Urticaria and angioedema the swelling is very similar, but hives only affect the skin and each rash lasts less than 24 hours, while angioedema can last several days.

Hives occur in the outer layer of the skin, while angioedema occurs under the skin in the subcutaneous tissue. Angioedema can also affect the Lining, such as the eyelids and lips, and can be painful. It often manifests as deep swelling around the mouth and eyes and sometimes affects the genitals, hands, or feet.

Severe angioedema can cause the throat or tongue to swell, creating difficulty breathing. It can also cause swelling of the Lining of the gastrointestinal tract, which can lead to gastrointestinal spasms.

You can get hives and angioedema at the same time. The treatment of hives and angioedema is similar. However, if breathing is interrupted, it is necessary to seek emergency medical attention right away so that the airways remain open.

Whether hives or angioedema, seek emergency medical attention if you have difficulty breathing, wheezing, tightness in the chest, swelling of the tongue/face, or dizziness.