What you need to know about trazodone


Trazodone is an antidepressant in the serotonin modulator class of drugs. It is used to treat depression and works by increasing the action of serotonin in your brain. In addition to being used to treat depression, it can be used to treat insomnia and anxiety.

Trazodone is available in tablets and extended-release tablets. Common brands include Desyrel, Desyrel Dividose, and Oleptro.

Robin Gentry / EyeEm / Getty Images


Trazodone is used to control the symptoms of depression , but it cannot cure it. Your healthcare provider may start with a low dose and gradually increase it.

Trazodone increases serotonin activity in the brain. Serotonin is a chemical that generally promotes psychological well-being. Trazodone is also indicated for the treatment of insomnia and symptoms of anxiety.

Before drinking

Before you are prescribed this medicine for depression, your healthcare provider will consider whether the potential benefits outweigh the risks. Trazodone can interact with many other medications. Talk to your doctor about all the medications, supplements, and vitamins that you are currently taking.

While some medications pose a lower risk of interaction, others may directly contraindicate their use or require careful consideration and / or monitoring of interactions.

If you are pregnant or breastfeeding, your healthcare provider may consider other treatment options in addition to trazodone.

Precautions and contraindications.

Trazodone should be used with caution in adolescents and young adults. Studies have shown that a small percentage of young people under the age of 24 who take trazodone may develop suicidal or self-harming thoughts.

Your healthcare provider will discuss with you a plan on how to contact the appropriate resources if you or your child have thoughts of self-harm while taking trazodone.

Trazodone should not be used in patients with a history of heart disease or a recent heart attack. This medicine can cause or worsen QT interval prolongation , which can cause an irregular heart rate, which can lead to fainting, seizures, or even death.

This heart rate problem is affected by the level of potassium, sodium, and magnesium in your blood, so your healthcare provider can monitor these levels before prescribing trazodone.

If you have a history of glaucoma , trazodone may make it worse. Your healthcare provider may ask you to have an eye exam before requesting one.

Other antidepressants

Besides trazodone, the most common antidepressants include:


Trazodone is available in regular-release and extended-release tablets. It is available in a versatile form. According to the Food and Drug Administration (FDA), the dosage should be as follows:

  • For depression, the normal starting dose is 150 milligrams (mg) per day. When taking regular pills, they are most likely 75 mg in the morning and 75 mg in the evening.
  • For the treatment of insomnia, the dose usually starts with 25-50 mg at night.

Your healthcare provider will then work with you to find the correct dose and may increase it every few days. You can increase the dose by 50 mg every few days, the maximum dose is 400 mg.

According to the journal Pharmacy and Therapeutics , the extended-release tablet dosage also starts at 150 mg per day. These tablets are taken at bedtime because they can cause drowsiness.

Your healthcare provider may increase your dose by 75 mg every three days until the correct dose is found. The maximum daily dose for extended-release tablets is 375 mg per day.

All indicated doses are indicated by the manufacturer of the drug. Check your prescription and talk to your doctor to make sure you are taking the correct dose.

How to take and store

  • Trazodone regular-release tablets should be taken with meals or snacks to prevent indigestion.
  • If you have been prescribed an extended-release tablet, it should be taken on an empty stomach and never chewed or crushed.

Try to take your prescription at the same time every day.

If you miss an appointment, take it as soon as you remember. If your next dose is coming up, skip the one you forgot and never double the prescription. Since trazodone can make you drowsy, you may have to wait until evening to take your dose.

It is safest to store this medicine in the original bottle with a tightly closed cap. Make sure it is out of the reach of children and stored in a cool, dry place. Hot and humid areas, such as the bathroom after you shower, are not the best place to store trazodone.

Side effects


The most common side effects of trazodone are mild and generally do not require dose or prescription changes.

Common side effects include :

  • Mild dry mouth
  • Bad taste
  • Muscle pain
  • Nausea
  • Constipation

Severe form

Because trazodone affects your mood and heart function, there are some side effects that need to be addressed right away.

Call your doctor immediately if you experience any of the following side effects:

  • Suicidal thoughts
  • Dizziness or lightheadedness
  • Difficulty breathing
  • Fast or slow heartbeat
  • Confusion
  • Unusual agitation or nervousness
  • Seizures

Overdose warning

Trazodone overdose can cause serious side effects and can be life-threatening.

Overdose symptoms can include :

  • Loss of consciousness
  • Seizures
  • Difficulty breathing
  • Threw up
  • Prolonged and painful erection in men.

If you or your child experience any overdose symptoms, call a poison control center right away.

Warnings and interactions

Trazodone should be used with caution in patients who :

  • Adolescents with a history of suicidal thoughts;
  • Are pregnant
  • You have a history of heart disease.
  • He recently suffered a heart attack
  • You have a history of irregular heart rhythms.
  • Have glaucoma
  • There are certain types of cancer.
  • Do you have high blood pressure
  • Have sickle cell anemia
  • You have liver or kidney disease.


When used in adolescents and young adults, trazodone has a black box warning, as it may induce suicidal thoughts. This side effect is rare, but it's best to have a plan in case it happens. Talk to your doctor about any changes in mood or thinking that you need to be aware of.

Make a list of emergency phone numbers you can call if you think about harming yourself. If you are the parent of a trazodone patient, talk honestly about this option and come up with a family plan together.

Trazodone can cause serotonin syndrome when taken with other antidepressants. This happens when there is too much serotonin in your body. You may experience tremors, diarrhea, fever, seizures, and loss of consciousness. If you notice any of these symptoms while taking trazodone, see your doctor immediately.

If you and your healthcare provider determine that trazodone is not suitable for you, do not stop using it because you may experience withdrawal symptoms. Most likely, your doctor will give you a reduction schedule.

Related Articles
Choosing foods to diet after a heart attack

All cardiovascular specialists agree that a healthy diet is important to reduce the risk of coronary artery disease (CHD) Read more

Different types of hysterectomies.

A hysterectomy is the surgical removal of all or part of a woman's uterus . Hysterectomy is usually done Read more

Esthetician: experience, specialties and training

An esthetician is a person who specializes in cosmetic skin care. Cosmetologists (sometimes called estheticians ) are not medical Read more

Benefits, Side Effects, Dosages, and Interactions.

CBD oil is an extract from Cannabis indica or Cannabis sativa , the same plants that produce marijuana when Read more