Clinical Trials
Atralin Gel for the Treatment of RosaceaCondition: RosaceaInterventions: Drug: vehicle gel; Drug: Atralin gel Sponsors: Lisa E. Maier; Bausch Health Americas, Inc. Terminated Wed, 19 May 2010 12:00:00 EDT Pembrolizumab and All-Trans Retinoic Acid Combination Treatment of Advanced MelanomaConditions: Stage IV Melanoma; Stage III Melanoma; Advanced MelanomaIntervention: Drug: Pembrolizumab with All-Trans Retinoic Acid Sponsors: University of Colorado, Denver; Merck Sharp & Dohme Corp. Active, not recruiting Tue, 27 Jun 2017 12:00:00 EDT Safety and Tolerability of Acanya Gel in Combination With Atralin Gel for Acne VulgarisCondition: Acne VulgarisIntervention: Drug: Benzoyl peroxide 2.5%/clindamycin phosphate 1.2% in the morning with with tretinoin 0.05% gel in the evening Sponsor: Zeichner, Joshua, M.D. Unknown status Fri, 07 Oct 2011 12:00:00 EDT A Trial of All-trans Retinoic Acid (ATRA) in Advanced Adenoid Cystic CarcinomaCondition: Adenoid Cystic CarcinomaIntervention: Drug: Tretinoin Sponsors: Dana-Farber Cancer Institute; The V Foundation; ACCRF Completed Thu, 27 Jun 2019 12:00:00 EDT Effectivity of 1 Finger Tip Unit Compared to 2 Finger Tip Units 0.05% Tretinoin CreamCondition: PhotoagingIntervention: Drug: 0.05% Tretinoin Sponsor: Dr.dr.Irma Bernadette, SpKK (K) Not yet recruiting Fri, 13 Aug 2021 12:00:00 EDT A Study Comparing Tretinoin Cream 0.025% and RETIN-A® Cream 0.025% in the Treatment of Acne VulgarisCondition: Acne VulgarisIntervention: Drug: Tretinoin Cream 0.025% Sponsor: Taro Pharmaceuticals USA Completed Tue, 26 Jan 2021 12:00:00 EST Clinical Evaluation of the Photoallergy Potential of Atralin GelCondition: HealthyIntervention: Drug: Atralin (tretinoin) gel, 0.05% Sponsor: Coria Laboratories, Ltd. Completed Tue, 29 Jan 2008 12:00:00 EST Ipilimumab and All-Trans Retinoic Acid Combination Treatment of Advanced MelanomaCondition: MelanomaInterventions: Drug: VESANOID; Drug: Ipilimumab Sponsor: University of Colorado, Denver Active, not recruiting Tue, 31 Mar 2015 12:00:00 EDT 90Y DOTA/Retinoic Acid for Neuroblastoma and Neuroendocrine Tumor (NET)Conditions: Neuroblastoma; Neuroendocrine TumorInterventions: Drug: Retinoic Acid; Drug: Placebo Sponsors: University of Iowa; Molecular Insight Pharmaceuticals, Inc. Withdrawn Wed, 13 Jan 2010 12:00:00 EST A Study That Evaluates the Decrease in Irritation When Using Additional Acne Treatment ProductsCondition: Acne VulgarisInterventions: Drug: Dapsone plus Tretinoin Gel; Drug: Tretinoin Gel Sponsor: Bausch Health Americas, Inc. Completed Mon, 14 Mar 2011 12:00:00 EDT 
Altreno for Chest RejuvenationConditions: Photodamaged Skin; PhotoagingInterventions: Drug: tretinoin 0.05% lotion (Altreno); Other: Vehicle Sponsors: Goldman, Butterwick, Fitzpatrick and Groff; Bausch Health Americas, Inc. Active, not recruiting Fri, 20 Sep 2019 12:00:00 EDT To Evaluate the Therapeutic Equivalence and Safety of TRETINOIN CREAM, 0.1% and RLD in the Treatment of Acne VulgarisCondition: Acne VulgarisInterventions: Drug: Tretinoin cream 0.1%; Drug: RETIN-A® Cream; Drug: Vehicle of the test product Sponsor: Taro Pharmaceuticals USA Completed Fri, 09 Feb 2018 12:00:00 EST Prevention of Drug Rash From Certain Cancer Therapies Using Tretinoin CreamCondition: Medication ReactionIntervention: Drug: Tretinoin Sponsor: Johns Hopkins University Withdrawn Fri, 06 May 2011 12:00:00 EDT Study to Determine the Phototoxity of Atralin (Tretinoin) Gel, 0.05%Condition: HealthyIntervention: Drug: Atralin (tretinoin) Gel, 0.05% Sponsor: Coria Laboratories, Ltd. Completed Tue, 29 Jan 2008 12:00:00 EST To Evaluate the Therapeutic Equivalence and Safety of TRETINOIN CREAM, 0.05% and RLD in the Treatment of Acne VulgarisCondition: Acne VulgarisInterventions: Drug: Tretinoin cream, 0.05%; Drug: RETIN-A® (tretinoin) cream, 0.05%; Drug: Vehicle of the test product Sponsor: Taro Pharmaceuticals USA Completed Wed, 14 Feb 2018 12:00:00 EST A Comparative Study of Adapalene Gel,0.3% Versus Tretinoin Emollient Cream, 0.05% for the Treatment of PhotoagingConditions: Photoaging; PhotodamageInterventions: Drug: Adapalene; Drug: Tretinoin Sponsor: Galderma Brasil Ltda. Completed Fri, 29 Jul 2011 12:00:00 EDT Comparison of Retinol 1.0% and Tretinoin 0.02% in the Treatment of Moderate to Severe Photodamage and WrinklesConditions: Photodamaged Skin; WrinklesInterventions: Drug: Retinol; Drug: Tretinoin Sponsor: Johns Hopkins University Completed Wed, 26 Jan 2011 12:00:00 EST Randomized,International Multi-center Clinical Trial of RIF Plus RA for Non-high-risk APLCondition: Acute Promyelocytic LeukaemiaIntervention: Drug: Compound Realgar-Indigo Naturalis Formula Plus Retinoic Acid Sponsors: Peking University People's Hospital; Ministry of Science and Technology of the People´s Republic of China Not yet recruiting Mon, 25 Nov 2019 12:00:00 EST Cabozantinib in Combination With 13-cis-Retinoic Acid in Children With Relapsed or Refractory Solid TumorsCondition: Solid TumorInterventions: Drug: Cabozantinib; Drug: 13-cis-retinoic acid Sponsors: Peter Zage; Exelixis Recruiting Thu, 02 Aug 2018 12:00:00 EDT PHNA, Efficacy of Tretinoin Cream on Post-phototherapy HyperpigmentationCondition: VitiligoInterventions: Drug: Tretinoin 0.05% cream; Drug: Placebo cream Sponsor: The Catholic University of Korea Completed Wed, 01 May 2019 12:00:00 EDT
Combination Therapy With Ursodeoxycholic Acid (UDCA) and All-Trans Retinoic Acid (ATRA) for Treatment of Primary Sclerosing CholangitisCondition: Cholangitis, SclerosingIntervention: Drug: Oral all-trans retinoic acid (ATRA) Sponsors: Yale University; Mayo Clinic Completed Thu, 20 Oct 2011 12:00:00 EDT Trial Comparing Treatment of Tretinoin or Superficial Dermabrasion for Stretch MarksConditions: Stretch Marks; Striae; TreatmentInterventions: Drug: Tretinoin cream 0.005%; Device: Superficial Dermabrasion Sponsor: Brazilan Center for Studies in Dermatology Completed Wed, 09 Dec 2009 12:00:00 EST Dapsone Gel 5% and Tretinoin Gel 0.025% Versus Tretinoin Gel 0.025% Monotherapy for Facial Acne VulgarisCondition: Acne VulgarisInterventions: Drug: Dapsone; Tretinoin; Drug: Tretinoin Sponsor: Allergan Completed Tue, 03 Feb 2009 12:00:00 EST Investigating the Potential Role of Aerosolized All-trans Retinoic Acid for Treating COVID-19 Anosmia and Regaining Sense of Smell.Condition: Post COVID-19 Anosmia (Loss of Smell)Interventions: Drug: Aerosolized All trans retinoic acid; Drug: Placebo/Control Sponsors: Amr kamel khalil Ahmed; Faculty of Medicine, Kafrelshiekh Univversity,Egypt. Not yet recruiting Thu, 12 Aug 2021 12:00:00 EDT RA-4: 13-cis Retinoic Acid for Treatment of Men With AzoospermiaCondition: Male Infertility, AzoospermiaIntervention: Drug: 13-cis retinoic acid Sponsor: University of Washington Completed Fri, 27 Oct 2017 12:00:00 EDT Combined Tretinoin and Arsenic Trioxide for Patients With Newly Diagnosed Acute Promyelocytic Leukemia Followed by Risk-Adapted Postremission TherapyCondition: Acute Promyelocytic LeukemiaIntervention: Drug: Tretinoin and Arsenic Trioxide Sponsors: Memorial Sloan Kettering Cancer Center; Northwestern University; New York Presbyterian Hospital; University of Southern California; Princess Margaret Hospital, Canada; National Heart, Lung, and Blood Institute (NHLBI) Completed Thu, 28 Jul 2011 12:00:00 EDT Study Comparing Acne in Patients Taking Oral Minocycline to Patients Taking Minocycline Plus Topical TretinoinCondition: Acne VulgarisInterventions: Drug: Minocycline; Drug: Minocycline plus tretinoin Sponsors: Derm Research @ 888 Inc.; Stiefel, a GSK Company Terminated Tue, 18 Oct 2005 12:00:00 EDT A Study to Determine the Safety and Efficacy of Atralin (Tretinoin 0.05%) Gel for the Treatment of RosaceaCondition: RosaceaInterventions: Drug: tretinoin gel 0.05%; Drug: vehicle Sponsor: Coria Laboratories, Ltd. Completed Fri, 22 Feb 2008 12:00:00 EST ZD6474 Alone and in Combination With Retinoic Acid in Pediatric NeuroblastomaCondition: NeuroblastomaInterventions: Drug: ZD6474; Drug: Retinoic Acid Sponsors: M.D. Anderson Cancer Center; AstraZeneca Terminated Fri, 21 Sep 2007 12:00:00 EDT Adapalene Gel 0.3% Versus Tretinoin 0.05% Emollient Cream for Treatment of PhotodamageCondition: PhotoagingInterventions: Drug: adapalene gel, 0.3%; Drug: tretinoin 0.05% emollient cream Sponsor: Galderma Laboratories, L.P. Completed Mon, 31 Mar 2008 12:00:00 EDT
Opsin Receptors in MelasmaCondition: MelasmaIntervention: Drug: Retinoic acid Sponsors: Universidad Autonoma de San Luis Potosí; Hospital Central "Dr. Ignacio Morones Prieto" Completed Thu, 04 Jun 2020 12:00:00 EDT 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of First Remission After Non-Myeloablative Therapy in Patients With High-Risk NeuroblastomaCondition: NeuroblastomaIntervention: Drug: 3F8 and 13-cis-retinoic acid Sponsor: Memorial Sloan Kettering Cancer Center Completed Tue, 17 Aug 2010 12:00:00 EDT Phase I/II Trial of ATRA and TCP in Patients With Relapsed or Refractory AML and no Intensive Treatment is PossibleCondition: AMLInterventions: Drug: Tranylcypromine; Drug: Tretinoin Sponsor: Martin-Luther-Universität Halle-Wittenberg Unknown status Fri, 10 Oct 2014 12:00:00 EDT 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of Second or Greater Remission of High-Risk NeuroblastomaCondition: NeuroblastomaIntervention: Biological: 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid Sponsor: Memorial Sloan Kettering Cancer Center Terminated Wed, 18 Aug 2010 12:00:00 EDT Bioequivalence Study of Tretinoin Gel 0.05% to Brand Tretinoin GelCondition: AcneIntervention: Drug: Tretinoin Sponsor: Spear Pharmaceuticals Completed Fri, 26 Sep 2014 12:00:00 EDT Split-face Tolerability Comparison Between Adapalene-Benzoyl Peroxide Gel Versus Tretinoin GelCondition: Acne VulgarisInterventions: Drug: Epiduo Gel; Drug: Retin-A Micro Microsphere 0.1% Sponsor: Galderma Laboratories, L.P. Completed Tue, 31 Jan 2012 12:00:00 EST Lithium Carbonate and Tretinoin in Treating Patients With Relapsed or Refractory Acute Myeloid LeukemiaConditions: Adult Acute Megakaryoblastic Leukemia (M7); Adult Acute Monoblastic Leukemia (M5a); Adult Acute Monocytic Leukemia (M5b); Adult Acute Myeloblastic Leukemia With Maturation (M2); Adult Acute Myeloblastic Leukemia Without Maturation (M1); Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Myelomonocytic Leukemia (M4); Adult Erythroleukemia (M6a); Adult Pure Erythroid Leukemia (M6b); Recurrent Adult Acute Myeloid LeukemiaInterventions: Drug: tretinoin; Drug: lithium carbonate; Other: laboratory biomarker analysis Sponsors: Paolo Caimi, MD; National Cancer Institute (NCI) Completed Fri, 29 Mar 2013 12:00:00 EDT An Efficacy Trial of Low Dose All-trans Retinoic Acid in Patients With Primary Sclerosing CholangitisCondition: Cholangitis, SclerosingIntervention: Drug: All-trans retinoic acid Sponsor: Yale University Terminated Sat, 02 Dec 2017 12:00:00 EST Assessing the Effects of Tretinoin Cream on Human Skin With Optical Imaging TechnologiesCondition: Collagen Fibril AlterationIntervention: Drug: Tretinoin cream 0.1% Sponsors: University of California, Irvine; Unilever R&D; Beckman Laser Institute University of California Irvine Completed Wed, 08 Apr 2015 12:00:00 EDT Combination of Chemopreventive Agents (All- Trans Retinoic Acid and Tamoxifen) as Potential Treatment for the Lung Complication of COVID-19Condition: the Lung Complication of COVID-19Interventions: Combination Product: Aerosolized All-Trans Retinoic acid plus oral Tamoxifen; Other: Standard treatment Sponsor: Kafrelsheikh University Not yet recruiting Tue, 29 Sep 2020 12:00:00 EDT
Aerosol Combination Therapy of All-trans Retinoic Acid and Isotretinoin as A Novel Treatment for Inducing Neutralizing Antibodies in COVID -19 Infected Patients Better Than Vaccine : An Innovative TreatmentCondition: COVID-19Interventions: Drug: Aerosolized 13 cis retinoic acid; Drug: Aerosolized All trans retinoic acid; Other: Placebo Sponsors: Kafrelsheikh University; Damietta University Not yet recruiting Wed, 20 May 2020 12:00:00 EDT Revlimid / All-Trans Retinoic Acid (ATRA) / Dexamethasone in Relapsed/Refractory Multiple MyelomaCondition: MyelomaInterventions: Drug: Lenalidomide; Drug: Dexamethasone; Drug: All-Trans Retinoic Acid (ATRA) Sponsors: M.D. Anderson Cancer Center; Celgene Corporation Terminated Fri, 15 Nov 2013 12:00:00 EST All-Trans Retinoic Acid (ATRA) and Atezolizumab for the Treatment of Recurrent or Metastatic Non-Small Cell Lung CancerConditions: Metastatic Lung Non-Small Cell Carcinoma; Recurrent Lung Non-Small Cell Carcinoma; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8Interventions: Biological: Atezolizumab; Drug: Tretinoin Sponsor: Dwight Owen Not yet recruiting Wed, 09 Jun 2021 12:00:00 EDT Bioequivalence Study of Generic Tretinoin 0.1% Microsphere Gel, 0.1% Retin-A Micro® and PlaceboCondition: AcneInterventions: Drug: Tretinoin microsphere 0.1%; Drug: Brand Retin-A Micro tretinoin microsphere gel 0.1%; Drug: placebo microsphere gel Sponsor: Spear Pharmaceuticals Completed Wed, 02 Jun 2010 12:00:00 EDT Evaluation of Irritation That Potentially Could be Caused by Two Facial Gels Applied to Opposite Sides of the FaceCondition: Acne VulgarisInterventions: Drug: Tretinoin Facial Gel; Drug: Adapalene/Benzoyl Peroxide Facial Gel Sponsor: Bausch Health Americas, Inc. Completed Thu, 06 Aug 2009 12:00:00 EDT Retinoic Acid Supplementation and Subjects With HypercholesterolemiaCondition: HypercholesterolemiaInterventions: Dietary Supplement: retinoic acid; Other: placebo Sponsor: Sun Yat-sen University Completed Wed, 15 Jul 2015 12:00:00 EDT High-Dose 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Consolidation of First Remission After Myeloablative Therapy and Autologous Stem-Cell TransplantationCondition: NeuroblastomaIntervention: Drug: 3F8 monoclonal antibody and 13-cis-Retinoic Acid Sponsor: Memorial Sloan Kettering Cancer Center Completed Tue, 17 Aug 2010 12:00:00 EDT Single Dose of 9-cis-retinoic Acid in Hepatic PatientsCondition: Hepatic InsufficiencyIntervention: Drug: 9-cis-retinoic acid Sponsor: University Hospital, Gentofte, Copenhagen Completed Wed, 03 Jul 2013 12:00:00 EDT Proof of Concept Study to Investigate the Recurrence of Acne Post IsotretinoinCondition: AcneInterventions: Drug: tretinoin microsphere 0.04% gel; Drug: vehicle gel Sponsors: Dermatrials Research; Johnson & Johnson Completed Tue, 14 Jul 2009 12:00:00 EDT Efficacy of Aerosol Combination Therapy of 13 Cis Retinoic Acid and Captopril for Treating Covid-19 Patients Via Indirect Inhibition of Transmembrane Protease, Serine 2 (TMPRSS2)Condition: Covid19Interventions: Combination Product: Aerosolized 13 cis retinoic acid plus Inhalation administration by nebulization captopril 25mg; Drug: Drug: Standard treatment Standard treatment Sponsor: Kafrelsheikh University Not yet recruiting Thu, 08 Oct 2020 12:00:00 EDT
A Study Comparing Combination Clindamycin Phosphate/Tretinoin Gel Alone Versus With Benzoyl Peroxide Foaming Cloths for Facial AcneCondition: Acne VulgarisInterventions: Drug: clindamycin phosphate 1.2%/tretinoin 0.025% gel alone; Drug: clindamycin phosphate 1.2%/tretinoin 0.025% gel plus benzoyl peroxide 6% foaming cloths Sponsor: Zeichner, Joshua, M.D. Unknown status Wed, 24 Aug 2011 12:00:00 EDT Retinoids in ANCA Small Vessel Vasculitis: Silencing AutoantigensCondition: Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisInterventions: Drug: Retinoic acid; Drug: Standard of care Sponsors: University of North Carolina, Chapel Hill; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Withdrawn Wed, 12 Jan 2011 12:00:00 EST Oral Isotretinoin Versus Topical Tretinoin for Actinic KeratosisCondition: Actinic KeratosisInterventions: Drug: Oral isotretinoin; Drug: Tretinoin 0,05% cream; Drug: Sunscreen FPS 60 Sponsors: Universidade Federal de Goias; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Theraskin; Germed Pharma Completed Thu, 30 Oct 2014 12:00:00 EDT A Study of Different Use Regimens Using Two Acne TreatmentsCondition: Acne VulgarisInterventions: Drug: benzoyl peroxide wash; Drug: Tretinoin gel Sponsor: Bausch Health Americas, Inc. Completed Fri, 22 May 2009 12:00:00 EDT Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 ( Isotretinoin in Treatment of COVID-19) (Randomized)Condition: COVID19Interventions: Drug: Drug Isotretinoin (13 cis retinoic acid ) capsules+standard treatment; Drug: Isotretinoin(Aerosolized 13 cis retinoic acid) +standard treatment; Drug: Isotretinoin (13 cis retinoic acid ) capsules; Drug: Aerosolized 13 cis retinoic acid; Drug: Standard treatment Sponsors: Kafrelsheikh University; 1-Foshan University Laboratory of Emerging Infectious Disease Institute of Translational Medicine The First Hospital of Jilin University China; 2-Montefiore Health System and Albert Einstein College of Medicine, Newyork, United States of America (U.S.A).; 2-Faculty of Science, Kafrelsheikh University, Egypt. Not yet recruiting Mon, 20 Apr 2020 12:00:00 EDT W0265-104: A Single-Center, Evaluator-Blinded, Randomized, Placebo-Controlled, Phase 1 Clinical Trial Evaluating the Photoallergic Potential of Topically Applied Clindamycin Phosphate 1.0% and Tretinoin 0.025% (CT Gel) in Healthy VolunteersCondition: Acne VulgarisInterventions: Drug: clindamycin1%/tretinoin 0.025% gel; Drug: vehicle gel Sponsor: GlaxoSmithKline Completed Mon, 05 Aug 2013 12:00:00 EDT Evaluation of Irritation That Could be Caused by Two Facial Gels Applied to Opposite Sides of the Face.Condition: Acne VulgarisInterventions: Drug: Adapalene Gel; Drug: Tretinoin Gel Sponsor: Bausch Health Americas, Inc. Completed Mon, 14 Jul 2008 12:00:00 EDT Liposomal Tretinoin in Treating Patients With Recurrent or Refractory Hodgkin's DiseaseCondition: LymphomaInterventions: Drug: Chemotherapy; Drug: Tretinoin Liposome Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI) Withdrawn Wed, 28 Apr 2004 12:00:00 EDT Efficiency And Safety Of Association Arbutin, Triamcinolone And Tretinoin In Treatment Of MelasmaCondition: MelasmaInterventions: Drug: arbutin, tretinoin, triamcinolone; Drug: Triluma Sponsor: Azidus Brasil Suspended Thu, 17 Jul 2008 12:00:00 EDT A Study Comparing Tretinoin Gel Microsphere, 0.1% and RETIN-A MICRO ® Gel Microsphere, 0.1% in the Treatment of Acne VulgarisCondition: Acne VulgarisInterventions: Drug: Tretinoin Gel Microsphere, 0.1%; Drug: RETIN-A MICRO® (Tretinoin) Gel Microsphere, 0.1%; Drug: Placebo Control Sponsor: Taro Pharmaceuticals USA Completed Wed, 12 May 2021 12:00:00 EDT
Determine the Efficacy of Topical Tretinoin Cream for the Prevention of Nonmelanoma Skin CancerConditions: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Skin NeoplasmsInterventions: Drug: Tretinoin 0.1% cream or placebo; Other: Placebo Sponsors: US Department of Veterans Affairs; Ortho Dermatologics Completed Mon, 01 Jan 2001 12:00:00 EST RA-2 13-cis Retinoic Acid (Isotretinoin)Conditions: Male Infertility; Klinefelter's Syndrome; Y-chromosome MicrodeletionsInterventions: Drug: 13-cis retinoic acid; Drug: Calcitriol Sponsor: University of Washington Completed Wed, 12 Feb 2014 12:00:00 EST IMG-7289, With and Without ATRA, in Patients With Advanced Myeloid MalignanciesConditions: Acute Myeloid Leukemia; Myelodysplastic SyndromeInterventions: Drug: IMG-7289; Drug: All-trans retinoic acid Sponsor: Imago BioSciences,Inc. Completed Mon, 25 Jul 2016 12:00:00 EDT Bioequivalence Study of Generic Tretinoin 0.04% Microsphere Gel, 0.04% Retin-A Micro® and PlaceboCondition: AcneInterventions: Drug: Tretinoin; Drug: placebo Sponsor: Spear Pharmaceuticals Completed Thu, 18 Nov 2010 12:00:00 EST Safety and Efficacy Study of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel to Treat RosaceaCondition: RosaceaInterventions: Drug: Clindamycin Phosphate 1.2% And Tretinoin 0.025% Gel; Drug: Placebo gel Sponsors: Massachusetts General Hospital; Medicis Pharmaceutical Corporation Completed Fri, 16 Jan 2009 12:00:00 EST Tretinoin in Treating Patients With Mycosis Fungoides or Sezary SyndromeCondition: LymphomaIntervention: Drug: tretinoin Sponsors: Northwestern University; National Cancer Institute (NCI) Completed Mon, 23 Aug 2004 12:00:00 EDT Study of Dasatinib and All-Trans Retinoic Acid for Relapsed/Refractory and/or Elderly Patients With Acute Myelogenous Leukemia (AML) or Myelodysplastic SyndromeConditions: Acute Myelogenous Leukemia; Myelodysplastic SyndromeInterventions: Drug: dasatinib (SPRYCEL); Drug: all trans retinoic acid (VESANOID) Sponsor: University of Pittsburgh Completed Mon, 04 May 2009 12:00:00 EDT Profiling the Skin Microbiome in Response to Altreno in Acne PatientsConditions: Acne; HealthyInterventions: Drug: Altreno; Drug: Benzoyl peroxide Sponsors: Beth Israel Deaconess Medical Center; Ortho Dermatologics Recruiting Mon, 14 Sep 2020 12:00:00 EDT De Novo Lipogenesis of Sebaceous Glands in AcneCondition: Acne VulgarisInterventions: Drug: Tretinoin; Drug: Isotretinoin Sponsor: University of California, Davis Completed Thu, 03 Dec 2015 12:00:00 EST Solar Lentigines Treatment With the Triple Combination CreamCondition: LentigoInterventions: Drug: Triple combination cream; Drug: Tretinoin 0.05% Sponsors: Pontificia Universidad Catolica de Chile; Galderma Laboratories, L.P. Completed Fri, 11 Sep 2009 12:00:00 EDT
Efficacy and Safety of Oral Isotretinoin for Cutaneous PhotodamageConditions: Photodamage; PhotoagingInterventions: Drug: oral isotretinoin; Drug: Tretinoin Sponsor: Federal University of São Paulo Unknown status Thu, 12 Feb 2009 12:00:00 EST A Study of Acne Treatment in Children Ages 9 to 11Condition: Acne VulgarisInterventions: Drug: Retin-A Micro 0.04% facial acne treatment; Drug: Vehicle control Sponsor: Bausch Health Americas, Inc. Completed Fri, 22 May 2009 12:00:00 EDT Efficacy & Safety of Clindamycin and Tretinoin in AcneCondition: AcneIntervention: Drug: Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel Sponsors: Callender Center for Clinical Research; Society Hill Dermatology Unknown status Wed, 28 Apr 2010 12:00:00 EDT 13-Cis Retinoic Acid With or Without Vitamin E for Prevention of Lung CancerConditions: Drug Toxicity; Lung CancerInterventions: Drug: 13-cis retinoic acid; Dietary Supplement: Tocopherol Sponsor: University of Colorado, Denver Completed Mon, 27 Jan 2003 12:00:00 EST Bioequivalence Study Comparing Clindamycin Phosphate (1.2%) and Tretinoin (0.025%) Topical Gel to Ziana and PlaceboCondition: MILD TO SEVERE ACNE VULGARISInterventions: Drug: CLIND PHOSPHATE (1.2%) AND TRETINOIN (0.025%) TOPICAL GEL; Drug: ZIANA®; Drug: Vehicle Control Sponsor: Actavis Mid-Atlantic LLC Completed Fri, 10 Dec 2010 12:00:00 EST Adherence to Study Medication Compared to Generic Topical Clindamycin Plus Generic Topical Tretinoin in Subjects With Mild to Moderate Acne VulgarisCondition: Acne VulgarisInterventions: Drug: clindamycin phosphate 1.2% and tretinoin 0.025%; Drug: clindamycin 1% gel; Drug: tretinoin 0.025% cream Sponsors: Wake Forest University; Medicis Pharmaceutical Corporation Completed Tue, 12 Jan 2010 12:00:00 EST A Phase II Trial of All-Trans-Retinoic Acid in Combination With Interferon-Alpha 2a in Children With Recurrent Neuroblastoma or Wilms' TumorConditions: Nephroblastoma; NeuroblastomaIntervention: Drug: IFN-alpha with retinoic acid Sponsor: National Cancer Institute (NCI) Completed Tue, 10 Dec 2002 12:00:00 EST Investigating the Potential Role of a Novel Quadrate Combination Therapy Mifepristone(Antiprogestrone), Tamoxifen, Retinoic Acid and Cannabidiol ( Selective Cyp 26 Inhibitor) for Treating Early Breast Cancer.Condition: Breast Cancer FemaleInterventions: Drug: All trans-retinoic acid; Drug: 13-Cis Retinoic Acid plus Tocopherol; Drug: Mifepristone; Drug: Cannabidiol; Drug: 9 cis retinoic acid; Drug: Tamoxifen; Drug: Standard therapy Sponsors: Mahmoud Ramadan mohamed Elkazzaz; Ministry of Health, Saudi Arabia Not yet recruiting Mon, 23 Aug 2021 12:00:00 EDT Arsenic Trioxide With or Without Tretinoin in Treating Patients With Hematologic Cancer That Has Not Responded to Previous TherapyConditions: Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic SyndromesInterventions: Drug: arsenic trioxide; Drug: tretinoin Sponsors: Washington University School of Medicine; National Cancer Institute (NCI) Terminated Thu, 20 May 2004 12:00:00 EDT To Immunize Patients With Extensive Stage SCLC Combined With Chemo With or Without All Trans Retinoic AcidCondition: Small Cell Lung CancerInterventions: Drug: Paclitaxel; Biological: Drug: Ad.p53-DC vaccines; Drug: All -trans Retinoic Acid (ATRA) Sponsor: H. Lee Moffitt Cancer Center and Research Institute Completed Mon, 18 Feb 2008 12:00:00 EST
Decitabine and Tretinoin in Treating Patients With Myelodysplastic SyndromesCondition: Myelodysplastic SyndromesInterventions: Drug: decitabine; Drug: tretinoin; Genetic: DNA methylation analysis; Genetic: cytogenetic analysis; Genetic: microarray analysis; Other: flow cytometry; Other: immunohistochemistry staining method Sponsors: Memorial Sloan Kettering Cancer Center; National Cancer Institute (NCI) Active, not recruiting Thu, 28 Sep 2006 12:00:00 EDT Temozolomide,Thiotepa and Carboplatin With Autologous Stem Cell Rescue Followed by 13-cis-retinoic Acid in Patients With Recurrent/Refractory Malignant Brain TumorsCondition: Brain TumorsIntervention: Drug: temozolomide, thiotepa, carboplatin, 13-cis-retinoic acid Sponsors: NYU Langone Health; Children's Hospitals and Clinics of Minnesota; Schneider Children's Hospital Completed Wed, 12 Sep 2007 12:00:00 EDT Tretinoin and Arsenic Trioxide With or Without Idarubicin in Treating Patients With Acute Promyelocytic LeukemiaCondition: LeukemiaInterventions: Drug: arsenic trioxide; Drug: idarubicin; Drug: tretinoin Sponsors: Memorial Sloan Kettering Cancer Center; National Cancer Institute (NCI); Cephalon Terminated Wed, 12 Sep 2007 12:00:00 EDT All-Trans Retinoic Acid (ATRA) Combining Dexamethasone Versus High-dose Dexamethasone for Initial Treatment of Primary Immune Thrombocytopenia (ITP)Conditions: Purpura; Idiopathic Thrombocytopenic PurpuraInterventions: Drug: All-Trans Retinoid Acid(ATRA); Drug: Dexamethasone Sponsor: Shandong University Withdrawn Thu, 20 Jun 2013 12:00:00 EDT Oral Liquid 13-cis-retinoic Acid (13-CRA)Condition: NeuroblastomaInterventions: Drug: Liquid 13-Cis Retinoic Acid; Drug: Extracted capsules 13-CRA Sponsor: Nova Laboratories Limited Completed Mon, 25 Sep 2017 12:00:00 EDT ATRA Trial - ACTIVITY OF ATRA IN COMBINATION WITH ANASTROZOLE IN PRE-OPERATIVE PHASE OF OPERABLE HR-POSITIVE/HER2-NEGATIVE EARLY BREAST CANCER eBC ATRA TRIALCondition: Breast Neoplasm FemaleInterventions: Drug: all-trans retinoic acid; Drug: Anastrozole 1mg Sponsor: Mario Negri Institute for Pharmacological Research Unknown status Thu, 03 Oct 2019 12:00:00 EDT Combined Retinoic Acid,Arsenic Trioxide and Chemo for Newly-diagnosed APLCondition: Acute Promyelocytic LeukemiaInterventions: Drug: ATRA+Arsenic; Drug: ATRA+Chemo Sponsors: Shanghai Jiao Tong University School of Medicine; Tang-Du Hospital; Peking University People's Hospital; First Affiliated Hospital of Zhejiang University; Tongji Hospital; Wuhan Union Hospital, China; First Hospital of China Medical University; Southwest Hospital, China; West China Hospital; Ningbo No. 1 Hospital; Qilu Hospital of Shandong University; Shandong Provincial Hospital; Union hospital of Fujian Medical University; First Affiliated Hospital of Guangxi Medical University; Guangdong Provincial People's Hospital; First Affiliated Hospital, Sun Yat-Sen University; The First Affiliated Hospital of Soochow University; The First Affiliated Hospital with Nanjing Medical University; The Second Affiliated Hospital of Dalian Medical University; Nanfang Hospital of Southern Medical University; The First Affiliated Hospital of Anhui Medical University; Institute of Hematology & Blood Diseases Hospital Unknown status Tue, 19 Nov 2013 12:00:00 EST A Phase I Trial of Tamoxifen and 9-Cis-Retinoic Acid in Breast Cancer PatientsConditions: Breast Cancer; Breast NeoplasmIntervention: Drug: 9-cis-Retinoic Acid Sponsor: National Cancer Institute (NCI) Completed Thu, 04 Nov 1999 12:00:00 EST A Pilot Study of the Combination of Retinoic Acid and Interferon-Alpha2a for the Treatment of Lymphoproliferative Disorders in Children With Immunodeficiency SyndromesConditions: HIV Infections; Immunologic Deficiency Syndromes; Lymphoproliferative DisordersIntervention: Drug: all-trans-retinoic acid with IFN-alpha2a Sponsor: National Cancer Institute (NCI) Completed Tue, 10 Dec 2002 12:00:00 EST Tretinoin With or Without Fenretinide in Treating Patients With Dysplastic Nevus SyndromeCondition: Melanoma (Skin)Interventions: Drug: fenretinide; Drug: tretinoin Sponsors: Eastern Cooperative Oncology Group; National Cancer Institute (NCI) Completed Thu, 26 Aug 2004 12:00:00 EDT
Combination Therapy in Amyotrophic Lateral Sclerosis (ALS)Condition: Amyotrophic Lateral SclerosisInterventions: Drug: Pioglitazone and Tretinoin; Drug: Tretinoin and Pioglitazone HCL; Drug: Placebo Sponsor: Phoenix Neurological Associates, LTD Completed Fri, 12 Jun 2009 12:00:00 EDT A Study of All-Trans Retinoic Acid (ATRA) and Bryostatin in Patients With Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)Conditions: Acute Myelogenous Leukemia; Myelodysplastic SyndromeInterventions: Drug: All-trans retinoic acid; Drug: Bryostatin 1 Sponsors: Dana-Farber Cancer Institute; Brigham and Women's Hospital Completed Mon, 29 Aug 2005 12:00:00 EDT Phenylbutyrate and Tretinoin in Treating Patients With Hematologic CancerConditions: Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative DiseasesInterventions: Drug: sodium phenylbutyrate; Drug: tretinoin Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST Evaluation of Irritation by Two Facial Gels Applied to Opposite Sides of the FaceCondition: Acne VulgarisInterventions: Drug: Tretinoin gel; Drug: Adapalene and Benzoyl peroxide Sponsor: Bausch Health Americas, Inc. Completed Fri, 12 Jun 2009 12:00:00 EDT All-trans Retinoic Acid (ATRA) in the Treatment of Recurrent/Metastatic Adenoid Cystic Carcinoma of the Head and NeckCondition: Adenoid Cystic Carcinoma of the Head and NeckInterventions: Drug: All-trans Retinoic Acid; Drug: VEGFR inhibitor; Drug: Chemotherapy Sponsor: Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University Recruiting Tue, 16 Jun 2020 12:00:00 EDT Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19Condition: Covid19Interventions: Drug: Drug: Isotretinoin(Aerosolized 13 cis retinoic acid) plus Aerosolized Itraconazole; Drug: Drug: Isotretinoin(Aerosolized 13 cis retinoic acid) Sponsor: Kafrelsheikh University Not yet recruiting Tue, 06 Oct 2020 12:00:00 EDT MUSE Study to Evaluate the Pharmacokinetics, Safety and Tolerability of S6G5T-3Condition: Acne VulgarisInterventions: Drug: S6G5T-3; Drug: Retin-A® 0.1% Cream Sponsor: Sol-Gel Technologies, Ltd. Completed Fri, 16 Aug 2019 12:00:00 EDT Investigating the Role of 13cis Retinoic Acid in the Treatment of COVID-19 and Enhancement of Its Spike Protein Based Vaccine Efficacy and Safety.Condition: Covid19 VaccineInterventions: Drug: Oral 13 cis retinoic acid; Drug: Aerosolized 13 cis retinoic acid; Combination Product: 13 cis retinoic acid doses orally in combination with spike protein based vaccine; Combination Product: Aerosolized 13 cis retinoic acid in combination with spike protein based vaccine; Biological: Biological: spike protein based vaccine such as ChAdOx1 nCoV-19 vaccine Sponsor: Kafrelsheikh University Not yet recruiting Fri, 29 Jan 2021 12:00:00 EST The Combination of ATRA and Danazol as Second-line Treatment in Adult Immune ThrombocytopeniaCondition: Autoimmune ThrombocytopeniaInterventions: Drug: All-trans retinoic acid; Drug: Danazol Sponsors: Peking University People's Hospital; Beijing Municipal Science & Technology Commission; Beijing Hospital; Qilu Hospital of Shandong University; Navy General Hospital, Beijing; Beijing Tongren Hospital Completed Fri, 17 Aug 2012 12:00:00 EDT UMCC 9609 Tretinoin in Preventing Cancer of the Cervix in Patients With Cervical NeoplasiaConditions: Cervical Cancer; Precancerous/Nonmalignant ConditionIntervention: Drug: tretinoin Sponsors: University of Michigan Rogel Cancer Center; National Cancer Institute (NCI) Completed Fri, 05 Dec 2003 12:00:00 EST
Efficacy and Safety of Therapy With Tri-Luma® Cream in Sequence With Glycolic Acid Peels for MelasmaCondition: MelasmaIntervention: Drug: Fluocinolone acetonide 0.1%/hydroquinone 4%/tretinoin 0.05% Cream in sequence with glycolic acid peels Sponsor: Galderma Laboratories, L.P. Completed Mon, 14 May 2007 12:00:00 EDT A Study of ATRA in the Treatment of ITPCondition: Immune ThrombocytopeniaIntervention: Drug: all trans retinoic acid Sponsors: Peking University People's Hospital; Qilu Hospital of Shandong University; Beijing Hospital; The Sixth Medical Center of PLA General Hospital Not yet recruiting Thu, 05 Nov 2020 12:00:00 EST Phase II 5-Azacytidine Plus VPA Plus ATRAConditions: Myelodysplastic Syndrome; Acute Myelogenous LeukemiaInterventions: Drug: 5-Azacytidine (5-aza); Drug: Valproic Acid; Drug: All-Trans Retinoic Acid (ATRA) Sponsors: M.D. Anderson Cancer Center; Celgene Corporation Completed Tue, 16 May 2006 12:00:00 EDT Study of TCP-ATRA for Adult Patients With AML and MDSConditions: Acute Myelogenous Leukemia; Myelodysplastic Syndromes; LeukemiaInterventions: Drug: Tranylcypromine; Drug: Tretinoin Sponsors: University of Miami; Women's Cancer Association; Gabrielle's Angel Foundation Completed Thu, 23 Oct 2014 12:00:00 EDT Pharmacokinetics of 9-cis-retinoic Acid (Alitretinoin, Toctino®) in Patients With Hepatic DiseaseCondition: Hepatic InsufficiencyIntervention: Drug: Alitretinoin Sponsor: University Hospital, Gentofte, Copenhagen Completed Fri, 17 Dec 2010 12:00:00 EST Study of Low-Dose Cytarabine and Etoposide With or Without All-Trans Retinoic Acid in Older Patients Not Eligible for Intensive Chemotherapy With Acute Myeloid Leukemia and NPM1 MutationCondition: Acute Myeloid Leukemia (AML)Interventions: Drug: Cytarabine; Drug: Etoposide; Drug: All-trans retinoic acid (ATRA) Sponsors: University of Ulm; German Federal Ministry of Education and Research Completed Wed, 10 Nov 2010 12:00:00 EST Advanced Cervical Cancer Trial in IndiaCondition: Cervical CancerInterventions: Drug: Interferon, Retinoic Acid and radiation; Drug: Cisplatin and radiation Sponsors: University of Louisville; James Graham Brown Cancer Center Completed Thu, 13 Jan 2011 12:00:00 EST Safety and Efficacy Study of Association Between Tretinoin and Clindamycin on the Treatment of Acne Mild and ModerateCondition: Acne VulgarisIntervention: Drug: application of the topic gel Sponsor: Igefarma Laboratorios S.A. Completed Fri, 06 Feb 2009 12:00:00 EST DNA Methylation in Malar Melasma and Its Change by Sunscreen, Retinoic Acid and Niacinamide.Condition: MelasmaInterventions: Drug: Retinoic acid; Device: colorimetry measurement; Drug: sunscreen; Drug: Niacinamide Sponsor: Universidad Autonoma de San Luis Potosí Completed Mon, 08 Jan 2018 12:00:00 EST A Study of Daratumumab With Pomalidomide, Dexamethasone, and All-Transretinoic Acid in Patients With Multiple MyelomaCondition: Multiple MyelomaInterventions: Drug: Daratumumab; Drug: Pomalidomide; Drug: All-trans retinoic acid; Drug: Dexamethasone Sponsors: Hackensack Meridian Health; Janssen, LP Not yet recruiting Thu, 07 Jan 2021 12:00:00 EST
Comparison of Redermic, Rejuva-A and Combination of Both Redermic and Rejuva-A in Subjects With Signs of AgingCondition: Skin AgingInterventions: Other: Redermic; Drug: Tretinoin (Rejuva-A) Sponsors: Cosmetique Active International; Innovaderm Research Inc. Completed Thu, 10 Sep 2009 12:00:00 EDT Daratumumab in Combination With ATRACondition: Multiple MyelomaIntervention: Drug: all-trans retinoic acid (ATRA) Sponsors: VU University Medical Center; Erasmus Medical Center; UMC Utrecht; University of Turin, Italy; Vejle Hospital Active, not recruiting Tue, 26 Apr 2016 12:00:00 EDT A Study of MAb-3F8 Plus Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Versus 13-cis-Retinoic Acid (RA) Plus GM-CSF in Primary Refractory Neuroblastoma PatientsCondition: Primary Refractory NeuroblastomaInterventions: Biological: MAb-3F8; Biological: Subcutaneous Granulocyte Macrophage Colony Stimulating Factor (GM-CSF); Biological: 13-cis-Retinoic Acid Sponsor: United Therapeutics Terminated Tue, 01 Sep 2009 12:00:00 EDT 5-azacytidine Valproic Acid and ATRA in AML and High Risk MDSConditions: Acute Myelogenous Leukaemia (AML); Myelodysplastic Syndrome (MDS)Intervention: Drug: 5 azacytidine - VALPROIC acid- Retinoic acid Sponsor: Assistance Publique - Hôpitaux de Paris Completed Tue, 20 Jun 2006 12:00:00 EDT Tretinoin and Arsenic Trioxide With or Without Gemtuzumab Ozogamicin in Treating Patients With Previously Untreated Acute Promyelocytic LeukemiaCondition: Acute Promyelocytic Leukemia With PML-RARAInterventions: Drug: Arsenic Trioxide; Drug: Gemtuzumab Ozogamicin; Other: Laboratory Biomarker Analysis; Drug: Tretinoin Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI) Recruiting Thu, 04 Aug 2011 12:00:00 EDT All-trans Retinoic Acid, and Arsenic +/- IdarubicinCondition: Acute Promyelocytic LeukemiaInterventions: Drug: All-Trans Retinoic Acid (ATRA); Drug: Arsenic Trioxide (ATO); Drug: Idarubicin; Drug: Gemtuzumab Ozogamicin Sponsor: M.D. Anderson Cancer Center Completed Tue, 19 Dec 2006 12:00:00 EST "AIDA" Protocol (LAP 0493)Condition: LeukemiaIntervention: Drug: all-trans retinoic acid (ATRA) Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto Recruiting Mon, 08 Feb 2010 12:00:00 EST The Lipid Profile of the Skin Surface in AcneCondition: AcneInterventions: Drug: Tretinoin or Adapalene; Drug: Isotretinoin Sponsor: University of California, Davis Completed Wed, 02 Jul 2014 12:00:00 EDT Combination of Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP and Isotretinoin Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory ComplicationsCondition: COVIDIntervention: Combination Product: Recombinant Bacterial ACE2 receptors -like enzyme of B38-CAP (rbACE2) plus Aerosolized 13 cis retinoic acid Sponsor: Kafrelsheikh University Not yet recruiting Mon, 11 May 2020 12:00:00 EDT Retinyl Palmitate-loaded Ethosomes in Acne VulgarisCondition: Facial Acne VulgarisInterventions: Drug: retinyl palmitate; Drug: Tretinoin Sponsor: Assiut University Unknown status Fri, 06 Sep 2019 12:00:00 EDT
W0265-103: A Single-Center, Evaluator-Blinded, Randomized, Placebo Controlled, Phase 1 Clinical Trial Evaluating The Phototoxic Potential Of Topically Applied Clindamycin 1.0% - Tretinoin 0.025% Gel (Ct Gel) In Healthy VolunteersCondition: Acne VulgarisInterventions: Drug: CT Gel (clindamycin 1% and tretinoin 0.025%); Other: Vehicle gel patch; Other: Blank patch Sponsors: Stiefel, a GSK Company; GlaxoSmithKline Completed Tue, 27 Aug 2013 12:00:00 EDT A Study of TAS1440 With ATRA in Subjects With r/r AMLCondition: Acute Myeloid LeukemiaInterventions: Drug: TAS1440; Drug: TAS1440 + ATRA Sponsor: Astex Pharmaceuticals, Inc. Recruiting Tue, 25 Feb 2020 12:00:00 EST A Pilot Study of 5-AZA and ATRA for Prostate Cancer With PSA-only Recurrence After Local TreatmentConditions: Prostatic Neoplasms; Prostate Neoplasms; Prostate CancerInterventions: Drug: 5-Azacitidine; Drug: all trans retinoic acid; Drug: Lupron Sponsor: Icahn School of Medicine at Mount Sinai Recruiting Thu, 28 Jun 2018 12:00:00 EDT Tretinoin and Arsenic Trioxide in Treating Patients With Untreated Acute Promyelocytic LeukemiaCondition: Acute Promyelocytic Leukemia With PML-RARAInterventions: Drug: Arsenic Trioxide; Drug: Cytarabine; Drug: Dexamethasone; Drug: Idarubicin; Other: Laboratory Biomarker Analysis; Drug: Mitoxantrone Hydrochloride; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Drug: Tretinoin Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Active, not recruiting Thu, 15 Jan 2015 12:00:00 EST Clinical Role of Testosterone and Dihydrotestosterone and Which of Them Should be Inhibited in COVID-19 Patients - A Double-edged Sword?Condition: Covid19Interventions: Combination Product: Aerosolized 13 cis retinoic acid plus Inhalation Inhaled testosterone; Drug: The standard therapy Sponsor: Kafrelsheikh University Not yet recruiting Tue, 10 Nov 2020 12:00:00 EST Study of Decitabine Alone or in Combination With Valproic Acid and All-trans Retinoic Acid in Acute Myeloid LeukemiaCondition: Acute Myeloid LeukemiaInterventions: Drug: Decitabine; Drug: VPA; Drug: ATRA Sponsor: University Hospital Freiburg Completed Tue, 24 Mar 2009 12:00:00 EDT Vaccine Therapy, Tretinoin, and Cyclophosphamide in Treating Patients With Metastatic Lung CancerCondition: Lung CancerInterventions: Biological: Vaccine Treatment; Drug: Cyclophosphamide; Drug: All-trans retinoic acid (ATRA) Sponsors: H. Lee Moffitt Cancer Center and Research Institute; National Cancer Institute (NCI); National Institutes of Health (NIH) Completed Mon, 28 Jan 2008 12:00:00 EST Disease Stabilization in AML by Treatment With ATRA, Valproic Acid and Low-dose CytarabineCondition: Acute Myelogenous LeukemiaIntervention: Drug: Cytarabine, all-trans retinoic acid, valproic acid Sponsor: University of Bergen Completed Thu, 15 Oct 2009 12:00:00 EDT Study of Sensitization of Non-M3 AML Blasts to ATRA by Epigenetic Treatment With Tranylcypromine (TCP)Conditions: Acute Myeloid Leukemia; Myelodysplastic SyndromeInterventions: Drug: tranylcypromine; Drug: all-trans retinoic acid; Drug: cytarabine Sponsors: Michael Luebbert; University Hospital Freiburg Recruiting Thu, 24 Mar 2016 12:00:00 EDT Tretinoin, Cytarabine, and Daunorubicin Hydrochloride With or Without Arsenic Trioxide Followed by Tretinoin With or Without Mercaptopurine and Methotrexate in Treating Patients With Acute Promyelocytic LeukemiaConditions: Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Promyelocytic Leukemia (M3); Childhood Acute Promyelocytic Leukemia (M3); Untreated Adult Acute Myeloid Leukemia; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid MalignanciesInterventions: Drug: tretinoin; Drug: daunorubicin hydrochloride; Drug: cytarabine; Drug: mercaptopurine; Drug: methotrexate; Drug: arsenic trioxide Sponsor: National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST
Study to Evaluate the Effect of a Nu Skin Product and Device for Brown SpotsCondition: HyperpigmentationInterventions: Other: Nu Skin Product; Other: Cosmetic instrument; Drug: Tretinoin cream 0.05; Other: CeraVe moisturizer Sponsor: Massachusetts General Hospital Completed Thu, 24 Jun 2010 12:00:00 EDT The Combination of Low-dose Rituximab and ATRA as the Treatment of Steroid-resistant/Relapse Immune ThrombocytopeniaCondition: Immune ThrombocytopeniaInterventions: Drug: Rituximab; Drug: All-trans retinoic acid Sponsors: Peking University People's Hospital; Beijing Hospital; Navy General Hospital, Beijing; Beijing Tongren Hospital Active, not recruiting Mon, 09 Oct 2017 12:00:00 EDT S0521, Combination Chemotherapy With or Without Gemtuzumab Followed By Tretinoin, Mercaptopurine, and Methotrexate or Observation in Treating Patients With Acute Promyelocytic LeukemiaCondition: LeukemiaInterventions: Drug: mercaptopurine; Drug: methotrexate; Drug: tretinoin Sponsors: Southwest Oncology Group; National Cancer Institute (NCI) Completed Wed, 27 Jun 2007 12:00:00 EDT Tretinoin Plus Interferon Alfa in Treating Patients With Metastatic Kidney CancerCondition: Kidney CancerInterventions: Biological: recombinant interferon alfa; Drug: tretinoin liposome Sponsor: Weill Medical College of Cornell University Completed Mon, 27 Jan 2003 12:00:00 EST Cladribine Based Induction Therapy With All-Trans Retinoic Acid and Midostaurin in Relapsed/Refractory AMLCondition: Leukemia, Myeloid, AcuteInterventions: Drug: Granulocyte colony-stimulating factor (G-CSF); Drug: Cladribine; Drug: Cytarabine; Drug: All-Trans Retinoic Acid (ATRA); Drug: Midostaurin Sponsor: Washington University School of Medicine Completed Tue, 13 Jul 2010 12:00:00 EDT Efficacy of Immunomudulatory Therapy With All-trans Retinoid Acid for Adults With Chronic Immune ThrombocytopeniaCondition: Immune Thrombocytopenic PurpuraIntervention: Drug: all-trans-retinoid acid Sponsor: First Affiliated Hospital of Suzhou Medical College Completed Mon, 20 Aug 2012 12:00:00 EDT Interferon Alfa, Isotretinoin, and Paclitaxel in Treating Patients With Recurrent Small Cell Lung CancerCondition: Lung CancerInterventions: Biological: interferon alpha; Drug: 13-cis-retinoic acid; Drug: paclitaxel Sponsors: Eastern Cooperative Oncology Group; National Cancer Institute (NCI) Completed Fri, 06 Jun 2003 12:00:00 EDT 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Acid for Primary Refractory Neuroblastoma in Bone MarrowCondition: NeuroblastomaIntervention: Biological: 3F8/GM-CSF Immunotherapy Plus 13-Cis-Retinoic Sponsor: Memorial Sloan Kettering Cancer Center Completed Wed, 18 Aug 2010 12:00:00 EDT All-Trans Retinoic Acid in Combination With Standard Induction and Consolidation Therapy in Older Patients With Newly Diagnosed Acute Myeloid LeukemiaCondition: Acute Myeloid LeukemiaInterventions: Drug: Cytarabine; Drug: Idarubicin; Drug: All-trans retinoic acid; Drug: Mitoxantrone; Drug: Etoposid Sponsor: University of Ulm Completed Thu, 08 Sep 2005 12:00:00 EDT AIDA 2000 GuidelinesCondition: Acute Promyelocytic LeukemiaIntervention: Drug: all-trans retinoic acid (ATRA) Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto Recruiting Mon, 08 Feb 2010 12:00:00 EST
Study on All-Trans Retinoic Acid, Induction and Consolidation Therapy, and Pegfilgrastim After Consolidation Therapy in Younger Patients With Newly Diagnosed Acute Myeloid LeukemiaCondition: Acute Myeloid LeukemiaInterventions: Drug: Cytarabine; Drug: Idarubicin; Drug: Etoposide; Drug: All-trans retinoic acid; Drug: Pegfilgrastim Sponsor: University of Ulm Completed Thu, 08 Sep 2005 12:00:00 EDT Double Blind Phase III Trial of Effects of Low Dose 13-Cisretinoic Acid on Prevention of Second Primaries in Stages I-II Head and Neck CancerCondition: Stage I-II Head and Neck CancerInterventions: Drug: 13-cis retinoic acid; Other: Placebo Sponsor: Eastern Cooperative Oncology Group Completed Tue, 12 Dec 2017 12:00:00 EST Addition of a Topical Steroid to a Topical Retinoid in Acne PatientsCondition: AcneInterventions: Drug: Triamcinolone; Drug: Tretinoin; Drug: Emollient Sponsor: Carilion Clinic Unknown status Thu, 10 Mar 2016 12:00:00 EST ALFA-0703 Study in Older Patients With Acute Myeloblastic Leukemia (AML)Condition: Acute Myeloid LeukemiaInterventions: Drug: Vesanoid (ATRA); Drug: AZACITIDINE (VIDAZA); Drug: CYTARABINE Sponsors: Acute Leukemia French Association; Assistance Publique - Hôpitaux de Paris Withdrawn Thu, 11 Feb 2010 12:00:00 EST Impact of a Novel Immune Modulating Dietary Supplement on House Dust Mite Induced Allergic RhinoconjunctivitisConditions: Dust Mite Allergy; Allergic RhinitisIntervention: Dietary Supplement: holo-BLG (beta-lactoglobulin) - a major component of the protein fraction of raw milk, is loaded with ligands such as retinoic acid, zinc and polyphenol-iron complexes. Sponsors: Ecarf Institute GmbH; Bencard Allergie GmbH Completed Mon, 20 Jul 2020 12:00:00 EDT Bexarotene, Tretinoin, and Combination Chemotherapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung CancerCondition: Lung CancerInterventions: Drug: bexarotene; Drug: capecitabine; Drug: carboplatin; Drug: cisplatin; Drug: docetaxel; Drug: tretinoin Sponsor: Raghu Nandan, M.D., Inc Unknown status Thu, 09 Aug 2007 12:00:00 EDT Isotretinoin, Interferon Alpha-2b, and Paclitaxel in Stage IV, Recurrent, or Persistent Cervical CancerCondition: Cervical CancerInterventions: Biological: recombinant interferon alpha-2b; Drug: isotretinoin; Drug: paclitaxel Sponsors: University of Medicine and Dentistry of New Jersey; National Cancer Institute (NCI) Terminated Tue, 30 Aug 2005 12:00:00 EDT Effect of All-trans Retinoic Acid With Chemotherapy Based on Paclitaxel and Cisplatin As First-line Treatment of Patients With Advanced Non-small Cell Lung Cancer and Expression of RAR-alfa and RAR-beta as Response BiomarkerCondition: Non Small Cell Lung CancerInterventions: Drug: atRA; Drug: Placebo Sponsor: National Institute of Cancerología Unknown status Fri, 01 Jan 2010 12:00:00 EST Temozolomide & RT Followed by Dose Dense vs Temozolomide & Retinoic Acid in Pts w/GlioblastomaConditions: Glioblastoma; GliomasIntervention: Drug: Temozolomide Sponsors: Memorial Sloan Kettering Cancer Center; Schering-Plough; Columbia University; Dana-Farber Cancer Institute Completed Tue, 20 Sep 2005 12:00:00 EDT Effect of All-trans Retinoic Acid With Chemotherapy Based in Paclitaxel and Cisplatin as First Line Treatment of Patients With Advanced Non-small Cell Lung CancerCondition: Non-Small-Cell Lung CarcinomaInterventions: Drug: ATRA; Other: PLACEBO Sponsors: National Institute of Cancerología; Instituto Nacional de Enfermedades Respiratorias Completed Wed, 13 Jan 2010 12:00:00 EST
Treatment of Non-high-risk Acute Promyelocytic Leukemia (APL) With Realgar-Indigo Naturalis Formula (RIF)Condition: Acute Promyelocytic LeukemiaInterventions: Drug: Realgar-Indigo naturalis formula; Drug: all-trans retinoic acid; Drug: Arsenic trioxide; Drug: Hydroxyurea Sponsors: First Affiliated Hospital Xi'an Jiaotong University; Tang-Du Hospital Recruiting Wed, 14 Sep 2016 12:00:00 EDT The Combination of ATRA and High-dose Dexamethasone as First-line Treatment in Adult Immune ThrombocytopeniaCondition: Immune ThrombocytopeniaInterventions: Drug: Dexamethasone; Drug: ATRA Sponsors: Peking University People's Hospital; Beijing Hospital; The Sixth Medical Center of PLA General Hospital; Beijing Aerospace General Hospital; Qilu Hospital of Shandong University; Beijing Tongren Hospital Completed Fri, 03 Jan 2020 12:00:00 EST A Clinical Study to Evaluate the Tolerability of a Topical Antibiotic and Retinoid Used in a Combined Regimen With a BPO WashCondition: Acne VulgarisInterventions: Drug: CTGel/ BPO Wash; Drug: Soap Free Cleanser and CTGel Sponsors: Stiefel, a GSK Company; GlaxoSmithKline Completed Fri, 01 May 2009 12:00:00 EDT Retinoic Acid Homeostasis in Neuropsychiatric DiseasesConditions: Major Depression; Alzheimer's Disease; Alcoholism; SchizophreniaIntervention: Sponsor: Charite University, Berlin, Germany Recruiting Fri, 08 May 2015 12:00:00 EDT Assessment of Atrophogenic Potential of Triple Combination Cream for Treatment of MelasmaCondition: MelasmaIntervention: Drug: Fluocinolone acetonide .1%, hydroquinone 4%, tretinoin .05% Sponsor: Galderma Laboratories, L.P. Completed Fri, 04 May 2007 12:00:00 EDT Intranasal Retinoic Acid Treatment for Patients With OlfactoryLOSS: A RANDOMIZED CONTROLLED TRIALCondition: Olfactory DisorderIntervention: Dietary Supplement: Vitamin A Sponsor: St. Paul's Hospital, Canada Recruiting Mon, 02 Jul 2018 12:00:00 EDT Differentiation Induction in Acute Myelogenous LeukemiaCondition: Acute Myelogenous LeukemiaInterventions: Drug: all-trans retinoic acid (ATRA); Drug: Valproic acid; Drug: Theophyllin Sponsor: University of Bergen Completed Thu, 15 Sep 2005 12:00:00 EDT Combination Chemotherapy in Treating Patients With Stage IIIB or Stage IV Non-small Cell Lung CancerCondition: Lung CancerInterventions: Drug: cisplatin; Drug: mitomycin C; Drug: tretinoin; Drug: vinorelbine tartrate Sponsor: Raghu Nandan, M.D., Inc Unknown status Mon, 27 Jan 2003 12:00:00 EST DLAAG in the Treatment of Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome With Blast ExcessConditions: Acute Myeloid Leukemia; Myelodysplastic SyndromeInterventions: Drug: Decitabine; Drug: Cytarabine; Drug: All-transretinoic acid; Drug: G-CSF Sponsor: Shanghai Tong Ren Hospital Unknown status Wed, 29 Nov 2017 12:00:00 EST Pilot Study of Tolerability and Effectivity of Two Combination Topical Acne ProductsCondition: Acne VulgarisInterventions: Drug: Acnatac® Gel left face; Drug: Epiduo® Gel right face; Drug: Acnatac® Gel right face; Drug: Epiduo® Gel left face Sponsor: GWT-TUD GmbH Completed Thu, 07 Apr 2016 12:00:00 EDT
Study to Determine Effect of Gentle Wounding to Stimulate Hair Follicle NeogenesisCondition: Central Centrifugal Cicatricial Alopecia (CCCA)Interventions: Drug: Retinoic acid; Device: Laser; Drug: Sham treatment; Device: Sham treatment Sponsor: Johns Hopkins University Enrolling by invitation Mon, 09 Apr 2018 12:00:00 EDT Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With NeuroblastomaCondition: NeuroblastomaIntervention: Drug: Imetelstat Sponsors: NCIC Clinical Trials Group; Geron Corporation Withdrawn Mon, 05 Aug 2013 12:00:00 EDT The Effect of the Alga Dunaliella Bardawil as a Source of 9-cis Retinoic Acid on Lipid Profile in Fibrate Treated Patients.Condition: Low HDL CholesterolIntervention: Drug: Dunaliella Sponsor: Sheba Medical Center Completed Mon, 12 Sep 2005 12:00:00 EDT Treatment of the Anemia of Myelodysplastic Syndromes by the Association of Epoetin Beta and All Trans Retinoic AcidCondition: Anemia in Myelodysplastic SyndromesIntervention: Drug: Epoetin/Atra Sponsor: Groupe Francophone des Myelodysplasies Unknown status Wed, 21 Feb 2007 12:00:00 EST Pharmacogenomics Study on Treatment of Psoriasis Vulgaris by Acitretin CapsulesCondition: Psoriasis VulgarisIntervention: Drug: Acitretin Capsules Sponsor: Central South University Unknown status Tue, 22 Mar 2016 12:00:00 EDT Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant GliomasCondition: Brain and Central Nervous System TumorsInterventions: Drug: Isotretinoin; Drug: Procarbazine Hydrochloride Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI) Withdrawn Mon, 13 Sep 2004 12:00:00 EDT Combination Treatment for Moderate to Severe AcneCondition: AcneIntervention: Drug: Minocycline, Clindamycin, Tretinoin, Benzoyl Peroxide Sponsor: Medicis Global Service Corporation Completed Tue, 21 Sep 2010 12:00:00 EDT Frontline Oral Arsenic Trioxide for APLCondition: Acute Promyelocytic LeukemiaIntervention: Drug: Oral Arsenic Trioxide Formulation Sponsor: The University of Hong Kong Recruiting Tue, 29 Dec 2020 12:00:00 EST Treatment w/ Tri-Luma® Cream & Intense Pulsed Light (IPL) vs a Mild Inactive Control Cream & Intense Pulsed Light (IPL) in MelasmaCondition: MelasmaInterventions: Drug: Fluocinolone acetonide 0.01%, hydroquinone 4%, tretinoin 0.05%; Drug: Cetaphil® Moisturizing Cream as Inactive Control Sponsor: Galderma Laboratories, L.P. Terminated Tue, 29 Apr 2008 12:00:00 EDT Phase IIb Randomised Trial of ATRA in a Novel Drug Combination for Pancreatic CancerCondition: Pancreatic CancerInterventions: Drug: ATRA; Drug: Gemcitabine; Drug: nab-paclitaxel Sponsors: Queen Mary University of London; Medical Research Council; Celgene Not yet recruiting Mon, 27 Jan 2020 12:00:00 EST
Stromal TARgeting for PAncreatic Cancer (STAR_PAC)Condition: Pancreatic AdenocarcinomaInterventions: Drug: ATRA; Drug: Gemcitabine; Drug: Nab-paclitaxel Sponsors: Barts & The London NHS Trust; Medical Research Council; Celgene Corporation; Cancer Research UK Cambridge Institute; King's College London; Royal Free Hospital NHS Foundation Trust; Imperial College Healthcare NHS Trust; Institute of Cancer Research, United Kingdom; Cambridge University Hospitals NHS Foundation Trust Completed Wed, 11 Oct 2017 12:00:00 EDT An Open-Label, Dose-Escalation/Dose-Expansion Safety Study of INCB059872 in Subjects With Advanced MalignanciesCondition: Solid Tumors and Hematologic MalignancyInterventions: Drug: INCB059872; Drug: all-trans retinoic acid (ATRA); Drug: azacitidine; Drug: nivolumab Sponsor: Incyte Corporation Active, not recruiting Fri, 18 Mar 2016 12:00:00 EDT A Clinical Study to Evaluate the Safety and Effectiveness of an Investigational Product Called CT GelConditions: Acne Vulgaris; AcneInterventions: Drug: CT Gel; Drug: Clindamycin Gel (clindamycin ); Drug: Tretinoin Gel (tretinoin); Drug: Vehicle Gel Sponsors: Stiefel, a GSK Company; GlaxoSmithKline Completed Tue, 03 Jun 2008 12:00:00 EDT Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome CoronavirusCondition: COVID-19Interventions: Drug: Drug: Isotretinoin plus Tamoxifen; Drug: Aerosolized Isotretinoin plus Tamoxifen Sponsor: Kafrelsheikh University Not yet recruiting Fri, 15 May 2020 12:00:00 EDT Vitamin E in Preventing the Side Effects of Isotretinoin in Former and Current Smokers Who Are Receiving Isotretinoin to Prevent Lung CancerCondition: Lung CancerInterventions: Dietary Supplement: Vitamin E (AT); Drug: Isotretinoin Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI) Withdrawn Mon, 13 Sep 2004 12:00:00 EDT Vorinostat and Isotretinoin in Treating Patients With High-Risk Refractory or Recurrent NeuroblastomaConditions: Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S NeuroblastomaInterventions: Drug: Isotretinoin; Other: Laboratory Biomarker Analysis; Other: Pharmacological Study; Drug: Vorinostat Sponsor: National Cancer Institute (NCI) Completed Fri, 24 Sep 2010 12:00:00 EDT Belinostat and Isotretinoin in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by SurgeryCondition: Adult Solid NeoplasmInterventions: Drug: Belinostat; Drug: Isotretinoin; Other: Pharmacological Study Sponsor: National Cancer Institute (NCI) Completed Thu, 08 Jun 2006 12:00:00 EDT Combination Chemotherapy With or Without Filgrastim and/or Tretinoin in Treating Patients With Acute Myeloid LeukemiaConditions: Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative NeoplasmsInterventions: Biological: filgrastim; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: etoposide; Drug: fludarabine phosphate; Drug: tretinoin Sponsor: Medical Research Council Completed Mon, 27 Jan 2003 12:00:00 EST Treatment Study for Children and Adolescents With Acute Promyelocytic LeukemiaCondition: Acute Promyelocytic LeukemiaInterventions: Drug: Mylotarg; Drug: Arsenic Trioxide; Drug: All-trans retinoic acid Sponsor: Associazione Italiana Ematologia Oncologia Pediatrica Recruiting Thu, 11 Mar 2021 12:00:00 EST Efficacy and Safety of ATO Plus ATRA in Nucleophosmin-1 Mutated Acute Myeloid LeukemiaCondition: AMLInterventions: Drug: Cytarabine; Drug: all-trans retinoic acid; Drug: Arsenic Trioxide Sponsor: Institute of Hematology & Blood Diseases Hospital Recruiting Wed, 25 Jan 2017 12:00:00 EST
ch14.18 Pharmacokinetic Study in High-risk NeuroblastomaCondition: NeuroblastomaInterventions: Biological: ch14.18 -NCI; Biological: ch14.18-UTC; Biological: Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF); Biological: Aldesleukin (IL-2); Drug: Isotretinoin Sponsor: United Therapeutics Completed Fri, 04 May 2012 12:00:00 EDT Effects of Early Vitamin A Supplementation on the Risk for Retinopathy of Prematurity in Extremely Preterm InfantsCondition: Retinopathy of PrematurityIntervention: Drug: Vitamin A Sponsors: Huiqing Sun; Zhengzhou University Completed Tue, 16 May 2017 12:00:00 EDT Sequential ATRA Then IL-2 for Modulation of Dendritic Cells and Treatment of Metastatic Renal Cell CancerCondition: Kidney CancerInterventions: Drug: IL-2; Drug: ATRA Sponsors: H. Lee Moffitt Cancer Center and Research Institute; National Cancer Institute (NCI); National Institutes of Health (NIH); Chiron Corporation Completed Fri, 07 Jan 2005 12:00:00 EST Effect of Isotretinoin on Immune Activation Among HIV-1 Infected Subjects With Incomplete CD4+ T Cell RecoveryCondition: HIV-1 InfectionIntervention: Drug: Isotretinoin Sponsors: AIDS Clinical Trials Group; National Institute of Allergy and Infectious Diseases (NIAID) Completed Fri, 25 Oct 2013 12:00:00 EDT Therapy for Children With NeuroblastomaCondition: NeuroblastomaInterventions: Drug: Gefitinib, Irinotecan, Cycophosphamide, Doxorubicin, Etoposide, Cisplatin, Topotecan, Carboplatin, Melphalan, 13-cis retinoic acid; Procedure: Radiation therapy, Surgery, Peripheral Stem cell transplant Sponsors: St. Jude Children's Research Hospital; AstraZeneca; National Institutes of Health (NIH) Completed Thu, 25 Aug 2005 12:00:00 EDT Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Promyelocytic LeukemiaCondition: LeukemiaInterventions: Drug: busulfan; Drug: cyclophosphamide; Drug: cytarabine; Drug: etoposide; Drug: idarubicin; Drug: mercaptopurine; Drug: methotrexate; Drug: mitoxantrone hydrochloride; Drug: thioguanine; Drug: tretinoin; Procedure: allogeneic bone marrow transplantation; Procedure: autologous bone marrow transplantation; Radiation: radiation therapy Sponsors: European Organisation for Research and Treatment of Cancer - EORTC; Gruppo Italiano Malattie EMatologiche dell'Adulto Unknown status Fri, 11 Apr 2003 12:00:00 EDT ATRA, Celecoxib, and Itraconazole as MaintenanceCondition: Relapsed Multiple MyelomaInterventions: Drug: ATRA; Drug: Celecoxib; Drug: Itraconazole Sponsor: University of Iowa Completed Fri, 27 Mar 2015 12:00:00 EDT NB2013-HR German (GPOH) / Dutch (DCOG) TrialCondition: NeuroblastomaInterventions: Drug: antibody ch14.18; Drug: GM-CSF; Drug: IL-2 i.v.; Drug: IL-2 s.c.; Drug: Retinoic acid Sponsor: University of Cologne Terminated Tue, 29 Dec 2015 12:00:00 EST Study for Patients With Newly Diagnosed, High-risk Acute Promyelocytic LeukemiaCondition: Acute Promyelocytic LeukemiaInterventions: Drug: Arsenic trioxide; Drug: Idarubicin; Drug: Cytarabine; Drug: Tretinoin; Drug: Mitoxantrone; Drug: Mercaptopurine; Drug: Methotrexate Sponsors: Technische Universität Dresden; Gruppo Italiano Malattie EMatologiche dell'Adulto; Groupe Francophone des Myelodysplasies; HOVON - Dutch Haemato-Oncology Association; Programa para el Tratamiento de Hemopatías Malignas; German Federal Ministry of Education and Research; Teva Pharmaceuticals Europe Recruiting Tue, 23 Feb 2016 12:00:00 EST Safety Study of Dinutuximab Combined With Immunotherapy to Treat NeuroblastomaConditions: Neuroblastoma; Neoplasm, Residual; Effects of ImmunotherapyIntervention: Drug: Dinutuximab. Immunotherapy Sponsor: Fundació Sant Joan de Déu Unknown status Mon, 23 Jun 2014 12:00:00 EDT
A Pilot Study of the Effects of Isotretinoin on Cognition, Learning and MemoryCondition: Acne VulgarisIntervention: Drug: Isotretinoin Sponsor: University of Aberdeen Completed Wed, 27 Jul 2011 12:00:00 EDT Decreasing Severity of Acne Vulgaris After the Use of a Combination of Anti-Acne CreamCondition: Acne VulgarisIntervention: Drug: Anti-Acne Preparations for Topical Use Sponsor: Sukma Skin Treatment Completed Tue, 08 Oct 2019 12:00:00 EDT Treatment of Acute Leukemia Relapse After AllotransplantationCondition: Acute Myeloid LeukemiaIntervention: Drug: Combined use of azacitidine, valproic acid, hydroxurea and eventually donor leukocyte infusions. Sponsor: University of Bergen Unknown status Wed, 08 Jun 2011 12:00:00 EDT An Open-Label Extension Study of Palovarotene Treatment in Fibrodysplasia Ossificans Progressiva (FOP)Condition: Fibrodysplasia Ossificans ProgressivaInterventions: Drug: Palovarotene dose level 1; Drug: Palovarotene dose level 2; Drug: Palovarotene dose level 3; Drug: Palovarotene dose level 4 Sponsor: Clementia Pharmaceuticals Inc. Active, not recruiting Thu, 30 Oct 2014 12:00:00 EDT The Effects of BAK on the Blood Aqueous Barrier of Pseudophakic PatientsCondition: Dry Eye SyndromesInterventions: Drug: Hydroxypropylmethylcellulose; Drug: Carboxymethylcellulose Sponsors: University of Campinas, Brazil; Merck Sharp & Dohme Corp. Completed Thu, 20 Jan 2011 12:00:00 EST The Effect Of A Controlled Daily Skin Care Regimen On Retinoic Acid ToleranceConditions: Sun-Damaged Skin; Retinoid IntoleranceInterventions: Drug: Tazorac; Drug: Dove Mild Cleanser; Drug: Dove Facial Moisturizer Sponsors: University of Michigan; Unilever R&D Completed Mon, 26 Feb 2007 12:00:00 EST Low-dose AZA, Pioglitazone, ATRA Versus Standard-dose AZA in Patients >=60 Years With Refractory AMLCondition: Acute Myeloid LeukemiaInterventions: Drug: low-dose Azacitidine; Drug: Pioglitazone; Drug: ATRA; Drug: standard-dose AZA Sponsors: University Hospital Regensburg; Anticancer Fund, Belgium; Celgene Terminated Mon, 24 Oct 2016 12:00:00 EDT RA Effect on Cell Surface Molecules in VivoCondition: HIV InfectionsIntervention: Drug: Acitretin Sponsor: Ottawa Hospital Research Institute Withdrawn Tue, 27 Nov 2018 12:00:00 EST Treatment of Acute Promyelocytic Leukemia With All-Trans Retinoic Acid (ATRA) and Idarubicin (AIDA)Condition: Acute Promyelocytic LeukemiaIntervention: Drug: AIDA Sponsor: PETHEMA Foundation Completed Fri, 27 Apr 2007 12:00:00 EDT Phase II Study Of Roferon and Accutane For Patients With T-Cell MalignanciesConditions: Lymphoma, T-Cell; Mycosis Fungoides; Hematologic NeoplasmsInterventions: Drug: Isotretinoin (Accutane); Drug: Interferon Alpha Sponsor: M.D. Anderson Cancer Center Completed Fri, 31 May 2002 12:00:00 EDT
Comparative Antimicrobial Efficacy of Two Topical Acne Therapies for the Treatment of Facial AcneCondition: AcneInterventions: Drug: Duac; Drug: Ziana gel Sponsors: Stiefel, a GSK Company; GlaxoSmithKline Completed Wed, 11 Feb 2009 12:00:00 EST Study of Chemotherapy in Combination With All-trans Retinoic Acid (ATRA) With or Without Gemtuzumab Ozogamicin in Patients With Acute Myeloid Leukemia (AML) and Mutant Nucleophosmin-1 (NPM1) Gene MutationCondition: Acute Myeloid LeukemiaInterventions: Drug: Gemtuzumab Ozogamicin (Mylotarg); Drug: standard chemotherapy Sponsor: University of Ulm Completed Wed, 06 May 2009 12:00:00 EDT Sirolimus Combined With ATRA for the Treatment of Auto-Immune AnemiaCondition: Autoimmune AnemiaIntervention: Drug: sirolimus and ATRA Sponsor: Peking Union Medical College Hospital Not yet recruiting Fri, 27 Mar 2020 12:00:00 EDT RWE of 1st Line Treatment With ATO/ATRA for Adult APLCondition: Promyelocytic Leukemia, Adult AcuteIntervention: Other: Evaluation of first line treatment with ATO/ATRA outcome Sponsor: Grupo Argentino de Tratamiento de la Leucemia Aguda Recruiting Fri, 21 May 2021 12:00:00 EDT Treatment Study for Children and Adolescents With Acute Promyelocitic LeukemiaCondition: Acute Promyelocytic LeukemiaInterventions: Drug: ATRA; Drug: ATRA + IDA Sponsor: Associazione Italiana Ematologia Oncologia Pediatrica Unknown status Fri, 22 Oct 2010 12:00:00 EDT Isotretinoin Plus Interferon in Treating Patients With Recurrent CancerConditions: Cervical Cancer; Esophageal Cancer; Head and Neck Cancer; Lung Cancer; Non-melanomatous Skin Cancer; Penile CancerInterventions: Biological: recombinant interferon alfa; Drug: isotretinoin Sponsors: Hoag Memorial Hospital Presbyterian; Cancer Biotherapy Research Group Completed Mon, 26 Jul 2004 12:00:00 EDT Erlotinib Hydrochloride and Isotretinoin in Treating Patients With Recurrent Malignant GliomaConditions: Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Adult Diffuse Astrocytoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Mixed Glioma; Adult Oligodendroglioma; Recurrent Adult Brain TumorInterventions: Drug: erlotinib hydrochloride; Drug: isotretinoin; Other: laboratory biomarker analysis; Genetic: protein expression analysis Sponsors: Wake Forest University Health Sciences; National Cancer Institute (NCI) Terminated Wed, 14 Apr 2010 12:00:00 EDT A Biomarker-Directed Phase 2 Trial of SY-1425 in Patients With Acute Myeloid Leukemia or Myelodysplastic SyndromeConditions: Acute Myeloid Leukemia; Myelodysplastic SyndromeInterventions: Drug: SY-1425 (tamibarotene); Drug: azacitidine; Drug: Daratumumab Sponsor: Syros Pharmaceuticals Active, not recruiting Tue, 21 Jun 2016 12:00:00 EDT Isotretinoin in Treating Young Patients With High-Risk NeuroblastomaCondition: NeuroblastomaInterventions: Drug: isotretinoin; Genetic: DNA analysis; Genetic: polymerase chain reaction; Other: laboratory biomarker analysis; Other: pharmacological study Sponsor: Children's Cancer and Leukaemia Group Unknown status Wed, 15 Jul 2009 12:00:00 EDT Isotretinoin Plus Dexamethasone in Treating Patients With Multiple MyelomaCondition: Multiple Myeloma and Plasma Cell NeoplasmInterventions: Drug: dexamethasone; Drug: isotretinoin Sponsors: Fox Chase Cancer Center; National Cancer Institute (NCI) Completed Thu, 11 Mar 2004 12:00:00 EST
An Open-Label Extension Study of Palovarotene to Prevent Heterotopic Ossification in People With Fibrodysplasia Ossificans Progressiva (FOP) in FranceCondition: Fibrodysplasia Ossificans ProgressivaIntervention: Drug: Palovarotene Sponsor: Clementia Pharmaceuticals Inc. Active, not recruiting Fri, 02 Dec 2016 12:00:00 EST Isotretinoin, Interferon Alfa-2b, Docetaxel, and Estramustine in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone TherapyCondition: Prostate CancerInterventions: Biological: recombinant interferon alfa-2b; Drug: docetaxel; Drug: estramustine phosphate sodium; Drug: isotretinoin; Genetic: polyacrylamide gel electrophoresis; Genetic: protein expression analysis; Other: immunohistochemistry staining method Sponsors: University of Medicine and Dentistry of New Jersey; National Cancer Institute (NCI) Terminated Thu, 15 Sep 2005 12:00:00 EDT MS-275 and Isotretinoin in Treating Patients With Metastatic or Advanced Solid Tumors or LymphomasConditions: Adult Grade III Lymphomatoid Granulomatosis; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Mycosis Fungoides/Sezary Syndrome; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström MacroglobulinemiaInterventions: Drug: entinostat; Drug: isotretinoin Sponsor: National Cancer Institute (NCI) Completed Thu, 09 Dec 2004 12:00:00 EST Gemtuzumab Ozogamicin in Combination With A-HAM in Refractory AML (GO-A-HAM)Condition: Leukemia, Myeloid, AcuteInterventions: Drug: Cytarabine; Drug: Mitoxantrone; Drug: Gemtuzumab Ozogamicin; Drug: All-trans-Retinoid Acid Sponsor: University of Ulm Completed Fri, 02 Sep 2005 12:00:00 EDT Vorinostat and Isotretinoin in Treating Patients With Advanced Kidney CancerConditions: Recurrent Renal Cell Cancer; Stage III Renal Cell Cancer; Stage IV Renal Cell CancerInterventions: Drug: vorinostat; Drug: isotretinoin Sponsor: National Cancer Institute (NCI) Terminated Thu, 11 May 2006 12:00:00 EDT Chemotherapy With or Without Biological Therapy in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone TherapyCondition: Prostate CancerInterventions: Biological: recombinant interferon alfa; Drug: estramustine phosphate sodium; Drug: isotretinoin; Drug: mitoxantrone hydrochloride; Drug: paclitaxel; Drug: vinorelbine ditartrate Sponsors: Eastern Cooperative Oncology Group; National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST Fractional Laser as Treatment Option for Various Pigment Disorders (Fractional-3)Condition: Pigmentation DisorderInterventions: Device: Fraxel Restore, Solta Medical Inc. (Non-ablative fractional laser); Drug: Modified Kligman's formula (Triple topical therapy) Sponsor: Netherlands Institute for Pigment Disorders Completed Thu, 11 Mar 2010 12:00:00 EST Chemotherapy Plus Monoclonal Antibody in Treating Patients With Acute Promyelocytic LeukemiaCondition: LeukemiaInterventions: Biological: filgrastim; Biological: lintuzumab; Drug: arsenic trioxide; Drug: idarubicin; Drug: tretinoin Sponsors: Memorial Sloan Kettering Cancer Center; National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST Vorinostat With or Without Isotretinoin in Treating Young Patients With Recurrent or Refractory Solid Tumors, Lymphoma, or LeukemiaConditions: Childhood Acute Promyelocytic Leukemia (M3); Childhood Atypical Teratoid/Rhabdoid Tumor; Childhood Burkitt Lymphoma; Childhood Chronic Myelogenous Leukemia; Childhood Diffuse Large Cell Lymphoma; Childhood Immunoblastic Large Cell Lymphoma; Juvenile Myelomonocytic Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Medulloblastoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Neuroblastoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Relapsing Chronic Myelogenous Leukemia; Unspecified Childhood Solid Tumor, Protocol SpecificInterventions: Drug: vorinostat; Drug: isotretinoin Sponsor: National Cancer Institute (NCI) Completed Thu, 22 Sep 2005 12:00:00 EDT Combination Chemotherapy Followed By Donor Bone Marrow or Umbilical Cord Blood Transplant in Treating Children With Newly Diagnosed Juvenile Myelomonocytic LeukemiaCondition: Juvenile Myelomonocytic LeukemiaInterventions: Drug: tipifarnib; Drug: isotretinoin; Drug: fludarabine phosphate; Drug: cytarabine; Radiation: radiation therapy; Drug: cyclophosphamide; Biological: anti-thymocyte globulin; Procedure: allogeneic bone marrow transplantation; Procedure: double-unit umbilical cord blood transplantation; Procedure: umbilical cord blood transplantation; Other: laboratory biomarker analysis Sponsor: National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST
Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation or Isotretinoin in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Acute Lymphocytic LeukemiaConditions: Chronic Myeloproliferative Disorders; Leukemia; Myelodysplastic Syndromes; ThrombocytopeniaInterventions: Biological: filgrastim; Dietary Supplement: vitamin E; Drug: busulfan; Drug: cytarabine; Drug: etoposide; Drug: fludarabine phosphate; Drug: isotretinoin; Drug: topotecan hydrochloride; Procedure: bone marrow ablation with stem cell support; Procedure: peripheral blood stem cell transplantation Sponsor: Drexel University College of Medicine Completed Tue, 27 Apr 2004 12:00:00 EDT Combination Chemotherapy Plus Biological Therapy in Treating Patients With Acute Myelogenous LeukemiaCondition: LeukemiaInterventions: Biological: recombinant interferon alfa; Drug: amifostine trihydrate; Drug: bromodeoxyuridine; Drug: cytarabine; Drug: idarubicin; Drug: idoxuridine; Drug: isotretinoin; Drug: mitoxantrone hydrochloride Sponsors: Rush University Medical Center; National Cancer Institute (NCI) Unknown status Mon, 24 May 2004 12:00:00 EDT Cytarabine (Ara-C) in Children With Acute Promyelocytic Leukemia (APL)Condition: LeukemiaInterventions: Drug: DNR:; Drug: Ara-c Sponsor: Xiaofan Zhu Completed Tue, 31 Aug 2010 12:00:00 EDT Multicentric Study Comparison Between Erythropoietin and Erythropoietin Associated to Differentiating Therapy With Acid 13-cis-retinoic and Dihydroxyvitamin D3 in Myelodysplastic Syndromes Without Excess of BlastsCondition: Myelodysplastic SyndromesInterventions: Drug: infusion A: rEPO; Drug: B Infusion rEPO combined with vitamins pills Sponsors: Fondazione Italiana Sindromi Mielodisplastiche-ETS; Centro di Riferimento per l'Epidemiologia e la Prev. Oncologica Piemonte Terminated Mon, 08 Dec 2008 12:00:00 EST Phase III Trial in Acute Promyelocytic Leukemia PatientsCondition: LeukemiaInterventions: Drug: arsenic trioxide; Drug: idarubicin; Drug: mercaptopurine; Drug: methotrexate; Drug: all-trans retinoic acid; Drug: all-trans retinoic acid (ATRA) Sponsors: Gruppo Italiano Malattie EMatologiche dell'Adulto; Study Alliance Leukemia (SAL) Group Unknown status Tue, 05 Jun 2007 12:00:00 EDT Interferon Alfa With or Without Isotretinoin in Treating Patients With Metastatic Kidney CancerCondition: Kidney CancerInterventions: Biological: recombinant interferon alfa; Drug: chemotherapy; Drug: isotretinoin Sponsor: European Organisation for Research and Treatment of Cancer - EORTC Completed Tue, 11 May 2004 12:00:00 EDT Vitamin A, Its Receptors and AsthmaCondition: AsthmaIntervention: Sponsor: University of Kansas Withdrawn Wed, 05 Mar 2008 12:00:00 EST Nivolumab With Chemotherapy in Refractory MDSCondition: Myelodysplastic SyndromesInterventions: Drug: Nivolumab; Drug: Azacitidine; Drug: Fludarabine; Drug: Cyclophosphamide; Drug: Cytarabine; Drug: all trans retinoic acid; Drug: Sildenafil; Drug: Melphalan Sponsor: St. Petersburg State Pavlov Medical University Terminated Wed, 23 Aug 2017 12:00:00 EDT S0535, Gemtuzumab and Combination Chemotherapy in Treating Patients With Previously Untreated Acute Promyelocytic LeukemiaCondition: LeukemiaInterventions: Drug: arsenic trioxide; Drug: gemtuzumab ozogamicin; Drug: mercaptopurine; Drug: methotrexate; Drug: tretinoin Sponsors: Southwest Oncology Group; National Cancer Institute (NCI) Completed Wed, 31 Oct 2007 12:00:00 EDT Allogeneic Stem Cell Transplantation Followed By Targeted Immune Therapy In Average Risk LeukemiaConditions: Acute Myelogenous Leukemia; Myelodysplastic Syndrome; Juvenile Myelomonocytic LeukemiaInterventions: Drug: Fludarabine; Drug: Busulfan; Drug: GVHD Prophylaxis; Drug: Gemtuzumab Ozogamicin; Drug: Anti-Thymocyte Globulin; Drug: Isotretinoin Sponsor: Columbia University Completed Wed, 25 Nov 2009 12:00:00 EST
Oral Arsenic Trioxide for Newly Diagnosed Acute Promyelocytic LeukaemiaCondition: Acute Promyelocytic LeukemiaIntervention: Drug: Oral arsenic Trioxide, ATRA and ascorbic acid Sponsor: The University of Hong Kong Recruiting Fri, 10 Aug 2018 12:00:00 EDT Comedone Extraction and Oral Doxycycline In The First Line Treatment of Moderate Acne VulgarisCondition: Acne VulgarisInterventions: Drug: Doxycycline Capsule; Procedure: Comedone extraction Sponsor: Indonesia University Completed Fri, 20 Dec 2019 12:00:00 EST Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic LeukemiaConditions: Childhood Acute Promyelocytic Leukemia (M3); Untreated Childhood Acute Myeloid Leukemia and Other Myeloid MalignanciesInterventions: Drug: arsenic trioxide; Drug: mitoxantrone hydrochloride; Other: diagnostic laboratory biomarker analysis; Drug: idarubicin; Drug: tretinoin; Drug: cytarabine; Drug: mercaptopurine tablet; Drug: methotrexate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Active, not recruiting Mon, 23 Mar 2009 12:00:00 EDT Alitretinoin vs Cyclosporine in Severe Recurrent Vesicular Hand EczemaCondition: Hand EczemaInterventions: Drug: Alitretinoin; Drug: cyclosporin A Sponsors: University Medical Center Groningen; ZonMw: The Netherlands Organisation for Health Research and Development Recruiting Fri, 20 Jan 2017 12:00:00 EST Alitretinoin vs Azathioprine in Severe Non-hyperkeratotic Hand EczemaCondition: Hand EczemaInterventions: Drug: Alitretinoin; Drug: Azathioprine Sponsor: University Medical Center Groningen Unknown status Fri, 20 Jan 2017 12:00:00 EST Microneedling Therapy With or Without Amnion Bilayer Sheeting on Scar TissueConditions: Scars, Hypertrophic; Burn ScarInterventions: Procedure: Microoneedling and Amnion Bilayer; Procedure: Microoneedling Sponsor: Dr.dr.Irma Bernadette, SpKK (K) Not yet recruiting Fri, 06 Aug 2021 12:00:00 EDT Combination Chemotherapy Followed by Stem Cell Transplant in High-risk Neuroblastoma PatientsCondition: NeuroblastomaInterventions: Drug: Cycles N8, N5 and N6; Drug: Cycles N5 and N6 Sponsor: University of Cologne Completed Fri, 03 Feb 2017 12:00:00 EST Long Term Continuous Infusion ch14.18/CHO Plus s.c. Aldesleukin (IL-2)Condition: NeuroblastomaInterventions: Drug: ch14.18/CHO; Drug: Aldesleukin; Drug: Isotretinoin Sponsors: St. Anna Kinderkrebsforschung; University Medicine Greifswald; St. Anna Children's Hospital, Vienna; Hospital Universitario La Fe; Istituto Giannina Gaslini; Gustave Roussy, Cancer Campus, Grand Paris; Schneider Children's Medical Center, Israel; Great Ormond Street Hospital for Children NHS Foundation Trust; University Hospital, Toulouse; Johann Wolfgang Goethe University Hospital; Jena University Hospital; Children's University Hospital, Ireland; University Hospital Tuebingen; Fondazione IRCCS Istituto Nazionale dei Tumori, Milano; Alder Hey Children's NHS Foundation Trust; University Hospitals Bristol and Weston NHS Foundation Trust; Newcastle-upon-Tyne Hospitals NHS Trust; The Leeds Teaching Hospitals NHS Trust; NHS Greater Glasgow and Clyde; Medical University of Graz; Medical University Innsbruck; Centre Leon Berard; Hospital Infantil Universitario Niño Jesús, Madrid, Spain; University Hospital Southampton NHS Foundation Trust; Institut Curie; Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Active, not recruiting Fri, 05 Oct 2012 12:00:00 EDT Combination Chemotherapy in Treating Patients With Acute Promyelocytic LeukemiaCondition: LeukemiaInterventions: Drug: arsenic trioxide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: mercaptopurine; Drug: methotrexate; Drug: tretinoin Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; National Cancer Institute (NCI) Completed Fri, 13 Jan 2006 12:00:00 EST Neuroblastoma Protocol 2008: Therapy for Children With Advanced Stage High Risk NeuroblastomaCondition: NeuroblastomaInterventions: Drug: Temsirolimus; Drug: Irinotecan; Procedure: Surgical Resection of Primary Tumor; Drug: Cyclophosphamide; Drug: Doxorubicin; Drug: Etoposide; Drug: Cisplatin; Drug: Topotecan; Procedure: PBSC; Radiation: Radiation Therapy; Drug: 13-cis-retinoic acid Sponsor: St. Jude Children's Research Hospital Terminated Tue, 16 Dec 2008 12:00:00 EST
Vorinostat, Isotretinoin and Temozolomide in Adults With Recurrent Glioblastoma Multiforme (GBM)Conditions: Glioblastoma Multiforme; Anaplastic GliomaInterventions: Drug: Vorinostat; Drug: Isotretinoin; Procedure: Surgical Resection; Drug: Temozolomide Sponsors: M.D. Anderson Cancer Center; Merck Sharp & Dohme Corp. Active, not recruiting Thu, 08 Nov 2007 12:00:00 EST Long-term Safety Study of Arsenic Trioxide in Newly Diagnosed, Low-to-intermediate Risk Acute Promyelocytic LeukemiaCondition: Acute Promyelocytic LeukemiaIntervention: Drug: Arsenic Trioxide Sponsor: Gruppo Italiano Malattie EMatologiche dell'Adulto Recruiting Fri, 23 Nov 2018 12:00:00 EST Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME TrialConditions: Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Anatomic Stage IV Breast Cancer AJCC v8; Anemia; Ann Arbor Stage III Hodgkin Lymphoma; Ann Arbor Stage III Non-Hodgkin Lymphoma; Ann Arbor Stage IIIA Hodgkin Lymphoma; Ann Arbor Stage IIIB Hodgkin Lymphoma; Ann Arbor Stage IV Hodgkin Lymphoma; Ann Arbor Stage IV Non-Hodgkin Lymphoma; Ann Arbor Stage IVA Hodgkin Lymphoma; Ann Arbor Stage IVB Hodgkin Lymphoma; Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative; Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Castration-Resistant Prostate Carcinoma; Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Hematopoietic and Lymphoid Cell Neoplasm; Locally Advanced Pancreatic Adenocarcinoma; Metastatic Breast Carcinoma; Metastatic Malignant Solid Neoplasm; Metastatic Pancreatic Adenocarcinoma; Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis; Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable; Primary Myelofibrosis; Prognostic Stage IV Breast Cancer AJCC v8; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Recurrent Chronic Lymphocytic Leukemia; Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Recurrent Hematologic Malignancy; Recurrent Hodgkin Lymphoma; Recurrent Myelodysplastic Syndrome; Recurrent Myelodysplastic/Myeloproliferative Neoplasm; Recurrent Myeloproliferative Neoplasm; Recurrent Non-Hodgkin Lymphoma; Recurrent Plasma Cell Myeloma; Recurrent Small Lymphocytic Lymphoma; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Refractory Chronic Lymphocytic Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Chronic Myelomonocytic Leukemia; Refractory Hematologic Malignancy; Refractory Hodgkin Lymphoma; Refractory Malignant Solid Neoplasm; Refractory Myelodysplastic Syndrome; Refractory Myelodysplastic/Myeloproliferative Neoplasm; Refractory Non-Hodgkin Lymphoma; Refractory Plasma Cell Myeloma; Refractory Primary Myelofibrosis; Refractory Small Lymphocytic Lymphoma; Stage II Pancreatic Cancer AJCC v8; Stage IIA Pancreatic Cancer AJCC v8; Stage IIB Pancreatic Cancer AJCC v8; Stage III Pancreatic Cancer AJCC v8; Stage IV Pancreatic Cancer AJCC v8; Stage IV Prostate Cancer AJCC v8; Stage IVA Prostate Cancer AJCC v8; Stage IVB Prostate Cancer AJCC v8; Unresectable Pancreatic AdenocarcinomaInterventions: Drug: Abemaciclib; Drug: Abiraterone; Drug: Afatinib; Biological: Bevacizumab; Drug: Bicalutamide; Procedure: Biospecimen Collection; Drug: Bortezomib; Drug: Cabazitaxel; Drug: Cabozantinib; Drug: Capecitabine; Drug: Carboplatin; Drug: Celecoxib; Drug: Cobimetinib; Drug: Copanlisib; Drug: Dabrafenib; Drug: Dacomitinib; Drug: Darolutamide; Drug: Dasatinib; Drug: Doxorubicin; Biological: Durvalumab; Drug: Enasidenib; Drug: Entrectinib; Drug: Enzalutamide; Drug: Erlotinib; Drug: Everolimus; Drug: Fluorouracil; Drug: Idelalisib; Drug: Imatinib; Biological: Ipilimumab; Drug: Lenvatinib; Drug: Leucovorin; Drug: Lorlatinib; Drug: Losartan; Drug: Nab-paclitaxel; Drug: Neratinib; Biological: Nivolumab; Drug: Olaparib; Drug: Oxaliplatin; Drug: Palbociclib; Drug: Panobinostat; Biological: Pembrolizumab; Biological: Pertuzumab; Drug: Ponatinib; Other: Quality-of-Life Assessment; Drug: Regorafenib; Drug: Ruxolitinib; Drug: Sirolimus; Drug: Sorafenib; Drug: Sunitinib; Drug: Trametinib; Biological: Trastuzumab Emtansine; Drug: Tretinoin; Drug: Vemurafenib; Drug: Venetoclax; Drug: Vismodegib; Drug: Vorinostat Sponsors: OHSU Knight Cancer Institute; Oregon Health and Science University Recruiting Mon, 18 Mar 2019 12:00:00 EDT Cytosine Arabinoside and Mitoxantrone for Patients With Juvenile Myelomonocytic Leukemia Receiving Repeat Stem Cell TransplantationCondition: LeukemiaInterventions: Drug: cyclosporine; Drug: cytarabine; Drug: filgrastim; Drug: methotrexate; Drug: methylprednisolone; Drug: mitoxantrone hydrochloride; Procedure: allogeneic bone marrow transplantation; Procedure: umbilical cord blood transplantation; Drug: Cis-Retinoic acid Sponsor: Masonic Cancer Center, University of Minnesota Terminated Thu, 07 Feb 2008 12:00:00 EST Fractional Laser as Treatment Option for Various Pigment DisordersCondition: Pigmentation DisorderIntervention: Device: Ablative fractional laser therapy Sponsor: Netherlands Institute for Pigment Disorders Completed Tue, 09 Mar 2010 12:00:00 EST Phase 1 Trial of ST-001 nanoFenretinide in Relapsed/Refractory T-cell Non-Hodgkin LymphomaConditions: T-cell Lymphoma; Cutaneous/Peripheral T-Cell Lymphoma; Peripheral T-cell Lymphoma; Peripheral T-Cell Lymphoma, Not Classified; Primary Cutaneous T-cell Lymphoma; Cutaneous T-Cell Lymphoma, Unspecified; Cutaneous T-cell Lymphoma; Follicular T-Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Sézary's Disease; Mycosis FungoidesIntervention: Drug: Fenretinide Sponsors: SciTech Development, LLC; Rush University Medical Center Not yet recruiting Tue, 21 Jan 2020 12:00:00 EST Stem Cell Transplant for Juvenile Myelomonocytic Leukemia (JMML)Condition: Juvenile Myelomonocytic LeukemiaInterventions: Biological: Stem Cell Transplant; Drug: Preparative Regimen Sponsor: Masonic Cancer Center, University of Minnesota Completed Wed, 14 Sep 2005 12:00:00 EDT Tandem High Dose Chemotherapy With 131I-MIBG Treatment in High Risk NeuroblastomaCondition: High Risk NeuroblastomaInterventions: Drug: Cyclophosphamide; Drug: Carboplatin; Drug: Etoposide; Radiation: 131I-MIBG; Drug: Thiotepa; Drug: Melphalan Sponsors: Samsung Medical Center; Ministry of Health, Republic of Korea Unknown status Thu, 23 Feb 2017 12:00:00 EST Tandem High-dose Chemotherapy and Autologous Stem Cell Rescue in Patients With High-risk NeuroblastomaCondition: NeuroblastomaInterventions: Drug: Cyclophosphamide; Drug: Etoposide; Drug: Carboplatin; Drug: Thiotepa; Drug: Melphalan; Radiation: Total body irradiation Sponsor: Samsung Medical Center Completed Wed, 19 Nov 2008 12:00:00 EST Lenalidomide and Dinutuximab With or Without Isotretinoin in Treating Younger Patients With Refractory or Recurrent NeuroblastomaConditions: Recurrent Neuroblastoma; Refractory NeuroblastomaInterventions: Biological: Dinutuximab; Drug: Isotretinoin; Other: Laboratory Biomarker Analysis; Drug: Lenalidomide; Other: Pharmacological Study Sponsor: National Cancer Institute (NCI) Active, not recruiting Mon, 22 Oct 2012 12:00:00 EDT
Comparison of Two Laser Therapy Methods for PDRCondition: Proiriftrative Diabetic RetinopathyInterventions: Procedure: conventional prp; Procedure: targeted prp Sponsor: Shahid Beheshti University of Medical Sciences Unknown status Tue, 02 Nov 2010 12:00:00 EDT A Companion Treatment Study for Patients With Moderate to Severe Acne VulgarisCondition: Acne VulgarisInterventions: Drug: Isotretinoin; Drug: Amzeeq 4% Topical Foam Sponsors: Edward Lain, MD; Vyne Therapeutics Inc. Recruiting Mon, 28 Jun 2021 12:00:00 EDT Isotretinoin in Treatment of COVID-19Condition: COVID-19Intervention: Drug: Isotretinoin Only Product in Oral Dose Form Sponsor: Tanta University Not yet recruiting Fri, 24 Apr 2020 12:00:00 EDT Efficacy and Safety of IDP-121 and IDP-121 Vehicle Lotion in the Treatment of Acne VulgarisCondition: AcneInterventions: Drug: IDP 121 Lotion; Drug: IDP-121 Vehicle Lotion Sponsor: Bausch Health Americas, Inc. Completed Wed, 16 Nov 2016 12:00:00 EST Efficacy and Safety of IDP-121 and IDP-121 Vehicle Lotion in the Treatment of Acne VulgarisCondition: AcneInterventions: Drug: IDP-121 Lotion; Drug: IDP-121 Vehicle Lotion Sponsor: Bausch Health Americas, Inc. Completed Thu, 13 Oct 2016 12:00:00 EDT Combination Chemotherapy, Biological Therapy, and Bone Marrow Transplantation in Treating Patients With Acute Myeloid LeukemiaConditions: Leukemia; NeutropeniaInterventions: Biological: filgrastim; Drug: amsacrine; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: etoposide; Drug: idarubicin; Drug: mitoxantrone hydrochloride; Drug: thioguanine; Drug: tretinoin; Procedure: allogeneic bone marrow transplantation; Procedure: autologous bone marrow transplantation; Procedure: peripheral blood stem cell transplantation; Radiation: radiation therapy Sponsor: Medical Research Council Unknown status Thu, 10 Apr 2003 12:00:00 EDT Chemotherapy and Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With NeuroblastomaCondition: NeuroblastomaInterventions: Biological: filgrastim; Drug: carboplatin; Drug: cisplatin; Drug: cyclophosphamide; Drug: dacarbazine; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: ifosfamide; Drug: melphalan; Drug: tretinoin; Drug: vincristine sulfate; Drug: vindesine; Procedure: autologous bone marrow transplantation; Procedure: conventional surgery; Procedure: peripheral blood stem cell transplantation; Radiation: radiation therapy Sponsor: Gesellschaft fur Padiatrische Onkologie und Hamatologie - Germany Completed Mon, 27 Jan 2003 12:00:00 EST Intensive Compared With Nonintensive Chemotherapy in Treating Older Patients With Acute Myeloid Leukemia or Myelodysplastic SyndromeConditions: Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative NeoplasmsInterventions: Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: etoposide; Drug: hydroxyurea; Drug: idarubicin; Drug: mitoxantrone hydrochloride; Drug: thioguanine; Drug: tretinoin; Drug: valspodar Sponsor: Leukemia Research Fund Completed Mon, 27 Jan 2003 12:00:00 EST Treatment of Melasma With Stabilized Kligman Preparation Associated or Not With Pulsed Dye LaserCondition: MelanosisInterventions: Procedure: pulsed dye laser treatment; Drug: Kligman's Trio Sponsor: Centre Hospitalier Universitaire de Nice Terminated Tue, 17 Mar 2009 12:00:00 EDT A Phase I Dose Escalation Study of GSK2879552 in Subjects With Acute Myeloid Leukemia (AML)Condition: Leukaemia, Myelocytic, AcuteInterventions: Drug: GSK2879552; Drug: ATRA Sponsor: GlaxoSmithKline Terminated Mon, 30 Jun 2014 12:00:00 EDT
High Dose Chemotherapy and Autologous Transplant for NeuroblastomaCondition: NeuroblastomaInterventions: Drug: Carboplatin; Biological: Autologous stem cell infusion; Biological: Granulocyte colony stimulating factor; Radiation: Radiation therapy; Drug: Isotretinoin (13-cis-retinoic acid); Drug: Melphalan; Drug: Etoposide Sponsor: Masonic Cancer Center, University of Minnesota Recruiting Mon, 06 Feb 2012 12:00:00 EST Genomic Based Assignment of Therapy in Advanced Urothelial CarcinomaConditions: Urothelial Carcinoma; Bladder Cancer; Urinary Bladder NeoplasmsInterventions: Drug: 75 approved agents; Other: COXEN Sponsor: National Cancer Institute (NCI) Completed Thu, 02 Jun 2016 12:00:00 EDT A Study for Improving the Outcome of Childhood Acute Promyeloid LeukemiaCondition: Childhood Acute Promyelocytic LeukemiaInterventions: Drug: ATO; Drug: RIF; Drug: ATRA; Drug: mitoxantrone; Drug: Ara-C; Drug: MTX; Drug: 6MP; Other: intrathecal injection Sponsor: South China Children's Leukemia Group Enrolling by invitation Fri, 25 Jul 2014 12:00:00 EDT A Biomarker Evaluation Trial of UAB30 in Renal Transplant Recipients at High Risk for Non-melanoma Skin CancerCondition: Non-melanoma Skin CancerInterventions: Drug: UAB30; Drug: Placebo Sponsor: University of Alabama at Birmingham Recruiting Tue, 31 Oct 2017 12:00:00 EDT Temozolomide Alone or in Combination With Thalidomide and/or Isotretinoin and/or Celecoxib in Treating Patients Who Have Undergone Radiation Therapy for Glioblastoma MultiformeCondition: Brain and Central Nervous System TumorsInterventions: Drug: Celecoxib; Drug: Isotretinoin; Drug: Temozolomide; Drug: Thalidomide Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI) Completed Fri, 03 Jun 2005 12:00:00 EDT Impact of Vitamin A on RAR Gene Expression in Multiple SclerosisCondition: Relapsing Remitting Multiple SclerosisInterventions: Drug: Dietary Supplement: vitamin A; Drug: placebo Sponsor: Tehran University of Medical Sciences Unknown status Fri, 12 Oct 2012 12:00:00 EDT Effects of Isotretinoin on the Growth Rate and Thickness of the Nail PlateConditions: Isotretinoin; Nail AbnormalityIntervention: Drug: Isotretinoin Sponsor: Sinan Özçelik Completed Wed, 09 Dec 2020 12:00:00 EST SY-1425 Plus Azacitidine in Participants With Newly Diagnosed RARA-positive Higher-Risk Myelodysplastic SyndromeCondition: Myelodysplastic SyndromesInterventions: Drug: SY-1425 + Azacitidine; Drug: SY-1425 Matched Placebo + Azacitidine Sponsor: Syros Pharmaceuticals Recruiting Mon, 15 Mar 2021 12:00:00 EDT Efficacy of Topical Antioxidants in Tretment of PhotoagingCondition: PhotoagingIntervention: Drug: Selenium Amino Acid Chelate (Selenium ACE cream) Sponsor: Sohag University Not yet recruiting Thu, 08 Apr 2021 12:00:00 EDT Treatment With Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination With Irinotecan and Temozolomide After Intensive Therapy for People With High-Risk Neuroblastoma (NBL)Conditions: Ganglioneuroblastoma, Nodular; High Risk NeuroblastomaInterventions: Biological: Dinutuximab; Drug: Irinotecan; Drug: Isotretinoin; Biological: Sargramostim; Drug: Temozolomide Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Recruiting Tue, 12 May 2020 12:00:00 EDT
Economic Analysis of Blood Product Transfusions According to the Treatment of Acute Myeloid Leukaemia in the ElderlyCondition: Acute Myeloid LeukemiaIntervention: Other: Transfusion Sponsor: Hospices Civils de Lyon Completed Wed, 27 Jul 2016 12:00:00 EDT Monoclonal Antibody Ch14.18, Sargramostim, Aldesleukin, and Isotretinoin After Autologous Stem Cell Transplant in Treating Patients With NeuroblastomaCondition: High Risk NeuroblastomaInterventions: Biological: Aldesleukin; Other: Diagnostic Laboratory Biomarker Analysis; Biological: Dinutuximab; Drug: Isotretinoin; Biological: Sargramostim Sponsor: National Cancer Institute (NCI) Completed Fri, 01 Jan 2010 12:00:00 EST Isotretinoin With or Without Dinutuximab, Aldesleukin, and Sargramostim Following Stem Cell Transplant in Treating Patients With NeuroblastomaConditions: Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S NeuroblastomaInterventions: Biological: Aldesleukin; Biological: Dinutuximab; Drug: Isotretinoin; Other: Laboratory Biomarker Analysis; Other: Pharmacological Study; Other: Quality-of-Life Assessment; Biological: Sargramostim Sponsor: National Cancer Institute (NCI) Active, not recruiting Mon, 27 Jan 2003 12:00:00 EST Effect of Home-fortification With Sprinkles in Hematologic and Nutritional Status in Preschool Children in MedellínCondition: MalnutritionInterventions: Dietary Supplement: Sachets containing a blend of micronutrients in powder form (Iron, Zinc, Folic Acid, Vitamin A and C), sprinkled onto home made food; Dietary Supplement: placebo Sponsor: CES University Unknown status Tue, 06 Aug 2013 12:00:00 EDT Study of Safety and Efficacy of Topical GSK2981278 Ointment in Plaque PsoriasisCondition: PsoriasisInterventions: Drug: GSK2981278 0.03%; Drug: GSK2981278 0.1%; Drug: GSK2981278 0.8%; Drug: GSK2981278 4%; Drug: Vehicle; Drug: Betamethasone valerate 0.1% Sponsor: GlaxoSmithKline Completed Mon, 14 Sep 2015 12:00:00 EDT Study of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic LeukemiaCondition: Acute Promyelocytic LeukemiaIntervention: Drug: NRX 195183 Soft Gelatin Capsule Sponsor: NuRx Pharmaceuticals, Inc. Unknown status Mon, 12 May 2008 12:00:00 EDT Dinutuximab, Sargramostim, and Combination Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell TransplantConditions: Ganglioneuroblastoma; High Risk NeuroblastomaInterventions: Procedure: Autologous Hematopoietic Stem Cell Transplantation; Drug: Carboplatin; Drug: Cisplatin; Drug: Cyclophosphamide; Drug: Dexrazoxane; Biological: Dinutuximab; Drug: Doxorubicin; Drug: Etoposide; Radiation: External Beam Radiation Therapy; Drug: Isotretinoin; Drug: Melphalan; Biological: Sargramostim; Drug: Thiotepa; Drug: Topotecan; Drug: Vincristine Sponsor: National Cancer Institute (NCI) Active, not recruiting Wed, 26 Dec 2018 12:00:00 EST Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or GanglioneuroblastomaConditions: Ganglioneuroblastoma; INRG Stage L2; INRG Stage M; INRG Stage MS; NeuroblastomaInterventions: Procedure: Autologous Hematopoietic Stem Cell Transplantation; Drug: Busulfan; Drug: Carboplatin; Drug: Cisplatin; Drug: Crizotinib; Drug: Cyclophosphamide; Drug: Dexrazoxane Hydrochloride; Biological: Dinutuximab; Drug: Doxorubicin Hydrochloride; Drug: Etoposide Phosphate; Radiation: External Beam Radiation Therapy; Radiation: Iobenguane I-131; Drug: Isotretinoin; Drug: Melphalan Hydrochloride; Biological: Sargramostim; Procedure: Therapeutic Conventional Surgery; Drug: Thiotepa; Drug: Topotecan Hydrochloride; Drug: Vincristine Sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Recruiting Tue, 25 Apr 2017 12:00:00 EDT Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous SystemConditions: Medulloblastoma; Pineoblastoma; Supratentorial Embryonal Tumor, Not Otherwise SpecifiedInterventions: Radiation: 3-Dimensional Conformal Radiation Therapy; Drug: Carboplatin; Drug: Cisplatin; Drug: Cyclophosphamide; Drug: Etoposide Phosphate; Drug: Isotretinoin; Other: Laboratory Biomarker Analysis; Procedure: Peripheral Blood Stem Cell Transplantation; Drug: Thiotepa; Drug: Vincristine Sulfate; Drug: Vorinostat Sponsor: National Cancer Institute (NCI) Active, not recruiting Mon, 23 Mar 2009 12:00:00 EDT Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed, Previously Untreated, High-Risk Medulloblastoma/PNETConditions: Anaplastic Medulloblastoma; MedulloblastomaInterventions: Drug: Carboplatin; Drug: Cisplatin; Drug: Cyclophosphamide; Biological: Filgrastim; Drug: Isotretinoin; Other: Laboratory Biomarker Analysis; Other: Quality-of-Life Assessment; Radiation: Radiation Therapy; Drug: Vincristine Sulfate Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Active, not recruiting Thu, 26 Oct 2006 12:00:00 EDT
Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk NeuroblastomaConditions: Localized Resectable Neuroblastoma; Localized Unresectable Neuroblastoma; Recurrent Neuroblastoma; Regional Neuroblastoma; Stage 4 Neuroblastoma; Stage 4S NeuroblastomaInterventions: Procedure: Autologous Hematopoietic Stem Cell Transplantation; Drug: Carboplatin; Drug: Cisplatin; Drug: Cyclophosphamide; Drug: Doxorubicin Hydrochloride; Drug: Etoposide; Radiation: External Beam Radiation Therapy; Biological: Filgrastim; Drug: Isotretinoin; Other: Laboratory Biomarker Analysis; Drug: Melphalan; Procedure: Peripheral Blood Stem Cell Transplantation; Other: Pharmacological Study; Drug: Thiotepa; Drug: Topotecan Hydrochloride; Drug: Vincristine Sulfate Liposome Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Active, not recruiting Wed, 05 Dec 2007 12:00:00 EST Airway Intervention Registry (AIR): Recurrent Respiratory Papillomatosis (RRP)Conditions: Recurrent Respiratory Papillomatosis; Human Papilloma VirusInterventions: Procedure: Microdebrider; Procedure: Cold-steel surgery (forceps); Procedure: Carbon dioxide laser; Procedure: Potassium titanyl phosphate (KTP) laser; Procedure: Pulsed dye laser; Procedure: Radiofrequency ablation; Procedure: Monopolar suction diathermy; Procedure: Plasma coagulation; Procedure: Other; Other: Adjuvant therapies Sponsors: Newcastle-upon-Tyne Hospitals NHS Trust; Alder Hey Children's NHS Foundation Trust; National Institute for Health Research, United Kingdom Recruiting Wed, 14 Mar 2018 12:00:00 EDT Therapy for Children With Advanced Stage NeuroblastomaCondition: NeuroblastomaInterventions: Drug: cyclophosphamide; Drug: topotecan; Biological: hu14.18K322A; Procedure: peripheral blood stem cell harvest; Procedure: surgical resection; Drug: cisplatin; Drug: etoposide; Drug: doxorubicin; Drug: vincristine; Drug: busulfan; Drug: melphalan; Biological: peripheral blood stem cell transplantation; Biological: natural killer cell infusion; Radiation: radiation therapy; Biological: GM-CSF; Biological: G-CSF; Drug: mesna; Drug: levetiracetam; Biological: interleukin-2; Drug: Isotretinoin; Device: CliniMACS Sponsors: St. Jude Children's Research Hospital; Cookies for Kids' Cancer; CURE Childhood Cancer, Inc. Active, not recruiting Mon, 20 May 2013 12:00:00 EDT An Efficacy and Safety Study of Palovarotene for the Treatment of MOCondition: Exostoses, Multiple HereditaryInterventions: Drug: Palovarotene 2.5 mg; Drug: Palovarotene 5.0 mg; Other: Placebo Sponsor: Clementia Pharmaceuticals Inc. Terminated Thu, 22 Feb 2018 12:00:00 EST An Efficacy and Safety Study of Palovarotene for the Treatment of Fibrodysplasia Ossificans Progressiva.Condition: Fibrodysplasia Ossificans ProgressivaIntervention: Drug: Palovarotene Sponsor: Clementia Pharmaceuticals Inc. Active, not recruiting Wed, 18 Oct 2017 12:00:00 EDT In-Home Evaluation of Episodic Administration of Palovarotene in Fibrodysplasia Ossificans Progressiva (FOP) SubjectsCondition: Fibrodysplasia Ossificans ProgressivaIntervention: Drug: Palovarotene Sponsor: Clementia Pharmaceuticals Inc. Terminated Thu, 13 Aug 2015 12:00:00 EDT An Efficacy and Safety Study of Palovarotene to Treat Preosseous Flare-ups in FOP SubjectsCondition: Fibrodysplasia Ossificans ProgressivaInterventions: Drug: Palovarotene; Drug: Placebo Sponsor: Clementia Pharmaceuticals Inc. Completed Tue, 15 Jul 2014 12:00:00 EDT Autologous Cell Suspension Grafting Using ReCell in Vitiligo and Piebaldism PatientsConditions: Segmental Vitiligo; PiebaldismInterventions: Device: ReCell; Device: Full surface CO2 laser 200 mJ; Device: Full surface CO2 laser 150 mJ; Device: Fractional CO2 laser 7.5 mJ, 20% Sponsors: Netherlands Institute for Pigment Disorders; Avita Medical Completed Mon, 01 Jun 2015 12:00:00 EDT Interventional Testing of Gene-environment Interactions Via the Verifomics Mobile ApplicationConditions: Obesity; Rhinitis; Rhinitis, Allergic; Respiratory Sounds; Dyspnea; Headache; Migraine Disorders; Arthritis; Arthralgia; Anxiety; Sleep Initiation and Maintenance Disorders; Sleep DeprivationInterventions: Dietary Supplement: Vitamin A; Dietary Supplement: Vitamin B6; Dietary Supplement: Vitamin C; Dietary Supplement: Nicotinamide; Dietary Supplement: Vitamin D3; Dietary Supplement: Vitamin E; Other: Broccoli; Other: Spinach; Dietary Supplement: Caffeine; Other: Coffee; Device: Axon Eyewear; Other: Chocolate Sponsor: Verifomics LLC Terminated Tue, 03 May 2016 12:00:00 EDT 131MIBG to Treat Malignant PheochromocytomaCondition: PheochromocytomaInterventions: Drug: [131]I-MIBG; Drug: 6-[18F]Fluorodopamine; Drug: [123]I-MIBG Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Completed Wed, 12 Dec 2001 12:00:00 EST
High Throughput Drug Sensitivity Assay and Genomics- Guided Treatment of Patients With Relapsed or Refractory Acute LeukemiaConditions: Recurrent Acute Leukemia of Ambiguous Lineage; Recurrent Acute Lymphoblastic Leukemia; Recurrent Acute Myeloid Leukemia; Refractory Acute Lymphoblastic Leukemia; Refractory Acute Myeloid Leukemia; Refractory Acute Leukemia of Ambiguous LineageInterventions: Other: Chemosensitivity Assay; Other: Cytology Specimen Collection Procedure; Genetic: Gene Expression Analysis; Genetic: Genetic Variation Analysis; Drug: In Vitro Sensitivity-Directed Chemotherapy Sponsors: University of Washington; National Cancer Institute (NCI) Active, not recruiting Wed, 16 Sep 2015 12:00:00 EDT European Low and Intermediate Risk Neuroblastoma ProtocolCondition: LOW AND INTERMEDIATE PAEDIATRIC NEUROBLASTOMA AND NEONATAL SUPRARENAL MASSESIntervention: Drug: chemotherapy Sponsor: Instituto de Investigacion Sanitaria La Fe Recruiting Fri, 16 Nov 2012 12:00:00 EST Phase I Dose-Escalation Trial of Clofarabine Followed by Escalating Doses of Fractionated Cyclophosphamide in Children With Relapsed or Refractory Acute LeukemiasConditions: Myelodysplastic Syndrome; Acute Myeloid Leukemia; Myeloproliferative Disorders; Acute Lymphocytic Leukemia; Acute Promyelocytic Leukemia; Acute Leukemia; Chronic Myelogenous Leukemia; Myelofibrosis; Chronic Myelomonocytic Leukemia; Juvenile Myelomonocytic LeukemiaInterventions: Drug: Clofarabine; Drug: Cyclophosphamide Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Genzyme, a Sanofi Company Terminated Fri, 27 Feb 2009 12:00:00 EST High-Dose Chemotherapy Plus Autologous Stem Cell Transplantation Compared With Intermediate-Dose Chemotherapy Plus Autologous Stem Cell Transplantation With or Without Isotretinoin in Treating Young Patients With Recurrent High-Grade GliomasConditions: Brain Tumor; Central Nervous System TumorInterventions: Biological: filgrastim; Drug: carboplatin; Drug: etoposide; Drug: isotretinoin; Drug: thiotepa; Procedure: autologous bone marrow transplantation; Procedure: peripheral blood stem cell transplantation Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Tue, 09 Mar 2004 12:00:00 EST Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With NeuroblastomaCondition: NeuroblastomaInterventions: Drug: carboplatin; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: topotecan hydrochloride; Drug: Isotretinoin; Procedure: Surgery; Drug: Filgrastim Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Wed, 11 Jul 2007 12:00:00 EDT Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With NeuroblastomaCondition: NeuroblastomaInterventions: Biological: filgrastim; Drug: carboplatin; Drug: cisplatin; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: isotretinoin; Drug: melphalan; Drug: topotecan hydrochloride; Drug: vincristine sulfate; Procedure: autologous bone marrow transplantation; Procedure: bone marrow ablation with stem cell support; Procedure: conventional surgery; Procedure: peripheral blood stem cell transplantation; Radiation: radiation therapy Sponsors: Children's Oncology Group; National Cancer Institute (NCI) Completed Mon, 27 Jan 2003 12:00:00 EST |