymethylcellulose
Sponsors:   University of Campinas, Brazil;   Merck Sharp & Dohme Corp.
Completed

Thu, 20 Jan 2011 12:00:00 EST

The Effect Of A Controlled Daily Skin Care Regimen On Retinoic Acid Tolerance

Conditions:   Sun-Damaged Skin;   Retinoid Intolerance
Interventions:   Drug: Tazorac;   Drug: Dove Mild Cleanser;   Drug: Dove Facial Moisturizer
Sponsors:   University of Michigan;   Unilever R&D
Completed

Mon, 26 Feb 2007 12:00:00 EST

Low-dose AZA, Pioglitazone, ATRA Versus Standard-dose AZA in Patients >=60 Years With Refractory AML

Condition:   Acute Myeloid Leukemia
Interventions:   Drug: low-dose Azacitidine;   Drug: Pioglitazone;   Drug: ATRA;   Drug: standard-dose AZA
Sponsors:   University Hospital Regensburg;   Anticancer Fund, Belgium;   Celgene
Terminated

Mon, 24 Oct 2016 12:00:00 EDT

RA Effect on Cell Surface Molecules in Vivo

Condition:   HIV Infections
Intervention:   Drug: Acitretin
Sponsor:   Ottawa Hospital Research Institute
Withdrawn

Tue, 27 Nov 2018 12:00:00 EST

Treatment of Acute Promyelocytic Leukemia With All-Trans Retinoic Acid (ATRA) and Idarubicin (AIDA)

Condition:   Acute Promyelocytic Leukemia
Intervention:   Drug: AIDA
Sponsor:   PETHEMA Foundation
Completed

Fri, 27 Apr 2007 12:00:00 EDT

Phase II Study Of Roferon and Accutane For Patients With T-Cell Malignancies

Conditions:   Lymphoma, T-Cell;   Mycosis Fungoides;   Hematologic Neoplasms
Interventions:   Drug: Isotretinoin (Accutane);   Drug: Interferon Alpha
Sponsor:   M.D. Anderson Cancer Center
Completed

Fri, 31 May 2002 12:00:00 EDT

Comparative Antimicrobial Efficacy of Two Topical Acne Therapies for the Treatment of Facial Acne

Condition:   Acne
Interventions:   Drug: Duac;   Drug: Ziana gel
Sponsors:   Stiefel, a GSK Company;   GlaxoSmithKline
Completed

Wed, 11 Feb 2009 12:00:00 EST

Study of Chemotherapy in Combination With All-trans Retinoic Acid (ATRA) With or Without Gemtuzumab Ozogamicin in Patients With Acute Myeloid Leukemia (AML) and Mutant Nucleophosmin-1 (NPM1) Gene Mutation

Condition:   Acute Myeloid Leukemia
Interventions:   Drug: Gemtuzumab Ozogamicin (Mylotarg);   Drug: standard chemotherapy
Sponsor:   University of Ulm
Completed

Wed, 06 May 2009 12:00:00 EDT

Sirolimus Combined With ATRA for the Treatment of Auto-Immune Anemia

Condition:   Autoimmune Anemia
Intervention:   Drug: sirolimus and ATRA
Sponsor:   Peking Union Medical College Hospital
Not yet recruiting

Fri, 27 Mar 2020 12:00:00 EDT

RWE of 1st Line Treatment With ATO/ATRA for Adult APL

Condition:   Promyelocytic Leukemia, Adult Acute
Intervention:   Other: Evaluation of first line treatment with ATO/ATRA outcome
Sponsor:   Grupo Argentino de Tratamiento de la Leucemia Aguda
Recruiting

Fri, 21 May 2021 12:00:00 EDT

Treatment Study for Children and Adolescents With Acute Promyelocitic Leukemia

Condition:   Acute Promyelocytic Leukemia
Interventions:   Drug: ATRA;   Drug: ATRA + IDA
Sponsor:   Associazione Italiana Ematologia Oncologia Pediatrica
Unknown status

Fri, 22 Oct 2010 12:00:00 EDT

Isotretinoin Plus Interferon in Treating Patients With Recurrent Cancer

Conditions:   Cervical Cancer;   Esophageal Cancer;   Head and Neck Cancer;   Lung Cancer;   Non-melanomatous Skin Cancer;   Penile Cancer
Interventions:   Biological: recombinant interferon alfa;   Drug: isotretinoin
Sponsors:   Hoag Memorial Hospital Presbyterian;   Cancer Biotherapy Research Group
Completed

Mon, 26 Jul 2004 12:00:00 EDT

Erlotinib Hydrochloride and Isotretinoin in Treating Patients With Recurrent Malignant Glioma

Conditions:   Adult Anaplastic Astrocytoma;   Adult Anaplastic Oligodendroglioma;   Adult Diffuse Astrocytoma;   Adult Giant Cell Glioblastoma;   Adult Glioblastoma;   Adult Gliosarcoma;   Adult Mixed Glioma;   Adult Oligodendroglioma;   Recurrent Adult Brain Tumor
Interventions:   Drug: erlotinib hydrochloride;   Drug: isotretinoin;   Other: laboratory biomarker analysis;   Genetic: protein expression analysis
Sponsors:   Wake Forest University Health Sciences;   National Cancer Institute (NCI)
Terminated

Wed, 14 Apr 2010 12:00:00 EDT

A Biomarker-Directed Phase 2 Trial of SY-1425 in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

Conditions:   Acute Myeloid Leukemia;   Myelodysplastic Syndrome
Interventions:   Drug: SY-1425 (tamibarotene);   Drug: azacitidine;   Drug: Daratumumab
Sponsor:   Syros Pharmaceuticals
Active, not recruiting

Tue, 21 Jun 2016 12:00:00 EDT

Isotretinoin in Treating Young Patients With High-Risk Neuroblastoma

Condition:   Neuroblastoma
Interventions:   Drug: isotretinoin;   Genetic: DNA analysis;   Genetic: polymerase chain reaction;   Other: laboratory biomarker analysis;   Other: pharmacological study
Sponsor:   Children's Cancer and Leukaemia Group
Unknown status

Wed, 15 Jul 2009 12:00:00 EDT

Isotretinoin Plus Dexamethasone in Treating Patients With Multiple Myeloma

Condition:   Multiple Myeloma and Plasma Cell Neoplasm
Interventions:   Drug: dexamethasone;   Drug: isotretinoin
Sponsors:   Fox Chase Cancer Center;   National Cancer Institute (NCI)
Completed

Thu, 11 Mar 2004 12:00:00 EST

An Open-Label Extension Study of Palovarotene to Prevent Heterotopic Ossification in People With Fibrodysplasia Ossificans Progressiva (FOP) in France

Condition:   Fibrodysplasia Ossificans Progressiva
Intervention:   Drug: Palovarotene
Sponsor:   Clementia Pharmaceuticals Inc.
Active, not recruiting

Fri, 02 Dec 2016 12:00:00 EST

Isotretinoin, Interferon Alfa-2b, Docetaxel, and Estramustine in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy

Condition:   Prostate Cancer
Interventions:   Biological: recombinant interferon alfa-2b;   Drug: docetaxel;   Drug: estramustine phosphate sodium;   Drug: isotretinoin;   Genetic: polyacrylamide gel electrophoresis;   Genetic: protein expression analysis;   Other: immunohistochemistry staining method
Sponsors:   University of Medicine and Dentistry of New Jersey;   National Cancer Institute (NCI)
Terminated

Thu, 15 Sep 2005 12:00:00 EDT

MS-275 and Isotretinoin in Treating Patients With Metastatic or Advanced Solid Tumors or Lymphomas

Conditions:   Adult Grade III Lymphomatoid Granulomatosis;   Anaplastic Large Cell Lymphoma;   Angioimmunoblastic T-cell Lymphoma;   Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue;   Intraocular Lymphoma;   Nodal Marginal Zone B-cell Lymphoma;   Primary Central Nervous System Non-Hodgkin Lymphoma;   Recurrent Adult Burkitt Lymphoma;   Recurrent Adult Diffuse Large Cell Lymphoma;   Recurrent Adult Diffuse Mixed Cell Lymphoma;   Recurrent Adult Diffuse Small Cleaved Cell Lymphoma;   Recurrent Adult Grade III Lymphomatoid Granulomatosis;   Recurrent Adult Hodgkin Lymphoma;   Recurrent Adult Immunoblastic Large Cell Lymphoma;   Recurrent Adult Lymphoblastic Lymphoma;   Recurrent Adult T-cell Leukemia/Lymphoma;   Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma;   Recurrent Grade 1 Follicular Lymphoma;   Recurrent Grade 2 Follicular Lymphoma;   Recurrent Grade 3 Follicular Lymphoma;   Recurrent Mantle Cell Lymphoma;   Recurrent Marginal Zone Lymphoma;   Recurrent Mycosis Fungoides/Sezary Syndrome;   Recurrent Small Lymphocytic Lymphoma;   Small Intestine Lymphoma;   Splenic Marginal Zone Lymphoma;   Stage IV Adult Burkitt Lymphoma;   Stage IV Adult Diffuse Large Cell Lymphoma;   Stage IV Adult Diffuse Mixed Cell Lymphoma;   Stage IV Adult Diffuse Small Cleaved Cell Lymphoma;   Stage IV Adult Hodgkin Lymphoma;   Stage IV Adult Immunoblastic Large Cell Lymphoma;   Stage IV Adult Lymphoblastic Lymphoma;   Stage IV Adult T-cell Leukemia/Lymphoma;   Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma;   Stage IV Grade 1 Follicular Lymphoma;   Stage IV Grade 2 Follicular Lymphoma;   Stage IV Grade 3 Follicular Lymphoma;   Stage IV Mantle Cell Lymphoma;   Stage IV Marginal Zone Lymphoma;   Stage IV Mycosis Fungoides/Sezary Syndrome;   Stage IV Small Lymphocytic Lymphoma;   Unspecified Adult Solid Tumor, Protocol Specific;   Waldenström Macroglobulinemia
Interventions:   Drug: entinostat;   Drug: isotretinoin
Sponsor:   National Cancer Institute (NCI)
Completed

Thu, 09 Dec 2004 12:00:00 EST

Gemtuzumab Ozogamicin in Combination With A-HAM in Refractory AML (GO-A-HAM)

Condition:   Leukemia, Myeloid, Acute
Interventions:   Drug: Cytarabine;   Drug: Mitoxantrone;   Drug: Gemtuzumab Ozogamicin;   Drug: All-trans-Retinoid Acid
Sponsor:   University of Ulm
Completed

Fri, 02 Sep 2005 12:00:00 EDT

Vorinostat and Isotretinoin in Treating Patients With Advanced Kidney Cancer

Conditions:   Recurrent Renal Cell Cancer;   Stage III Renal Cell Cancer;   Stage IV Renal Cell Cancer
Interventions:   Drug: vorinostat;   Drug: isotretinoin
Sponsor:   National Cancer Institute (NCI)
Terminated

Thu, 11 May 2006 12:00:00 EDT

Chemotherapy With or Without Biological Therapy in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy

Condition:   Prostate Cancer
Interventions:   Biological: recombinant interferon alfa;   Drug: estramustine phosphate sodium;   Drug: isotretinoin;   Drug: mitoxantrone hydrochloride;   Drug: paclitaxel;   Drug: vinorelbine ditartrate
Sponsors:   Eastern Cooperative Oncology Group;   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

Fractional Laser as Treatment Option for Various Pigment Disorders (Fractional-3)

Condition:   Pigmentation Disorder
Interventions:   Device: Fraxel Restore, Solta Medical Inc. (Non-ablative fractional laser);   Drug: Modified Kligman's formula (Triple topical therapy)
Sponsor:   Netherlands Institute for Pigment Disorders
Completed

Thu, 11 Mar 2010 12:00:00 EST

Chemotherapy Plus Monoclonal Antibody in Treating Patients With Acute Promyelocytic Leukemia

Condition:   Leukemia
Interventions:   Biological: filgrastim;   Biological: lintuzumab;   Drug: arsenic trioxide;   Drug: idarubicin;   Drug: tretinoin
Sponsors:   Memorial Sloan Kettering Cancer Center;   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

Vorinostat With or Without Isotretinoin in Treating Young Patients With Recurrent or Refractory Solid Tumors, Lymphoma, or Leukemia

Conditions:   Childhood Acute Promyelocytic Leukemia (M3);   Childhood Atypical Teratoid/Rhabdoid Tumor;   Childhood Burkitt Lymphoma;   Childhood Chronic Myelogenous Leukemia;   Childhood Diffuse Large Cell Lymphoma;   Childhood Immunoblastic Large Cell Lymphoma;   Juvenile Myelomonocytic Leukemia;   Recurrent Childhood Acute Lymphoblastic Leukemia;   Recurrent Childhood Acute Myeloid Leukemia;   Recurrent Childhood Grade III Lymphomatoid Granulomatosis;   Recurrent Childhood Large Cell Lymphoma;   Recurrent Childhood Lymphoblastic Lymphoma;   Recurrent Childhood Medulloblastoma;   Recurrent Childhood Small Noncleaved Cell Lymphoma;   Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor;   Recurrent Neuroblastoma;   Recurrent/Refractory Childhood Hodgkin Lymphoma;   Relapsing Chronic Myelogenous Leukemia;   Unspecified Childhood Solid Tumor, Protocol Specific
Interventions:   Drug: vorinostat;   Drug: isotretinoin
Sponsor:   National Cancer Institute (NCI)
Completed

Thu, 22 Sep 2005 12:00:00 EDT

Combination Chemotherapy Followed By Donor Bone Marrow or Umbilical Cord Blood Transplant in Treating Children With Newly Diagnosed Juvenile Myelomonocytic Leukemia

Condition:   Juvenile Myelomonocytic Leukemia
Interventions:   Drug: tipifarnib;   Drug: isotretinoin;   Drug: fludarabine phosphate;   Drug: cytarabine;   Radiation: radiation therapy;   Drug: cyclophosphamide;   Biological: anti-thymocyte globulin;   Procedure: allogeneic bone marrow transplantation;   Procedure: double-unit umbilical cord blood transplantation;   Procedure: umbilical cord blood transplantation;   Other: laboratory biomarker analysis
Sponsor:   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST

Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation or Isotretinoin in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Acute Lymphocytic Leukemia

Conditions:   Chronic Myeloproliferative Disorders;   Leukemia;   Myelodysplastic Syndromes;   Thrombocytopenia
Interventions:   Biological: filgrastim;   Dietary Supplement: vitamin E;   Drug: busulfan;   Drug: cytarabine;   Drug: etoposide;   Drug: fludarabine phosphate;   Drug: isotretinoin;   Drug: topotecan hydrochloride;   Procedure: bone marrow ablation with stem cell support;   Procedure: peripheral blood stem cell transplantation
Sponsor:   Drexel University College of Medicine
Completed

Tue, 27 Apr 2004 12:00:00 EDT

Combination Chemotherapy Plus Biological Therapy in Treating Patients With Acute Myelogenous Leukemia

Condition:   Leukemia
Interventions:   Biological: recombinant interferon alfa;   Drug: amifostine trihydrate;   Drug: bromodeoxyuridine;   Drug: cytarabine;   Drug: idarubicin;   Drug: idoxuridine;   Drug: isotretinoin;   Drug: mitoxantrone hydrochloride
Sponsors:   Rush University Medical Center;   National Cancer Institute (NCI)
Unknown status

Mon, 24 May 2004 12:00:00 EDT

Cytarabine (Ara-C) in Children With Acute Promyelocytic Leukemia (APL)

Condition:   Leukemia
Interventions:   Drug: DNR:;   Drug: Ara-c
Sponsor:   Xiaofan Zhu
Completed

Tue, 31 Aug 2010 12:00:00 EDT

Multicentric Study Comparison Between Erythropoietin and Erythropoietin Associated to Differentiating Therapy With Acid 13-cis-retinoic and Dihydroxyvitamin D3 in Myelodysplastic Syndromes Without Excess of Blasts

Condition:   Myelodysplastic Syndromes
Interventions:   Drug: infusion A: rEPO;   Drug: B Infusion rEPO combined with vitamins pills
Sponsors:   Fondazione Italiana Sindromi Mielodisplastiche-ETS;   Centro di Riferimento per l'Epidemiologia e la Prev. Oncologica Piemonte
Terminated

Mon, 08 Dec 2008 12:00:00 EST

Phase III Trial in Acute Promyelocytic Leukemia Patients

Condition:   Leukemia
Interventions:   Drug: arsenic trioxide;   Drug: idarubicin;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: all-trans retinoic acid;   Drug: all-trans retinoic acid (ATRA)
Sponsors:   Gruppo Italiano Malattie EMatologiche dell'Adulto;   Study Alliance Leukemia (SAL) Group
Unknown status

Tue, 05 Jun 2007 12:00:00 EDT

Interferon Alfa With or Without Isotretinoin in Treating Patients With Metastatic Kidney Cancer

Condition:   Kidney Cancer
Interventions:   Biological: recombinant interferon alfa;   Drug: chemotherapy;   Drug: isotretinoin
Sponsor:   European Organisation for Research and Treatment of Cancer - EORTC
Completed

Tue, 11 May 2004 12:00:00 EDT

Vitamin A, Its Receptors and Asthma

Condition:   Asthma
Intervention:  
Sponsor:   University of Kansas
Withdrawn

Wed, 05 Mar 2008 12:00:00 EST

Nivolumab With Chemotherapy in Refractory MDS

Condition:   Myelodysplastic Syndromes
Interventions:   Drug: Nivolumab;   Drug: Azacitidine;   Drug: Fludarabine;   Drug: Cyclophosphamide;   Drug: Cytarabine;   Drug: all trans retinoic acid;   Drug: Sildenafil;   Drug: Melphalan
Sponsor:   St. Petersburg State Pavlov Medical University
Terminated

Wed, 23 Aug 2017 12:00:00 EDT

S0535, Gemtuzumab and Combination Chemotherapy in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia

Condition:   Leukemia
Interventions:   Drug: arsenic trioxide;   Drug: gemtuzumab ozogamicin;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: tretinoin
Sponsors:   Southwest Oncology Group;   National Cancer Institute (NCI)
Completed

Wed, 31 Oct 2007 12:00:00 EDT

Allogeneic Stem Cell Transplantation Followed By Targeted Immune Therapy In Average Risk Leukemia

Conditions:   Acute Myelogenous Leukemia;   Myelodysplastic Syndrome;   Juvenile Myelomonocytic Leukemia
Interventions:   Drug: Fludarabine;   Drug: Busulfan;   Drug: GVHD Prophylaxis;   Drug: Gemtuzumab Ozogamicin;   Drug: Anti-Thymocyte Globulin;   Drug: Isotretinoin
Sponsor:   Columbia University
Completed

Wed, 25 Nov 2009 12:00:00 EST

Oral Arsenic Trioxide for Newly Diagnosed Acute Promyelocytic Leukaemia

Condition:   Acute Promyelocytic Leukemia
Intervention:   Drug: Oral arsenic Trioxide, ATRA and ascorbic acid
Sponsor:   The University of Hong Kong
Recruiting

Fri, 10 Aug 2018 12:00:00 EDT

Comedone Extraction and Oral Doxycycline In The First Line Treatment of Moderate Acne Vulgaris

Condition:   Acne Vulgaris
Interventions:   Drug: Doxycycline Capsule;   Procedure: Comedone extraction
Sponsor:   Indonesia University
Completed

Fri, 20 Dec 2019 12:00:00 EST

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic Leukemia

Conditions:   Childhood Acute Promyelocytic Leukemia (M3);   Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies
Interventions:   Drug: arsenic trioxide;   Drug: mitoxantrone hydrochloride;   Other: diagnostic laboratory biomarker analysis;   Drug: idarubicin;   Drug: tretinoin;   Drug: cytarabine;   Drug: mercaptopurine tablet;   Drug: methotrexate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Active, not recruiting

Mon, 23 Mar 2009 12:00:00 EDT

Alitretinoin vs Cyclosporine in Severe Recurrent Vesicular Hand Eczema

Condition:   Hand Eczema
Interventions:   Drug: Alitretinoin;   Drug: cyclosporin A
Sponsors:   University Medical Center Groningen;   ZonMw: The Netherlands Organisation for Health Research and Development
Recruiting

Fri, 20 Jan 2017 12:00:00 EST

Alitretinoin vs Azathioprine in Severe Non-hyperkeratotic Hand Eczema

Condition:   Hand Eczema
Interventions:   Drug: Alitretinoin;   Drug: Azathioprine
Sponsor:   University Medical Center Groningen
Unknown status

Fri, 20 Jan 2017 12:00:00 EST

Microneedling Therapy With or Without Amnion Bilayer Sheeting on Scar Tissue

Conditions:   Scars, Hypertrophic;   Burn Scar
Interventions:   Procedure: Microoneedling and Amnion Bilayer;   Procedure: Microoneedling
Sponsor:   Dr.dr.Irma Bernadette, SpKK (K)
Not yet recruiting

Fri, 06 Aug 2021 12:00:00 EDT

Combination Chemotherapy Followed by Stem Cell Transplant in High-risk Neuroblastoma Patients

Condition:   Neuroblastoma
Interventions:   Drug: Cycles N8, N5 and N6;   Drug: Cycles N5 and N6
Sponsor:   University of Cologne
Completed

Fri, 03 Feb 2017 12:00:00 EST

Long Term Continuous Infusion ch14.18/CHO Plus s.c. Aldesleukin (IL-2)

Condition:   Neuroblastoma
Interventions:   Drug: ch14.18/CHO;   Drug: Aldesleukin;   Drug: Isotretinoin
Sponsors:   St. Anna Kinderkrebsforschung;   University Medicine Greifswald;   St. Anna Children's Hospital, Vienna;   Hospital Universitario La Fe;   Istituto Giannina Gaslini;   Gustave Roussy, Cancer Campus, Grand Paris;   Schneider Children's Medical Center, Israel;   Great Ormond Street Hospital for Children NHS Foundation Trust;   University Hospital, Toulouse;   Johann Wolfgang Goethe University Hospital;   Jena University Hospital;   Children's University Hospital, Ireland;   University Hospital Tuebingen;   Fondazione IRCCS Istituto Nazionale dei Tumori, Milano;   Alder Hey Children's NHS Foundation Trust;   University Hospitals Bristol and Weston NHS Foundation Trust;   Newcastle-upon-Tyne Hospitals NHS Trust;   The Leeds Teaching Hospitals NHS Trust;   NHS Greater Glasgow and Clyde;   Medical University of Graz;   Medical University Innsbruck;   Centre Leon Berard;   Hospital Infantil Universitario Niño Jesús, Madrid, Spain;   University Hospital Southampton NHS Foundation Trust;   Institut Curie;   Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Active, not recruiting

Fri, 05 Oct 2012 12:00:00 EDT

Combination Chemotherapy in Treating Patients With Acute Promyelocytic Leukemia

Condition:   Leukemia
Interventions:   Drug: arsenic trioxide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: mercaptopurine;   Drug: methotrexate;   Drug: tretinoin
Sponsors:   Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;   National Cancer Institute (NCI)
Completed

Fri, 13 Jan 2006 12:00:00 EST

Neuroblastoma Protocol 2008: Therapy for Children With Advanced Stage High Risk Neuroblastoma

Condition:   Neuroblastoma
Interventions:   Drug: Temsirolimus;   Drug: Irinotecan;   Procedure: Surgical Resection of Primary Tumor;   Drug: Cyclophosphamide;   Drug: Doxorubicin;   Drug: Etoposide;   Drug: Cisplatin;   Drug: Topotecan;   Procedure: PBSC;   Radiation: Radiation Therapy;   Drug: 13-cis-retinoic acid
Sponsor:   St. Jude Children's Research Hospital
Terminated

Tue, 16 Dec 2008 12:00:00 EST

Vorinostat, Isotretinoin and Temozolomide in Adults With Recurrent Glioblastoma Multiforme (GBM)

Conditions:   Glioblastoma Multiforme;   Anaplastic Glioma
Interventions:   Drug: Vorinostat;   Drug: Isotretinoin;   Procedure: Surgical Resection;   Drug: Temozolomide
Sponsors:   M.D. Anderson Cancer Center;   Merck Sharp & Dohme Corp.
Active, not recruiting

Thu, 08 Nov 2007 12:00:00 EST

Long-term Safety Study of Arsenic Trioxide in Newly Diagnosed, Low-to-intermediate Risk Acute Promyelocytic Leukemia

Condition:   Acute Promyelocytic Leukemia
Intervention:   Drug: Arsenic Trioxide
Sponsor:   Gruppo Italiano Malattie EMatologiche dell'Adulto
Recruiting

Fri, 23 Nov 2018 12:00:00 EST

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

Conditions:   Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Anatomic Stage IV Breast Cancer AJCC v8;   Anemia;   Ann Arbor Stage III Hodgkin Lymphoma;   Ann Arbor Stage III Non-Hodgkin Lymphoma;   Ann Arbor Stage IIIA Hodgkin Lymphoma;   Ann Arbor Stage IIIB Hodgkin Lymphoma;   Ann Arbor Stage IV Hodgkin Lymphoma;   Ann Arbor Stage IV Non-Hodgkin Lymphoma;   Ann Arbor Stage IVA Hodgkin Lymphoma;   Ann Arbor Stage IVB Hodgkin Lymphoma;   Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative;   Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Castration-Resistant Prostate Carcinoma;   Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Hematopoietic and Lymphoid Cell Neoplasm;   Locally Advanced Pancreatic Adenocarcinoma;   Metastatic Breast Carcinoma;   Metastatic Malignant Solid Neoplasm;   Metastatic Pancreatic Adenocarcinoma;   Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis;   Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable;   Primary Myelofibrosis;   Prognostic Stage IV Breast Cancer AJCC v8;   Recurrent Acute Lymphoblastic Leukemia;   Recurrent Acute Myeloid Leukemia;   Recurrent Chronic Lymphocytic Leukemia;   Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Recurrent Hematologic Malignancy;   Recurrent Hodgkin Lymphoma;   Recurrent Myelodysplastic Syndrome;   Recurrent Myelodysplastic/Myeloproliferative Neoplasm;   Recurrent Myeloproliferative Neoplasm;   Recurrent Non-Hodgkin Lymphoma;   Recurrent Plasma Cell Myeloma;   Recurrent Small Lymphocytic Lymphoma;   Refractory Acute Lymphoblastic Leukemia;   Refractory Acute Myeloid Leukemia;   Refractory Chronic Lymphocytic Leukemia;   Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Refractory Chronic Myelomonocytic Leukemia;   Refractory Hematologic Malignancy;   Refractory Hodgkin Lymphoma;   Refractory Malignant Solid Neoplasm;   Refractory Myelodysplastic Syndrome;   Refractory Myelodysplastic/Myeloproliferative Neoplasm;   Refractory Non-Hodgkin Lymphoma;   Refractory Plasma Cell Myeloma;   Refractory Primary Myelofibrosis;   Refractory Small Lymphocytic Lymphoma;   Stage II Pancreatic Cancer AJCC v8;   Stage IIA Pancreatic Cancer AJCC v8;   Stage IIB Pancreatic Cancer AJCC v8;   Stage III Pancreatic Cancer AJCC v8;   Stage IV Pancreatic Cancer AJCC v8;   Stage IV Prostate Cancer AJCC v8;   Stage IVA Prostate Cancer AJCC v8;   Stage IVB Prostate Cancer AJCC v8;   Unresectable Pancreatic Adenocarcinoma
Interventions:   Drug: Abemaciclib;   Drug: Abiraterone;   Drug: Afatinib;   Biological: Bevacizumab;   Drug: Bicalutamide;   Procedure: Biospecimen Collection;   Drug: Bortezomib;   Drug: Cabazitaxel;   Drug: Cabozantinib;   Drug: Capecitabine;   Drug: Carboplatin;   Drug: Celecoxib;   Drug: Cobimetinib;   Drug: Copanlisib;   Drug: Dabrafenib;   Drug: Dacomitinib;   Drug: Darolutamide;   Drug: Dasatinib;   Drug: Doxorubicin;   Biological: Durvalumab;   Drug: Enasidenib;   Drug: Entrectinib;   Drug: Enzalutamide;   Drug: Erlotinib;   Drug: Everolimus;   Drug: Fluorouracil;   Drug: Idelalisib;   Drug: Imatinib;   Biological: Ipilimumab;   Drug: Lenvatinib;   Drug: Leucovorin;   Drug: Lorlatinib;   Drug: Losartan;   Drug: Nab-paclitaxel;   Drug: Neratinib;   Biological: Nivolumab;   Drug: Olaparib;   Drug: Oxaliplatin;   Drug: Palbociclib;   Drug: Panobinostat;   Biological: Pembrolizumab;   Biological: Pertuzumab;   Drug: Ponatinib;   Other: Quality-of-Life Assessment;   Drug: Regorafenib;   Drug: Ruxolitinib;   Drug: Sirolimus;   Drug: Sorafenib;   Drug: Sunitinib;   Drug: Trametinib;   Biological: Trastuzumab Emtansine;   Drug: Tretinoin;   Drug: Vemurafenib;   Drug: Venetoclax;   Drug: Vismodegib;   Drug: Vorinostat
Sponsors:   OHSU Knight Cancer Institute;   Oregon Health and Science University
Recruiting

Mon, 18 Mar 2019 12:00:00 EDT

Cytosine Arabinoside and Mitoxantrone for Patients With Juvenile Myelomonocytic Leukemia Receiving Repeat Stem Cell Transplantation

Condition:   Leukemia
Interventions:   Drug: cyclosporine;   Drug: cytarabine;   Drug: filgrastim;   Drug: methotrexate;   Drug: methylprednisolone;   Drug: mitoxantrone hydrochloride;   Procedure: allogeneic bone marrow transplantation;   Procedure: umbilical cord blood transplantation;   Drug: Cis-Retinoic acid
Sponsor:   Masonic Cancer Center, University of Minnesota
Terminated

Thu, 07 Feb 2008 12:00:00 EST

Fractional Laser as Treatment Option for Various Pigment Disorders

Condition:   Pigmentation Disorder
Intervention:   Device: Ablative fractional laser therapy
Sponsor:   Netherlands Institute for Pigment Disorders
Completed

Tue, 09 Mar 2010 12:00:00 EST

Phase 1 Trial of ST-001 nanoFenretinide in Relapsed/Refractory T-cell Non-Hodgkin Lymphoma

Conditions:   T-cell Lymphoma;   Cutaneous/Peripheral T-Cell Lymphoma;   Peripheral T-cell Lymphoma;   Peripheral T-Cell Lymphoma, Not Classified;   Primary Cutaneous T-cell Lymphoma;   Cutaneous T-Cell Lymphoma, Unspecified;   Cutaneous T-cell Lymphoma;   Follicular T-Cell Lymphoma;   Angioimmunoblastic T-cell Lymphoma;   Sézary's Disease;   Mycosis Fungoides
Intervention:   Drug: Fenretinide
Sponsors:   SciTech Development, LLC;   Rush University Medical Center
Not yet recruiting

Tue, 21 Jan 2020 12:00:00 EST

Stem Cell Transplant for Juvenile Myelomonocytic Leukemia (JMML)

Condition:   Juvenile Myelomonocytic Leukemia
Interventions:   Biological: Stem Cell Transplant;   Drug: Preparative Regimen
Sponsor:   Masonic Cancer Center, University of Minnesota
Completed

Wed, 14 Sep 2005 12:00:00 EDT

Tandem High Dose Chemotherapy With 131I-MIBG Treatment in High Risk Neuroblastoma

Condition:   High Risk Neuroblastoma
Interventions:   Drug: Cyclophosphamide;   Drug: Carboplatin;   Drug: Etoposide;   Radiation: 131I-MIBG;   Drug: Thiotepa;   Drug: Melphalan
Sponsors:   Samsung Medical Center;   Ministry of Health, Republic of Korea
Unknown status

Thu, 23 Feb 2017 12:00:00 EST

Tandem High-dose Chemotherapy and Autologous Stem Cell Rescue in Patients With High-risk Neuroblastoma

Condition:   Neuroblastoma
Interventions:   Drug: Cyclophosphamide;   Drug: Etoposide;   Drug: Carboplatin;   Drug: Thiotepa;   Drug: Melphalan;   Radiation: Total body irradiation
Sponsor:   Samsung Medical Center
Completed

Wed, 19 Nov 2008 12:00:00 EST

Lenalidomide and Dinutuximab With or Without Isotretinoin in Treating Younger Patients With Refractory or Recurrent Neuroblastoma

Conditions:   Recurrent Neuroblastoma;   Refractory Neuroblastoma
Interventions:   Biological: Dinutuximab;   Drug: Isotretinoin;   Other: Laboratory Biomarker Analysis;   Drug: Lenalidomide;   Other: Pharmacological Study
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Mon, 22 Oct 2012 12:00:00 EDT

Comparison of Two Laser Therapy Methods for PDR

Condition:   Proiriftrative Diabetic Retinopathy
Interventions:   Procedure: conventional prp;   Procedure: targeted prp
Sponsor:   Shahid Beheshti University of Medical Sciences
Unknown status

Tue, 02 Nov 2010 12:00:00 EDT

A Companion Treatment Study for Patients With Moderate to Severe Acne Vulgaris

Condition:   Acne Vulgaris
Interventions:   Drug: Isotretinoin;   Drug: Amzeeq 4% Topical Foam
Sponsors:   Edward Lain, MD;   Vyne Therapeutics Inc.
Recruiting

Mon, 28 Jun 2021 12:00:00 EDT

Isotretinoin in Treatment of COVID-19

Condition:   COVID-19
Intervention:   Drug: Isotretinoin Only Product in Oral Dose Form
Sponsor:   Tanta University
Not yet recruiting

Fri, 24 Apr 2020 12:00:00 EDT

Efficacy and Safety of IDP-121 and IDP-121 Vehicle Lotion in the Treatment of Acne Vulgaris

Condition:   Acne
Interventions:   Drug: IDP 121 Lotion;   Drug: IDP-121 Vehicle Lotion
Sponsor:   Bausch Health Americas, Inc.
Completed

Wed, 16 Nov 2016 12:00:00 EST

Efficacy and Safety of IDP-121 and IDP-121 Vehicle Lotion in the Treatment of Acne Vulgaris

Condition:   Acne
Interventions:   Drug: IDP-121 Lotion;   Drug: IDP-121 Vehicle Lotion
Sponsor:   Bausch Health Americas, Inc.
Completed

Thu, 13 Oct 2016 12:00:00 EDT

Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid Leukemia

Conditions:   Leukemia;   Neutropenia
Interventions:   Biological: filgrastim;   Drug: amsacrine;   Drug: cyclophosphamide;   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: etoposide;   Drug: idarubicin;   Drug: mitoxantrone hydrochloride;   Drug: thioguanine;   Drug: tretinoin;   Procedure: allogeneic bone marrow transplantation;   Procedure: autologous bone marrow transplantation;   Procedure: peripheral blood stem cell transplantation;   Radiation: radiation therapy
Sponsor:   Medical Research Council
Unknown status

Thu, 10 Apr 2003 12:00:00 EDT

Chemotherapy and Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma

Condition:   Neuroblastoma
Interventions:   Biological: filgrastim;   Drug: carboplatin;   Drug: cisplatin;   Drug: cyclophosphamide;   Drug: dacarbazine;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: ifosfamide;   Drug: melphalan;   Drug: tretinoin;   Drug: vincristine sulfate;   Drug: vindesine;   Procedure: autologous bone marrow transplantation;   Procedure: conventional surgery;   Procedure: peripheral blood stem cell transplantation;   Radiation: radiation therapy
Sponsor:   Gesellschaft fur Padiatrische Onkologie und Hamatologie - Germany
Completed

Mon, 27 Jan 2003 12:00:00 EST

Intensive Compared With Nonintensive Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

Conditions:   Leukemia;   Myelodysplastic Syndromes;   Myelodysplastic/Myeloproliferative Neoplasms
Interventions:   Drug: cytarabine;   Drug: daunorubicin hydrochloride;   Drug: etoposide;   Drug: hydroxyurea;   Drug: idarubicin;   Drug: mitoxantrone hydrochloride;   Drug: thioguanine;   Drug: tretinoin;   Drug: valspodar
Sponsor:   Leukemia Research Fund
Completed

Mon, 27 Jan 2003 12:00:00 EST

Treatment of Melasma With Stabilized Kligman Preparation Associated or Not With Pulsed Dye Laser

Condition:   Melanosis
Interventions:   Procedure: pulsed dye laser treatment;   Drug: Kligman's Trio
Sponsor:   Centre Hospitalier Universitaire de Nice
Terminated

Tue, 17 Mar 2009 12:00:00 EDT

A Phase I Dose Escalation Study of GSK2879552 in Subjects With Acute Myeloid Leukemia (AML)

Condition:   Leukaemia, Myelocytic, Acute
Interventions:   Drug: GSK2879552;   Drug: ATRA
Sponsor:   GlaxoSmithKline
Terminated

Mon, 30 Jun 2014 12:00:00 EDT

High Dose Chemotherapy and Autologous Transplant for Neuroblastoma

Condition:   Neuroblastoma
Interventions:   Drug: Carboplatin;   Biological: Autologous stem cell infusion;   Biological: Granulocyte colony stimulating factor;   Radiation: Radiation therapy;   Drug: Isotretinoin (13-cis-retinoic acid);   Drug: Melphalan;   Drug: Etoposide
Sponsor:   Masonic Cancer Center, University of Minnesota
Recruiting

Mon, 06 Feb 2012 12:00:00 EST

Genomic Based Assignment of Therapy in Advanced Urothelial Carcinoma

Conditions:   Urothelial Carcinoma;   Bladder Cancer;   Urinary Bladder Neoplasms
Interventions:   Drug: 75 approved agents;   Other: COXEN
Sponsor:   National Cancer Institute (NCI)
Completed

Thu, 02 Jun 2016 12:00:00 EDT

A Study for Improving the Outcome of Childhood Acute Promyeloid Leukemia

Condition:   Childhood Acute Promyelocytic Leukemia
Interventions:   Drug: ATO;   Drug: RIF;   Drug: ATRA;   Drug: mitoxantrone;   Drug: Ara-C;   Drug: MTX;   Drug: 6MP;   Other: intrathecal injection
Sponsor:   South China Children's Leukemia Group
Enrolling by invitation

Fri, 25 Jul 2014 12:00:00 EDT

A Biomarker Evaluation Trial of UAB30 in Renal Transplant Recipients at High Risk for Non-melanoma Skin Cancer

Condition:   Non-melanoma Skin Cancer
Interventions:   Drug: UAB30;   Drug: Placebo
Sponsor:   University of Alabama at Birmingham
Recruiting

Tue, 31 Oct 2017 12:00:00 EDT

Temozolomide Alone or in Combination With Thalidomide and/or Isotretinoin and/or Celecoxib in Treating Patients Who Have Undergone Radiation Therapy for Glioblastoma Multiforme

Condition:   Brain and Central Nervous System Tumors
Interventions:   Drug: Celecoxib;   Drug: Isotretinoin;   Drug: Temozolomide;   Drug: Thalidomide
Sponsors:   M.D. Anderson Cancer Center;   National Cancer Institute (NCI)
Completed

Fri, 03 Jun 2005 12:00:00 EDT

Impact of Vitamin A on RAR Gene Expression in Multiple Sclerosis

Condition:   Relapsing Remitting Multiple Sclerosis
Interventions:   Drug: Dietary Supplement: vitamin A;   Drug: placebo
Sponsor:   Tehran University of Medical Sciences
Unknown status

Fri, 12 Oct 2012 12:00:00 EDT

Effects of Isotretinoin on the Growth Rate and Thickness of the Nail Plate

Conditions:   Isotretinoin;   Nail Abnormality
Intervention:   Drug: Isotretinoin
Sponsor:   Sinan Özçelik
Completed

Wed, 09 Dec 2020 12:00:00 EST

SY-1425 Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic Syndrome

Condition:   Myelodysplastic Syndromes
Interventions:   Drug: SY-1425 + Azacitidine;   Drug: SY-1425 Matched Placebo + Azacitidine
Sponsor:   Syros Pharmaceuticals
Recruiting

Mon, 15 Mar 2021 12:00:00 EDT

Efficacy of Topical Antioxidants in Tretment of Photoaging

Condition:   Photoaging
Intervention:   Drug: Selenium Amino Acid Chelate (Selenium ACE cream)
Sponsor:   Sohag University
Not yet recruiting

Thu, 08 Apr 2021 12:00:00 EDT

Treatment With Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination With Irinotecan and Temozolomide After Intensive Therapy for People With High-Risk Neuroblastoma (NBL)

Conditions:   Ganglioneuroblastoma, Nodular;   High Risk Neuroblastoma
Interventions:   Biological: Dinutuximab;   Drug: Irinotecan;   Drug: Isotretinoin;   Biological: Sargramostim;   Drug: Temozolomide
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Recruiting

Tue, 12 May 2020 12:00:00 EDT

Economic Analysis of Blood Product Transfusions According to the Treatment of Acute Myeloid Leukaemia in the Elderly

Condition:   Acute Myeloid Leukemia
Intervention:   Other: Transfusion
Sponsor:   Hospices Civils de Lyon
Completed

Wed, 27 Jul 2016 12:00:00 EDT

Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With Neuroblastoma

Condition:   High Risk Neuroblastoma
Interventions:   Biological: Aldesleukin;   Other: Diagnostic Laboratory Biomarker Analysis;   Biological: Dinutuximab;   Drug: Isotretinoin;   Biological: Sargramostim
Sponsor:   National Cancer Institute (NCI)
Completed

Fri, 01 Jan 2010 12:00:00 EST

Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With Neuroblastoma

Conditions:   Localized Resectable Neuroblastoma;   Localized Unresectable Neuroblastoma;   Recurrent Neuroblastoma;   Regional Neuroblastoma;   Stage 4 Neuroblastoma;   Stage 4S Neuroblastoma
Interventions:   Biological: Aldesleukin;   Biological: Dinutuximab;   Drug: Isotretinoin;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study;   Other: Quality-of-Life Assessment;   Biological: Sargramostim
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Mon, 27 Jan 2003 12:00:00 EST

Effect of Home-fortification With Sprinkles in Hematologic and Nutritional Status in Preschool Children in Medellín

Condition:   Malnutrition
Interventions:   Dietary Supplement: Sachets containing a blend of micronutrients in powder form (Iron, Zinc, Folic Acid, Vitamin A and C), sprinkled onto home made food;   Dietary Supplement: placebo
Sponsor:   CES University
Unknown status

Tue, 06 Aug 2013 12:00:00 EDT

Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque Psoriasis

Condition:   Psoriasis
Interventions:   Drug: GSK2981278 0.03%;   Drug: GSK2981278 0.1%;   Drug: GSK2981278 0.8%;   Drug: GSK2981278 4%;   Drug: Vehicle;   Drug: Betamethasone valerate 0.1%
Sponsor:   GlaxoSmithKline
Completed

Mon, 14 Sep 2015 12:00:00 EDT

Study of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic Leukemia

Condition:   Acute Promyelocytic Leukemia
Intervention:   Drug: NRX 195183 Soft Gelatin Capsule
Sponsor:   NuRx Pharmaceuticals, Inc.
Unknown status

Mon, 12 May 2008 12:00:00 EDT

Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant

Conditions:   Ganglioneuroblastoma;   High Risk Neuroblastoma
Interventions:   Procedure: Autologous Hematopoietic Stem Cell Transplantation;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Cyclophosphamide;   Drug: Dexrazoxane;   Biological: Dinutuximab;   Drug: Doxorubicin;   Drug: Etoposide;   Radiation: External Beam Radiation Therapy;   Drug: Isotretinoin;   Drug: Melphalan;   Biological: Sargramostim;   Drug: Thiotepa;   Drug: Topotecan;   Drug: Vincristine
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Wed, 26 Dec 2018 12:00:00 EST

Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or Ganglioneuroblastoma

Conditions:   Ganglioneuroblastoma;   INRG Stage L2;   INRG Stage M;   INRG Stage MS;   Neuroblastoma
Interventions:   Procedure: Autologous Hematopoietic Stem Cell Transplantation;   Drug: Busulfan;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Crizotinib;   Drug: Cyclophosphamide;   Drug: Dexrazoxane Hydrochloride;   Biological: Dinutuximab;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide Phosphate;   Radiation: External Beam Radiation Therapy;   Radiation: Iobenguane I-131;   Drug: Isotretinoin;   Drug: Melphalan Hydrochloride;   Biological: Sargramostim;   Procedure: Therapeutic Conventional Surgery;   Drug: Thiotepa;   Drug: Topotecan Hydrochloride;   Drug: Vincristine Sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Recruiting

Tue, 25 Apr 2017 12:00:00 EDT

Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System

Conditions:   Medulloblastoma;   Pineoblastoma;   Supratentorial Embryonal Tumor, Not Otherwise Specified
Interventions:   Radiation: 3-Dimensional Conformal Radiation Therapy;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Cyclophosphamide;   Drug: Etoposide Phosphate;   Drug: Isotretinoin;   Other: Laboratory Biomarker Analysis;   Procedure: Peripheral Blood Stem Cell Transplantation;   Drug: Thiotepa;   Drug: Vincristine Sulfate;   Drug: Vorinostat
Sponsor:   National Cancer Institute (NCI)
Active, not recruiting

Mon, 23 Mar 2009 12:00:00 EDT

Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNET

Conditions:   Anaplastic Medulloblastoma;   Medulloblastoma
Interventions:   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Cyclophosphamide;   Biological: Filgrastim;   Drug: Isotretinoin;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment;   Radiation: Radiation Therapy;   Drug: Vincristine Sulfate
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Active, not recruiting

Thu, 26 Oct 2006 12:00:00 EDT

Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma

Conditions:   Localized Resectable Neuroblastoma;   Localized Unresectable Neuroblastoma;   Recurrent Neuroblastoma;   Regional Neuroblastoma;   Stage 4 Neuroblastoma;   Stage 4S Neuroblastoma
Interventions:   Procedure: Autologous Hematopoietic Stem Cell Transplantation;   Drug: Carboplatin;   Drug: Cisplatin;   Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Radiation: External Beam Radiation Therapy;   Biological: Filgrastim;   Drug: Isotretinoin;   Other: Laboratory Biomarker Analysis;   Drug: Melphalan;   Procedure: Peripheral Blood Stem Cell Transplantation;   Other: Pharmacological Study;   Drug: Thiotepa;   Drug: Topotecan Hydrochloride;   Drug: Vincristine Sulfate Liposome
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Active, not recruiting

Wed, 05 Dec 2007 12:00:00 EST

Airway Intervention Registry (AIR): Recurrent Respiratory Papillomatosis (RRP)

Conditions:   Recurrent Respiratory Papillomatosis;   Human Papilloma Virus
Interventions:   Procedure: Microdebrider;   Procedure: Cold-steel surgery (forceps);   Procedure: Carbon dioxide laser;   Procedure: Potassium titanyl phosphate (KTP) laser;   Procedure: Pulsed dye laser;   Procedure: Radiofrequency ablation;   Procedure: Monopolar suction diathermy;   Procedure: Plasma coagulation;   Procedure: Other;   Other: Adjuvant therapies
Sponsors:   Newcastle-upon-Tyne Hospitals NHS Trust;   Alder Hey Children's NHS Foundation Trust;   National Institute for Health Research, United Kingdom
Recruiting

Wed, 14 Mar 2018 12:00:00 EDT

Therapy for Children With Advanced Stage Neuroblastoma

Condition:   Neuroblastoma
Interventions:   Drug: cyclophosphamide;   Drug: topotecan;   Biological: hu14.18K322A;   Procedure: peripheral blood stem cell harvest;   Procedure: surgical resection;   Drug: cisplatin;   Drug: etoposide;   Drug: doxorubicin;   Drug: vincristine;   Drug: busulfan;   Drug: melphalan;   Biological: peripheral blood stem cell transplantation;   Biological: natural killer cell infusion;   Radiation: radiation therapy;   Biological: GM-CSF;   Biological: G-CSF;   Drug: mesna;   Drug: levetiracetam;   Biological: interleukin-2;   Drug: Isotretinoin;   Device: CliniMACS
Sponsors:   St. Jude Children's Research Hospital;   Cookies for Kids' Cancer;   CURE Childhood Cancer, Inc.
Active, not recruiting

Mon, 20 May 2013 12:00:00 EDT

An Efficacy and Safety Study of Palovarotene for the Treatment of MO

Condition:   Exostoses, Multiple Hereditary
Interventions:   Drug: Palovarotene 2.5 mg;   Drug: Palovarotene 5.0 mg;   Other: Placebo
Sponsor:   Clementia Pharmaceuticals Inc.
Terminated

Thu, 22 Feb 2018 12:00:00 EST

An Efficacy and Safety Study of Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva.

Condition:   Fibrodysplasia Ossificans Progressiva
Intervention:   Drug: Palovarotene
Sponsor:   Clementia Pharmaceuticals Inc.
Active, not recruiting

Wed, 18 Oct 2017 12:00:00 EDT

In-Home Evaluation of Episodic Administration of Palovarotene in Fibrodysplasia Ossificans Progressiva (FOP) Subjects

Condition:   Fibrodysplasia Ossificans Progressiva
Intervention:   Drug: Palovarotene
Sponsor:   Clementia Pharmaceuticals Inc.
Terminated

Thu, 13 Aug 2015 12:00:00 EDT

An Efficacy and Safety Study of Palovarotene to Treat Preosseous Flare-ups in FOP Subjects

Condition:   Fibrodysplasia Ossificans Progressiva
Interventions:   Drug: Palovarotene;   Drug: Placebo
Sponsor:   Clementia Pharmaceuticals Inc.
Completed

Tue, 15 Jul 2014 12:00:00 EDT

Autologous Cell Suspension Grafting Using ReCell in Vitiligo and Piebaldism Patients

Conditions:   Segmental Vitiligo;   Piebaldism
Interventions:   Device: ReCell;   Device: Full surface CO2 laser 200 mJ;   Device: Full surface CO2 laser 150 mJ;   Device: Fractional CO2 laser 7.5 mJ, 20%
Sponsors:   Netherlands Institute for Pigment Disorders;   Avita Medical
Completed

Mon, 01 Jun 2015 12:00:00 EDT

Interventional Testing of Gene-environment Interactions Via the Verifomics Mobile Application

Conditions:   Obesity;   Rhinitis;   Rhinitis, Allergic;   Respiratory Sounds;   Dyspnea;   Headache;   Migraine Disorders;   Arthritis;   Arthralgia;   Anxiety;   Sleep Initiation and Maintenance Disorders;   Sleep Deprivation
Interventions:   Dietary Supplement: Vitamin A;   Dietary Supplement: Vitamin B6;   Dietary Supplement: Vitamin C;   Dietary Supplement: Nicotinamide;   Dietary Supplement: Vitamin D3;   Dietary Supplement: Vitamin E;   Other: Broccoli;   Other: Spinach;   Dietary Supplement: Caffeine;   Other: Coffee;   Device: Axon Eyewear;   Other: Chocolate
Sponsor:   Verifomics LLC
Terminated

Tue, 03 May 2016 12:00:00 EDT

131MIBG to Treat Malignant Pheochromocytoma

Condition:   Pheochromocytoma
Interventions:   Drug: [131]I-MIBG;   Drug: 6-[18F]Fluorodopamine;   Drug: [123]I-MIBG
Sponsor:   Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Completed

Wed, 12 Dec 2001 12:00:00 EST

High Throughput Drug Sensitivity Assay and Genomics- Guided Treatment of Patients With Relapsed or Refractory Acute Leukemia

Conditions:   Recurrent Acute Leukemia of Ambiguous Lineage;   Recurrent Acute Lymphoblastic Leukemia;   Recurrent Acute Myeloid Leukemia;   Refractory Acute Lymphoblastic Leukemia;   Refractory Acute Myeloid Leukemia;   Refractory Acute Leukemia of Ambiguous Lineage
Interventions:   Other: Chemosensitivity Assay;   Other: Cytology Specimen Collection Procedure;   Genetic: Gene Expression Analysis;   Genetic: Genetic Variation Analysis;   Drug: In Vitro Sensitivity-Directed Chemotherapy
Sponsors:   University of Washington;   National Cancer Institute (NCI)
Active, not recruiting

Wed, 16 Sep 2015 12:00:00 EDT

European Low and Intermediate Risk Neuroblastoma Protocol

Condition:   LOW AND INTERMEDIATE PAEDIATRIC NEUROBLASTOMA AND NEONATAL SUPRARENAL MASSES
Intervention:   Drug: chemotherapy
Sponsor:   Instituto de Investigacion Sanitaria La Fe
Recruiting

Fri, 16 Nov 2012 12:00:00 EST

Phase I Dose-Escalation Trial of Clofarabine Followed by Escalating Doses of Fractionated Cyclophosphamide in Children With Relapsed or Refractory Acute Leukemias

Conditions:   Myelodysplastic Syndrome;   Acute Myeloid Leukemia;   Myeloproliferative Disorders;   Acute Lymphocytic Leukemia;   Acute Promyelocytic Leukemia;   Acute Leukemia;   Chronic Myelogenous Leukemia;   Myelofibrosis;   Chronic Myelomonocytic Leukemia;   Juvenile Myelomonocytic Leukemia
Interventions:   Drug: Clofarabine;   Drug: Cyclophosphamide
Sponsors:   Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins;   Genzyme, a Sanofi Company
Terminated

Fri, 27 Feb 2009 12:00:00 EST

High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade Gliomas

Conditions:   Brain Tumor;   Central Nervous System Tumor
Interventions:   Biological: filgrastim;   Drug: carboplatin;   Drug: etoposide;   Drug: isotretinoin;   Drug: thiotepa;   Procedure: autologous bone marrow transplantation;   Procedure: peripheral blood stem cell transplantation
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Tue, 09 Mar 2004 12:00:00 EST

Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With Neuroblastoma

Condition:   Neuroblastoma
Interventions:   Drug: carboplatin;   Drug: cyclophosphamide;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: topotecan hydrochloride;   Drug: Isotretinoin;   Procedure: Surgery;   Drug: Filgrastim
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Wed, 11 Jul 2007 12:00:00 EDT

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma

Condition:   Neuroblastoma
Interventions:   Biological: filgrastim;   Drug: carboplatin;   Drug: cisplatin;   Drug: cyclophosphamide;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: isotretinoin;   Drug: melphalan;   Drug: topotecan hydrochloride;   Drug: vincristine sulfate;   Procedure: autologous bone marrow transplantation;   Procedure: bone marrow ablation with stem cell support;   Procedure: conventional surgery;   Procedure: peripheral blood stem cell transplantation;   Radiation: radiation therapy
Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
Completed

Mon, 27 Jan 2003 12:00:00 EST