References from scientific journals

Trihexyphenidyl for dystonia in cerebral palsy.

Harvey AR, Baker LB, Reddihough DS, Scheinberg A, Williams K. Harvey AR, et al. Cochrane Database Syst Rev. 2018 May 15;5(5):CD012430. doi: 10.1002/14651858.CD012430.pub2. Cochrane Database Syst Rev. 2018. PMID: 29763510 Free PMC article. Review.

OBJECTIVES: To assess the effects of trihexyphenidyl in people with dystonic cerebral palsy, according to the World Health Organization's (WHO) International Classification of Functioning, Disability and Health (ICF) domains of impairment, activity and participation. ...Th …
OBJECTIVES: To assess the effects of trihexyphenidyl in people with dystonic cerebral palsy, according to the World Health Organizati …

Misuse of Trihexyphenidyl (Artane) on Reunion Island.

Torrents R, Ferré JF, Konareff A, Hemery P, Sherwin K, Lassalle C, Simon N, Scerra S. Torrents R, et al. J Clin Psychopharmacol. 2018 Jun;38(3):250-253. doi: 10.1097/JCP.0000000000000882. J Clin Psychopharmacol. 2018. PMID: 29620695

BACKGROUND: Trihexyphenidyl (THP) is an anticholinergic drug misused to procure hallucination, sedation, and anxiolysis. ...
BACKGROUND: Trihexyphenidyl (THP) is an anticholinergic drug misused to procure hallucination, sedation, and anxiolysis. ...

Trihexyphenidyl abuse.

[No authors listed] [No authors listed] Am J Psychiatry. 1977 Nov;134(11):1315. doi: 10.1176/ajp.134.11.aj134111315. Am J Psychiatry. 1977. PMID: 911000 No abstract available.


Trihexyphenidyl dependence.

McInnis M, Petursson H. McInnis M, et al. Acta Psychiatr Scand. 1984 Jun;69(6):538-42. doi: 10.1111/j.1600-0447.1984.tb02528.x. Acta Psychiatr Scand. 1984. PMID: 6741602

Trihexyphenidyl, a synthetic anticholinergic, is frequently used concurrently with neuroleptics to control extrapyramidal side effects. We present two case reports of trihexyphenidyl abuse which concur with the increasing concern expressed regarding the abuse potent …
Trihexyphenidyl, a synthetic anticholinergic, is frequently used concurrently with neuroleptics to control extrapyramidal side effect …

Trihexyphenidyl induced malignant hyperthermia in a patient with Parkinson's disease complicated with pneumonia: A case report.

Zhao J, Xu G, Feng C, Chen Y, Kang Y, Liu F, Ma W. Zhao J, et al. Medicine (Baltimore). 2020 May;99(20):e20129. doi: 10.1097/MD.0000000000020129. Medicine (Baltimore). 2020. PMID: 32443324 Free PMC article.

INTRODUCTION: Drug-induced fever is easy to overlook in respiratory departments. High fever is a rare side effect of trihexyphenidyl, which can be used clinically to treat Parkinson's disease. ...CONCLUSION: High fever and SIADH can be a rare adverse reaction to trihexy …
INTRODUCTION: Drug-induced fever is easy to overlook in respiratory departments. High fever is a rare side effect of trihexyphenidyl, …

Trihexyphenidyl abuse.

Mohan D, Mohandas E, Dube S. Mohan D, et al. Br J Addict. 1981;76(2):195-7. doi: 10.1111/j.1360-0443.1981.tb00223.x. Br J Addict. 1981. PMID: 6944087 No abstract available.


Trihexyphenidyl and torticollis.

Scherokman B, Jabbari B, Gunderson CH, Miller JM, Rappaport HL. Scherokman B, et al. Neurology. 1986 Dec;36(12):1626. doi: 10.1212/wnl.36.12.1626. Neurology. 1986. PMID: 3537844 Clinical Trial. No abstract available.


Trihexyphenidyl withdrawal encephalopathy.

Johkura K, Matsumoto S, Hasegawa O, Kuroiwa Y. Johkura K, et al. Ann Neurol. 1997 Jan;41(1):133-4. doi: 10.1002/ana.410410124. Ann Neurol. 1997. PMID: 9005879 No abstract available.


Permeability and transport mechanism of trihexyphenidyl hydrochloride in Caco-2 cell monolayer model with a validated UPLC-MS/MS method.

Lu C, Fu K, Cao K, Wei J, Zhou J, Zhao D, Li N, Lu Y, Chen X, Zhang Y. Lu C, et al. J Pharm Biomed Anal. 2020 Jan 30;178:112924. doi: 10.1016/j.jpba.2019.112924. Epub 2019 Oct 21. J Pharm Biomed Anal. 2020. PMID: 31672580

A rapid and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was applied to investigate the permeability characteristics and transport mechanism of trihexyphenidyl hydrochloride (TH) in D-hanks with the Caco-2 cells model. …
A rapid and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was applied to investigate t …

Withdrawal of trihexyphenidyl.

McInnis M, Petursson H. McInnis M, et al. Acta Psychiatr Scand. 1985 Mar;71(3):297-303. doi: 10.1111/j.1600-0447.1985.tb01287.x. Acta Psychiatr Scand. 1985. PMID: 3984771 Clinical Trial.

In a group of 22 psychiatric patients receiving long-term antipsychotic medication concurrently with trihexyphenidyl the effects of trihexyphenidyl withdrawal were studied double-blind and placebo controlled. ...The majority of the parameters regained baseline value …
In a group of 22 psychiatric patients receiving long-term antipsychotic medication concurrently with trihexyphenidyl the effects of …